Preoperative prediction of pituitary neuroendocrine tumor invasion using multiparametric MRI radiomics.

Objective: The invasiveness of pituitary neuroendocrine tumor is an important basis for formulating individualized treatment plans and improving the prognosis of patients. Radiomics can predict invasiveness preoperatively. To investigate the value of multiparameter magnetic resonance imaging (mpMRI) radiomics in predicting pituitary neuroendocrine tumor invasion into the cavernous sinus (CS) before surgery.

Structure characteristics of a novel pectic polysaccharide from Fructus Corni and its protective effect on alcoholic fatty liver.

Alcoholic fatty liver disease (AFLD) is characterized by the accumulation of hepatic lipid and has no effective treatment yet. Fructus Corni is a traditional Chinese medicinal herb, and its extractions have demonstrated hepatoprotective properties. We hypothesize that the polysaccharides in Fructus Corni might have therapeutic effects on AFLD.

Descriptive epidemiology and prognostic factors of atypical teratoid/rhabdoid tumors in the United States, 2001-2021.

Atypical teratoid rhabdoid tumor (AT/RT) is a rare embryonal central nervous system tumor with a dismal prognosis that occurs mostly in early childhood. Since recent epidemiological and prognostic information is limited, we aimed to describe and analyze AT/RT-related incidences, temporal trends and prognostic factors. Incidence and survival data between 2001 and 2021 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database.

Antibiotic resistance genes in anaerobic digestion: Unresolved challenges and potential solutions.

Antimicrobial resistance (AMR) threatens public health, necessitating urgent efforts to mitigate the global impact of antibiotic resistance genes (ARGs). Anaerobic digestion (AD), known for volatile solid reduction and energy generation, also presents a feasible approach for the removal of ARGs. This review encapsulates the existing understanding of ARGs and antibiotic-resistant bacteria (ARB) during the AD process, highlighting unresolved challenges pertaining to their detection and quantification.

EnrichRBP: an automated and interpretable computational platform for predicting and analyzing RNA-binding protein events.

Motivation: Predicting RNA-binding proteins (RBPs) is central to understanding post-transcriptional regulatory mechanisms. Here, we introduce EnrichRBP, an automated and interpretable computational platform specifically designed for the comprehensive analysis of RBP interactions with RNA.

Results: EnrichRBP is a web service that enables researchers to develop original deep learning and machine learning architectures to explore the complex dynamics of RNA-binding proteins.

Learning curve analysis of extraperitoneal single-site robotic-assisted radical prostatectomy: a CUSUM-based approach.

This study applied cumulative sum (CUSUM) analysis to evaluate trends in operative time and blood loss, It aims to identify key milestones in mastering extraperitoneal single-site robotic-assisted radical prostatectomy (ss-RARP). A cohort of 100 patients who underwent ss-RARP, performed by a single surgeon at the First Affiliated Hospital of Guangzhou Medical University between March 2021 and June 2023, was retrospectively analyzed. To evaluate the learning curve, the CUSUM (Cumulative Sum Control Chart) technique was applied, revealing the progression and variability over time.

The novel pleuromutilin derivative 22-((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both and .

Objective: Mycoplasmas are structurally simple pathogenic microorganisms that can cause a wide range of diseases in humans and animals and conventional antibiotic therapies of fluoroquinolones and tetracyclines are toxic to young children and young animals and macrolide resistance is increasing. In this context, new anti-mycoplasma antimicrobial agents need to be developed. 22-((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxypleuromutilin (compound 16C) is a novel acetamine phenyl pleuromutilin derivative.

Amphibious Soft Robots Based on Programmable Actuators Fabricated by Brushing Chinese Ink on Paper.

Soft robots based on actuators that can work in both on-ground and on-water situations are environmentally adaptable and can accomplish tasks in complex environments. However, most current amphibious actuators need external stimuli to move on water and require complex preparation processes. Herein, amphibious Ink-paper/polyethylene programmable actuators and robots are proposed, which are fabricated by rapidly brushing Chinese ink on paper.

Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins.

Background: TNF-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor superfamily. TRAIL selectively induces apoptosis in tumor cells while sparing normal cells, which makes it an attractive candidate for cancer therapy. Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors have demonstrated safety and tolerability in clinical trials.

Efficacy and Safety of Chemotherapy or EGFR-TKIs as First-Line Therapy in NSCLC Patients Harboring Non-Ex 20 Ins Uncommon EGFR Mutations: A Retrospective Study in China.

Background: Uncommon EGFR mutations are a kind of heterogeneous group of mutations with various responses to EGFR-TKIs and are often excluded from most prospective clinical trials. In this real-world retrospective study, we retrospectively compared the efficacy and safety of chemotherapy or various generations of EGFR-TKIs as first-line therapy in NSCLC Chinese patients harboring non-ex 20 ins uncommon EGFR mutations.

Methods: We enrolled 139 NSCLC patients with non-ex 20 ins uncommon EGFR mutations in this study retrospectively.

Cardiovascular disease prediction model based on patient behavior patterns in the context of deep learning: a time-series data analysis perspective.

To address the limitations of traditional cardiovascular disease prediction models in capturing dynamic changes and personalized differences in patients, we propose a novel LGAP model based on time-series data analysis. This model integrates Long Short-Term Memory (LSTM) networks, Graph Neural Networks (GNN), and Multi-Head Attention mechanisms. By combining patients' time-series data (such as medical records, physical parameters, and activity data) with relationship graph data, the model effectively identifies patient behavior patterns and their interrelationships, thereby improving the accuracy and generalization of cardiovascular disease risk prediction.

Non-Specific Lipid Transfer Protein StLTP6 Promotes Virus Infection by Inhibiting Jasmonic Acid Signalling Pathway in Response to PVS TGB1.

Plant viruses rely on host factors for successful infection. Non-specific lipid transfer proteins (nsLTPs) play critical roles in plant-pathogen interactions; however, their functions and underlying molecular mechanisms in viral infections remain largely unknown. Jasmonic acid (JA) is a crucial regulatory hormone in the process of plant resistance to viral infection.

Nonlinear optical properties of BiSeTe for harmonic mode-locked and broadband Q-switched pulses generation.

The nonlinear optical properties of bismuth selenium telluride (BiSeTe), a few-layer two-dimensional topological insulator material, have been investigated in this work. An erbium-doped fiber laser (EDFL) based on BiSeTe (BST) nanosheets as saturable absorber (SA) was demonstrated. The BST SA with saturation intensity and modulation depth of 4.

Complete excision of a giant chondrosarcoma within the cavernous sinus: a case report and literature review.

Background: Primary skull base chondrosarcoma (SBC) is a rare malignant central nervous system tumor, often involving the cavernous sinus. Complete excision of tumors invading this region is exceptionally challenging due to the presence of the internal carotid artery and numerous nerves within the cavernous sinus, particularly in cases with substantial tumor volume.

Case Presentation: This report describes a rare case of a massive primary SBC pushing the lateral wall of the cavernous sinus, measuring approximately 6.

Impact of fasting blood glucose on prognosis after acute large vessel occlusion reperfusion: results from a multicenter analysis.

Objective: To analyze the effect of fasting blood glucose levels after reperfusion of acute large vessel occlusion (ALVO) on patient functional prognosis.

Methods: Retrospectively included ALVO patients from three large stroke centers in China, all of whom achieved vascular reperfusion after mechanical thrombectomy or bridging thrombolysis. The prognosis scores of all patients at 90 ± 7 days post-recanalization were categorized into a good prognosis group (mRS 0-2) and a poor prognosis group (mRS 3-6).

Development and mechanism exploration of a quantitative model for Escherichia coli transformation efficiency based on ultrasonic power.

Ultrasonic-mediated plasmid transformation is a promising microbial transformation strategy with broad application prospects that has attracted interest across various fields. Limited research exists on developing a quantitative model to understand the relationship between transformation efficiency and ultrasonic power. Within the ultrasonic range that did not damage plasmids, the maximum transformation efficiency reached at 4.

Efficacy and Safety of Bevacizumab Combined with Temozolomide in the Treatment of Glioma: A Systematic Review and Meta-Analysis of Clinical Trials.

Objective: Glioma is the most common malignant brain tumor in neurosurgery. Bevacizumab (BEV) is a monoclonal antibody that inhibits tumors by inhibiting vascular endothelial growth factor and reducing tumor angiogenesis. To evaluate the efficacy and safety of BEV combined with temozolomide (TMZ) in glioma, we performed a meta-analysis.

Study of Self-Locking Structure Based on Surface Microstructure of Dung Beetle Leg Joint.

Dung beetle leg joints exhibit a remarkable capacity to support substantial loads, which is a capability significantly influenced by their surface microstructure. The exploration of biomimetic designs inspired by the surface microstructure of these joints holds potential for the development of efficient self-locking structures. However, there is a notable absence of research focused on the surface microstructure of dung beetle leg joints.

Bionic Design of High-Performance Joints: Differences in Failure Mechanisms Caused by the Different Structures of Beetle Femur-Tibial Joints.

Beetle femur-tibial joints can bear large loads, and the joint structure plays a crucial role. Differences in living habits will lead to differences in femur-tibial joint structure, resulting in different mechanical properties. Here, we determined the structural characteristics of the femur-tibial joints of three species of beetles with different living habits.