Clinical evaluation and risk factors of head-up tilt test in children.

The head-up tilt test (HUTT) is a fundamental tool for the clinical diagnosis of unexplained syncope. While HUTT has been extensively employed in adult populations for over three decades, its application in pediatric cases remains relatively limited. A comprehensive literature review was conducted to perform a multi-dimensional evaluation of HUTT in pediatric patients.

Multivariate predictive model of the therapeutic effects of metoprolol in paediatric vasovagal syncope: a multi-centre study.

Background: Metoprolol therapy for paediatric vasovagal syncope (VVS) has yielded inconsistent results, necessitating predictive markers. We aimed to develop and validate models to identify paediatric VVS patients likely to benefit from metoprolol.

Methods: 478 metoprolol-treated paediatric patients with VVS were enrolled from three syncope units and divided into retrospective training (March 2017-March 2023, n = 323) and prospective validation cohorts (April 2023-March 2024, n = 155).

Oligomerized Electron Acceptors with Alkynyl Linkages to Suppress Electron-Photon Coupling for Low-Energy-Loss Organic Solar Cells.

A novel series of alkynyl-linked oligomerized electron acceptors have been synthesized via Sonogashira coupling. The alkynyl linkages can enhance molecular planarity and aggregation, suppress electron-phonon coupling, and reduce non-radiative losses. Binary organic solar cells (OSCs) achieved an efficiency of 17.

Research progress in diagnosis and treatment of psychogenic pseudosyncope in children.

Psychogenic pseudosyncope is one of the primary causes of transient loss of consciousness in children and adolescents, essentially classified as a conversion disorder that significantly impacts patients' quality of life. Clinically, psychogenic pseudosyncope shares certain similarities with vasovagal syncope in terms of pre-syncope symptoms and triggers, making it sometimes difficult to differentiate and easily misdiagnosed. Therefore, placing emphasis upon the characteristics of psychogenic pseudosyncope is crucial for early identification and treatment, which holds significant importance for the mental and psychological health of children and adolescents.

Antioxidant and hepatic fibrosis-alleviating effects of selenium-modified Bletilla striata polysaccharide.

Liver fibrosis is a significant precursor to cirrhosis and liver cancer, yet effective treatments remain elusive. Our previous studies demonstrated that Bletilla striata polysaccharide (BSP) has therapeutic effects, though it performed poorly at medium concentrations. To address this limitation, BSP underwent selenization modification.

Differential diagnostic value of P wave dispersion and QT interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescents.

Background: Both psychogenic pseudosyncope (PPS) and vasovagal syncope (VVS) in children and adolescents are diseases of transient loss of consciousness. It is difficult to distinguish them clinically. This paper will study the differential diagnostic value of P wave dispersion (Pd) and QT interval dispersion (QTd) between PPS and VVS.

Identification of candidate genes for leaf size by QTL mapping and transcriptome sequencing in Brassica napus L.

Leaf is the main photosynthetic organ at the seedling stage of rapeseed and leaf size is a crucial agronomic trait affecting rapeseed yield. Understanding the genetic mechanisms underlying leaf size is therefore important for rapeseed breeding. In this study, QTL mapping for three traits related to leaf size, i.

Gaussianmorph: deformable medical image registration with Gaussian noise constraints.

Deep learning-based image registration methods offer advantages of time efficiency and registration outcomes by automatically extracting enough image features. Currently, more and more scholars choose to use cascaded networks to achieve coarse-to-fine registration. Although cascaded networks take a lot of time in the training and inference stages, they can improve registration performance.

Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway.

Background: Immunosuppressive phenotype compromised immunotherapy efficacy of hepatocellular carcinoma. Tumor cells intrinsic mitochondria dynamics could pass effects on the extracellular microenvironment through mtDNA stress. PGAM5 anchors at mitochondria and regulates mitochondria functions.

Fenofibrate Inhibits LPS and Zymosan-induced Inflammatory Responses through Sonic Hedgehog in IMG Cells.

Background: Neuroinflammatory responses are strongly associated with the pathogenesis of progressive neurodegenerative conditions and mood disorders. Modulating microglial activation is a potential strategy for developing protective treatments for central nervous system (CNS)-related diseases. Fibrates, widely used in clinical practice as cholesterol-lowering medications, exhibit numerous biological activities, such as anticancer and antiinflammatory activities.

High-Throughput Formation of Pre-Vascularized hiPSC-Derived Hepatobiliary Organoids on a Chip via Nonparenchymal Cell Grafting.

Liver organoids have been increasingly adopted as a critical in vitro model to study liver development and diseases. However, the pre-vascularization of liver organoids without affecting liver parenchymal specification remains a long-lasting challenge, which is essential for their application in regenerative medicine. Here, the large-scale formation of pre-vascularized human hepatobiliary organoids (vhHBOs) is presented without affecting liver epithelial specification via a novel strategy, namely nonparenchymal cell grafting (NCG).

Development and Evaluation of a Virtual Reality Program for Immediate Newborn Care Training in Nursing Education: A Feasibility Study.

Introduction: Nursing education equips students with the skills necessary to navigate the clinical environment. Repetitive training in complex skills ensures patient and student safety. Immersive virtual reality (VR) offers a realistic and safe environment for such repetitive learning processes.

Attention demands modulate brain electrical microstates and mental fatigue induced by simulated flight tasks.

Prolonged engagement in tasks with varying attention demands is thought to elicit distinct forms of mental fatigue, potentially indicating variations in neural activity. This study aimed to investigate the association between mental fatigue and changes in electroencephalogram microstate dynamics during tasks with varying attention demands.In the present study, we employed a 2 × 2 repeated measures ANOVA to analyze the temporal parameters of four distinct microstates (A, B, C, and D) across different levels of attention demands (high vs.

Cerium Dioxide-Induced Abundant Cu/Cu Sites for Electrocatalytic Reduction of Carbon Dioxide to C Products.

In recent years, the electrochemical reduction of carbon dioxide (CORR) has made many advances in C production. Cu/Cu site is beneficial for C-C coupling process, but the oxidation state of copper cannot be well maintained during the reaction process, resulting in a decrease in catalyst activity. Based on this consideration, in this work, transition metal oxide CeO with a hollow cube structure and oxygen vacancies was introduced to stabilize and increase Cu/Cu active sites (CeCu).

IGF2BP3/CTCF Axis-Dependent NT5DC2 Promotes M2 Macrophage Polarization to Enhance the Malignant Progression of Lung Squamous Cell Carcinomas.

Background: Lung squamous cell carcinoma (LUSC) is a type of lung cancer that develops in the squamous cells. It is known to be promoted by the activation of various signaling pathways and the dysregulation of key regulatory molecules. One such molecule, 5'-nucleotidase domain containing 2 (NT5DC2), has been identified as a critical regulator in various cancers including lung cancer.

Rare posterior mediastinal hemangiomas invading the spinal cord through the intervertebral foramen and causing acute symptoms: illustrative case.

Background: Hemangioma is a rare vascular tumor characterized by endothelial cell proliferation that primarily occurs in soft tissues. While most cases in the paraspinal posterior mediastinum are clinically indolent, they can also exhibit aggressive growth, leading to severe clinical outcomes and necessitating urgent treatment.

Observations: A 61-year-old right-handed female presented with reduced lower-extremity mobility that had begun 4 days earlier.

Rescue analgesia with a transversus abdominis plane block alleviates moderate-to-severe pain and improves oxygenation after abdominal surgery: a randomized controlled trial.

Background: Abdominal surgery is a common surgical procedure that is frequently associated with substantial postoperative pain. However, rescue analgesia using opioids is associated with several adverse effects. The transversus abdominis plane block (TAPB) has been demonstrated to be effective as part of multimodal analgesia.

Exploring Caregiver Burden and Related Factors Among Primary Caregivers of Patients With Cancer in Taiwan.

Objectives: To explore burden and its related factors among primary caregivers of patients with cancer.

Sample & Setting: This study was conducted in an oncology ward at a medical center in southern Taiwan. A total of 137 dyads of patients with cancer and their primary caregivers were recruited.

LAP2α orchestrates alternative lengthening of telomeres suppression through telomeric heterochromatin regulation with HDAC1: unveiling a potential therapeutic target.

In response to the challenge of telomere attrition during DNA replication, cancer cells predominantly employ telomerase or, in 10-15% of cases, the alternative lengthening of telomeres (ALT). The intricate details of ALT, however, remain elusive. In this study, we unveil that the knockdown of lamina-associated polypeptide 2 alpha (LAP2α) in ALT cells results in telomere dysfunction, triggering a notable increase in ALT-associated hallmarks, including high frequencies of PML bodies (APBs), C-rich extrachromosomal circles (C-circles), and telomere sister chromatid exchange (T-SCE).