Multiscale brain age prediction reveals region-specific accelerated brain aging in Parkinson's disease.

Brain biological age, which measures the aging process in the brain using neuroimaging data, has been used to assess advanced brain aging in neurodegenerative diseases, including Parkinson disease (PD). However, assuming that whole brain degeneration is uniform may not be sufficient for assessing the complex neurodegenerative processes in PD. In this study we constructed a multiscale brain age prediction models based on structural MRI of 1240 healthy participants.

COVID-19-Associated Acute Brain Dysfunction Related to Sepsis.

In global term, as of November 30, 2020, over 30 million people has been infected by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more than 10,000,000 of them died of acute organ failure. Our reviews have shown that coronavirus disease 2019 (COVID-19) patients with pneumonia and acute respiratory distress syndrome (ARDS) have life-threatening acute brain dysfunction (ABD), ranging from altered mental status/delirium to stupor/coma. Altered mental status/delirium was the most common manifestation of ABD caused by severe COVID-19.

The time course of acute Percheron artery ischemic coma on imaging: A retrospective cohort study.

We were to investigate the time course of lesions for awakening in acute Percheron artery ischemic coma (PAIC), which was previously unknown. Patients who had newly identified acute PAIC events in 2012-2015 and had not received thrombolytic therapy were enrolled retrospectively. The time course of lesions in PAIC was investigated by diffusion-weighted imaging (DWI).

Acute and episodic vestibular syndromes caused by ischemic stroke: predilection sites and risk factors.

Objective: This study was performed to investigate the predilection sites of acute vestibular syndrome (AVS) and episodic vestibular syndrome (EVS) caused by acute infarcts.

Methods: This retrospective cohort study was performed at a stroke center in a tertiary teaching hospital. We diagnosed patients with AVS/EVS caused by acute ischemic stroke using diffusion-weighted imaging (DWI) and magnetic resonance angiography.

New Silent Cerebral Infarction in Patients with Acute Non-Cerebral Amyloid Angiopathy Intracerebral Hemorrhage as a Predictor of Recurrent Cerebrovascular Events.

BACKGROUND The aim of this study was to investigate the incidence and related risk factors of new silent cerebral infarction in patients with acute non-cerebral amyloid angiopathy (non-CAA) intracerebral hemorrhage (ICH) and to explore clinical cerebrovascular event recurrence within 1 year. MATERIAL AND METHODS This prospective study observed 152 patients with non-CAA ICH diagnosed by computed tomography within 3 days after onset. All patients underwent magnetic resonance imaging on day 14 to identify silent cerebral infarction, and their subsequent clinical cerebrovascular events were followed up regularly within 1 year.

[Clinical outcomes of buttress plating in treating posterior Pilon fractures through modified posteromedial approach].

Objective: To explore clinical outcomes of buttress plating in treating posterior Pilon fracture by amodified posteromedial approach.

Methods: From July 2014 to January 2015, 10 patients with posterior Pilon fracture were respectively analyzed, including 7 females and 3 males, aged from 31 to 54 years old. One patient were type , 3 patients were type IIand 6 patients were type III according to classification of Pilon fracture by YU Guang-rong.

[Study on rapid recognition technique of schistosome susceptibility water body I Animal skin making and effect assessment].

Objective: To develop a bionic animal skin and evaluate its detective effect of cercariae so as to provide a new technique for the monitoring of the schistosome susceptibility water body.

Methods: A bionic animal skin was made with pigskin and the experiments were carried out for evaluating its detective effects of cercariae in laboratory and simulate fields, and at the same time, the sentinel mouse method was used as the control.

Results: In the laboratory, the cercariae were found in 10-, 30-, 60-cercaria subgroups in the bionic animal skin group after 1 and 2 hours, but the cercariae were found only in the 60-cercaria subgroup in the sentinel mouse group.

[Clinical efficacy of locked fibular nail for the treatment of lateral malleolus fractures in elderly patients with diabetes].

Objective: To explore clinical outcome of locked fibular nail in treating lateral malleolus fractures in elderly patients with diabetes.

Methods: From July 2012 to July 2014, clinical data of 22 diabetic patients with lateral malleolus fractures were respectively analyzed, including 15 females and 7 males, aged from 62 to 84 years old with an average of (69.3±13.

[Dynamic simulation analysis of effects of project of ditching for drain on snail control and flood prevention security in Dongting Lake region].

Objective: To evaluate the effects of the project of ditching for drain on snail control and flood prevention security and explore the optimal engineering design plan in Dongting Lake region.

Methods: A retrospective study was performed on the previous studies about the project of ditching for drain. The reference values of project indices were determined.

[Osseous bridge resection for the treatment of adult talocalaneal coalitions without arthritis].

Objective: To analyze clinical outcomes of osseous-bridge resection for the treatment of adult symptomatic talocalcaneal coalitions without arthritis.

Methods: The clinical data of 12 patients (15 feet) with symptomatic talocalcaneal coalitions without arthtitis from January 2013 to June 2016 were respectively analyzed. All cases were secondary talocalcaneal coalition.

[Evaluation on molluscicidal effect of chlorosalicylicamide on Oncomelania hupensis in schistosomiaisis endemic areas of eight provinces in China].

Objective: To evaluate the effects of a novel molluscicide, the salt quinoid-2', 5-dichloro-4'-nitrosalicylanilide from niclosamide (LDS), with 10% wettable powder, in main schistosomiasis epidemic areas of China, including Hunan, Jiangxi, Hubei, Anhui, Jiangsu, Sichuan, Yunnan and Zhejiang Province.

Methods: In the immersion test, 6 effective concentrations of 10% LDS were tested respectively: 0.1, 0.

[Effect of ditching for drain on control of Oncomelania hupensis snail in beaches of Dongting Lake].

Objective: To evaluate the effect of ditching for drain on the control of the breed of Oncomelania hupensis snails in beaches of Dongting Lake.

Methods: From November, 2009 to November, 2012, an 0. hupensis snail infested beach of the Yueyang jail and an O.

[Impact of environmental changes on Oncomelania snail distribution in Dongting Lake beach].

Objective: To study the impact of environmental changes on the distribution and the growth and decline of Oncomelania snails in Dongting Lake beaches after the implementation of Three Gorges Project.

Methods: T-embankment of Junshan District where there was a greater human factor related to the snail spread and a lake beach named Dongkou of Junshan District where there was a less human factor related to the snail spread were selected as study areas. The various ground elevations were measured and the high points were marked with GPS.

Hemorrhagic pure sensory strokes in the thalamus and striatocapsular area: causes, clinical features and long-term outcome.

Background: Although there have been sporadic reports of patients with hemorrhagic pure sensory strokes (HPSS) in the thalamus and striatocapsular areas, the causes, clinical featuring and long-term outcome have not been adequately investigated.

Methods: We recruited 7 consecutive patients without hemiparetic stroke who had HPSS in the thalamic and striatocapsular areas. A CT scan was performed to verify brain imaging patterns, and their causes, clinical featuring and long-term outcome were observed.

[Long-term effects of TCV116 on cardiac function changes after myocardial infarction].

Objective: To investigate the long-term effects of TCV116 (candesartan cilexetil) on cardiac function changes after myocardial infarction.

Methods: Myocardial infarction (MI) was induced by ligation of the left anterior descending coronary artery in rats. One week after the surgical performance,the surviving rats were randomly assigned to the following treatment groups: (1) MI rats with no therapy; (2) MI rats treated with TCV116 2 mg/kg per day; (3) Sham-operated control and (4) Sham-operated rats treated with TCV116 2 mg/kg per day.