Yu-Shiba-Rusinov states assisted by asymmetric Coulomb repulsion in a bipartite molecular device.

Interfacing magnetism with superconducting condensates are promising candidates holding Majorana bound states with which fault-tolerant quantum computation could be implemented. Within this field, understanding the detailed dynamics is important both for fundamental reasons and for the development of innovative quantum technologies. Herein, motivated by a molecular magnet TbPcinteracting with a superconducting Pb(111) substrate, which results in spin-orbital Yu-Shiba-Rusinov (YSR) states, as is affirmed by a theoretical simulation with the aid of the numerical renormalization group technique (see Xia20226388), we study the YSR states and quantum phase transitions (QPTs) in a bipartite molecular device adsorbed on ans-wave superconducting substrate.

Topographic Differences in Superficial Macular Vessel Density in Eyes with Early Primary Open-Angle Glaucoma and Normal Tension Glaucoma.

Introduction: The aim of the study was to compare macular vascular microcirculation in early primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), and normal subjects.

Methods: 99 patients with early glaucoma (99 eyes: 60 POAG and 39 NTG) and 78 normal subjects were included. All subjects underwent optical coherence tomography angiography scan at 6 × 6 mm macular area.

Prognostic value of polymorphism rs2352028 and clinical characteristics in Chinese lung cancer patients.

rs2352028 is associated with the risk of lung cancer, but its relationship with lung cancer prognosis is unclear. The authors collected blood samples from 888 patients with lung cancer and used a Cox proportional hazards model to analyze the association between prognosis and  polymorphism rs2352028. rs2352028 C > T was associated with a better prognosis.

Phase transitions induced by exchange coupling, magnetic field, and temperature in a strongly correlated molecular trimer with a triangular topology.

Regulating the physical properties such as the quantum phase and the Kondo effect of molecular electronic devices near critical points may play a key role in increasing the robustness of quantum memory, which is a crucial component in quantum information processing. Molecules with a triangular topology are ideal prototypes to reveal the competition among magnetic frustration, Kondo screening, and local inter-molecule exchange interactions. Herein, motivated by a recent work investigating the single-electron tunneling through a redox-active edge-fused porphyrin trimer by using a Hubbard dimer model [J.

Correlation anisotropy driven Kosterlitz-Thouless-type quantum phase transition in a Kondo simulator.

The precise manipulation of the quantum states of individual atoms/molecules adsorbed on metal surfaces is one of the most exciting frontiers in nanophysics, enabling us to realize novel single molecular logic devices and quantum information processing. Herein, by modeling an iron phthalocyanine molecule adsorbed on the Au(111) surface with a two-impurity Anderson model, we demonstrate that the quantum states of such a system could be adjusted by the uniaxial magnetic anisotropy . For negative , the ground state is dominated by a parallel configuration of the component of local spins, whereas it turns to be an antiparallel one when becomes positive.

Prediction of lung cancer risk in Chinese population with genetic-environment factor using extreme gradient boosting.

Background: Detecting early-stage lung cancer is critical to reduce the lung cancer mortality rate; however, existing models based on germline variants perform poorly, and new models are needed. This study aimed to use extreme gradient boosting to develop a predictive model for the early diagnosis of lung cancer in a multicenter case-control study.

Materials And Methods: A total of 974 cases and 1005 controls in Shanghai and Taizhou were recruited, and 61 single nucleotide polymorphisms (SNPs) were genotyped.

Trapping integrated molecular devices local transport circulation.

Interactions between quantum systems and their environments may always result in inevitable decoherence. Isolation of the quantum system from the undesired environmental noise is a great challenge for ideal quantum information processing. Herein, based on a parallelly shaped control-target molecular nanomagnet structure, we report a novel strategy which decouples the target molecular device from its surrounding conduction baths.

Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness, Functional Subzones, and Macular Ganglion Cell-Inner Plexiform Layer in Differentiating Patients With Mild, Moderate, and Severe Open-angle Glaucoma.

Unlabelled: PRéCIS:: Based on 6 functional subzones of peripapillary retinal nerve fiber layer (pRNFL) thickness, the glaucoma detection ability of zone 2 and zone 4 was high and comparable with that of mean pRNFL in glaucoma groups.

Purpose: To compare diagnostic performance of pRNFL subzones, mean pRNFL thickness, and macular ganglion cell-inner plexiform layer (mGCIPL) in mild, moderate, and severe open-angle glaucoma.

Materials And Methods: One hundred eighty-one patients with open-angle glaucoma (318 eyes: 122 mild, 60 moderate, and 136 severe glaucoma) and 70 normal subjects underwent spectral-domain optical coherence tomography measurements.

Repeatability and agreement of two anterior segment OCT in myopic patients before implantable collamer lenses implantation.

Aim: To evaluate the intra-operator repeatability of time domain and swept-source Fourier domain anterior segment optical coherence tomography (AS-OCT), namely, Visante AS-OCT and Casia SS-1000 OCT, in measuring the preoperative parameters of implantable collamer lens (ICL) in myopic eyes, as well as the agreement between the two devices.

Methods: A total of 97 eyes from 49 myopes were investigated in this prospective case series study. The anterior chamber depth (ACD), angle-to-angle distance (ATA), pupil diameter (PD) and crystalline lens rise (CLR) in all subjects were measured for three times during one session by the same operator.

Synchronously voltage-manipulable spin reversing and selecting assisted by exchange coupling in a monomeric dimer with magnetic interface.

The use of the molecular spin state as a quantum of next-generation information technology is receiving impressive research attention, within which the fundamental issues include manipulating the phase transition between the spin-up and -down states and generating spin polarized current. The spinterface between ferromagnetic electrodes and a molecular bridge represents one of the most intriguing elements in this context. Herein, by means of the celebrated numerical renormalization group technique, we present an original way to realize spin reversal in a monomeric dimer.

Emergent electronically-controllable local-field-inducer based on a molecular break-junction with magnetic radical.

Molecular spintronics devices are receiving extensive research attention, due to their potential applications as the smallest memory and logic elements. A most fundamental issue in this field lies in generating spin polarized currents. In this communication, with the aid of the celebrated Wilson's numerical renormalization group (NRG) method, we propose theoretically a novel strategy to induce a local magnetic field that only affects the strongly correlated molecule under consideration, and could easily be manipulated through purely electronic technologies.

Bidirectional spin filter in a triple orbital molecule junction by tuning the magnetic field along a single direction.

Metal-molecule-metal junction is considered the basing block and key element of molecular spintronic devices, within which to generate spin polarized currents is one of the most fundamental issues for quantum computation and quantum information. In this paper, by employing a parallel triple orbital molecule junction with large inter-orbital tunneling couplings, we propose theoretically a bidirectional spin filter where both spin-up and spin-down currents could be obtained by simply adjusting the external magnetic field to different regimes along a single direction, and the filtered efficiencies could reach almost 100%. The Zeeman effect and the occupancy switching for the bonding and anti-bonding states are found to be responsible for the spin selective transport.

Diagnostic ability of ganglion cell complex thickness to detect glaucoma in high myopia eyes by Fourier domain optical coherence tomography.

Aim: To evaluate the ability of macular ganglion cell complex (GCC) thickness using Fourier domain optical coherence tomography (FD-OCT) to detect glaucoma in highly myopic eyes.

Methods: Cross-sectional study. A total of 114 participants, consecutively were enrolled.

Creeping motion of self interstitial atom clusters in tungsten.

The formation and motion features of self interstitial atom (SIA) clusters in tungsten are studied by molecular dynamics (MD) simulations. The static calculations show that the SIA clusters are stable with binding energy over 2 eV. The SIA clusters exhibit a fast one dimensional (1D) motion along 〈111〉.

Diagnostic accuracy of anti-alpha-fodrin antibodies for primary Sjögren's syndrome.

Objectives: To estimate the diagnostic accuracy of anti-alpha-fodrin antibodies for primary Sjögren's syndrome (pSS).

Methods: Sixty-four pSS subjects and 108 non-pSS patients were prospectively enrolled in this study. Serum anti-alpha-fodrin IgA and IgG were detected by ELISA in a blind fashion.

Adsorption configurations and scanning voltage determined STM images of small hydrogen clusters on bilayer graphene.

By density functional theory calculations, the scanning tunneling microscopy (STM) images of various hydrogen clusters adsorbed on bilayer-graphene are systematically simulated. The hydrogen configurations of the STM images observed in the experiments have been thoroughly figured out. In particular, two kinds of hydrogen dimers (ortho-dimer, para-dimer) and two kinds of tetramers (tetramer-A, -B) are determined to be the hydrogen configurations corresponding to the ellipsoidal-like STM images with different structures and sizes.

Axonal loss and blood flow disturbances in the natural course of indirect traumatic optic neuropathy.

Background: Indirect traumatic optic neuropathy (TON) is an acute injury of the optic nerve associated with severe visual dysfunction, which may be a result of secondary mechanical injury and vascular disorder of the optic nerve due to trauma. We analyzed the natural course of axonal loss and blood flow disturbances in patients with indirect TON to find a possible therapeutic window.

Methods: A cohort of 54 patients with indirect TON recruited between October 2008 and October 2010 at Beijing Tongren Hospital was retrospectively analyzed.

Efficacy of laser peripheral iridoplasty and iridotomy on medically refractory patients with acute primary angle closure: a three year outcome.

Background: Argon laser peripheral iridoplasty (ALPI) is proved to be effective in lowering intraocular pressure (IOP) of patients with mild acute primary angle closure (APAC). It is unclear whether this laser treatment is equally efficient in managing patients with severe APAC. This study aimed to evaluate the IOP-lowering efficacy of ALPI and laser peripheral iridotomy (LPI) on patients with refractory APAC, who have previously responded poorly to intensive medical therapy.

Triamcinolone intravitreal injection and intraocular pressure in macular edema associated with retinal vein occlusion.

Purpose: To study the risk factors of increased intraocular pressure (IOP) response to triamcinolone acetonide intravitreal (IVTA) injection in eyes with macular edema associated with retinal vein occlusion.

Methods: Eighty-nine eyes with macular edema associated with retinal vein occlusion first received periocular injection of 40 mg triamcinolone acetonide (TA) and were followed for one month. According to the diversity of IOP after periocular TA (PTA) injection, they were divided into the elevation IOP group (group A, 26 eyes) and the normal IOP group (group B, 63 eyes).

[MicroRNA profiling in T cells of peripheral blood mononuclear cell from patients with primary biliary cirrhosis].

Objective: To explore the expression pattern of microRNA (miRNA) in T cells of peripheral blood mononuclear cell (PBMC) from patients with primary biliary cirrhosis (PBC).

Methods: The expression profile of miRNA in T cells of PBMC was determined by microarray assay and validated by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR).

Results: In comparison with the healthy controls, 23 miRNA were down-regulated and 2 miRNA had a higher expression (all P < 0.

[Clinical analysis of long term safety after implantation of iris-fixed phakic intraocular lens Verisyse].

Objective: To analyze the long-term safety of implantation of iris-fixed phakic intraocular lens (IOL) Verisyse for the treatment of high myopia.

Methods: One hundred and eighteen eyes of 59 cases implanted Verisyse for high myopia in Eye Center of Tongren Hospital from Jan. 2005 to Jan.

Enhanced expression of proneurotrophins in elevated introcular pressure-induced rat retinal ischemia.

Background: Proneurotrophins such as the precursor of nerve growth factor (proNGF) and the precursor of brain-derived neurotrophic factor (proBDNF) interacted with sortilin and p75(NTR) to form a complex capable of activating an apoptotic signaling. We found that the expression of p75(NTR) and sortilin was increased in ischemic retina induced by elevated intraocular pressure (IOP), but the protein expression changes of proNGF and proBDNF in the same situation were not clear. This study aimed to ascertain the protein expression changes of proNGF and proBDNF in ischemic retina induced by elevated IOP.

Modulation of the thermodynamic, kinetic, and magnetic properties of the hydrogen monomer on graphene by charge doping.

The thermodynamic, kinetic, and magnetic properties of the hydrogen monomer on doped graphene layers were studied by ab initio simulations. Electron doping heightens the diffusion potential barrier, while hole doping lowers it. However, both kinds of dopings heighten the desorption potential barrier.

Time course degeneration and expression of glial fibrillary acidic protein in mer-knockout mice.

Background: Müller cells in the mammalian retina normally express low levels of glial fibrillary acidic protein (GFAP); however, its expression is upregulated in response to the loss of retinal neurons. The change in expression of GFAP is one of the earliest indicators of retinal damage and is correlated with the time course of disease. The aim of this study was to investigate the time course of degeneration and the expression of GFAP in the retina of mer knockout mice.