Publications by authors named "Wang Zhenzhong"

Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systematically identified by the UPLC/Q-TOF-MS/MS method for the first time. A total of 94 components, including 32 prototypes and 62 metabolites, were tentatively characterized in rat plasma and various tissues samples.

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African swine fever virus (ASFV) causes highly contagious swine disease, African swine fever (ASF), thereby posing a severe socioeconomic threat to the global pig industry and underscoring that effective antiviral therapies are urgently required. To identify safe and efficient anti-ASFV compounds, a natural compound library was screened by performing an established cell-based ELISA in an ASFV-infected porcine alveolar macrophage (PAM) model. In total, 6 effective anti-ASFV compounds with low cytotoxicity were identified.

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Article Synopsis
  • Tianshu capsule (TSC) is a traditional Chinese medicine that shows promise in treating migraines, prompting a study to explore its compound effects and pharmacokinetics.
  • The research utilized advanced chromatography techniques to identify 46 compounds in blood and brain of rats after TSC administration, highlighting four key ingredients (Gastrodin, ferulic acid, senkyunolide G, and senkyunolide I).
  • Findings revealed that these compounds, especially senkyunolide I, quickly reached the brain and showed differences in absorption between healthy and migraine-affected rats, indicating a need for deeper investigation into TSC's therapeutic mechanisms.
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The management of hypertension and diabetes poses significant challenges to China's healthcare system, necessitating seamless patient progression through screening, diagnosis, management, and control. Utilizing the care cascade model, this study aims to systematically identify patient drop-offs and devise strategies to address healthcare delivery bottlenecks for hypertension and diabetes in rural China. This study consists of three phases.

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While graph neural networks (GNNs) have become the de facto standard for graph-based node classification, they impose a strong assumption on the availability of sufficient labeled samples. This assumption restricts the classification performance of prevailing GNNs on many real-world applications suffering from low-data regimes. Specifically, features extracted from scarce labeled nodes could not provide sufficient supervision for the unlabeled samples, leading to severe overfitting.

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Article Synopsis
  • * Chronic inflammation is linked to several diseases, and understanding how natural products interact with targets can lead to new drug development and better treatment strategies
  • * Recent strategies over the past 5 years focus on identifying natural product targets using computational methods, proteomics, and biological experiments, aiding in understanding their mechanisms of action and improving drug development efficiency
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Background: Arthritis notably elevates mortality risk. It remains unclear whether the cardiovascular health (CVH) metrics improves the risk of all-cause mortality in patients with all types of arthritis.

Methods: This study data from the National Health and Nutrition Examination Survey to probe the link between CVH and all-cause mortality among arthritis sufferers in the United States.

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Optically transparent polyimide (PI) films with good atomic oxygen (AO) resistance have been paid extensive attention as thermal controls, optical substrates for solar cells or other components for low Earth orbit (LEO) space applications. However, for common PI films, it is usually quite difficult to achieve both high optical transparency and AO resistance and maintain the intrinsic thermal stability of the PI films at the same time. In the current work, we aimed to achieve the target by using the copolymerization methodology using the fluorinated dianhydride 9,9-bis(trifluoromethyl)xanthene-2,3,6,7-tetracarboxylic dianhydride (6FCDA), the fluorinated diamine 2,2-bis [4-(4-aminophenoxy)phenyl]hexafluoropropane (BDAF) and the polyhedral oligomeric silsesquioxane (POSS)-containing diamine -[(heptaisobutyl-POSS)propyl]-3,5-diaminobenzamide (DABA-POSS) as the starting materials.

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In this paper, a method for rapidly determining the content of chlorogenic acid, neochlorogenic acid, cryptochlorogenic acid, gardeniside, and strychnoside in Reduning Injection(RI) was established based on near-infrared spectroscopy(NIRS), midinfrared spectroscopy(MIRS), and spectral fusion technology. Six pretreatment methods and five variable screening methods were investigated, and the best method was selected to establish a partial least square(PLS) model of two single spectra. At the same time,the NIRS and MIRS were fused with equal weights and characteristic bands, and the PLS model was established.

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Article Synopsis
  • Chinese dragon's blood is a red resin used in China to help treat heart and brain problems, especially after a stroke.
  • Longxuetongluo Capsule (LTC) is made from this resin and is being studied to see how it can protect heart cells from damage after blood flow returns to the heart.
  • In experiments with rats and heart cells, researchers found that LTC might help reduce damage to the heart by fixing some of the cell problems caused by low oxygen and sugar levels.
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  • Aster tataricus L.f. (known as "Zi wan" or "Fan huncao") is a traditional Chinese herb with a history of use for over 2000 years, primarily for treating cough, asthma, inflammation, and tumors.
  • The review identifies 186 compounds in the plant, highlighting its natural remedies for cough and various pharmacological effects, but also notes potential liver toxicity.
  • Future research is necessary to understand its mechanisms of action, safety, and to explore its applications further despite its documented benefits in traditional medicine.
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Luteolin-7--glucoside(L7G), a glycosylation product of luteolin, is present in a variety of foods, vegetables, and medicinal herbs and is commonly used in dietary supplements due to its health benefits. Meanwhile, luteolin-7--glucoside is an indicator component for the quality control of honeysuckle in the pharmacopoeia. However, its low content in plants has hindered its use in animal pharmacological studies and clinical practice.

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Reduning injection (RDN) is a traditional chinese medicine injection widely used in clinical practice. In this study, qualitative and quantitative analysis of RDN were conducted by UPLC-Orbitrap MS/MS simultaneously. Totally 118 compounds were identified and 34 compounds were quantified in RDN.

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Four previously unreported phenylpropanoid glycosides (-), together with four known analogues (-), were isolated from the leaves of . The structures of these new compounds were elucidated based on spectroscopic analysis (HR-ESI-MS, NMR, IR, UV) and chemical methods. In addition, the neuroprotective activities of all the isolates were evaluated by measuring their cell viability in HO-induced OLN-93 cell injury model.

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Background: Barlow's disease (BD) is a common etiology of degenerative mitral valve (MV) disease, often causing significant mitral regurgitation (MR). The pathology of BD is challenging for surgeons performing MV repair (MVR). However, most MVR effectiveness studies have been based on survival and risk of reoperation.

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This study aimed to identify novel biomarkers associated with cuproptosis in human nonobstructive azoospermia (NOA). We obtained 4 NOA microarray datasets (GSE145467, GSE9210, GSE108886, and GSE45885) from the NCBI Gene Expression Omnibus database and merged them into training set. Another NOA dataset (GSE45887) was used as validation set.

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Background: Leaflet augmentation is often required to correct an inadequate leaflet size due to leaflet thickening, contracture and junctional fusion in patients with tricuspid valve regurgitation (TR) after left-side valve surgery (LSVS). However, the ideal material for leaflet augmentation remains controversial. This article aims to compare the medium- and long-term results of tricuspid valve repair with bovine pericardium (BP) and expanded Polytetrafluoroethylene (ePTFE) patches for the augmentation of tricuspid leaflets and to compare the durability of the two materials.

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Background: Heart failure (HF) is a complex cardiovascular syndrome with high mortality. Santalum album L. (SAL) is a traditional Chinese medicine broadly applied for various diseases treatment including HF.

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A new pair of butylphthalide diastereomers, dangguinolide A () and dangguinolide B (), together with two known butylphthalide were isolated from . Their structures were determined by extensive spectroscopic analyses, and the absolute configurations of and were assigned NMR calculations and ECD calculations. Their anti-inflammatory activities have evaluated .

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Hybrid copper(I) halides have garnered a significant amount of attention as potential substitutes in luminescence and scintillation applications. Herein, we report the discovery and crystal growth of new zero-dimensional compounds, (CHN)CuI and (CHN)CuBr. The bromide and iodide have a triclinic structure with space group 1̅ and an orthorhombic structure with space group , respectively.

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A magnetic biochar nanomaterial derived from fungal hyphae was introduced into the sample preparation field. The magnetic fungal hyphae-derived biomass carbon (MFHBC) could be produced by a controllable hydrothermal method. In order to obtain the best sorbent for magnetic solid-phase extraction (MSPE), the reaction conditions containing temperature, time and the consumption of fungal hyphae were investigated.

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Background: Perioperative management and cardiac surgery in pregnant women with anti-phospholipid syndrome combined with heart valve disease have been rarely reported.

Case Presentation: We describe a case of transcatheter mitral valve-in-valve replacement in a pregnant woman with bioprosthetic valve failure and anti-phospholipid syndrome at 18 weeks' gestation. The patient underwent a cesarean section delivery at 34 weeks of gestation, resulting in the birth of a healthy baby.

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Recommendation system (RS) is an important information filtering tool in nowadays digital era. With the growing concern on privacy, deploying RSs in a federated learning (FL) manner emerges as a promising solution, which can train a high-quality model on the premise that the server does not directly access sensitive user data. Nevertheless, some malicious clients can deduce user data by analyzing the uploaded model parameters.

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Icaritin, a hydrolysate from total flavonoids of Epimedii (TFE), which has better anti-hepatoma activity than its glycosylated form. In this work, immobilized enzymes 4LP-Tpebgl3@Na-Y and DtRha@ES-107 were used to hydrolyze TFE to prepare icaritin. Five different hydrophobic deep eutectic solvents (HDES) were prepared and the most ideal HDES was successfully selected, which was composed of dodecyl alcohol and thymol with the molar ratio of 2:1.

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