Turning Waste into Treasure: Functionalized Biomass-Derived Carbon Dots for Superselective Visualization and Eradication of Gram-Positive Bacteria.

Gram-positive bacteria pose significant threats to human health, necessitating the development of targeted bacterial detection and eradication strategies. Nevertheless, current approaches often suffer from poor targeting specificity. Herein, the study utilizes purple rice lixivium to synthesize biomass carbon dots (termed BCDs) with wheat germ agglutinin-like residues for precisely targeting Gram-positive bacteria.

3D printed dysphagia diet using pea protein gel modified by xanthan gum with different pyruvate group content.

3D printing offers a promising solution for the increasing demand for visually appealing dysphagia diets. Xanthan gum (XG) is a critical component in various thickeners specialized for dysphagia diets, in which pyruvate group is important, but relative study remains scarce. This study tried to create 3D printed dysphagia diet using composite gels of pea protein (PPI) and XG with various pyruvate content (XG: 5.

Nanoscale Manipulation of Single-Molecule Conformational Transition through Vibrational Excitation.

Controlling molecular actions on demand is a critical step toward developing single-molecule functional devices. Such control can be achieved by manipulating the interactions between individual molecules and their nanoscale environment. In this study, we demonstrate the conformational transition of a single pyrrolidine molecule adsorbed on a Cu(100) surface, driven by vibrational excitation through tunneling electrons using scanning tunneling microscopy.

A Systematic Literature Review of Trauma Systems: An Operations Management Perspective.

Background: Trauma systems provide comprehensive care across various settings, from prehospital services to rehabilitation, integrating clinical and social care aspects. Established in the 1970s, these systems are pivotal yet under-researched in their operational management. This study aims to fill this gap by focussing on the integration of operations management (OM) techniques to enhance the efficiency and effectiveness of trauma systems.

Effects of elastic ankle braces on dynamic stability in patients with functional ankle instability.

Objective: To investigate the protective effects of ankle braces in patients with functional ankle instability.

Methods: This retrospective study involved 30 participants recruited from January 2023 to December 2023 at School of Physical Education, Nanchang University. These participants were divided into an ankle brace group wearing braces and a control group without braces.

Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China.

Background: Hemorrhagic fever with renal syndrome (HFRS) is a climate-sensitive zoonotic disease that poses a significant public health burden worldwide. While previous studies have established associations between meteorological factors and HFRS incidence, there remains a critical knowledge gap regarding the heterogeneity of these effects across diverse epidemic regions. Addressing this gap is essential for developing region-specific prevention and control strategies.

Proteolysis-targeting influenza vaccine strains induce broad-spectrum immunity and in vivo protection.

Generating effective live vaccines from intact viruses remains challenging owing to considerations of safety and immunogenicity. Approaches that can be applied in a systematic manner are needed. Here we created a library of live attenuated influenza vaccines by using diverse cellular E3 ubiquitin ligases to generate proteolysis-targeting (PROTAR) influenza A viruses.

Numerical Study on the Shear Behavior of a Late-Model Cold-Formed Stainless Steel C-Shaped Beam.

The failure mode of thin-walled C-channel beams typically manifests as premature local buckling of the compression flange, leading to insufficient utilization of material strength in both the flange and the web. To address this issue, this study adopts the approach of increasing the number of bends to reinforce the flange and adding V-shaped stiffeners in the middle of the web to reduce the width-to-thickness ratio of the plate elements, thereby delaying local buckling and allowing for greater plastic deformation. However, the challenge lies in the irregular cross-sectional shape and complex buckling patterns.

MicroRNA analysis reveals 2 modules that antagonistically regulate xylem tracheary element development in Arabidopsis.

Tracheary elements (TEs) are vital in the transport of various substances and contribute to plant growth. The differentiation of TEs is complex and regulated by a variety of microRNAs (miRNAs). However, the dynamic changes in miRNAs during each stage of TE differentiation remain unclear, and the miRNA regulatory network is not yet complete.

Chemical cross-linking facilitates antigen uptake and presentation and provides improved protection from Mpox with a dual-antigen subunit vaccine.

Antigen uptake, processing, and presentation are crucial for the immune responses of protein-based vaccines. Herein, we introduced a reversible chemical cross-linking strategy to engineer protein antigens, which can be tracelessly removed upon antigen-presenting cell (APC) uptake and cellular reduction. The chemically cross-linked antigen proteins presented significantly enhanced uptake and epitope presentation by APC.

Wheat2035: Integrating Pan-omics and Advanced Biotechnology for Future Wheat Design.

Wheat (Triticum aestivum L.) production is vital for global food security, providing energy and protein to millions of people worldwide. Recent advancements in wheat research have led to significant increases in production, fueled by technological and scientific innovation.

Comprehensive review of extraction, purification, structural characteristics, pharmacological activities, structure-activity relationship and application of seabuckthorn protein and peptides.

Seabuckthorn (Hippophae rhamnoides) is an excellent plant that has the concomitant function of both medicine and foodstuff with high nutritional and health-promoting properties. As a pivotal bioactive component mainly existing in the seeds and leaves, seabuckthorn protein and its derived peptides have aroused wide attention owing to their multifaceted pharmacological activities, including anti-hypertensive, hypoglycemic, anti-obesity, anti-freeze, immunomodulatory, anti-inflammatory, sobriety, anti-oxidant and anti-neurodegenerative functions. Despite these promising attributes, the application of seabuckthorn peptides as functional food and medicines are impeded due to lack of a comprehensive understanding of pharmacological activities and intricate structure-activity relationship.

Genetic associations between immune-related plasma proteins and neurodegenerative diseases.

Background: Immune dysregulation is commonly associated with neurodegenerative diseases (NDs), yet the underlying causes and mechanisms still require further investigation.

Objective: This study investigates the correlation between immune-related plasma proteins and the risk of NDs by integrating genome-wide association study (GWAS) data for Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) with plasma proteome analysis.

Methods: By analyzing GWAS data for 4907 immune-related plasma proteins, this research evaluates the direct impact of plasma proteins on the risk of four NDs: AD, PD, ALS, and MS.

Multi-omics analysis reveals the genetic aging landscape of Parkinson's disease.

Parkinson's disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer's disease. Despite numerous studies, specific age-related factors remain unidentified. This study employed a multi-omics approach to investigate the link between PD and aging.

Passivated hydrogel interface: Armor against foreign body response and inflammation in small-diameter vascular grafts.

The development of small-diameter vascular grafts (SDVGs) still faces significant challenges, particularly in overcoming blockages within vessels. A key issue is the foreign-body response (FBR) triggered by the implants, which impairs the integration between grafts and native vessels. In this study, we applied an interfacial infiltration strategy to create a stable, hydrophilic, and passivated hydrogel coating on SDVGs.

[Determination of eight phthalate metabolites in urine of pregnant women and evaluation of neonatal birth outcomes based on solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry].

Phthalates (PAEs) are endocrine-disrupting chemicals that are widely present in everyday life and enter the human body through various pathways. The release of PAEs into the environment through pathways that include leaching, evaporation, abrasion, and the use of personal care products exposes humans to PAEs via ingestion, inhalation, and dermal absorption. Pregnant women, as a particularly vulnerable population, risk adverse newborn growth and development when exposed to PAEs.

Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion.

Background: Although tumor necrosis factor receptor 2 (TNFR2) has been recognized as an attractive next-generation candidate target for cancer immunotherapy, the factors that regulate the gene expression and their mechanistic effects on tumor-infiltrating regulatory T cells (Treg cells) remain poorly understood.

Methods: Single-cell RNA sequencing analysis was employed to analyze the phenotypic and functional differences between TNFR2 Treg cells and TNFR2 Treg cells. Malignant pleural effusion (MPE) from humans and mouse was used to investigate the potential mechanisms by which lactate regulates TNFR2 expression.

Association between prenatal exposure to phthalate esters and blood pressure in children aged 3-7 years: A prospective cohort study.

Background: An increasing number of animal studies have indicated that exposure to phthalate esters (PAEs) may cause high blood pressure. However, population-based evidence is limited, particularly for pregnant women and young children.

Objective: To examine the correlation between prenatal exposure to phthalate ester metabolites (mPAEs) and blood pressure in preschool children.

Global, regional and national burden of osteoarthritis in 1990-2021: a systematic analysis of the global burden of disease study 2021.

Objectives: To describe the prevalence and incidence of osteoarthritis as well as years lived with disability (YLDs) due to osteoarthritis in 204 countries and territories from 1990 to 2021 by age, sex and socio-demographic index (SDI, a composite of socio-demographic factors).

Methods: Data were acquired from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021). The burden of osteoarthritis was estimated for 204 countries and territories from 1990 to 2021by incidence, prevalence and YLDs.

Fish Fin-Derived Non-Invasive Flexible Bioinspired Contact Lens for Continuous Ophthalmic Drug Delivery.

Efficient drug delivery is crucial for glaucoma patients. Flexible biomedical devices that enable sustained ocular drug delivery and can regulate the drug release rate according to physiological conditions are highly desirable for glaucoma treatments, addressing both low drug bioavailability and poor patient compliance from manual drug administration, and improving treatment outcomes. Inspired by the structure and reciprocating motion of fish dorsal fins, a drug-eluting contact lens based on deformable microstructures for non-invasive ocular surface drug delivery is developed.

Epidemiological investigation of adult emergency infusion adverse drug reactions (EIADR) in Nanjing, China: a prospective cross-sectional study (EIADR II).

Objective: To analyze the clinical characteristics of adverse drug reactions (ADRs) in adults receiving emergency infusions at a tertiary hospital.

Methods: We conducted a prospective observational cohort study involving 585 adult patients who experienced adverse drug reactions (ADRs) between 20 November 2019, and 20 November 2023, during intravenous infusions in the emergency infusion room of a tertiary hospital. The analysis included patients' gender, age, type of drugs involved, organ-system involvement, clinical manifestations of ADRs, severity grading of ADRs, and preventability of ADRs.

MaxEnt and Marxan modeling to predict the potential habitat and priority planting areas of in Yunnan, China under climate change scenario.

Introduction: (Arabica coffee) is an important cash crop in Yunnan, China. Ongoing climate change has made coffee production more difficult to sustain, posing challenges for the region's coffee industry. Predictions of the distribution of potentially suitable habitats for Arabica coffee in Yunnan could provide a theoretical basis for the cultivation and rational management of this species.

Design of information management model based on multiobjective optimization algorithm in intelligent electric financial system.

The electric power infrastructure is the cornerstone of contemporary society's sustenance and advancement. Within the intelligent electric power financial system, substantial inefficiency and waste in information management persist, leading to an escalating depletion of resources. Addressing diverse objectives encompassing economic, environmental, and societal concerns within the power system helps the study to undertake a comprehensive, integrated optimal design and operational scheduling based on a multiobjective optimization algorithm.