Base-catalyzed hydrolysis mechanism of polychlorinated dibenzo-p-dioxins based on quantitative structure-activity relationship.

Polychlorinated dibenzo-p-dioxins (PCDDs) are persistent organic pollutants that pose considerable threats to ecological and human health owing to their high toxicity potential. Understanding the mechanisms for underlying the base-catalyzed hydrolysis of PCDDs in aquatic environments is essential for assessing their environmental behaviour and ecological risks. Herein, we combined quantitative structure-activity relationship (QSAR) models with density functional theory calculations to analyse the base-catalyzed hydrolysis mechanisms of PCDDs.

The relationship between atherogenic index of plasma and plaque vulnerabilities: an optical coherence tomography study.

Background: Atherogenic index of plasma (AIP) has been recommended as a marker of plasma atherogenicity. The impact of AIP on plaque characteristics is not fully understood.

Purpose: The study investigates the relationship between AIP and coronary plaque features in patients with acute coronary syndrome (ACS).

MT-SCnet: multi-scale token divided and spatial-channel fusion transformer network for microscopic hyperspectral image segmentation.

Introduction: Hybrid architectures based on convolutional neural networks and Transformers, effectively captures both the local details and the overall structural context of lesion tissues and cells, achieving highly competitive segmentation results in microscopic hyperspectral image (MHSI) segmentation tasks. However, the fixed tokenization schemes and single-dimensional feature extraction and fusion in existing methods lead to insufficient global feature extraction in hyperspectral pathology images.

Methods: Base on this, we propose a multi-scale token divided and spatial-channel fusion transformer network (MT-SCnet) for MHSIs segmentation.

Hierarchical transformer speech depression detection model research based on Dynamic window and Attention merge.

Depression Detection of Speech is widely applied due to its ease of acquisition and imbuing with emotion. However, there exist challenges in effectively segmenting and integrating depressed speech segments. Multiple merges can also lead to blurred original information.

Improved lymph node detection in minimally invasive radical surgery for colorectal cancer using nanocarbon tracer.

To investigate the influencing factors of lymph node detection after minimally invasive radical surgery in patients with colorectal cancer (CRC) and the application value of carbon nanoparticle tracing. A total of 120 patients with CRC who underwent minimally invasive radical surgery were included. They were divided into groups according to whether they were grouped by carbon nano-tracers, and the baseline data were matched by propensity score method.

Expression of the lncRNA TPT1-AS1 in lung squamous cell carcinoma and its prognostic value.

Objective: Lung squamous cell carcinoma is typically associated with a poor prognosis, highlighting the need for a reliable prognostic marker. Given that the long noncoding RNA TPT1-AS1 has demonstrated aberrant expression in numerous cancers, the prognostic significance of TPT1-AS1 in LUSC was examined.

Methods: The present study included 115 patients diagnosed with LUSC.

Predicting frailty in older patients with chronic pain using explainable machine learning: A cross-sectional study.

Frailty is common among older adults with chronic pain, and early identification is crucial in preventing adverse outcomes like falls, disability, and dementia. However, effective tools for identifying frailty in this population remain limited. This study aimed to explore frailty risk factors in older adults with chronic pain and to develop 9 machine learning models for frailty identification.

Collagenase Chemonucleolysis for Treating Cervical Disc Herniation: An Exploratory, Single-Arm, Open-Label, Multicenter Clinical Trial.

Introduction: Cervical disc herniation (CDH) is the most common cause of cervical radiculopathy and causes persistent neck pain and neurological deficits. Collagenase chemonucleolysis has been successfully applied to treat lumbar disc herniation, which has a similar pathological mechanism to CDH. However, its application for CDH remains under-researched, and there is an even greater lack of high-quality clinical evidence.

Potential Mechanisms of Epicardial Adipose Tissue Influencing Heart Failure with Preserved Ejection Fraction.

Heart failure (HF) is the predominant terminal stage and the leading cause of mortality in cardiac disease. Heart failure with preserved ejection fraction (HFpEF) affects roughly 50% of HF patients globally. Due to the global aging population, the prevalence, morbidity, and mortality of HFpEF have gradually increased.

Mycobacterium marinum MMAR_0267-regulated copper utilization facilitates bacterial escape from phagolysosome.

The host limits Mycobacterium tuberculosis (Mtb) by enriching copper in high concentrations. This research investigates how Mtb escapes copper stress. The membrane protein encoded by Mtb Rv0102, when its homolog in M.

Application of a dual-modality colorimetric analysis method to inkjet printing lateral flow detection of Salmonella typhimurium.

Lateral flow assay (LFA) color signal quantification methods were developed by utilizing both International Commission on Illumination (CIE) LAB (CIELAB) color space and grayscale intensity differences. The CIELAB image processing procedure included calibration, test, control band detection, and color difference calculation, which can minimize the noise from the background. The LFA platform showcases its ability to accurately discern relevant colorimetric signals.

Spatial Activation of Autophagy in Human Placenta-Related Tissue During Labor: A Possible Mechanism for Labor Onset.

Introduction: To explore the mechanisms of labor by investigating the autophagy of placental and fetal membranes tissue in normal pregnant women.

Methods: Placenta and fetal membranes were collected from women with singleton pregnancies without any medical complications and from women who delivered vaginally (labor-initiated group; L group) or by caesarean section (labor-noninitiated group; NL group). Autophagosomes were observed by transmission electron microscopy (TEM).

The synergistic effect of the atherogenic index of plasma and hyperuricemia on the prediction of coronary chronic total occlusion lesion: an observational cross-sectional study.

Background: The atherogenic index of plasma (AIP) and hyperuricemia (HUA) have been shown to be closely associated with morbidity and mortality of coronary artery disease. However, studies targeting predictive value of AIP and HUA for chronic total occlusion (CTO) lesions are still lacking.

Methods: In total, 5,238 patients meeting the eligibility criteria were recruited in this analysis.

The effect of hsCRP on TyG index-associated cardiovascular risk in patients with acute coronary syndrome undergoing PCI.

The effect of systemic inflammation, represented by high-sensitivity C-reactive protein (hsCRP), on triglyceride glucose (TyG) index-associated cardiovascular risk in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) has not yet been determined. This study was a retrospective analysis of a single-center prospective registry and finally included 1701 patients (age, 60 ± 10 years; male, 76.7%).

Prognostic Significance of Peripheral Artery Disease in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.

Background: Peripheral artery disease (PAD) elevates the risk of adverse outcomes. The current work aimed to evaluate the influence of PAD in acute coronary syndrome (ACS) cases administered percutaneous coronary intervention (PCI), and to determine whether PAD adds incremental prognostic value to the global registry of acute coronary events (GRACE) scale.

Methods: To retrospectively analyze a single-center, prospective cohort trial, we consecutively included ACS cases administered PCI.

Hierarchical lncRNA regulatory network in early-onset severe preeclampsia.

Background: Recent studies have shown that several long non-coding RNAs (lncRNAs) in the placenta are associated with preeclampsia (PE). However, the extent to which lncRNAs may contribute to the pathological progression of PE is unclear.

Results: Here, we report a hierarchical regulatory network involved in early-onset severe PE (EOSPE).

Analysis of Factors Associated with Cough Persistence After Thoracoscopic Lung Cancer Resection in Elderly Lung Cancer Patients and Discussion of Prevention Strategies.

Objective: The aim was to investigate the factors associated with cough persistence after thoracoscopic lung cancer resection in elderly lung cancer patients and preventive strategies.

Methods: In this study, 103 elderly patients with lung cancer who attended the department of thoracic surgery of our hospital from March 2019 to January 2023 were selected for retrospective analysis, all of whom underwent thoracoscopic lung cancer resection and were divided into the cough group (n = 37) and the no-cough group (n = 66) based on the presence or absence of persistent cough in the postoperative period. The clinical data of the patients were analyzed using univariate analysis and multifactorial logistic regression analysis.

Scalable Fabrication of Large-Scale, 3D, and Stretchable Circuits.

Stretchable electronics have demonstrated excellent potential in wearable healthcare and conformal integration. Achieving the scalable fabrication of stretchable devices with high functional density is the cornerstone to enable the practical applications of stretchable electronics. Here, a comprehensive methodology for realizing large-scale, 3D, and stretchable circuits (3D-LSC) is reported.

Genome-Wide Identification, Expression and Response to Estrogen of Vitellogenin Gene Family in Sichuan Bream ().

To enhance our understanding of teleost reproductive physiology, we identified six Sichuan bream () vitellogenin genes (-) and characterized their sequence structures. We categorized them into type Ⅰ (,, and ), type Ⅱ () and type Ⅲ () based on differences in their subdomain structure. The promoter sequence of has multiple estrogen response elements, and their abundance appears to correlate with the responsiveness of gene expression to estrogen.

Investigating the role of TGF-β and BDNF in cancer-related depression: a primary cross-sectional study.

Background: Cancer-related depression is a well-documented condition that significantly impacts long-term quality of life. Brain-derived neurotrophic factor (BDNF), a neurotrophin essential for neurogenesis and neuronal plasticity, has been implicated in various neuropsychological disorders including depression associated with cancer. Cytokines, on the other hand, play a crucial role in regulating depression, potentially by influencing BDNF expression.

Effect of low-intensity focused ultrasound therapy on postpartum uterine involution in puerperal women: A randomized controlled trial.

Background: Short-term poor uterine involution manifests as uterine contraction weakness. This is one of the important causes of postpartum hemorrhage, posing a serious threat to the mother's life and safety. The study aims to investigate whether low-intensity focused ultrasound (LIFUS) can effectively shorten lochia duration, alleviate postpartum complications, and accelerate uterine involution compared with the sham treatment.

Synthesis of Double Trivalent Perovskite Quantum Dots CsBiSbX (X = Cl, Br, I) for Efficient CO Photoreduction Performance.

Non-toxic Bi halides have great potential in the field of CO photoreduction, but strong charge localization limits their charge separation and transfer. In this study, a series of CsBiSbX (X = Cl, Br, I) perovskite quantum dots (PQDs) are synthesized by antisolvent recrystallization at room temperature, in which CsBiSbBr PQDs has high selectivity (94.51%) and yield (15.