Publications by authors named "Wangdong Zhu"
The elimination of malaria requires high-quality surveillance data to quickly detect and respond to individual cases. This study aims to analyze the epidemiological characteristics of malaria and ascertain the long-term epidemic trends of malaria by 2020 in Handan China. Case-level data for the period 2011 to 2020 were extracted from Chinese Information System for Disease Control and Prevention.
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- Multiple anti-HER receptor antibodies like cetuximab, trastuzumab, and pertuzumab are common treatments for metastatic cancer, but drug resistance often arises due to HER-MET crosstalk.
- The study developed two new tetra-specific antibodies, FL518 and CRTB6, that target EGFR, HER2, HER3, and VEGF, effectively disrupting HER-MET interactions.
- These new tetra-specific antibodies demonstrated superior efficacy against anti-HER-resistant cancer cells compared to traditional bispecific antibodies, suggesting a novel approach to overcoming drug resistance.
Although the molecular mechanism has not yet been clarified until now, it is very interesting that Alzheimer's disease (AD), hypertension (HTN), and cerebral amyloid angiopathy (CAA) often occur synchronously and possess many similar pathological characteristics. Herein, we hypothesize that a feedback signaling loop, consisted of Pin1, endothelial nitric oxide synthase (eNOS), and amyloid-β (Aβ), may contribute to the interesting pathological phenomenon. First, Pin1 inhibits the production of Aβ, and enhances the activity of eNOS.
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