Integration of Transcriptomics and Proteomics to Elucidate Inhibitory Effect and Mechanism of Antifungalmycin B from Marine in Treating .

(TM) is an opportunistic pathogenic fungus that mainly infects immunocompromised patients. Currently, the global prevalence of talaromycosis caused by TM is increasing, leading to an increased demand for anti-TM drugs. In our previous study, a novel 28-membered macrolide compound, antifungalmycin B (ANB), was isolated from GXIMD 06359, exhibiting significant antifungal properties.

A Wide-Range, Highly Stable Intelligent Flexible Pressure Sensor Based on Micro-Wrinkled SWCNT/rGO-PDMS with Efficient Thermal Shrinkage.

Flexible pressure sensors have drawn growing attention in areas like human physiological signal monitoring and human-computer interaction. Nevertheless, it still remains a significant challenge to guarantee their long-term stability while attaining a wide detection range, a minute pressure testing limit, and high sensitivity. Inspired by the wrinkles on animal skins, this paper introduces a flexible pressure sensor with wrinkled microstructures.

Multiple Scattering-Enhanced Fluorescence Within Randomly Oriented Low-Index Polymer Nanofiber Sensors.

Fluorescence enhancement technologies play a crucial role in biological and chemical sensors. Currently, effective fluorescence sensors primarily rely on noble metals and high-index dielectric nanostructures. While effective, they are plagued by optical losses and complex fabrication processes.

Cystatin B Promotes the Proliferation, Migration, and Invasion of Intrahepatic Cholangiocarcinoma.

: Cystatin B (CSTB) has been demonstrated to play a significant role in the pathogenesis of a number of diseases, including the evolution and progression of multiple cancers. Nevertheless, the function of CSTB in intrahepatic cholangiocarcinoma (iCCA) is yet to be fully elucidated. : By analyzing transcriptome sequencing data from the FU-iCCA cohort, the iCCA-27 cohort, and three public databases, we identified genes associated with iCCA prognosis and selected CSTB as the subject of our study.

Circular RNA ZNF277 Sponges miR-378d to Inhibit the Intracellular Survival of by Upregulating Rab10.

Circular RNAs (circRNAs) are covalently closed non-coding RNAs formed by back-splicing, lacking a 5' cap and poly-A tail. They could act as important regulatory factors in the host's anti-tuberculosis immune process, but only a few have been identified, and their molecular mechanisms remain largely unclear. Here, we identified a novel circRNA, circ-ZNF277, which responds to () infection in THP-1 cells.

Construction of a 'Simple, Fast and Accurate' Evaluation Method for Profile Control and Plugging Effect of Gel Plugging Agent Based on Simulations.

At present, the evaluation perspective of the gel plugging agent assessment method is incomprehensive, due to which the experimental results deviate from the field data. By analyzing the current indoor evaluation methods and the factors controlling the sealing capability of gel plugging agents, an experimental device and method for evaluating the blocking effect of oilfield gel plugging agents has been designed. In contrast to traditional assessment methods, the proposed approach offers advantages such as simple operation, rapid experimentation, and accurate results.

Lipid Droplets Metabolism Mediated by ANXA7-PPARγ Signaling Axis Regulates Spinal Cord Injury Repair in Mice.

Spinal cord injury is characterized by high incidence and high disability, and the specific targets and drugs have not yet been explored. Lipid droplet is a type of organelles that regulates lipid metabolism and oxidative stress. And the regulatory mechanisms of lipid droplets on spinal cord injury remain unclear.

Association of depression, traditional risk factor control and genetic risk with incident cardiovascular disease among individuals with prediabetes: A population-based prospective study from UK biobank.

Background: The relationship between depression and cardiovascular disease (CVD) in individuals with prediabetes, its relative importance compared with traditional risk factors and whether genetic risk modifies this association remain unclear.

Aims: To explore the potential interactive effects of controlling traditional risk factors and depression on CVD, and to assess how depression compares with traditional risk factors in terms of its relative contribution to CVD risk in individuals with prediabetes.

Materials And Methods: We analysed a prospective cohort of 42,020 individuals from the UK Biobank, all free of prevalent CVD.

Neurological Emergency Treatment Strategy: A Neuron-Targeted Regulation System for Reactive Oxygen Species Metabolism through Ferroptosis Modulation.

Spinal cord injury (SCI) represents a significant clinical challenge. Following SCI, the implementation of protective measures for neurons is critically important. Current clinical applications of hormone pulse therapy exhibit variable efficacy and considerable side effects, highlighting an urgent need for therapeutic strategies.

Single-cell landscape of peripheral blood mononuclear cells in patients with Graves' disease.

Background: Graves' Disease (GD) is a thyroid-specific autoimmune disease and the most common cause of hyperthyroidism. Its pathogenesis is associated with the disruption of immune tolerance and autoantibody production. However, the mechanisms underlying immune abnormalities remain incompletely elucidated.

Short-Term Outcomes of Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: A Systematic Review and Meta-Analysis.

Background And Aims: Pancreatic cysts (PCs) are increasingly detected through abdominal imaging, prompting exploration of alternatives such as endoscopic ultrasound-guided PC ablation due to the risks and costs associated with surgery. This study conducts a systematic review and meta-analysis of endoscopic ultrasound-guided PC ablation's short-term efficacy and complications for PC management.

Methods: A systematic review and meta-analysis were carried out on PubMed, Ovid, Cochrane, and TRIP electronic databases.

Analytical and clinical validation of a novel MeltPlus TB-NTM/RIF platform for simultaneous detection of , and rifampicin resistance.

Background: Rapid and accurate diagnosis of tuberculosis, particularly rifampin (RIF)-resistant tuberculosis (RR-TB) and (NTM), is essential for implementing appropriate proper therapy to benefit patients and improve TB/NTM patient management.

Methods: In this study, we developed a novel MeltPlus MTB-NTM/RIF platform, designed to simultaneously detect (MTBC), NTM and RIF resistance. The platform was evaluated for its limit of detection (LOD) and specificity before clinical validation, followed by a prospective single-center study in patients with presumptive TB cases.

Diagnosis of Benign and Malignant Newly Developed Nodules on the Surgical Side After Breast Cancer Surgery Based on Machine Learning.

To enhance the diagnostic accuracy of new nodules on the surgical side after breast cancer surgery using machine learning techniques and to explore the role of multifeature fusion. Data from 137 breast cancer postoperative patients with new nodules from January 2016 to April 2024 were analyzed. Clinical, ultrasound, immunohistochemistry, and surgical features were combined.

Carcinoembryonic antigen trajectory predicts pathological complete response in advanced gastric cancer after neoadjuvant chemotherapy.

Aims: This study aims to develop a simple, clinically applicable classification system to predict pCR based on carcinoembryonic antigen (CEA) trajectory during NAC.

Methods: This study included 366 AGC patients who received NAC followed by radical gastrectomy. CEA levels were measured before, during, and after NAC, with changes classified into three trajectory types: Type I (>=80% decline), Type II (>=40% but <80% decline), and Type III (<40% decline or increase).

Assessing left ventricular function in patients with hyperthyroidism across varied heart rates via press-strain loop analysis: a retrospective cross-sectional study.

Background: In the early stages of hyperthyroidism (HTH), cardiovascular symptoms are not prominent, and heart function impairment may occur before structural changes. The non-invasive left ventricular (LV) pressure-strain loop (PSL) allows for early, quantitative assessment of changes in LV systolic function. However, previous studies have not grouped hyperthyroid patients based on the presence or absence of tachycardia.

An automatic deep-learning approach for the prediction of post-stroke epilepsy after an initial intracerebral hemorrhage based on non-contrast computed tomography imaging.

Background: Post-stroke epilepsy (PSE) is a common and significant complication that often occurs after stroke, and affects patients' prognosis and overall quality of life. In recent years, non-contrast computed tomography (NCCT) has become the preferred method for the clinical diagnosis of intracerebral hemorrhage (ICH). This study aimed to develop and validate a triple deep-learning model, simply named, the post-stroke epilepsy network (PSENet), to predict PSE in ICH patients based on NCCT.

A medical insurance fund operation performance evaluation system under the DRG payment mode reform.

Background: An evaluation system for comprehensively measuring medical insurance fund operational performance under China's Diagnosis Related Groups (DRG) payment reform holds critical theoretical and practical significance, especially for enhancing the efficiency of medical insurance fund utilization and the quality of healthcare services. However, few studies undertake performance evaluations of medical insurance funds under DRG payments, especially those incorporating the Analytic Hierarchy Process (AHP)-Entropy Weight Method (EWM)- Fuzzy Comprehensive Evaluation (FCE) method model.

Methods: This study utilizes operational data from medical insurance funds across eight cities in S Province, China, from 2020 to 2022.

Nomogram for overall survival in ampullary adenocarcinoma using the surveillance, epidemiology, and end results database and external validation.

Background: Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract. Currently, only a few cases have been reported, resulting in limited information on survival.

Aim: To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.

Lithiophilic-Gradient, Li Supplementary Interphase Design for Lean Lithium Metal Batteries.

The practicability of anode-less/free lithiummetal batteries (LMBs) is impeded by unregulated dendrite formation on thedeposition substrate. Herein, this study presents a lithiophilic-gradient, layer-stacked interfacial design for the lean lithium metal battery (LLMB) model. Engineered via a facile wet-chemistry approach, the high entropy metalphosphide (HEMP) particles with tunable lithiophilic species are dispersedwithin reduced graphene oxide (RGO).

Grassland bud and shoot demographic responses to single and recurrent droughts vary across an aridity gradient.

Clonal demographic traits play important roles in regulating community dynamics. Yet, it remains unclear how the responses of these clonal traits to drought might depend on previous drought exposure, and how drought responses vary among grasslands. We conducted a repeated drought experiment across four grasslands along an aridity gradient in northern China.

Enabling Unconventional "Alternating-Distal" N Reduction Pathway for Efficient Ammonia Electrosynthesis.

The general understanding on the reaction path is that the electrocatalytic N reduction follows either individual associative alternating or distal pathways, where efficient N activation and selective NH production are very challenging. Herein, an unconventional "alternating-distal" pathway was achieved by shifting the "*NHNH→*NHNH" to "*NHNH→*NH + NH" step to boost NH synthesis with an amorphous CeMnO electrocatalyst. In this unconventional process, N activation was realized through π back donation on the Mn site, while the Mn/Ce dual active sites could regulate the intermediate configurations to avoid the nitrogen-containing by-product formation.

UPLC-Q-TOF-MS, Network Pharmacology and Molecular Docking to Reveal the Antidepressant Mechanism of the Different Components of Medicinal and Edible Lilies (Lilium sp. pl).

Background And Objectives: To explore the mechanism of action of the differential components of medicinal and edible lilies in treating depression by network pharmacology using UPLC-Q-TOF-MS technology.

Methods: The chemical composition of medicinal and edible lilies was analyzed, screening for unique medicinal compounds. Searched for depression-related targets.

Measuring Mini SmartApp usability for ankylosing spondylitis from the perspective of patients and health providers.

Objective: To identify beneficial experiences, areas needing improvement, and potential additional value, with a view to providing a reference for the application of mobile health management in clinical practice.

Methods: This study applied a mixed research approach to measure the mini smartApp usability among participants who were diagnosed with ankylosing spondylitis at rheumatology and immunology department of the Affiliated Hospital of Nantong University between October 2022 to March 2023 and research staff. This study lasted two weeks.