Interfacially crosslinked β-cyclodextrin polymer composite porous membranes for fast removal of organic micropollutants from water by flow-through adsorption.

Persistent organic micropollutants have seriously damaged aquatic ecological equilibrium and affected human health. Conventional adsorbents are limited due to slow adsorption rate. Therefore, it's significant to integrate adsorbent into porous membrane to develop a highly efficient continuous filtration method for water purification.

Macroporous membranes doped with micro-mesoporous β-cyclodextrin polymers for ultrafast removal of organic micropollutants from water.

Herein, we report novel macroporous membranes doped with micro-mesoporous β-cyclodextrin polymers (β-CDP), named β-CDP membranes, for water decontamination by the flow-through process. These membranes combine excellent adsorption behavior of β-CDP and the advantages of membranes filtration including low energy consumption and easy scale-up. Filtration adsorption results demonstrated that the optimal β-CDP membrane removed > 99.

Hierarchically micro-mesoporous β-cyclodextrin polymers used for ultrafast removal of micropollutants from water.

Persistent organic pollutants, including plasticizers, pesticides, pharmaceuticals and endocrine disrupters, have posed a serious threat to water safety and human health. Addressing this problem calls out new materials of purifying water with high efficiency. Here, a series of cross-linked β-cyclodextrin polymers (β-CDPs) with hierarchically micro-mesoporous structure and high surface area were first synthesized by introducing polymer of intrinsic microporosity (PIM) and used for adsorptive removal of organic micropollutants from water.

Poly (N-vinyl imidazole) gel-filled membrane adsorbers for highly efficient removal of dyes from water.

Energy-efficient and time-saving process for recovery of hazardous dyes from wastewater is highly desired in dyeing industry. In this work, poly(N-vinyl imidazole) (PVI) gel-filled membrane adsorbers were developed for highly efficient recovery of dyes through adsorption filtration. The membrane adsorbers were fabricated via dip-coating of Nylon macroporous membranes in PVI solutions followed by quaternization crosslinking with p-xylylene dichloride (XDC).

A crosslinked β-cyclodextrin polymer used for rapid removal of a broad-spectrum of organic micropollutants from water.

Organic micropollutants in aquatic environment such as plasticizer, pesticide and pharmaceuticals, have posed a serious threat to human health and are emerging as a great challenge to humanity. Traditional water treatment techniques fail to achieve high removal efficiency for low concentration of organic micropollutants. Here we demonstrate a water-insoluble crosslinked β-cyclodextrin (β-CD) polymer able to remove a broad-spectrum of organic micropollutants from water by rapid adsorption.

A zinc chelator TPEN attenuates airway hyperresponsiveness and airway inflammation in mice in vivo.

Background: Zinc is an essential element required for the cell metabolism, including gene transcription, signal transduction, immunity, and apoptosis. The pathophysiological role of zinc in asthma, however, is not entirely clear. Mast cells have been implicated in atopic asthma, and zinc deprivation has been reported to reduce mast cell activation.

[Inflammatory memory of pulmonary local lymphocytes in asthmatic mice].

Objective: To investigate if long-lived inflammatory memory exists in the airway of asthmatic mice, and whether pulmonary local lymphocytes could transfer the inflammatory memory.

Methods: 97 mice were divided into six groups by random number meter: asthma group (group A, n = 50), long term group (group B, n = 20), control group of long term (group C, n = 6), adoptive transfer group (group D, n = 12, subgroups D1, D2 and D3 divided based on the transferred cells counts), adoptive transfer control group (group E, n = 6), and naive group( group F, n = 3). There were subgroups using BSA (bovine serum album) substituting OVA (ovalbumin) for the second challenge, named subgroup B-BSA in group B and subgroup D-BSA in group D.

[Effect of tyrosine kinase inhibitors on airway remodeling in bronchial asthma].

Objective: To investigate the effect of tyrosine kinase inhibitors (TKIs) on asthmatic rat airway remodeling.

Methods: The inhibitive effects of three TKIs (Genistein, jin-zhuan-ting and Tyrphostin AG1478) on proliferation of primary cultures of rat tracheal epithelial cells were assessed by MTT assay. Then, jin-zhuan-ting was adopted in the asthmatic rat model; immunohistofluorescene method was used to stain phosphorylated tyrosine (P-tyr) for disclosing the activation of EGFR; Sirius Red staining of submucosal collagen I and III was performed, and an analysis was made on the correlation between EGFR activation and collagen I and III deposition.