Treatment and surveillance for non-muscle-invasive bladder cancer: a clinical practice guideline (2021 edition).

Non-muscle invasive bladder cancer (NMIBC) is a major type of bladder cancer with a high incidence worldwide, resulting in a great disease burden. Treatment and surveillance are the most important part of NIMBC management. In 2018, we issued "Treatment and surveillance for non-muscle-invasive bladder cancer in China: an evidence-based clinical practice guideline".

Improvement in NO Gas Sensing Properties of Semiconductor-Type Sensors by Loading Pt into BiVO Nanocomposites at Room Temperature.

In the present study, we report the first attempt to prepare a conducive environment for Pt/BiVO nanocomposite material reusability for the promotion of sustainable development. Here, the Pt/BiVO nanocomposite was prepared using a hydrothermal method with various weight percentages of platinum for use in NO gas sensors. The surface morphologies and structure of the Pt/BiVO nanocomposite were characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD).

Conductive Polymer (Graphene/PPy)-BiPO Composite Applications in Humidity Sensors.

In this particular experiment, a chain of conductive polymer graphene/polypyrrole (Gr/PPy) and BiPO-or (Gr/PPy)-BiPO-materials were prepared and used as moisture-sensitive materials. The structure and morphology of the conductive polymer (Gr/PPy)-BiPO materials were analyzed using an X-ray diffractometer, scanning electron microscopy, transmission electron microscopy, and energy-dispersive X-ray spectroscopy. Moreover, properties such as hysteresis loop, impedance, sensing response, and response and recovery time were calculated and evaluated using an inductance-capacitance-resistance analyzer.

Gr/3D-ZnO Nanocomposites as Humidity Sensors with Enhanced Sensing Response.

This work introduces a novel humidity sensor based on a nanocomposite material comprising graphene decorated with three-dimensional flower-like structures of zinc oxide (Gr/3D-ZnO) fabricated via a hydrothermal method with various weight percentages of graphene. The surface structure and morphology of the Gr/3D-ZnO nanocomposite were analyzed using XRD, EDS, SEM, TEM, and Raman spectroscopy. The influence of humidity on the electrical properties of the nanocomposite was also investigated.

Evaluation Humidity Sensing Properties of Graphene/HS-TiO₂ Nanocomposites.

This paper reports on a nanocomposite synthesized by sol-gel procedure comprising graphene sheets with hollow spheres of titanium dioxide (G/HS-TiO₂) with varying weight percentages of graphene for the purpose of humidity sensors. The surface morphology of the nanocomposite was characterized using transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDX). The structural properties were examined using X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR).

Actein inhibits glioma growth via a mitochondria-mediated pathway.

Previous studies indicate that the triterpene glycoside Actein from the herb black cohosh inhibits growth of human breast cancer cells. This study sought to investigate the effects of Actein on glioma cell growth and explore the potential mechanisms. Our results showed that administration of Actein significantly inhibited glioma cell viability in a dose- and time-dependent manner.

Antioxidant and antimicrobial activities of commercial rice wine extracts of Taiwanese Allium fistulosum.

The antioxidant and antibacterial activities of commercial rice wine extracts obtained from different plant parts of Allium fistulosum were assayed. The results showed that commercial rice wine extracts of A. fistulosum contained 28.

YAP is closely correlated with castration-resistant prostate cancer, and downregulation of YAP reduces proliferation and induces apoptosis of PC-3 cells.

Yes-associated protein 65 (YAP65) has been implicated as an oncogene, and its expression is increased in human cancer. Previous studies have demonstrated that alterations in YAP activity may result in tumourigenesis of the prostate. With androgen deprivation therapies becoming progressively ineffective, often leading to life‑threatening androgen‑resistant prostate cancer (CRPC).

Methylation‑associated inactivation of LATS1 and its effect on demethylation or overexpression on YAP and cell biological function in human renal cell carcinoma.

Large tumor suppressor 1 (LATS1) gene is one of the key factors in Hippo signaling pathway. Inactivation of LATS1 by promoter methylation was found in colorectal cancer (CRC), head and neck squamous cell carcinoma (HNSCC), astrocytoma, breast cancer and it was proved to be a tumor suppressor. However, its role is unclear in renal cell carcinoma (RCC).

YAP is overexpressed in clear cell renal cell carcinoma and its knockdown reduces cell proliferation and induces cell cycle arrest and apoptosis.

Yes-associated protein (YAP) has been reported to be an oncogene in a number of malignancies. It constitutes an important regulatory mechanism for the Hippo pathway, a key regulator of cell growth and apoptosis. The present study aimed to investigate the clinical significance and the role of YAP in the development of clear cell renal cell carcinoma (ccRCC).

Discordance and clinical significance of ER, PR, and HER2 status between primary breast cancer and synchronous axillary lymph node metastasis.

Discordance of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status between primary breast cancer, metastatic lesion and synchronous axillary lymph node metastasis has been reported in the series studies. Systemic treatment of primary invasive breast cancer patients with synchronous axillary metastasis is currently based on the biomarker characteristics of the primary tumor; however, hormone receptors and HER2 status may change throughout tumor progression from the primary tumor to the synchronous axillary metastasis. As local metastasis, the synchronous axillary lymph node metastasis may represent the potentially metastatic breast cancer cells much better than the primary tumor.

A detector of an invisible carpet cloaking structure.

Based on transformation optics, we propose a device to detect the presence of a carpet cloaking structure at near field. By using complementary media, the detective device can optically cancel a certain volume of reflective metal and reveal the hidden medium inside the metal. The detective performance of this device is confirmed by full-wave finite-element simulations.

Isolation and enrichment of PC-3 prostate cancer stem-like cells using MACS and serum-free medium.

Prostate cancer stem-like cells (PCSLCs) are considered to be the 'seed' of prostate cancer. The aim of this study was to confirm that the PC-3 cells, which we isolated and enriched from PC-3 cells through magnetic bead cell sorting (MACS) and serum-free medium (SFM) culture, were PCSLCs. Combinations of MACS, flow cytometry (FCM), SFM and immunocytochemistry (ICC) were used to ensure the positive expression of CD133 and CD44 on PC-3 and sphere-forming cell membranes.

Integrin-linked kinase functions as a tumor promoter in bladder transitional cell carcinoma.

The aim of this study was to elucidate the role of the integrin-linked kinase (ILK) gene in development of human bladder transitional cell carcinoma (BTCC). Expression of ILK protein and ILK mRNA in 56 cases of human BTCC tissue and in 30 cases of adjacent normal bladder tissue was detected by immunohistochemistry S-P and reverse transcription polymerase chain reaction (RT-PCR), respectively. Four specific miRNA RNAi vectors targeting human ILK were synthesized and transfected into BIU-87 cells by liposome to obtain stable expression cell strains.

Watching outside while under a carpet cloak of invisibility.

We demonstrate in this work a unique approach for watching outside while hiding in a carpet cloaking based on transformation optics. Unlike conventional carpet cloaking, which screens all the incident electromagnetic waves, we break the cloak and allow incident light get into the carpet. Hence outside information is detected inside the cloak.

[Design and application of adjustable triangle external fixator for the treatment of calcaneal fractures].

Objective: To design a kind of adjustable triangle external fixator, and to use it for treating calcaneal fractures.

Methods: The external fixator was installed into extremity near the both sides of three Kirschner wires crossing the calcaneal tubercle, the lower end of the tibia and the first cuneiform. The support rod length was adjusted to ensure the Kirschner wires affecting the calcaneal tubercle, so the Böhler angle and anteroposterior diameter of the calcaneus were recovered.