Prognostic and clinical significance of contrast enhancement in WHO grade 2 oligodendrogliomas.

Purpose: To investigate the prognostic significance of contrast enhancement (CE) in grade 2 oligodendroglioma (ODG) and explore its clinical implications.

Methods: Patients diagnosed with isocitrate dehydrogenase (IDH)-mutant, 1p/19q co-deleted ODG between 2009 and 2016 were retrospectively enrolled from a single institution. The presence of CE was identified on preoperative MRIs, and clinical, radiologic, and histopathological data that was extracted.

MFSD6 is an entry receptor for respiratory enterovirus D68.

Enterovirus D68 (EV-D68) is a leading non-polio enterovirus that causes severe respiratory diseases and poliomyelitis-like illness in children. Viral entry represents a potential multifaceted target for antiviral intervention; however, there are no approved inhibitors to block EV-D68. Here, we identify the functionally undescribed membrane protein major facilitator superfamily-domain-containing protein 6 (MFSD6) as an EV-D68 entry factor amenable to therapeutic intervention.

Roles of SIRT3 in cardiovascular and neurodegenerative diseases.

Sirtuin-3 (SIRT3) in mitochondria has nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase activity. As such, SIRT3 is crucial in cardiovascular and neurodegenerative diseases. Advanced proteomics and transcriptomics studies have revealed that SIRT3 expression becomes altered when the heart or brain is affected by external stimuli or disease, such as diabetic cardiomyopathy, atherosclerosis, myocardial infarction, Alzheimer's disease, Huntington's disease, and Parkinson's disease.

LiZrF protective layer enabled high-voltage LiCoO positive electrode in sulfide all-solid-state batteries.

The application of high-voltage positive electrode materials in sulfide all-solid-state lithium batteries is hindered by the limited oxidation potential of sulfide-based solid-state electrolytes (SSEs). Consequently, surface coating on positive electrode materials is widely applied to alleviate detrimental interfacial reactions. However, most coating layers also react with sulfide-based SSEs, generating electronic conductors and causing gradual interface degradation and capacity fading.

Theoretical analysis of bearing mechanism and engineering application of pipe roof in a highway tunnel.

Establishing a reasonable and precise theoretical model for pipe roof is crucial for advancing pre-support technology in tunnel construction. By considering the processes of tunnel excavation and support, as well as the reduced constraint reaction force on the pipe roof in unexcavated section due to the disturbance at the tunnel face, this paper establishes a load-structure model for pipe roof based on the Euler-Bernoulli beam theory. The Pasternak elastic foundation model is utilized to ascertain the constraint reaction force exerted by primary support and surrounding soil ahead of the tunnel face on the pipe roof.

Construction and validation of a senescence-related gene signature for early prediction and treatment of osteoarthritis based on bioinformatics analysis.

The aim of this study is to screen key target genes of osteoarthritis associated with aging and to preliminarily explore the associated immune infiltration cells and potential drugs. Differentially expressed senescence-related genes (DESRGs) selected from Cellular senescence-related genes (SRGs) and differentially expressed genes (DEGs) were analyzed using Gene Ontology enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and protein-protein interaction networks. Hub genes in DESRGs were selected based on degree, and diagnostic genes were further screened by gene expression and receiver operating characteristic (ROC) curve.

Degradable Radical Polymer Cathode for Lithium Battery with Long-Term Cycling Capability.

Polymer-based organic electrodes for rechargeable batteries are attractive due to their design flexibility, sustainability, and environmental compatibility. Unfortunately, waste management of conventional polymer materials typically involves incineration, which emits greenhouse gases. Consequently, degradable polymers should be ideal candidates for future green batteries.

Towards Highly Stable Sn Electrolyte for Aqueous Tin Batteries Using Hydroquinone Antioxidant.

Sn redox chemistry in aqueous acidic electrolyte was characterized with high reversibility and kinetics, which is considered as competitive anode material for aqueous batteries. Unfortunately, divalent Sn is unstable in aqueous electrolyte. It was revealed that Sn is easy to be oxidized to tetravalent Sn by dissolved oxygen and then forms precipitate through hydrolysis process, leading to serious performance decay.

Evaluating spatial effect of transportation planning factors on taxi CO emissions.

In recent years, the impact of transportation activities on carbon (CO) emissions has gained global attention. In China, the severity of CO emissions from transportation is a pressing issue, necessitating the development of effective emission reduction strategies. This study uses taxi GPS data from Xi'an, China, to explore the spatial patterns and influencing factors of CO2 emissions.

Establishment of a Rabbit Model of Rib Tethering-Induced Early-Onset Scoliosis: Insights into Lung Evaluation using Design-Based Stereology.

Study Design: Experimental Study.

Objective: To create an EOS rabbit model and use a design-based stereological method to quantitatively assess lung structure changes at 24 weeks of age.

Summary Of Background Data: Scoliosis affects thoracic and lung development, impacting children's chest and lung growth.

Solid-Phase Synthesis of Poly(imino anthraquinone)s for Low-Cost and High-Performance Bipolar Organic Cathode Materials.

Organic polymer cathode materials have emerged as promising candidates for constructing sustainable lithium and post-lithium batteries. However, it remains a significant challenge to synthesize electroactive polymers with the desired energy density and cycling stability in a cost-effective manner. Herein, we present a simple yet effective solid-phase method for synthesizing a series of bipolar quinone-amine polymers, specifically, poly(imino anthraquinone)s (PIAQs).

Disrupted topologic efficiency of white matter structural connectome in migraine: a graph-based connectomics study.

Objective: To delineate the structural connectome alterations in patients with chronic migraine (CM), episodic migraine (EM), and healthy controls (HCs).

Background: The pathogenesis of migraine chronification remains elusive, with structural brain network changes potentially playing a key role. However, there is a paucity of research employing graph theory analysis to explore changes in the whole brain structural networks in patients with CM and EM.

Nanoengineering of Phosphate/Phosphonate Drugs via Competitive Replacement with Metal-Phenolic Networks to Overcome Breast Tumor with Lung and Bone Metastasis.

Phosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, and exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, and enzyme-inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competitive coordination strategy for nanoengineering phosphate/phosphonate drugs is introduced.

[Risk factors of perioperative deep venous thrombosis of lower extremities in elderly patients with femoral neck fracture].

Objective: To investigate the incidence of perioperative deep venous thrombosis (DVT) of lower extremities and its risk factors in elderly patients with femoral neck fracture.

Methods: The clinical data of 4 109 elderly patients with femoral neck fracture admitted between August 2012 and November 2020 and met the selection criteria were retrospectively analyzed. Among them, there were 1 137 males and 2 972 females; their ages ranged from 65 to 101 years, with an average of 77.

Asystole Following Jaw Thrust Maneuver: A Case Report.

The jaw thrust maneuver is a fundamental airway management tool to prevent the tongue from obstructing the upper airway in unconscious patients. Known complications of the jaw thrust maneuver include spinal cord injury if the cervical spine is unstable and exacerbation of an existing mandibular injury. However, this procedure is frequently associated with pain, and the associated consequences, especially the parasympathetic response, are rarely seen or discussed.

Development and mechanism exploration of a quantitative model for Escherichia coli transformation efficiency based on ultrasonic power.

Ultrasonic-mediated plasmid transformation is a promising microbial transformation strategy with broad application prospects that has attracted interest across various fields. Limited research exists on developing a quantitative model to understand the relationship between transformation efficiency and ultrasonic power. Within the ultrasonic range that did not damage plasmids, the maximum transformation efficiency reached at 4.