Development and validation of a real-time prediction model for acute kidney injury in hospitalized patients.

Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no prediction model targeting AKI among general hospitalized patients in developing countries has been published. Here we show a simple, real-time, interpretable AKI prediction model for general hospitalized patients developed from a large tertiary hospital in China, which has been validated across five independent, geographically distinct, different tiered hospitals.

Perspectives on photodynamic therapy combined with immunotherapy in treatment of colorectal cancer: an overview based on experimental studies.

Colorectal cancer (CRC) is one of the major cancers threatening human health, with high mortality, tumor drug resistance and metastasis, considered to be one of the most difficult diseases to treat. Due to its advantages of non-invasive, strongly targeted and limit side effects, Photodynamic therapy (PDT) has become a promising primary treatment for CRC. Remarkably, PDT has been shown to activate T cell-adaptive immune response and induce immunogenic cell death (ICD).

Novel inhibition of sortase A by plantamajoside: implications for controlling multidrug-resistant infections.

In confronting the significant challenge posed by multidrug-resistant (MDR) pathogens, particularly methicillin-resistant (MRSA), the development of innovative anti-infective strategies is essential. Our research focuses on sortase A (SrtA), a vital enzyme for anchoring surface proteins in . We discovered that plantamajoside (PMS), a phenylpropanoid glycoside extracted from .

Risk Factors for Wound Complications After Obstetric Anal Sphincter Injury.

Importance: Wound complications after obstetric anal sphincter injury (OASI) can amplify morbidity and affect quality of life.

Objective: The objective of this study was to evaluate for characteristics associated with wound complications after OASI.

Study Design: This was a retrospective cohort study of patients with an OASI who were evaluated in a postpartum pelvic floor healing clinic between November 1, 2020, and May 16, 2023.

Folic Acid-Modified Milk Exosomes Delivering c-Kit siRNA Overcome EGFR-TKIs Resistance in Lung Cancer by Suppressing mTOR Signaling and Stemness.

The EGFR-TKIs (epidermal growth factor receptor-tyrosine kinases inhibitors) offer significant benefits to lung cancer patients with sensitive EGFR mutations; however, the development of acquired resistance poses a significant challenge and leads to poor prognosis. Thus, exploring novel therapeutic strategies to overcome EGFR-TKI resistance is urgently needed. This study introduces an innovative approach utilizing folic acid-modified milk exosomes loaded with c-kit siRNA (FA-mExo-siRNA-c-kit) to target EGFR-TKI resistance in lung cancer.

Health-related quality of life profiles in patients with rheumatoid arthritis: a latent profile analysis.

Background: Rheumatoid arthritis (RA) is a common rheumatic disease that most commonly affects joints and negatively impacts individuals' health-related quality of life (HRQoL). Although some studies have explored HRQoL of RA patients, existing studies treated RA patients as a homogeneous group based on their overall HRQoL and ignore the heterogeneity of patients' HRQoL patterns. This study aimed to identify subgroups of RA patients based on their HRQoL and variables associated with group membership.

Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species.

Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies have focused on the metabolomic differences among the Angelica species.

Natural Degradation Behavior of Poly(lactic acid) Nanocomposite Films and the Adsorption Behavior of Degraded Products on Cu(II).

In this study, the degradation behavior of poly(lactic acid) nanocomposite films (PLA/Hec-g@PS) under extreme natural environments was investigated, and the degraded PLA based films were applied to adsorb Cu(II). During the early and midstages of degradation, the surface roughness and crack propagation rate of PLA/Hec-g@PS films were significantly lower than those of PLA films. This could be due to the fact that Hec-g@PS enhanced the interaction forces between C-O-C + CH and C═O in the PLA chains, thereby mitigating the degradation of PLA.

[Risk Factors of Primary Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Myeloid Malignancies].

Objective: To analyze the risk factors of primary poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with myeloid malignancies and the impact of primary PGF on survival.

Methods: The clinical data of 146 patients with myeloid malignancies who underwent allo-HSCT in our hospital from January 2015 to December 2021 were retrospectively studied. Some relevant clinical parameters which may affect the development of primary PGF after allo-HSCT were selected for univariate and multivariate analysis, as well as performed survival analysis.

Exploring the Prognostic Role of Red Blood Cell Distribution Width in Aortic Valve Calcification Evaluations via Multi-Slice Computed Tomography.

Background: Previous reports have indicated an association between red blood cell distribution width (RDW) and cardiovascular disease. However, few relevant studies exist on the relationship between RDW and aortic valve calcification (AVC). Explore the correlation and predictive value of RDW concerning the occurrence and severity of aortic valve calcification.

Vascular dysfunction in Hutchinson-Gilford progeria syndrome.

Most patients with Hutchinson-Gilford progeria syndrome (HGPS) succumb to cardiovascular disease. Recent studies by Barettino et al., Cardoso et al.

Prevalence of lumbar disc herniation and its associated factors: A cross-sectional study in Gansu.

Background And Objective: The prevalence rate of LDH and its influencing factors in Gansu is unclear. This study aims to analyze the prevalence of LDH and influencing factors in Gansu.

Methods: A stratified multi-stage random sampling method was used to obtain representative samples of residents more than 18 years old from <1500m, 1500-3500m, and >3500m altitude sites in Gansu, China, in June 2022 to August 2022.

Mortality prediction of inpatients with NSTEMI in a premier hospital in China based on stacking model.

Background: Acute myocardial infarction (AMI) remains a leading cause of hospitalization and death in China. Accurate mortality prediction of inpatient is crucial for clinical decision-making of non-ST-segment elevation myocardial infarction (NSTEMI) patients.

Methods: In this study, a total of 3061 patients between January 1, 2017 and December 31, 2022 diagnosed with NSTEMI were enrolled in this study.

Identification of a gene score related to antigen processing and presentation machinery for predicting prognosis in head and neck squamous cell carcinoma and its potential implications for immunotherapy.

Background: Despite its crucial role in immune surveillance and cell survival of tumors, the significance of MHC antigen processing and presentation machinery (APM) is still not fully understood in head and neck squamous cell carcinoma (HNSCC). We sought to develop an APM gene score (APMGS) to predict prognosis and reveal the molecular and immune traits of the APMGS-defined subgroups in HNSCC.

Methods: Based on the APM-related genes acquired from 6 databases, 117 combined machine learning algorithms were applied to develop APMGS with The Cancer Genome Atlas (TCGA)-HNSCC database and validated with the Gene Expression Omnibus (GEO) dataset.

Lower Child Opportunity Index is Associated with Lower Exercise Capacity Post-Fontan Palliation.

The Child Opportunity Index (COI) is a validated measurement that uses a composite index of 29 indicators of social determinants of health linked to the US Census. Patients post-Fontan palliation for single ventricle physiology often have reduced exercise capacity compared to the general population. Our hypothesis is that COI levels are directly associated with exercise capacity and inversely with late outcomes.

Research on adverse event classification algorithm of da Vinci surgical robot based on Bert-BiLSTM model.

This study aims to enhance the classification accuracy of adverse events associated with the da Vinci surgical robot through advanced natural language processing techniques, thereby ensuring medical device safety and protecting patient health. Addressing the issues of incomplete and inconsistent adverse event records, we employed a deep learning model that combines BERT and BiLSTM to predict whether adverse event reports resulted in patient harm. We developed the Bert-BiLSTM-Att_dropout model specifically for text classification tasks with small datasets, optimizing the model's generalization ability and key information capture through the integration of dropout and attention mechanisms.

The predictive role of the hs-CRP/HDL-C ratio for long-term mortality in the general population: evidence from a cohort study.

Background: The high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio, a composite marker of low-grade inflammation and lipid metabolism, is reportedly associated with the occurrence of new cardiovascular diseases (CVDs) in certain people. However, the predictive value of the hs-CRP/HDL-C ratio for long-term mortality in the general population remains unclear.

Methods: This retrospective cohort study included data from 9,492 adults obtained from the National Health and Nutrition Examination Survey (NHANES) (2015-2018) in the United States.

Enhancement of alfalfa growth resistance by arbuscular mycorrhiza and earthworm in molybdenum-contaminated soils: From the perspective of soil nutrient turnover.

Molybdenum (Mo) acts as a crucial nutrient for plant development, yet excessive soil exposure can cause detrimental effects. Molybdenosis symptoms remain subtle in many plants, largely due to the safeguarding functions of soil organisms, the fundamental biological mechanisms lack clarity. In this study, we explored the potential mechanisms for amending Mo-exposed soils with soil microbe-arbuscular mycorrhizal fungi (AMF) and soil fauna, specifically earthworms, to enhance model plant-alfalfa growth resistance through soil nutrient turnover perspectives.

Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive.

Background: Anti-mitochondrial M2 antibody (AMA-M2) is a specific marker for primary biliary cholangitis (PBC) and it could be also presented in non-PBC individuals.

Methods: A total of 72173 Chinese health check-up individuals tested AMA-M2, of which non-PBC AMA-M2 positive individuals were performed follow-up. Baseline data of both clinical characteristics and laboratory examinations were collected in all AMA-M2-positive individuals.

Decoding aging in the heart via single cell dual omics of non-cardiomyocytes.

To understand heart aging at the single-cell level, we employed single-cell dual omics (scRNA-seq and scATAC-seq) in profiling non-myocytes (non-CMs) from young, middle-aged, and elderly mice. Non-CMs, vital in heart development, physiology, and pathology, are understudied compared to cardiomyocytes. Our analysis revealed aging response heterogeneity and its dynamics over time.

Novel techniques of liver segmental and subsegmental pedicle anatomy from segment 1 to segment 8.

Background: Laparoscopic anatomical liver resection has become more challenging because some subsegmental Glissonean pedicles are hard to dissect. Here, we introduce how to dissect every (sub) segmental Glissonean pedicle from the first porta hepatis and perform standardized (sub) segmentectomy [from segment 1 (S1) to S8].

Aim: To summarize our methods of laparoscopic anatomical segmental and subsegmental liver resection.

Thiostrepton suppresses colorectal cancer progression through reactive oxygen species related endoplasmic reticulum stress.

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Due to the poor therapeutic efficacy of CRC treatments and poor prognosis of the disease, effective treatment strategies are urgently needed. As long-term proteotoxic stress is a major cause of cell death, agents that induce proteotoxic stress offer a promising strategy for cancer intervention.

KLF2-dependent transcriptional regulation safeguards the heart against pathological hypertrophy.

Background: Our previous single-cell RNA sequencing study in the adult human heart revealed that cardiomyocytes from both the atrium and ventricle display high activities of Krüppel-like factor 2 (KLF2) regulons. However, the role of the transcription factor KLF2 in cardiomyocyte biology remains largely unexplored.

Methods And Results: We employed transverse aortic constriction surgery in male C57BL/6 J mice to develop an in vivo model of cardiac hypertrophy, and generated different in vitro cardiac hypertrophy models in neonatal rat ventricular myocytes and human embryonic stem cell-derived cardiomyocytes.

Probiotic treatment induces changes in intestinal microbiota but does not alter SCFA levels in peritoneal dialysis patients-a randomized, placebo-controlled trial.

The gut microbiota alterations interact with the pathogenesis and progression of chronic kidney disease (CKD). Probiotics have received wide attention as a potential management in CKD. We investigated the effects of Lactobacillus paracasei N1115 (LP N1115) on intestinal microbiota and related short-chain fatty acids (SCFAs) in end stage kidney disease patients on peritoneal dialysis (PD) in a single-center, prospective, randomized, double-blind, placebo-controlled study.

Effect of oxidation on finely segmented products of snakehead: Digestibility and microstructure.

The present study was performed to investigate the digestive profiles of snakeheads' belly muscles (BM), tail muscles (TM) dorsal muscles (DM), and eye muscles (EM), with further explorations of relevant factors. Kinetic models were adopted to describe the digestion process with crucial parameters. BM showed the highest digestibility and digestive rate, followed by DM, TM, and EM.