Sucrose laurate and nisin synergistically inhibit Bacillus subtilis by multiple antibacterial targets and play promising application potential in bread preservation.

Sucrose laurate, a commonly used emulsifier, was investigated to explore its preservative effect combined with nisin using Bacillus subtilis as indicator. The results suggested that sucrose laurate and nisin exhibited synergistic antibacterial effect with the fractional inhibitory concentration index of 0.5.

Comparative analysis of (Aspleniaceae) chloroplast genomes from China.

is one of the two genera in the large fern family Aspleniaceae. A previous study explored the molecular phylogeny of this genus using several chloroplast DNA fragments and identified three major clades, one of which is the monophyletic Old World clade with southwestern China as its diversity center. To date, there were only a few studies conducted on chloroplast genomes in or Aspleniaceae, limiting the understanding of the plastome features and its role in evolution of this group.

CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy.

CD40, a member of the tumor necrosis factor (TNF) receptor superfamily, plays an important role not only in the immune system but also in tumor progression. CD40 ligation reportedly promotes autophagy in immune cells. However, the effects of CD40 ligation on autophagy and its mechanism in solid tumor cells are still unclear.

The Discovery of Oxathiapiprolin as a Potential Agent for the Control of Litchi Downy Blight Caused by and the Study of Its Mechanism of Action.

Oxathiapiprolin, a novel fungicide targeting oxysterol-binding proteins (OSBP), has proven to be effective against various oomycete diseases, but its effects on pathogens remain underexplored. In this study, we demonstrated that oxathiapiprolin inhibits mycelium growth, sporangium production, zoospore release, and oospore production in , with 50% effective concentrations ranging from 0.000153 to 0.

Promoting macrophage phagocytosis of cancer cells for effective cancer immunotherapy.

Cancer therapy has been revolutionized by immunotherapeutic agents exploiting adaptive antitumor immunity in the past two decades. However, the overall response rate of these immunotherapies is limited, and patients also develop resistance upon treatment, promoting a rapidly growing exploration of anti-tumor innate immunity for effective cancer therapy. Among these, macrophage immunotherapy through harnessing macrophage phagocytosis has been thrust into the spotlight due to its potential for simultaneously inducing cancer cell killing effect and mobilizing adaptive antitumor responses.

Comprehensive characterization of anthraquinones in using mass spectrometry molecular networking and metabolomics-based herb discrimination.

is a widely used folk medicine in China, renowned for its various bioactivities. The key active components, anthraquinones, have not been comprehensively profiled due to their complex chemical nature. Establishing a high-throughput strategy to systematically characterize these anthraquinones is essential.

Elucidating core microbiota in yellow wine (Huangjiu) through flavor-oriented synthesis and construction of microbial communities.

Huangjiu, a traditional Chinese alcoholic beverage with a history spanning thousands of years, holds significant cultural and economic value in China. Despite its importance, the complexity of Huangjiu fermentation and the intricate interactions within its microbial community remain underexplored. This study addresses this gap by identifying the core volatile organic compounds (VOCs) and key microorganisms that define the flavor profile of Huangjiu.

Telomere-to-telomere genome assembly of a male goat reveals variants associated with cashmere traits.

A complete goat (Capra hircus) reference genome enhances analyses of genetic variation, thus providing insights into domestication and selection in goats and related species. Here, we assemble a telomere-to-telomere (T2T) gap-free genome (2.86 Gb) from a cashmere goat (T2T-goat1.

Maltodextrin vitamin E succinate: A novel antioxidant emulsifier for formulating functional nanoemulsions.

A new multifunctional emulsifier was synthesized by coupling maltodextrin with a dextrose equivalent of 19 to vitamin E succinate. Two emulsifiers with varying degrees of vitamin E succinate substitution were prepared based on different mass ratios of vitamin E succinate to maltodextrin. The molecular structure and purity of these emulsifiers were analyzed.

Role of inflammasomes in Toxoplasma and Plasmodium infections.

Background: The detection of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) by multimeric protein complexes, known as inflammasomes, triggers an inflammatory response, which is a critical component of the innate immune system. This inflammatory response plays a pivotal role in host resistance against parasitic infections, presenting a significant global health challenge.

Methods: We systematically searched for relevant articles from the Pubmed and the Web of Science database to summarize current insights into how inflammasomes function in preventing infections caused by the apicomplexan parasites Toxoplasma and Plasmodium.

Robot-assisted technique can achieve accurate screw placement in four-corner fusion and reduce operative difficulty: a cadaver study.

Background: The purpose of this study is to explore the feasibility and accuracy of a robot-assisted technique in four-corner fusion compared with traditional freehand operation.

Methods: Twenty cadaver specimens were randomly assigned to the robot-assisted group and freehand groups. Three screws were placed percutaneously to fix the capitate-lunate joint, lunate-triquetrum joint, and triquetrum-hamate-capitate joint in each specimen by robot-assisted or freehand technique.

Hybrid Particle Size Template Method for Controllable Synthesis of Nitrogen-Doped Multilevel Porous Carbon as High-Rate Zn-Ion Hybrid Supercapacitor Cathode Materials.

Achieving high rate performance without compromising energy density has always been a critical objective for zinc-ion hybrid supercapacitors (ZHSCs). The pore structure and surface properties of carbon cathode materials play a crucial role. We propose utilizing a hybrid particle size (20 and 40 nm) magnesium oxide templates to regulate the pore structure of nitrogen-doped porous carbon derived from the soybean isolate.

Iodine(III)-Mediated Photochemical C-H Azolation.

A systematic radical polarity analysis framework is formulated herein for the projection of radical reactivity patterns. An iodine(III)-mediated photochemical C-H azolation reaction has been envisaged and developed based on the set of empirical guidelines. The synthesis features an environmentally benign reagent, mild reaction conditions, an operationally simple protocol, and a broad substrate scope.

The complete chloroplast genome sequence of (Sapindoideae, Sapindaceae).

Blume 1847 is an evergreen small tree belonging to the Sapindaceae family. It is distributed in South China to SE Asia and the Solomon Islands. However, the chloroplast genome of has yet to be reported.

Manganese-Catalyzed Cycloalkene Ring Expansion Synthesis of Azaheterocycles.

Herein, a Mn catalytic protocol has been developed for the cycloalkene ring expansion synthesis of azaheterocycles, allowing broad-substrate-scope access to pyridine and isoquinoline derivatives. The initial monoaddition of an azidyl radical to alkene and further as-generated C-radical addition to O, followed by intramolecular rearrangement and aromatization, showcase a distinct Mn-catalyzed radical reactivity mode. The reaction features a short reaction time and a broad substrate scope, with applications demonstrated in complex structure elaboration and gram-scale vismodegib synthesis.

Identification of Key Proteins Related to Cashmere Fiber Diameter by Integrated Proteomics and Bioinformatic Analyses in the Alpas and Alxa Goat Breeds.

Background: Goats () have always been a source of fiber for human use and hold an important place in international high-end textiles. Fiber diameter is the most concerning economic indicator for producers. Understanding the formation mechanism of fiber diameter and its related key proteins can help optimize and control the production of cashmere.

A Full-Process, Fine-Grained, and Quantitative Rehabilitation Assessment Platform Enabled by On-Skin Sensors and Multi-Task Gait Transformer Model.

Rehabilitation of patients with lower limb movement disorders is a gradual process, which requires full-process assessments to guide the implementation of rehabilitation plans. However, the current methods can only complete the assessment in one stage and lack objective and quantitative assessment strategies. Here, a full-process, fine-grained, and quantitative rehabilitation assessments platform (RAP) supported by on-skin sensors and a multi-task gait transformer (MG-former) model for patients with lower limb movement disorders is developed.

Advanced core-shell hollow carbon nanofibers for ion and electron accessibility in sodium ion batteries.

One-dimensional core-shell hollow carbon nanofibers (HCNFs) have been synthesized by coaxial electrospinning, deacetylation and carbonization, which exhibit multi-surface properties that enhance electrolyte infiltration and facilitate ion/electron transport. The nitrogen-doped hard carbon outer shell compensates for the low conductivity of amorphous carbon, and the inner core carbon supports the stability of core-shell hollow structures. This unique structure ensures the accessibility of electrons/ions during electrochemical reactions and contributes to the superior rate performance of HCNFs.

PungentDB: Bridging traditional Chinese medicine of medicine food homology and modern food flavor chemistry.

Merging traditional Chinese medicine's (TCM) principles of medicine-food homology with modern flavor chemistry, this research unveils PungentDB (http://www.pungentdb.org.

Excretory/secretory antigens from Trichinella spiralis muscle larvae ameliorate HFD-induced non-alcoholic steatohepatitis via driving macrophage anti-inflammatory activity.

No approved effective therapy for non-alcoholic steatohepatitis (NASH) is currently available. Trichinella spiralis (T. spiralis) infection and their products have positive impact on several metabolic diseases.

Biochemical analyses reveal new insights into RCAN1/Rcn1 inhibition of calcineurin.

Calcineurin is a serine/threonine protein phosphatase that is highly conserved from yeast to human and plays a critical role in many physiological processes. Regulators of calcineurin (RCANs) are a family of endogenous calcineurin regulators, which are capable of inhibiting the catalytic activity of calcineurin in vivo and in vitro. In this study, we first characterized the biochemical properties of yeast calcineurin and its endogenous regulator Rcn1, a yeast homolog of RCAN1.

Research hotspots and trends in nursing for diabetic foot ulcers: A bibliometric analysis from 2013 to 2023.

Background: Nursing can effectively prevent and ameliorate diabetic foot ulcers (DFU). However, there is a lack of literature on the bibliometric analysis of DFU nursing. This study aimed to analyze the research hotspots and development trends in DFU nursing over the past 10 years to provide references for future related research.