Effects of iodine-125 seeds on the methylation of SFRP and P16 in colorectal cancer.

The current study investigated the effects of iodine-125 seeds on the gene methylation of SFRP and P16 in colorectal cancer. Mouse models of human colorectal cancer were randomly divided into an experimental group (n=25) and a control group (n=25). The control group was implanted with blank seeds (0 MBq) and the experimental group with iodine-125 seeds (14.