Preparation, characterization and antimicrobial properties of double lysine-modified chitosan and its preservation ability in chicken meat refrigeration.

In this study, to increase the antimicrobial activity of chitosan, lysine was grafted onto chitosan, resulting in a novel derivative named double lysine-modified chitosan (DL-chitosan). The use of H NMR, FT-IR, SEM, TG and DTG analyses provided compelling evidence of the structure of the newly developed derivatives. The MICs of DL-chitosan ranged from 0.

Efficient synthesis of high-active multi-subunit hemoglobins through balanced expression of globins and robust heme-supply in Saccharomyces cerevisiae.

The biosynthesis of multi-subunit hemoglobins that can be used in artificial oxygen carriers, artificial foods and medical diagnostics has become a hot research issue. However, the imbalanced expression of different subunits and insufficient heme-supply limit the efficient production of multi-subunit hemoglobins. After the equalized synthesis of different globins through the regulation at transcriptional and translational levels, the improvement of heme-supply by relieving the feedback inhibition of heme on Hem1p and the enhancement of key rate-limiting enzymes in yeast, a robust platform for the expression of high-active hemoglobins was constructed.

On value compatibility: reflections on the ethical framework for pandemic healthcare distribution.

An ethical framework for pandemic healthcare distribution typically encompasses multiple ethical values. However, integrating various ethical values and distributive principles into a single framework raises concerns about their compatibility and the overall coherence of the framework. This issue of value compatibility could lead to moral inconsistencies within the ethical framework, leading to practical indetermination when facing conflicting implications.

Organelle-Targeted Photo-triggered Delivery of Acetylperoxyl Radicals for Redox Homeostasis Modulation.

Dysfunction of subcellular organelles initiates complex pathophysiological cascades and underlies numerous diseases, underscoring the need for organelle-specific therapeutic interventions. Precise spatiotemporal control of reactive oxygen species (ROS) generation within organelles offers a promising intervention approach. Herein, we report the design and synthesis of a novel series of organelle-targeted, photoactivatable acetylperoxyl radical donors () based on an acetyl-caged rhodamine scaffold.

Construction of Carbon Dot-Based Color-Tunable Circularly Polarized Long Afterglow via in Situ Phosphorescence Resonance Energy Transfer.

Carbon dots (CDs) with circularly polarized long afterglow (CPLA) properties have received increasing attention as a cutting-edge research field. However, because the CDs with both long afterglow and chirality are difficult to prepare and the afterglow color of most phosphorescent CDs is mainly concentrated in short wavelengths, it is still a formidable challenge to explore a facile route to achieve intrinsic CD-based color-tunable CPLA materials on a large scale. Herein, we developed a facile gram-scale synthesis method to prepare intrinsic CD-based color-tunable CPLA materials via a simple hydrothermal mixture of boric acid, arginine, and various fluorescent dyes.

Label-free optical mapping for large-area biomechanical dynamics of multicellular systems.

Mapping cellular activities over large areas is crucial for understanding the collective behaviors of multicellular systems. Biomechanical properties, such as cellular traction forces, serve as critical regulators of physiological states and molecular configurations. However, existing technologies for mapping large-area biomechanical dynamics, which arise from changes in cellular traction forces, are limited by their small field of view and scanning-based nature.

A Wide-Range, Highly Stable Intelligent Flexible Pressure Sensor Based on Micro-Wrinkled SWCNT/rGO-PDMS with Efficient Thermal Shrinkage.

Flexible pressure sensors have drawn growing attention in areas like human physiological signal monitoring and human-computer interaction. Nevertheless, it still remains a significant challenge to guarantee their long-term stability while attaining a wide detection range, a minute pressure testing limit, and high sensitivity. Inspired by the wrinkles on animal skins, this paper introduces a flexible pressure sensor with wrinkled microstructures.

Preparation, structure and properties of litchi pericarp polysaccharide.

A high purity polysaccharide (UELPP-A1) was isolated from the crude polysaccharide of litchi pericarp (UELPP) by column chromatography, and acetylated polysaccharide (AC-UELPP) was obtained by acetylation modification of the crude polysaccharide of litchi pericarp. The physicochemical properties and in vitro antioxidant activity of UELPP-A1 and AC-UELPP were compared. The C/H on UELPP-A1 was assigned by Congo red test, FTIR, 1D and 2D NMR, and its structural characteristics were characterized.

Tunable nonlinear absorption properties of TiCT MXene for all-optical bipolar modulation applications.

The demand for ultrafast and multifunctional all-optical modulators based on two-dimensional nonlinear optical materials is continuously growing in the era of big data and artificial intelligence. Herein, we report the experimental realization of the first, to the best of our knowledge, all-optical bipolar modulator that is based on pump intensity-dependent nonlinear absorption of TiCT MXene. This tunable nonlinear absorption with a conversion threshold of approximately 65 GW/cm is characterized and analyzed by the Z-scan technology, and TiCT MXene shows a stronger nonlinear absorption coefficient of 10cm/GW than most of two-dimensional materials.

Sleep as a Protective Factor: Multiple Forms of Discrimination and Substance Use Intention Among Racially and Ethnically Minoritized United States Youth.

Purpose: Research has rarely examined biobehavioral factors in mitigating substance use (SU) risks associated with discrimination among racially and ethnically minoritized youth. This study investigated sleep duration as a potential moderator of the association between multiple forms of discrimination based on race and ethnicity, sexual orientation, and weight (i.e.

Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis.

Purpose: Numerous prior analyses have highlighted a potential link between androgen suppression therapy (AST) and bladder cancer (BCa). However, there is a notable gap in research specifically examining the influence of finasteride on BCa risk and clinical outcomes. This study aimed to evaluate preventive and therapeutic value of finasteride for BCa patients.

StatGel: An Innovative hydrogel carrying STAT3-targeted small molecule inhibitor for the treatment of abdominal adhesions.

Adhesions in the abdominal cavity are among the most common complications post abdominal surgery, resulting from excessive fibrous tissue proliferation and collagen synthesis due to various factors. To date, physical barrier materials have been approved for preventing adhesions, though their effectiveness remains unsatisfactory. One of the important causes of abdominal adhesions is the excessive proliferation of fibrotic cells, and our previous research indicated that STAT3 is a promising therapeutic target for anti-fibrosis.

The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer.

Most patients with colorectal cancer do not achieve durable clinical benefits from immunotherapy, underscoring the existence of alternative immunosuppressive mechanisms. Here we found that activation of the lactate receptor HCAR1 signaling pathway induced the expression of chemokines CCL2 and CCL7 in colorectal tumor cells, leading to the recruitment of immunosuppressive CCR2 polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) to the tumor microenvironment. Ablation of Hcar1 in mice with colorectal tumors significantly decreased the abundance of tumor-infiltrating CCR2 PMN-MDSCs, enhanced the activation of CD8 T cells and, consequently, reduced tumor burden.

Global identification and regulatory network analysis reveal the significant roles of lncRNAs during anther and pollen development in Arabidopsis.

A high-throughput sequencing identified 1283 lncRNAs in anthers at different stages in Arabidopsis and their relationship with protein-coding genes and miRNAs during anther and pollen development were analyzed. Long non-coding RNAs (lncRNAs) are important regulatory molecules involved in various biological processes. However, their roles in male reproductive development and interactions with miRNAs remained elusive.

A physics informed neural network approach to quantify antigen presentation activities at single cell level using omics data.

Antigen processing and presentation via major histocompatibility complex (MHC) molecules are central to immune surveillance. Yet, quantifying the dynamic activity of MHC class I and II antigen presentation remains a critical challenge, particularly in diseases like cancer, infection and autoimmunity where these pathways are often disrupted. Current methods fall short in providing precise, sample-specific insights into antigen presentation, limiting our understanding of immune evasion and therapeutic responses.

Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4-regulated ferroptosis.

Background: Indole phytoalexins, plant-derived compounds present in cruciferous vegetables, have demonstrated anticancer properties. Brassinin (BSN), derived from Brassica campestris L. var.

LINC02418 suppresses endometrial cancer progression via regulating miR-494-3p/RASGRF1 axis.

Long non-coding RNAs (lncRNAs) have emerged as pivotal regulatory molecules in cancer biology. Among these, long intergenic non-protein coding RNA 02418 (LINC02418), a recently identified lncRNA, has been linked to endometrial cancer (EC), although its function and operational mechanisms are largely unclear. The present investigation aims to elucidate the molecular mechanism through which LINC02418 influences EC pathogenesis.

Everyday ethnic discrimination and early substance use based on hair samples in high-risk racial/ethnic minority early adolescents.

Objectives: Although racially and ethnically minoritized youth are more likely to experience adverse effects of substance use, and substance use before age 14 is strongly associated with an elevated risk of later substance use disorders, there is limited research identifying risk factors for early substance use. The study examined the role of experiencing ethnic discrimination from teachers, other adults outside of school, and other students in predicting early substance use (measured with hair toxicology reports).

Methods: The study used data from the Adolescent Brain Cognitive Development Study.

Peer discrimination and diurnal cortisol output in a rural boarding school in China: Empirical findings and methodological considerations.

Adolescents' experiences of discrimination and their health consequences are understudied in non-Western cultures. Using data from 90 rural Chinese adolescents ( = 13.70; 49% female), this study examined cumulative and daily experiences of peer discrimination (based on socioeconomic status, gender, parental migration status, appearance, grades) and their associations with diurnal cortisol output.

Adolescent health and the intersectionality of ethnicity/race, sex, and sexual orientation: A national probability sample from the Adolescent Brain Cognitive Development study.

Although children with marginalized sociodemographic characteristics are exposed to increased health risk and disparities, there is a paucity of population-based research on health status of children occupying multiple social marginalities. The present study investigated implications of children's intersectional sociodemographic characteristics on health risk indicators. In this longitudinal cohort study, we used longitudinal data from the ongoing Adolescent Brain Cognitive Development study.

Lightweight MXene Composite Films with Hollow Egg-Box Structures: Enhanced Electromagnetic Shielding Performance Beyond Pure MXene.

MXene is widely used in the electromagnetic interference (EMI) shielding field. However, the high electromagnetic reflectivity of pure MXene causes potential secondary EMI pollution. This study presents a hollow egg-box structure used in MXene composite film, by which the reflectivity (R) could decrease from 0.

Metabolic-Immune Suppression Mediated by the SIRT1-CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma.

Metabolic reprogramming of tumor cells dynamically reshapes the distribution of nutrients and signals in the tumor microenvironment (TME), affecting intercellular interactions and resulting in metabolic immune suppression. Increased glucose uptake and metabolism are characteristic of many tumors. Meanwhile, the progression of colorectal carcinoma (CRC) relies on lipid metabolism.

A multifunctional graphene oxide-based nanodrug delivery system for tumor targeted diagnosis and treatment under chemotherapy-photothermal-photodynamic synergy.

Traditional cancer therapies, such as chemotherapy, often lack specificity, resulting in severe toxic side effects and limited therapeutic efficacy. There is an urgent need to develop innovative multifunctional nanomedicine carriers that integrate precise diagnosis, targeted therapy, real-time monitoring, and the synergistic effects of multiple therapeutic approaches. In this study, a composite nanodrug delivery system (GO-HA-Ce6-GNRs) based on graphene oxide (GO) was innovatively prepared, which was functionalized with the targeting molecule hyaluronic acid (HA), the photosensitizer chlorin e6 (Ce6), and the photothermal material gold nanorods (GNRs).