Synthesis of Terminal Vinylindoles via Rh -Catalyzed Direct C-H Alkenylation with Potassium Vinyltrifluoroborate.

An efficient Rh -catalyzed direct C2-alkenylation of indoles using readily available potassium vinyltrifluoroborate under mild conditions has been developed. This protocol features wide substrate scope and excellent functional group compatibility, enabling a facile access to diverse terminal vinylindoles in moderate to good yields. Furthermore, the C2-alkenylated indole can be easily transformed into 9H-carbazole through a ring-closing metathesis/aromatization cascade.

[Differential diagnosis of benign and malignant solitary pulmonary nodule with computer-aided detection].

Objective: To investigate the morphological features of benign and malignant solitary pulmonary nodules (SPNs) and explore the radiological evidences for the differentiation of SPNs.

Methods: With SPN Dicom View software, we analyzed and compared images obtained from 23 patients with malignant SPNs and 22 patients with benign SPNs who received CT scanning with or without contrast medium injection.

Results: The enhancement in malignant SPNs group was significantly higher than in the benign SPNs group (P < 0.