Integrated Network Pharmacology and Metabolomics to Investigate the Effects and Possible Mechanisms of Ginsenoside Rg Glycine Ester Derivative Against Hypoxia.

Previous studies have suggested that ginsenoside Rg glycine ester derivative (RG) exhibits therapeutic potential in mitigating hypoxia. This study aimed to elucidate the potential mechanism of RG in hypoxia injury through a combined approach of metabolomics and network pharmacology. Initially, a CoCl-induced cell hypoxia model was established, and the therapeutic impact of RG on biochemical indices was evaluated.

Progression and mortality of patients with cystic fibrosis in China.

Background: Patients with cystic fibrosis (CF) are rare in China and differ significantly from the Caucasian populations in terms of clinical and genetic characteristics. However, the progression and mortality of Chinese patients with CF have not been well described.

Results: This study included all 67 patients from the Peking Union Medical College Hospital CF cohort, with a median followed up time of 5.

Estimating avoidable burden of stillbirth attributable to greenness improvement in Iran.

Introduction: Expanding evidence suggests beneficial impacts of greenspace on human health, yet the relationships between greenness and stillbirth remain unknown. This study aimed to quantify the risk and burden of stillbirth associated with maternal greenness exposure during pregnancy.

Methods: A total of 3,982,304 eligible birth records across 31 provinces in Iran from 2013 to 2018 were included in this study.

Combination of age-adjusted d-dimer, platelet distribution width and other factors predict preoperative deep venous thrombosis in elderly patients with femoral neck fracture.

Purpose: This retrospective cohort study aimed to identify factors associated with preoperative deep venous thrombosis (DVT) in elderly patients with femoral neck fractures, and to investigate whether combining these factors could improve the ability to predict DVT.

Method: Medical records and laboratory test results were reviewed patients presenting with a femoral neck fracture and receiving routine chemoprophylaxis for DVT between January 2020 and December 2023 in a tertiary referral, university-affiliated hospital. Preoperative DVT was confirmed by Doppler ultrasound or CT venography.

Synergy of Copper Doping and Carbon Defect Engineering in Promoting C-C Coupling for Enhanced CO Photoreduction to Ethanol Activity.

Photocatalytic conversion of carbon dioxide (CO) to fuel provides an ideal pathway to achieving carbon neutrality. One significant hindrance in achieving the reduction of CO to higher energy density multicarbon products (C) was the difficulty in coupling C-C bonds efficiently. Copper (Cu) is considered the most suitable metal catalyst for C-C coupling to form C products in the CO reduction reaction (CORR), but it encounters challenges such as low product selectivity and slow catalytic efficiency.

Deep Learning Model for the Differential Diagnosis of Nasal Polyps and Inverted Papilloma by CT Images: A Multicenter Study.

Rationale And Objectives: Nasal polyps (NP) and inverted papilloma (IP) are benign tumors within the nasal cavity, each necessitating distinct treatment approaches. Herein, we investigate the utility of a deep learning (DL) model for distinguishing between NP and IP.

Materials And Methods: A total of 1791 patients with nasal benign tumors from two hospitals were retrospectively enrolled.

Integrating tumour and lymph node radiomics features for predicting disease-free survival in locally advanced esophageal squamous cell cancer after neoadjuvant chemotherapy and complete resection.

Purpose: To investigate the utility of combined tumour and lymph node (LN) radiomics features in predicting disease-free survival (DFS) among patients with locally advanced esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemotherapy and resection.

Methods: We retrospectively enrolled 176 ESCC patients from January 2013 to December 2016. Tumour and targeted LN segmentation were performed on venous phase CT images.

The impact of long-term exposure to NO, O, and their oxidative potential on adolescents' mental health, and the protective role of school-based greenness.

Recent increases in nitrogen dioxide (NO) and ozone (O), two highly reactive and oxidative pollutants, have raised concerns about their potential impact on adolescent mental health. This study leveraged data from the Chinese National Survey on Students' Constitution and Health (CNSSCH) in 2019, a nationally representative cross-sectional survey of Chinese adolescents. A total of 149,697 adolescents aged 10-18 years were included in this study.

MC-LR induced apoptosis in human embryonic kidney (HEK293) cells through activation of TNF-R1/RIPK1 pathway.

In recent years, the outbreak of cyanobacterial blooms has become increasingly frequent. Microcystin-LR (MC-LR), a metabolite of cyanobacteria, poses a significant threat to the ecosystem and human health. Several studies have demonstrated that MC-LR might induce renal cell apoptosis, as a consequence of tissue damage.

Study on the fusion of improved YOLOv8 and depth camera for bunch tomato stem picking point recognition and localization.

When harvesting bunch tomatoes, accurately identifying certain fruiting stems proves challenging due to their obstruction by branches and leaves, or their similarity in colour to the branches, main vines, and lateral vines. Additionally, irregularities in the growth pattern of the fruiting pedicels further complicate precise picking point localization, thus impacting harvesting efficiency. Moreover, the fruit stalks being too short or slender poses an obstacle, rendering it impossible for the depth camera to accurately obtain depth information during depth value acquisition.

Total saponins from Panax japonicus mediate the paracrine interaction between adipocytes and macrophages to promote lipolysis in the adipose tissue during aging via the NLRP3 inflammasome/GDF3/ATGL axis.

Adipocytic lipolysis is strongly related to the increase of visceral fat, decrease of exercise capacity, and various other metabolic syndromes during aging. It is significantly influenced by the paracrine relationship between adipocytes and the adipose tissue macrophages (ATMs), and the cytokines secreted by ATMs have endocrine effects on adjacent tissues. We previously reported that the total saponins from Panax japonicus (TSPJs) can enhance lipid metabolism.

The relationship of serum klotho levels and triglyceride glucose index-related indicators.

Background: Klotho, an anti-aging protein, is linked to energy metabolism. There is limited research on the association of serum klotho and triglyceride glucose (TyG) index-related indicators. Our research aims to investigate the relationship of serum klotho with TyG-BMI (body mass index), TyG-WC (waist circumference), and TyG-WHtR (waist-to-height ratio).

Longer duration of high-dose corticosteroids provides benefit for hospitalized COVID-19 patients with high oxygen requirement.

The optimal corticosteroids dose in patients with coronavirus disease 2019 (COVID-19) requiring high oxygen remains unknown. In this retrospective study of patients with COVID-19 requiring high oxygen and receiving corticosteroids, the efficacy, safety, and duration of high-dose treatment were evaluated. The primary outcome was all-cause mortality during follow-up.

Cellular Senescence: A Bridge Between Diabetes and Microangiopathy.

Cellular senescence is a state of permanent cell cycle arrest and plays an important role in many vascular lesions. This study found that the cells of diabetic patients have more characteristics of senescence, which may cause microvascular complications. Cell senescence, as one of the common fates of cells, links microangiopathy and diabetes.

An electronic medical record retrieval system can be used to identify missed diagnosis in patients with primary ciliary dyskinesia.

Background: Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous disease. Due to difficulty accessing diagnostic services and a lack of awareness of the syndrome, clinicians often fail to recognize the classic phenotype, leading to missed diagnoses.

Methods: Relevant medical records were accessed through The BIG DATA QUERY AND ANALYSIS SYSTEM of Peking Union Medical College Hospital from September 1, 2012 to March 31, 2024.

Enhanced Photocatalytic Synthesis of Urea from co-Reduction of N and CO on Z-Schematic SrTiO-FeS-CoWO Heterostructure.

The photocatalytic co-reduction of CO and N is a sustainable method for urea synthesis under mild conditions. However, high-yield synthesis of urea is a challenge due to the sluggish kinetics of the C-N coupling reaction. Herein, we have successfully engineered a Z-scheme photocatalyst, SrTiO-FeS-CoWO, for boosting photocatalytic urea synthesis via enhancing the initial CO and N adsorption step and reducing the energy barrier for the C-N coupling reaction.

Adjuvant chemoradiotherapy plus PD-1 inhibitor for pN3 gastric cancer: a randomized, multicenter, Phase III trial.

D2 surgery followed by adjuvant chemotherapy has been established as the standard of care for patients with locally advanced gastric cancer in Asian countries. However, its efficacy is still unsatisfactory, especially for pathological N3 disease. The RACING trial is a randomized, multicenter, Phase III trial designed to compare the efficacy and safety of chemotherapy alone versus chemotherapy in combination with PD-1 inhibitor and radiotherapy in patients with pN3 gastric or gastroesophageal junction adenocarcinoma.

Synthesis, biological evaluation and mechanism study based on network pharmacology of amino acids esters of 20(S)-protopanaxadiol as novel anticancer agents.

As one of the metabolites of ginseng, 20(S)-protopanaxadiol (PPD) is a compound with dammarane-type tetracyclic triterpene, which performs a wide range of anticancer activities. In this study, PPD was used as a lead. A series of compounds were synthesized respectively with 11 amino acids through esterification and were evaluated for their cytotoxicity against several cancer cell lines.

FOXN3 Regulates Autophagic Activity to Suppress Drug Resistance in Melanoma Cells.

Background: The forkhead box (FOX) family member FOXN3 has been reported to inhibit transcriptional activity associated with regulating tumor development. However, the role of FOXN3 in the pathogenesis of melanoma is not well understood.

Objective: To investigate the biological functions of FOXN3 in drug resistance of melanoma.

Stepwise Assembly of DNA Nanostructures in a Surface-Based Method.

Hierarchical assembly of DNA nanostructures has already led to superstructures of ever-increasing level of complexity. Processing control in building nanostructures hierarchically is desirable but remains underexplored. Here, we present the stepwise assembly of DNA origami nanostructures by a surface-based method.

Basic activities of daily living symptoms as central and bridging symptoms in the networks of functional and psychological disorders among older adults with different chronic disease patterns.

Objective: To examine chronic disease patterns and analyze the interrelations among Basic Activities of Daily Living, Instrumental Activities of Daily Living, anxiety, and depression in older adults.

Methods: A total of 3,454 participants diagnosed with at least one chronic disease were included. Latent class analysis and network analysis were employed to analyze the data.

Constructing CoO Nanowire@NiCoO Nanosheet Hierarchical Array as Electrode Material for High-Performance Supercapacitor.

The CoO nanowire@NiCoO nanosheet hierarchical array was constructed on Ni foam using hydrothermal and annealing approaches in turn, from which a NiCoO nanosheet could self-assemble on the CoO nanowire. The structure and morphology of the CoO nanowire@NiCoO nanosheet hierarchical array were characterized via XRD, EDS, SEM, and FESEM, respectively. The electrochemical performance of the composite array was measured via a cyclic voltammetry curve, galvanostatic current charge-discharge, charge-discharge cycle, and electrochemical impedance and then compared with the CoO nanowire.

Sports-Related Genomic Predictors Are Associated with Athlete Status in Chinese Sprint/Power Athletes.

The aim of this study was to assess the relationship between variant loci significantly associated with sports-related traits in the GWAS Catalog database and sprint/power athlete status, as well as to explore the polygenic profile of elite athletes. Next-generation sequencing and microarray technology were used to genotype samples from 211 elite athletes who had achieved success in national or international competitions in power-based sports and from 522 non-athletes, who were healthy university students with no history of professional sports training. Variant loci collected from databases were extracted after imputation.