Using partially shared radiomics features to simultaneously identify isocitrate dehydrogenase mutation status and epilepsy in glioma patients from MRI images.

Prediction of isocitrate dehydrogenase (IDH) mutation status and epilepsy occurrence are important to glioma patients. Although machine learning models have been constructed for both issues, the correlation between them has not been explored. Our study aimed to exploit this correlation to improve the performance of both of the IDH mutation status identification and epilepsy diagnosis models in patients with glioma II-IV.

Design and synthesis of fluorinated polyimides with low thermal expansion and enhanced dielectric properties.

Modern microelectronics industries urgently require dielectric materials with low thermal expansion coefficients, low dielectric constants, and minimal dielectric loss. However, the design principles of materials with low dielectric constants and low thermal expansion are contradictory. In this study, a new diamine monomer containing a dibenzocyclooctadiene unit (DBCOD-NH) was designed and synthesized, which was subsequently polymerized with high fluorine content 4,4'-hexafluoroisopr-opylidene diphthalic anhydride and 4,4'-diamino-2,2'-bis(trifleoromethyl)biphenyl to obtain a series of fluorinated polyimides (PIs).

High-Pressure Polymerization of Phenol toward Degree-4 Carbon Nanothread.

Saturated sp-carbon nanothreads (CNTh) have garnered significant interest due to their predicted high Young's modulus and thermal conductivity. While the incorporation of heteroatoms into the central ring has been shown to influence the formation of CNTh and yield chemically homogeneous products, the impact of pendant groups on the polymerization process remains underexplored. In this study, we investigate the pressure-induced polymerization of phenol, revealing two phase transitions occurring below 0.

TNFAIP3 affects ferroptosis after traumatic brain injury by affecting the deubiquitination and ubiquitination pathways of the HMOX1 protein and ACSL3.

The occurrence and progression of traumatic brain injury involve a complex process. The pathophysiological mechanisms triggered by neuronal damage include various forms of programmed cell death, including ferroptosis. We observed upregulation of TNFAIP3 in mice after traumatic brain injury.

Characteristics of low-temperature oxidative heating and gas production in coal storage under forced convection: Influencing factors and mechanisms.

Slow oxidation of coal during storage and transportation poses significant risks, making it essential to identify hot spots and understand the heat generation and gas production patterns in coal stockpiles. This study leverages the advantages of adiabatic oxidation experiments, which account for time effects, to accurately describe the low-temperature oxidation process of coal through warming and gas production dimensions. Additionally, the warming and gas production patterns of three-dimensional coal stockpiles with varying stacking parameters were investigated.

Dynamic O-GlcNAcylation coordinates etoposide-triggered tumor cell pyroptosis by regulating p53 stability.

O-GlcNAcylation, a modification of nucleocytoplasmic proteins in mammals, plays a critical role in various cellular processes. However, the interplay and their underlying mechanisms in chemotherapy-induced tumor regression between O-GlcNAcylation and pyroptosis, a form of programmed cell death associated with innate immunity, remains unclear. Here, we observed that during the etoposide-induced pyroptosis of SH-SY5Y and A549 cells, overall O-GlcNAcylation levels are substantially reduced.

Efficacy and safety of Neurocognitive Adaptive Training for Depression combined with SSRIs for treating cognitive impairment among patients with late-life depression: a 12-week, randomized controlled study.

Background: This randomized, open-label study examined the therapeutic effects of Neurocognitive Adaptive Training for Depression (NCAT-D) combined with selective serotonin reuptake inhibitors (SSRIs) on cognitive impairment among patients with late-life depression (LLD).

Method: Study data were collected from May 5, 2021, to April 21, 2023. Outpatients who met the diagnostic criteria for major depressive disorder according to the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) (i.

Efficient and Stable Inverted Perovskite Solar Cells Enabled by Inhibiting Voids via a Green Additive.

The buried interface in inverted perovskite solar cells (PSCs) is critical for determining device performance. However, during annealing, the perovskite crystallized downward from the film's top surfaces, and the use of dimethyl sulfoxide (DMSO) often resulted in voids at the perovskite bottom surface, which negatively impacted PSC performance. In this study, a green solid-state additive, piracetam (PA), was introduced into a perovskite precursor to reduce void formation.

Reconstruction of Hole Transport Layer via Co-Self-Assembled Molecules for High-Performance Inverted Perovskite Solar Cells.

Adjusting the hole transport layer (HTL) to optimize its interface with perovskite is crucial for minimizing interface recombination, enhancing carrier extraction, and achieving efficient and stable inverted perovskite solar cells (PSCs). However, as a commonly used HTL, the self-assemble layer (SAM) of [2-(3,6-dimethoxy-9H-carbazol-9-yl)ethyl] phosphonic acid (MeO-2PACz) tends to form clusters and micelles during the deposition process, leading to inadequate coverage of the ITO substrate. Here, a Co-SAM strategy is employed by incorporating 4-mercaptobenzoic acid (SBA) and 4-trifluoromethyl benzoic acid (TBA) as additives into MeO-2PACz to fabricate a Co-SAM-based HTL.

Making Interfacial Solar Evaporation of Seawater Faster than Fresh Water.

Interfacial solar evaporation-based seawater desalination is regarded as one of the most promising strategies to alleviate freshwater scarcity. However, the solar evaporation rate of real seawater is significantly constricted by the ubiquitous salts present in seawater. In addition to the common issue of salt accumulation on the evaporation surface during solar evaporation, strong hydration between salt ions and water molecules leads to a lower evaporation rate for real seawater compared to pure water.

Strong Silkworm Silk Fibers through CNT-Feeding and Forced Reeling.

High-performance silk fibers, with their eco-friendly degradability and renewability, have long captivated researchers as an alternative to synthetic fibers. Spider dragline silk, renowned for its exceptional strength (>1 GPa), has an extremely low yield, hindering its widespread use. While domesticated silkworms (Bombyx mori) can produce silk fibers industrially, their moderate strength (≈0.

Mechanism of inhibition of melanoma by fucoxanthin simulated in vitro digestion products in cell models constructed using human malignant melanoma cells (A375) and keratinocytes (HaCaT).

Recently, the increasing incidence of malignant melanoma has become a major public health concern owing to its poor prognosis and impact on quality of life. Consuming foods with potent antitumor compounds can help prevent melanoma and maintain skin health. Fucoxanthin (FX), a naturally occurring carotenoid found in brown algae, possesses antitumor properties.

The involvement of epidural fat in ossification of the ligamentum flavum: From the perspective of exosomal proteome.

Ossification of the ligamentum flavum (OLF) is the primary etiology of thoracic spinal stenosis. The functional properties of epidural fat (EF), an adipose tissue located in close proximity to ligamentum flavum (LF), have been scarcely investigated. The metabolic state of adipocytes significantly influences their functionality, and exosomes play a pivotal role in intercellular communication.

The rigid-flexible balanced molecular crosslinking network transition interface: An effective strategy for improving the performance of bamboo fibers/poly(butadiene succinate-co-butadiene adipate) biocomposites.

The poor interfacial compatibility of natural fiber-reinforced polymer composites has become a major challenge in the development of industry-standard high-performance composites. To solve this problem, this study constructs a novel rigid-flexible balanced molecular crosslinked network transition interface in composites. The interface improves the interfacial compatibility of the composites by balancing the stiffness and strength of the fibers and the matrix， effectively improving the properties of the composites.

Identification of SLC7A11-AS1/SLC7A11 pair as a ferroptosis-related therapeutic target for hepatocellular carcinoma.

Hepatocellular carcinoma (HCC), a prevalent malignancy worldwide, poses significant challenges in terms of prognosis, necessitating innovative therapeutic approaches. Ferroptosis offers notable advantages over apoptosis, holding promise as a novel therapeutic approach for HCC complexities. Moreover, while the interaction between long non-coding RNAs (lncRNAs) and mRNAs is pivotal in various physiological and pathological processes, their involvement in ferroptosis remains relatively unexplored.

Research trends and hotspots of ketamine from 2014 to 2023: a bibliometric analysis.

Background: Despite this growing interest, there remains a lack of comprehensive and systematic bibliometric analyses of ketamine research. This study aimed to summarize the progress in ketamine research through bibliometric analysis, providing insights into the development and direction of the field.

Methods: Publications related to ketamine were retrieved from the Web of Science Core Collection (WoSCC) database on February 15, 2024.

Both intra- and peri-tumoral radiomics signatures can be used to predict lymphatic vascular space invasion and lymphatic metastasis positive status from endometrial cancer MR imaging.

Objectives: To identify lymphatic vascular space invasion (LVSI) and lymphatic node metastasis (LNM) status of endometrial cancer (EC) patients, using radiomics based on MRI images.

Methods: Five hundred and ninety-eight EC patients between January 2015 and September 2020 from two institutions were retrospectively included. Tumoral regions on DWI, T1CE, and T2W images were manually outlined.

O-GlcNAcylation regulates the stability of transferrin receptor (TFRC) to control the ferroptosis in hepatocellular carcinoma cells.

Ferroptosis is an iron-dependent programmed cell death (PCD) enforced by lipid peroxidation accumulation. Transferrin receptor (TFRC), one of the signature proteins of ferroptosis, is abundantly expressed in hepatocellular carcinoma (HCC). However, post-translational modification (PTM) of TFRC and the underlying mechanisms for ferroptosis regulation remain less understood.

Whole Genome Sequence-Based Analyses of Drug Resistance Characteristics, Genetic Diversity, and Transmission Dynamics of Drug-Resistant in Urumqi City.

Objective: This study aims to analyze the drug resistance spectrum, genetic diversity, and transmission dynamics to provide a basis for the prevention and control of drug-resistant (DR) tuberculosis (TB) epidemics.

Methods: This retrospective study is based on routine national drug resistance surveillance. The demographic, epidemiological, and clinical information on DR-TB patients from 2016 to 2021 was collected and used for phenotypic drug susceptibility testing and whole-genome sequencing.

Determination of p53abn endometrial cancer: a multitask analysis using radiological-clinical nomogram on MRI.

Objectives: We aimed to differentiate endometrial cancer (EC) between TP53mutation (P53abn) and Non-P53abn subtypes using radiological-clinical nomogram on EC body volume MRI.

Methods: We retrospectively recruited 227 patients with pathologically proven EC from our institution. All these patients have undergone molecular pathology diagnosis based on the Cancer Genome Atlas.

Role of epidural fat in the local milieu: what we know and what we don't.

Purpose: Traditionally, the epidural fat (EF) is known as a physical buffer for the dural sac against the force and a lubricant facilitating the relative motion of the latter on the osseous spine. Along with the development of the studies on EF, controversies still exist on vital questions, such as the underlying mechanism of the spinal epidural lipomatosis. Meanwhile, the scattered and fragmented researches hinder the global insight into the seemingly dispensable tissue.

Fully Automated Identification of Lymph Node Metastases and Lymphovascular Invasion in Endometrial Cancer From Multi-Parametric MRI by Deep Learning.

Background: Early and accurate identification of lymphatic node metastasis (LNM) and lymphatic vascular space invasion (LVSI) for endometrial cancer (EC) patients is important for treatment design, but difficult on multi-parametric MRI (mpMRI) images.

Purpose: To develop a deep learning (DL) model to simultaneously identify of LNM and LVSI of EC from mpMRI images.

Study Type: Retrospective.

Histogram Feature Analysis of Tumor Body on Diffusion-weighted MR Imaging in Differentiation between Granulosa Cell Tumors and Other Sex-cord Tumors in Ovary: Comparison with Histological Results.

Objective: We aimed to differentiate granulosa cell tumors (GCT) from other ovarian sex-cord tumors (OSCs) based on feature analysis of the tumor body on MR imaging.

Methods: We retrospectively enrolled 27 patients with pathologically proven sex-cord tumours (14 GSTs, 8 fibromas, 4 fibrothecomas, and 1 sclerosing stromal tumour) from our institution. All MRI examinations were performed at least one month prior to surgery.

Enhancing Nigrosome-1 Sign Identification via Interpretable AI using True Susceptibility Weighted Imaging.

Background: Nigrosome 1 (N1), the largest nigrosome region in the ventrolateral area of the substantia nigra pars compacta, is identifiable by the "N1 sign" in long echo time gradient echo MRI. The N1 sign's absence is a vital Parkinson's disease (PD) diagnostic marker. However, it is challenging to visualize and assess the N1 sign in clinical practice.