Publications by authors named "Wang-Dui BaSang"
Dynamics of apoptosis-related gene expression during follicular development in yak.
J Anim Physiol Anim Nutr (Berl)
November 2021
The potential reproduction power of domestic animals is limited by a complicated follicular atresia process. P53, caspase-9 (Casp9), Bax, Bcl-2 and Fas play a crucial role in the ovarian mitochondrion-dependent apoptosis and death receptor pathway. In accordance with this study, the expression levels of Casp9, Bax, Bcl-2 and Fas were analysed in ovaries and oviducts of yak by immunohistochemistry (IHC).
View Article and Find Full Text PDFDroughtmaster is a tropical breed of beef cattle that can survive in hot climates and easily adapt to torrid environments. These traits are important in livestock breeding. In this study, we genotyped five single-nucleotide polymorphisms (SNPs) of the gene from 190 cattle belonging to three different breeds (Droughtmaster, Angus and Simmental) by using snapshot technology.
View Article and Find Full Text PDFMajor histocompatibility complex (MHC) genes are critical for disease resistance or susceptibility responsible for host-pathogen interactions determined mainly by extensive polymorphisms in the MHC genes. Here, we examined the diversity and phylogenetic pattern of MHC haplotypes reconstructed using three MHC-linked microsatellite markers in 55 populations of five Bovidae species and compared them with those based on neutral autosomal microsatellite markers (NAMs). Three-hundred-and-forty MHC haplotypes were identified in 1453 Bovidae individuals, suggesting significantly higher polymorphism and heterozygosity compared with those based on NAMs.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzes the genome of domestic yaks from the Qinghai-Tibet Plateau to understand their adaptation to high-altitude environments through selective sweep analysis of copy number variations (CNVs).
- Researchers identified 531 CNVs using genome data from 29 yaks, with most located in crucial genomic regions that may influence high-altitude adaptation.
- Seven candidate CNVs linked to significant genes were found, which are involved in key signaling pathways related to the physiological adjustments of yaks living in hypoxic conditions.
This study aims to identify the relative Copy number variation (CNV) associated with the litter size of Dazu black goats based on the unpublished CNV analytical results of our previously published sequencing data, in which the litter-size groups were classified into extreme low- and high-yield groups. Firstly, to compare the existence of valuable CNV in Dazu black goats with different fertility levels with mixed pools. We obtained 4992 and 4888 CNVs from the HY and LY, which overlapping 1461 genes, and classified on the original CNV type.
View Article and Find Full Text PDFArticle Synopsis
- * A genome-wide selective sweep analysis of 31 Dazu black goats identified 33,917,703 genetic variants, including SNPs and indels, revealing two novel candidate genes associated with litter size.
- * These candidate genes were linked to various biological processes and displayed different patterns of linkage disequilibrium in high-yield versus low-yield goats, highlighting the complex factors influencing litter size variability in domestic animals.
Article Synopsis
- The domestic yak is a key animal for farming on the Qinghai-Tibet Plateau, having adapted over time to its high-altitude environment.
- A study used next-gen sequencing to analyze the genetic adaptations of yaks to different altitudes, identifying over 15 million SNPs and recognizing 21 candidate genes through selective sweep analysis.
- The identified genes may shed light on how yaks have evolved to survive at high altitudes, supporting theories about their ecological adaptability and providing insights into molecular mechanisms involved in altitude adaptation.