The effect of triple-dose-intravenous tranexamic acid on blood loss in patients undergoing total hip arthroplasty without affecting blood coagulopathy: A prospective thromboelastographic analysis.

Objective: This study aimed to assess the safety and efficacy of triple-dose intravenous tranexamic acid (TXA) in patients following total hip arthroplasty (THA) using thromboelastography (TEG).

Methods: One hundred thirty patients undergoing THA were prospectively enrolled in the study. According to the intravenous infusion TXA dose, patients were divided into single-dose (n=65; mean age=60.

Enhancing the biosynthesis of 2-keto-L-gulonic acid through multi-strategy metabolic engineering in Pseudomonas putida KT2440.

2-KGA, a precursor for the synthesis of Vitamin C, is currently produced in China utilizing the "two-step fermentation" technique. Nevertheless, this method exhibits many inherent constraints. This study presents a comprehensive metabolic engineering strategy to establish and optimize a one-step 2-KGA fermentation process from D-sorbitol in Pseudomonas putida KT2440.

Preoperative Prevalence and Risk Factors For Calf Muscular Vein Thrombosis in Elderly Patients with Hip Fracture.

Objective: Increasing evidence has shown that calf muscular vein thrombosis (CMVT) can develop into proximal deep vein thrombosis, even causing pulmonary embolism. However, opinions about the prevalence and risk factors are still controversial. This study aimed to investigate the prevalence and risk factors for CMVT in elderly patients with hip fractures to facilitate their preoperative management.

Role of tumor-associated macrophages in common digestive system malignant tumors.

Many digestive system malignant tumors are characterized by high incidence and mortality rate. Increasing evidence has revealed that the tumor microenvironment (TME) is involved in cancer initiation and tumor progression. Tumor-associated macrophages (TAMs) are a predominant constituent of the TME, and participate in the regulation of various biological behaviors and influence the prognosis of digestive system cancer.

Intraindividual variance of lower limb rotation in patients with bilateral knee osteoarthritis.

Purpose: To determine the side-to-side difference in intraindividual rotation alignment of patients with bilateral varus-type knee osteoarthritis (OA) and compare it with control subjects.

Methods: This retrospective study enrolled 60 patients with bilateral varus-type knee OA and 50 control subjects. All cases underwent bilateral lower limb CT angiography.

What Drives Internet Entrepreneurial Intention to Use Technology Products? An Investigation of Technology Product Imagination Disposition, Social Support, and Motivation.

Technological products such as computer, communication, and consumer electronic products, apps, smart wearables, and streaming services have become inseparable from people's lives. In technological fields of practice, imagination, creativity, innovation, and entrepreneurship may influence one another. A vivid imagination can generate creativity and trigger the entrepreneurial intention to "bring new things to the market.

Tourniquet use in primary total knee arthroplasty is associated with a hypercoagulable status: a prospective thromboelastography trial.

Study Design: Prospective study.

Purpose: The main purpose of this study was to investigate whether the use of a tourniquet changes the blood coagulation state following primary total knee arthroplasty (TKA) by means of conventional coagulation tests and thromboelastography (TEG) analyses.

Methods: A total of 154 patients who underwent primary unilateral TKA from January 2018 to October 2020 were enrolled.

Preparation and Characterization of Nanosized Bi-Doped SnO₂/Reduced Graphene Oxide 3D Hybrids for Visible-Light-Driven Photocatalysis.

The nanosized Bi-doped SnO2/reduced graphene oxide 3D hybrids have been synthesized via one-step hydrothermal method. The structures, morphologies, photocatalytic activities of the as-prepared samples were discussed, respectively. The formation mechanism of the as-prepared hybrids was also proposed.

Tetraspanin 1 is involved in survival, proliferation and carcinogenesis of pancreatic cancer.

Pancreatic cancer (PCC) is one of the most difficult cancers to treat and the 10th leading cause of cancer-related death in worldwide. Studies have demonstrated that the tetraspanin 1 (Tspan1) is overexpressed in various cancers and may be a potential therapeutic strategy for the treatment of different cancers. However, the possible role of Tspan1 in PCC is still unknown.

[Comparison of statics characteristics between anterior transpedicular screws system and vertebral body screws system in lower cervical spine].

Objective: To compare statics characteristics between anterior transpedicular screws (ATPS) system and vertebral body screws (VBS) system in lower cervical spine.

Methods: Sixteen fresh cervical specimens were collected and dissected into 32 different units (functional spinal unit, FSU), 8 units in C3,4, C4,5, C5,6 and C6,7 each. The subjects were randomly divided into group A and B.

Identification of neurons responsible for feeding behavior in the Drosophila brain.

Drosophila melanogaster feeds mainly on rotten fruits, which contain many kinds of sugar. Thus, the sense of sweet taste has evolved to serve as a dominant regulator and driver of feeding behavior. Although several sugar receptors have been described, it remains poorly understood how the sensory input is transformed into an appetitive behavior.

Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro.

Nogo-66 is a 66-amino-acid-residue extracellular domain of Nogo-A, which plays a key role in inhibition neurite outgrowth of central nervous system through binding to the Nogo-66 receptor (NgR) expressed on the neuron. Recent studies have confirmed that NgR is also expressed on the surface of macrophages/microglia in multiple sclerosis, but its biological effects remain unknown. In the present study, our results demonstrated that Nogo-66 triggered microglia anti-adhesion and inhibited their migration in vitro, which was mediated by NgR.

[Influence of pedicle screws with different insertion depth on neighboring uninfused segments in a goat lumbar spinal fusion model].

Objective: To observe the influences of pedicle screws in various insertion depth on the adjacent segment disc degeneration following lumbar spinal fusion. To explore the relationship between the internal fixation rigidity and incidence of adjacent segment disease.

Methods: Sixteen hybrid male Bohr goats of 10 months old, weighting between 25 and 30 kg, were randomly devided into a control group (N group), and 3 experimental groups, each group had 4 goats.

[Biomechanical comparison of three methods of internal fixation for distal femoral fractures].

Objective: To compare the biomechanics of three internal fixations for distal femoral fractures,and to choose suitable clinical internal fixation according to experimental date.

Methods: The fracture models of femoral condydle were made on 12 fresh cadaver femurs (C1 type of AO classification). The fractures were fixed by supracondylar intramedullary interlocking nails (A), L-shaped condyle plates (B) and compressed plates (C) respectively.

[Biomechanical study on transarticular screw and plate fixation syetem in the lower cervical spine].

Objective: To compare the cervical stabilities of transarticular screw fixation alone, and transarticular screw and plate fixation system.

Methods: Twelve specimens of cervical vertebra containing C2-T1 were obtained from human cadaver. The three-column instability model was made at C4.

[Biomechanical research in treating unstable Pilon fracture with anatomic plate of distal tibia].

Objective: To investigate the mechanical characteristics of new anatomic plate of distal tibia from view of biomechanics.

Methods: Twelve fresh adult moist ankle specimens were randomly divided into four block groups (every group had 3 specimens), 3 tibial specimens as a normal control (normal group N), 9 specimens were resulted in unstable distal tibial Pilon fracture. Using steel plate fixation with a new anatomic distal tibial plate (group A), reconstruction plate (group B), clover plate (group C).

[Influence of the fusion of bone graft in spine of rabbit treated with lower intensity ultrasound].

Objective: To observe the influence of the fusion of bone graft in spine of rabbits which were treated with lower intensity ultrasound.

Methods: Forty 12-month-old rabbits were made to be the models of bone graft in post-lateral between two homonymy processus transverses in lumbar, and divided into treatment group (B) and control group (A) randomly. Twenty rabbits of treatment group were treated with lower intensity ultrasound, killed after six weeks, and took radiological examination, measured indexs of biomechanics.

[Stress test and clinical application of the minimal-invasive dynamic hip screw].

Objective: To recognize the effect of minimal-invasive dynamic hip screw (MIDHS) on the treatment of intertrochanteric fracture of the hip by biomechanical test and preliminary clinical application.

Methods: Ten artifical made intertrochanteric fractures of femoral specimen from five cadavers were divided into two groups randomly. The fractures in first group were fixed by MIDHS and other group were fixed by dynamic hip (DHS).

[A biomechanical evaluation of the sacroiliac anatomy type bar-plate internal fixation system].

Objective: To evaluate the biomechanical personality of the sacroiliac anatomy type Bar-plate system (SABP), which was of fixation usage to the fracture or dislocation of the sacroliliac joint.

Methods: Twenty fresh and freeze cadaver pelvises were prepared with pelvic fracture model,compared with different internal fixation systems such as Galveston technique, transiliac rod fixation, reconstruction plate and sacroiliac joint screws using experimental stress analysis methods,and then the stability of the pelvic was obtained and evaluated.

Results: Using new SABP system to treat pelvic sacroiliac joint fracture and dislocation was higher 10%, 11%, 16%, 21% in the strength; more 12%, 14%, 21%, 31% in rigidity; less 13%, 14%, 22%, 25% in straining;less 10%, 12%, 16%, 20% in shifting than the Galveston technique, transiliac rod fixation, reconstruction plate and sacroiliac joint screws, with remarkable statistic difference (P < 0.

[Biomechanical study of new type two-head automatic pressure external fixator (TAPEF) for the treatment of intertrochanteric fracture].

Objective: To investigate the mechanical characteristics of new type two-head automatic pressure external fixator in the view of biomechanics.

Methods: Fifteen fresh and humid specimens were selected and divided into experimental group (5 cases) and control group (10 cases). The control group were respectively applied with DHS (5 cases) and traditional external fixator (5 cases).

Study of the morphology and biomechanics of sacral fracture.

Objective: To observe the morphological characteristics of sacral fracture under different impact loads.

Method: Ten fresh pelvic specimens were loaded in dynamic or static state. A series of mechanical parameters including the pressure strain and velocity were recorded.

Effect of autocontrol micromotion intramedullary interlocking nail on fracture healing: an experimental study.

Objective: To investigate the effect of autocontrol micromotion locking nail (AMLN) on experimental fracture healing and its mechanism.

Methods: 16 goats undergoing both sides of transverse osteotomy of the femoral shafts were fixed intramedullary with AMLN and Gross-Kempf (GK) nail, respectively. The follow-up time was 7, 14, 28 and 56 days.