Publications by authors named "Wang-Yang Chen"
Article Synopsis
- This study investigates the effects of Panax notoginseng saponins (PNS) on diabetic kidney disease (DKD) using network pharmacology, molecular docking, and animal experiments.
- Key targets identified for PNS include AKT1, STAT3, and others, with relevant pathways related to cancer and signaling highlighted in the analysis.
- Animal trials showed that PNS significantly lowered blood glucose levels and improved kidney damage in diabetic mice, indicating its potential therapeutic effect on DKD.
Background: Intellectual disability (ID) is a heterogeneous neurodevelopmental disorder with a complex genetic underpinning in its etiology. Chromosome microarray (CMA) is recommended as the first-tier diagnostic test for ID due to high detection rate of copy number variation (CNV).
Methods: To identify an appropriate clinical detection scheme for ID in Han Chinese patients, whole genome low-coverage sequencing was performed as the first-tier diagnostic test, and medical exome sequencing (MES) as the second-tier diagnostic test for patients with negative results of CNVs.
Polycomb group (PcG) complexes modify histones to silence tumor suppressor genes, which exhibit an important function in tumorigenesis and progression. The chromobox (Cbx) protein family is a critical component of PcG-mediated repression. Cbx2, a member of the Cbx protein family, is hypothesized to exhibit a vital role in breast cancer.
View Article and Find Full Text PDFCirculating microRNAs (miRNAs) were recognized to be potential non-invasive biomarkers for colorectal cancer (CRC) detection and prediction. Meanwhile, the association of the expression of plasma miRNAs with the risk of CRC patients has rarely been analyzed. Therefore, we conducted this study to evaluate the value of plasma miRNAs for CRC diagnosis and risk estimation.
View Article and Find Full Text PDFContext: Numerous observational epidemiologic studies have evaluated the association between physical activity and prostate cancer (PCa); however, the existing results are inconsistent.
Objective: To determine the association between physical activity and risk of PCa.
Evidence Acquisition: A systematic search was performed using the Medline, Embase, and Web of Science databases through 15 May 2011 to identify all English-language articles that examined the effect of physical activity on the risk of PCa.