Efficacy and safety of over-the-scope clips (OTSC®) for closure of gastrointestinal fistulas less than 2 cm.

Background And Aim: Gastrointestinal (GI) fistula is a complication of surgery associated with potential morbidity and mortality. The aim of this study was to evaluate the efficacy and safety of over-the-scope clips (OTSC®) for closing GI fistulas.

Methods: Patients with GI fistula who underwent endoscopic closure using OTSC® were enrolled.

Induction of mA methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance.

Background: Therapeutic resistance occurs in most patients with multiple myeloma (MM). One of the key mechanisms for MM drug resistance comes from the interaction between MM cells and adipocytes that inhibits drug-induced apoptosis in MM cells; MM cells reprogram adipocytes to morph into different characterizations, including exosomes, which are important for tumor-stroma cellular communication. However, the mechanism by which exosomes mediate the cellular machinery of the vicious cycle between MM cells and adipocytes remains unclear.

Multi-Model Ensemble Deep Learning Method to Diagnose COVID-19 Using Chest Computed Tomography Images.

Deep learning based analyses of computed tomography (CT) images contribute to automated diagnosis of COVID-19, and ensemble learning may commonly provide a better solution. Here, we proposed an ensemble learning method that integrates several component neural networks to jointly diagnose COVID-19. Two ensemble strategies are considered: the output scores of all component models that are combined with the weights adjusted adaptively by cost function back propagation; voting strategy.

Development of Mitochondria-Targeted Small-Molecule Dyes for Myocardial PET and Fluorescence Bimodal Imaging.

Mitochondria-targeting positron emission tomography (PET) and fluorescent dual-modal probes are rarely reported. As one of the most promising lipophilic cations, F16 and its derivatives (F16s) have never been used for myocardial imaging. In this work, 14 F16s are synthesized and evaluated for cardiac imaging.

Low-Dimensional InSe Compounds: From Material Preparations to Device Applications.

Nanostructured InSe compounds have been widely used in electronics, optoelectronics, and thermoelectrics. Recently, the revelation of ferroelectricity in low-dimensional (low-D) InSe has caused a new upsurge of scientific interest in nanostructured InSe and advanced functional devices. The ferroelectric, thermoelectric, and optoelectronic properties of InSe are highly correlated with the crystal structure.

Activity of PD-1 Inhibitor Combined With Anti-Angiogenic Therapy in Advanced Sarcoma: A Single-Center Retrospective Analysis.

Immune checkpoint inhibitors (ICIs) are employed to treat various cancers, including soft tissue sarcomas (STSs), and less than 20% of patients benefit from this treatment. Vascular endothelial growth factor (VEGF) promotes the immunosuppressive tumor microenvironment and contributes to ICI-resistant therapy. Anti-VEGF receptor tyrosine-kinase inhibitors (TKIs) combined with ICIs have shown antitumor activity in patients with alveolar soft-part sarcoma (ASPS).

Local Growth Mediated by Plasmonic Hot Carriers: Chirality from Achiral Nanocrystals Using Circularly Polarized Light.

Plasmonic nanocrystals and their assemblies are excellent tools to create functional systems, including systems with strong chiral optical responses. Here we study the possibility of growing chiral plasmonic nanocrystals from strictly nonchiral seeds of different types by using circularly polarized light as the chirality-inducing mechanism. We present a novel theoretical methodology that simulates realistic nonlinear and inhomogeneous photogrowth processes in plasmonic nanocrystals, mediated by the excitation of hot carriers that can drive surface chemistry.

Cascade Cyclization of Azadienes with Difluoroenoxysilanes: A One-Pot Formal [4 + 2] Approach to Fluorinated Polyfused Heterocycles.

A TfOH-promoted synthesis of fluorinated polyfused heterocycles via the cascade cyclization of azadienes and difluoroenoxysilanes has been developed, leading to the facile construction of fluorinated benzofuro[3,2-]pyridines, 5-indeno[1,2-]pyridines, and 5,6-dihydrobenzo[]quinolines. This one-pot formal [4 + 2] approach involves 1,4-difluoroalkylation, desulfonylation, cyclization, and dehydrated and dehydrofluorinated aromatization and represents the first application of difluoroenoxysilane in cascade transformations. Furthermore, this methodology is highlighted by the synthesis of three fluoro analogues of bioactive molecules with potent topoisomerase inhibitory activities.

Broadband thin-film and metamaterial absorbers using refractory vanadium nitride and their thermal stability.

Strong absorption of the full spectrum of sunlight at high temperatures is desired for photothermal devices and thermophotovoltaics. Here, we experimentally demonstrate a thin-film broadband absorber consisting of a vanadium nitride (VN) film and a SiO anti-reflective layer. Owing to the intrinsic high loss of VN, the fabricated absorber exhibits high absorption over 90% in the wide range of 400-1360 nm.

Laser-induced dynamic alignment and nonlinear-like optical transmission in liquid suspensions of 2D atomically thin nanomaterials.

Nonlinear optical property of atomically thin materials suspended in liquid has attracted a lot of attention recently due to the rapid development of liquid exfoliation methods. Here we report laser-induced dynamic orientational alignment and nonlinear-like optical response of the suspensions as a result of their intrinsic anisotropic properties and thermal convection of solvents. Graphene and graphene oxide suspensions are used as examples, and the transition to ordered states from initial optically isotropic suspensions is revealed by birefringence imaging.

Intestinal CD11b B Cells Ameliorate Colitis by Secreting Immunoglobulin A.

The intestinal mucosal immune environment requires multiple immune cells to maintain homeostasis. Although intestinal B cells are among the most important immune cells, little is known about the mechanism that they employ to regulate immune homeostasis. In this study, we found that CD11b B cells significantly accumulated in the gut lamina propria and Peyer's patches in dextran sulfate sodium-induced colitis mouse models and patients with ulcerative colitis.

Aggregation-induced emission luminogens for image-guided surgery in non-human primates.

During the past two decades, aggregation-induced emission luminogens (AIEgens) have been intensively exploited for biological and biomedical applications. Although a series of investigations have been performed in non-primate animal models, there is few pilot studies in non-human primate animal models, strongly hindering the clinical translation of AIE luminogens (AIEgens). Herein, we present a systemic and multifaceted demonstration of an optical imaging-guided surgical operation via AIEgens from small animals (e.

Endoscopic Evaluation at 1 Month After Ileocolic Resection for Crohn's Disease Predicts Future Postoperative Recurrence and Is Safe.

Background: Endoscopy remains the gold standard for evaluating postoperative recurrence in Crohn's disease. Timely therapy adjustment according to endoscopic findings can improve long-term outcomes.

Objective: We aimed to determine the characteristics, clinical values, and safety of the endoscopic evaluation at 1 month after surgery.

MiR-29c inhibits the metastasis of oral squamous cell carcinoma and promotes its cell cycle arrest by targeting SERPINH1.

Background: A large number of studies have shown that the imbalance of micro RNA (miRNA) and its target genes can promote the development of tumors. The purpose of this study was to investigate the biological role and molecular mechanism of serpin peptidase inhibitor clade H member 1 (SERPINH1) and its upstream regulator miR-29c in oral squamous cell carcinoma (OSCC).

Methods: The expression levels of SERPINH1 and miR-29c were detected by quantitative reverse transcription polymerase chain reaction (RT-qPCR) and western blotting.

Trojan Horse-Like Nano-AIE Aggregates Based on Homologous Targeting Strategy and Their Photodynamic Therapy in Anticancer Application.

Photodynamic therapy (PDT) has become a promising candidate for cancer theranostics; however, traditional photosensitizers (PSs) usually exhibit weak fluorescence and poor reactive oxygen species (ROS) generation efficiency when aggregated. Recently, aggregation-induced emission (AIE) luminogens have shown great potential in the development of novel PSs owing to their excellent aggregation-induced ROS generation (AIG-ROS) activity. However, there are still concerns that must be addressed.

Decoration of BiVO Photoanodes with Near-Infrared Quantum Dots for Boosted Photoelectrochemical Water Oxidation.

Broadening light absorption and improving charge carrier separation are very critical to boost the water splitting efficiency in photoelectrochemical (PEC) systems. We herein reported a heterostructured photoanode consisting of BiVO and eco-friendly, near-infrared (NIR) CuInSeS@ZnS core-shell quantum dots (QDs) for PEC water oxidation. The decoration of core-shell QDs concurrently extends the absorption range of BiVO from the ultraviolet-visible to NIR region and promotes the effective separation and transfer of photo-excited electrons and holes.

Dust pollution in cold region Surface Mines and its prevention and control.

The application of traditional dust reduction methods in surface mines is limited, particularly during winter due to long-term drought and a rainless environment. Therefore, it is essential to investigate dust pollution in cold region mines and get insights into its scientific prevention and control. This research analyzed dust pollution (concentration of TSP, PM10, PM2.

Microfluidic encapsulated manganese organic frameworks as enzyme mimetics for inflammatory bowel disease treatment.

Metal organic frameworks (MOFs) with physicochemical properties and adjustable structures have been proposed as very attractive materials. The studies on development of such functional materials tended to fabricate featured MOF objects with fascinating catalytic capabilities to utilize their biomedical values. In this paper, we present novel biocompatible manganese metal organic framework (Mn-MOF)-based catalase mimetics with microfluidic microcapsule encapsulation for intravital inflammatory bowel disease (IBD) treatment.

Metal-based electrocatalysts for room-temperature Na-S batteries.

Room-temperature sodium-sulfur (RT Na-S) batteries have recently captured intensive research attention from the community and are regarded as one of promising next-generation energy storage devices since they not only integrate the advantages in high abundance and low commercial cost of elemental Na/S but also exhibit exceptionally high theoretical capacity and energy density. Whereas, the notorious shuttle effect of soluble intermediates and sluggish kinetics remain two main obstacles for RT Na-S batteries to step into new developmental stage. Recently, impressive advancements of metal-based electrocatalysts have offered a viable solution to stabilize S cathodes and unlocked new opportunities for RT Na-S batteries.

Novel lysosome-targeted fluorescent molecular rotors based on a cyanine-like modular system and their application in living cells.

Two novel fluorescence molecular rotors DpIn and NaIn were designed and synthesized involving of indolium units linked with meta-diphenol or ortha-naphthalenediol moiety, respectively. They underwent intramolecular charge transfer to form a cyanine-like modular system at a physiological pH. In glycerol aqueous solutions, the probe DpIn exhibited NIR strong emission (3-fold) at ca.

A Bibliometric Analysis of 8,276 Publications During the Past 25 Years on Cholangiocarcinoma by Machine Learning.

Introduction: Cholangiocarcinoma (CCA) is the second most common hepatic malignancy. Progress and developments have also been made in the field of CCA management along with increasing scientific publications during the past decades, which reflect topics of general interest and suggest the future direction of studies. The purpose of this bibliometric study is to summarize scientific publications during the past 25 years in the field of CCA using a machine learning method.

CCD2 Access Tunnel Design for a Broader Substrate Profile in Crocetin Production.

Crocetin, a high-value apocarotenoid in saffron, is widely applied to the fields of food and medicine. However, the existing method of obtaining crocetin through large-scale cultivation is far from meeting the market demand. Microbial synthesis of crocetin is a potential alternative to traditional resources, and it is found that carotenoid cleavage dioxygenase (CCD) is the critical enzyme to synthesize crocetin.

Chiral Optofluidics with a Plasmonic Metasurface Using the Photothermal Effect.

Plasmonic metasurfaces with the photothermal effect have been increasingly investigated for optofluidics. Meanwhile, along with the expanding application of circularly polarized light, a growing number of investigations on chiral plasmonic metasurfaces have been conducted. However, few studies have explored the chirality and the thermal-induced convection of such systems simultaneously.

Electrophoretic deposition of collagen/chitosan films with copper-doped phosphate glasses for orthopaedic implants.

Coatings with bioactive properties play a key role in the success of orthopaedic implants. Recent studies focused on composite coatings incorporating biocompatible elements that can increase the nucleation of hydroxyapatite (HA), the mineral component of bone, and have promising bioactive and biodegradable properties. Here we report a method of fabricating composite collagen, chitosan and copper-doped phosphate glass (PG) coatings for biomedical applications using electrophoretic deposition (EPD).