Environmental disposal of sulphide-rich and desulfurized tailings: Thickening, rheological, mechanical, and leaching performance.

The surface disposal of sulphide-rich tailings (compared to ordinary tailings, it contains many sulphides) will cause environmental and groundwater pollution, and it is an eco-friendly method to prepare cemented paste backfill (CPB) from sulphide-rich tailings and backfill it into underground goafs. However, the thickening performance of sulphide-rich and desulfurized tailings is unclear, the sulphide-rich CPB strength cannot meet the standard. Therefore, a comprehensive study was conducted on its thickening performance through settling columns and dynamic thickening experiments, mechanics, and leaching tests were also conducted.

The Complete Mitochondrial Genome of the Siberian Scoter and Its Phylogenetic Relationship in Anseriformes.

The Siberian Scoter () is a medium sea duck distinct from due to the absence of hybridization and differences in morphological characteristics. However, knowledge of its phylogenetic relationships within Anseriformes is limited due to a lack of molecular data. In this study, the complete mitogenome of was firstly sequenced, then annotated and used to reconstruct the phylogenetic relationships of 76 Anseriformes species.

Combined climate change and dispersal capacity positively affect occupancy of agricultural wetlands.

Global warming significantly impacts amphibian populations globally, and modeling helps understand these effects. Here, we used MaxEnt and MigClim models to predict the impact of climate change on habitat suitability for . Our results indicate that temperature is a key factor affecting distribution.

MRI-based clinical-radiomics nomogram to predict early neurological deterioration in isolated acute pontine infarction: a two-center study in Northeast China.

Objective: To predict the appearance of early neurological deterioration (END) among patients with isolated acute pontine infarction (API) based on magnetic resonance imaging (MRI)-derived radiomics of the infarct site.

Methods: 544 patients with isolated API were recruited from two centers and divided into the training set (n = 344) and the verification set (n = 200). In total, 1702 radiomics characteristics were extracted from each patient.

LncRNA 220, a newly discovered long non-conding RNA inhibiting apoptosis and autophagy in Kupffer cells in LPS-induced endotoxemic mice through the XBP1u-PI3K-AKT pathway.

Sepsis is recognized as a potentially fatal condition characterized by acute organ dysfunction resulting from an imbalanced immune response to infection. Acute liver injury (ALI) arises as an inflammatory outcome of immune response dysregulation associated with sepsis. Kupffer cells, which are liver-specific macrophages, are known to have a significant impact on ALI, although the precise regulatory mechanism remains unclear.

Quantitative distribution and quantized ecological threat of microplastics in farmland: Shanghai as an example.

The occurrence of microplastics (MPs) in farmlands poses a threat to soil health and crop yield. There needs to be more research on the role of cropping patterns in the accumulation of MPs and quantizing the threat of MPs on soil health and crop yield. In this study, a field study was carried out to explore the role of cropping patterns in the accumulation of MPs in agricultural soil in Shanghai, China.

, a novel long noncoding RNA regulating autophagy in the liver tissues of endotoxemic mice through a competing endogenous RNA mechanism.

Sepsis is an often-deadly complication of infection that can lead to multiple organ failure. Previous studies have demonstrated that autophagy has a protective effect on liver injury in sepsis. Here, we report a novel long noncoding RNA (lncRNA), named lipopolysaccharide (LPS)-induced liver autophagy regulator (), which was highly induced in the liver tissues of endotoxemic mice.

Hydrothermal carbonization of biogas slurry and cattle manure into soil conditioner mitigates ammonia volatilization from paddy soil.

Hydrothermal carbonization of biogas slurry and animal manure into hydrochar could enhance waste recycling waste and minimize ammonia (NH) volatilization from paddy fields. In this study, cattle manure-derived hydrochar prepared in the presence of Milli-Q water (CMWH) and biogas slurry (CMBSH), and biogas slurry-based hydrochar embedded with zeolite (ZHC) were applied to rice-paddy soil. The results demonstrated that CMBSH and ZHC treatments could significantly mitigate the cumulative NH volatilization and yield-scale NH volatilization by 27.

Inhibition of Son of Sevenless Homologue 1 (SOS1): Promising therapeutic treatment for KRAS-mutant cancers.

Kristen rat sarcoma (KRAS) is one of the most common oncogenes in human cancers. As a guanine nucleotide exchange factor, Son of Sevenless Homologue 1 (SOS1) represents a potential therapeutic concept for the treatment of KRAS-mutant cancers because of its activation on KRAS and downstream signaling pathways. In this review, we provide a comprehensive overview of the structure, biological function, and regulation of SOS1.

Co-hydrothermal carbonization of sludge and food waste for hydrochar valorization: Effect of mutual interaction on sulfur transformation.

Co-hydrothermal carbonization of sludge and food waste is a promising method for hydrochar valorization. The sulfur content and form of hydrochar are the key parameters that determine its further utilization. However, the effect of the chemical composition of food waste on sulfur redistribution remains unknown.

The native reed-specific bird, reed parrotbill, has been detected in exotic smooth cordgrass.

After the smooth cordgrass invaded coastal China, native birds started avoiding the green desert, and bird diversity declined. After many years, a few passerine birds began to enter and use smooth cordgrass, but only birds with a nonspecialised habitat. In this study, we found that a native reed-specific bird, the parrotbill flocked and sang in a smooth cordgrass habitat throughout the overwintering period near Sheyang Port in Yancheng, Jiangsu Province.

Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease.

Concomitant inhibition of butyrylcholinesterase (BChE) and histone deacetylase 6 (HDAC6) is supposed to be effective in the treatment of Alzheimer's disease (AD). Inspired by our previous efforts in designing BChE inhibitors, herein, selective BChE and HDAC6 dual inhibitors were successfully identified through the fusion of the core pharmacophoric moiety of BChE and HDAC6 inhibitors. After the structure-activity relationship (SAR) studies, two compounds ( and ) were confirmed to have superior inhibitory activity against BChE (the IC against BChE are 4.

A blockchain-based traceable and secure data-sharing scheme.

The traditional data-sharing model relies on a centralized third-party platform, which presents challenges such as poor transaction transparency and unsecured data security. In this article, we propose a blockchain-based traceable and secure data-sharing scheme. Firstly, we designed an attribute encryption-based method to protect data and enable fine-grained shared access.

An Isolated and Deeply Divergent Species from Fujian, China.

It is important to describe lineages before they go extinct, as we can only protect what we know. This is especially important in the case of microendemic species likely to be relict populations, such as salamanders in southern China. Here, we unexpectedly sampled individuals in Fujian province, China, and then worked on determining their taxonomic status.

Development and validation of cuproptosis-related lncRNA signatures for prognosis prediction in colorectal cancer.

Background: Cuproptosis, a novel form of programmed cell death, plays an essential role in various cancers. However, studies of the function of cuproptosis lncRNAs (CRLs) in colorectal cancer (CRC) remain limited. Thus, this study aims to identify the cuprotosis-related lncRNAs (CRLs) in CRC and to construct the potential prognostic CRLs signature model in CRC.

Further analysis of natural antibodies against ischemic stroke.

Background: Our previous study revealed that circulating levels of IgG natural antibodies (NAbs) for vascular endothelial growth factor receptor 1 (VEGFR1) were significantly decreased in patients with arteriosclerosis compared with control subjects. To enhance the sensitivity of an enzyme-linked immunosorbent assay (ELISA) developed in-house for antibody testing, the present work was designed to investigate additive signals in the in-house ELISA developed with the combination of two or more linear peptide antigens derived from target proteins of interest, including VEGFR1, oxidized low-density lipoprotein receptor 1 (LOX-1), interleukins 6 (IL6) and 8 (IL8).

Methods: A total of 218 patients with ischemic stroke and 198 healthy controls were enrolled and an in-house ELISA was developed with linear peptides derived from VEGFR1, LOX-1, IL6, and IL8 to detect their IgG levels in plasma.

Exogenous melatonin enhances tomato heat resistance by regulating photosynthetic electron flux and maintaining ROS homeostasis.

Heat stress reduces plant growth and reproduction and increases agricultural risks. As a natural compound, melatonin modulates broad aspects of the responses of plants to various biotic and abiotic stresses. However, regulation of the photosynthetic electron transfer, reactive oxygen species (ROS) homeostasis and the redox state of redox-sensitive proteins in the tolerance to heat stress induced by melatonin remain largely unknown.

Occurrence of veterinary antibiotics in animal manure, compost, and agricultural soil, originating from different feedlots in suburbs of Shanghai, East China.

The present study aims to monitor and assess the occurrence of veterinary antibiotics (VAs) in animal manure, compost, and fertilized soil, originating from different large-scale feedlots. The corresponding concentrations of 39 types of VAs in 8 large-scale feedlots of pig, dairy cow, and poultry were sampled in different seasons and analyzed using LC-MS. The results indicated that 17 types, 16 types, and 5 types of VAs were detected in the swine manure, compost, and fertilized soil with the concentrations of 0.

Systemic Stereoselectivity Study of Fenobucarb: Environmental Behaviors in Greenhouse Vegetables, Fruits, Earthworms, and Soils and Its Cytotoxicity.

Fenobucarb (2--butylphenyl methylcarbamate, BPMC) is a potent carbamate pesticide with high insecticidal activity. In this study, the enantioselective accumulation of BPMC in earthworms () and dissipation in cabbage, Chinese cabbage, strawberry, and soils were investigated. The samples were prepared using the QuEChERS method and analyzed using fast and sensitive chiral high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) analysis.

[Emission Characteristics, Transformation Mechanism, and Reduction Potential of Ammonia Emissions from a Crop Rotation System in Yangtze River Delta].

To study the characteristics and reduction potential of the ammonia emissions of a crop rotation system in the Yangtze River Delta, we monitored and compared the ammonia fluxes from two rotation systems:a conventional rice/winter wheat rotation system and a rice-shrimp cultivation/Chinese milk vetch rotation system. This study was conducted through closing chamber methods to investigate the influencing factors and transformation mechanism of ammonium emissions between the two studied cultivation patterns. Additionally, we established the temporal-spatial emission inventory by sorting out the local ammonia emission factors of farmland in the Yangtze River Delta in the last ten years.

Exosomal miRNA-223-3p as potential biomarkers in patients with cerebral small vessel disease cognitive impairment.

Background: Cerebrovascular disease is a common clinical illness. Many patients with cerebrovascular disease can be accompanied by cognitive impairment. The exosomal microRNA (miRNA)-223-3p is related to vascular endothelial injury, synaptic function, inflammatory response, and other mechanisms.

Co-hydrothermal carbonization of sewage sludge and model compounds of food waste: Influence of mutual interaction on nitrogen transformation.

This study reports the transformation behavior of nitrogen during the co-hydrothermal carbonization of sewage sludge and model compounds (microcrystalline cellulose, starch, lignin, and xylan) of food waste at 220 °C, with a focus on the reaction routes between starch/xylan and NH. Most of the nitrogen in the raw sludge was transformed into organic-N (44.6%) and NH (23.