Older adult's acceptance and uptake of referral after screening for cognitive impairment: a cross-sectional study in China.

Background: Previous studies have shown that the referral situation after cognitive screening is not optimistic. However, little is known about the situation in China. The current study assessed the cognitive function of older adults with an Eight-item Ascertain Dementia (AD8) score of ≥ 2 in a community health center and investigated their willingness to accept referrals.

Real-time frame-registered resonant fluorescence scanning laser ophthalmoscopy for quantifying static and dynamic cellular properties in the mouse retina: publisher's note.

This publisher's note contains a correction to Opt. Lett.50, 1329 (2025)10.

Ilex asprella polysaccharides alleviate liver injury via antioxidative, anti-inflammatory, and gut microbiota modulating effect.

Ilex asprella, a valued plant traditionally used as food and medicine, is recognized for its effect on liver protection. Polysaccharides, as the key active components in Ilex asprella (IAP), its biological activities are still unexplored. Therefore, this study investigated the preventive effects of IAP on liver injury in vivo.

Mannose-modified erythrocyte membrane-coated Chuanmingshen violaceum polysaccharide PLGA nanoparticles to improve immune responses in mice.

This study developed a poly(lactic-co-glycolic acid) (PLGA) biomimetic nanoparticle (Man-RBC-CVPP) containing Chuanmingshen violaceum polysaccharide (CVP) and coated with a macrophage-targeting mannose receptor (DSPE-PEG-Man) modified RBCM. In vitro experiments demonstrated that Man-RBC-CVPP enhances antigen uptake and immune responses in RAW264.7 cells and can induce an immune response in mouse macrophages by activating the TLR4-mediated NF-κB signaling pathway.

Correction: Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG PAM recognition.

[This corrects the article DOI: 10.1371/journal.pbio.

Magnetic Field-Driven Ion Selectivity Boosts LiF-Rich SEI Formation for Enhanced Lithium Metal Battery Performance Across Temperatures.

Lithium metal anodes are considered highly promising electrode materials due to their exceptional theoretical capacity and low reduction potential. However, their path to large-scale commercialization has been obstructed by significant challenges such as uncontrolled volume expansion, severe side reactions, and dendrite formation. To tackle these issues, our study introduces a covalent modification of separators using tannic acid (TA) and Co, coupled with the application of an external magnetic field.

Seed Extract Attenuates Glycolipid Metabolism Disorder in Hyperlipidemia Mice Through PPAR Signaling Pathway Based on Metabolomics and Network Pharmacology.

Hyperlipidemia is characterized by a high level of blood lipid which poses a serious threat to human health. seed is a traditional crop of medicine and food homology with a wide range of pharmacological actions. To make clear the attenuation effect of seed against hyperlipidemia, low and high doses of seed extract (CSE) were orally administered to hyperlipidemia model mice developed by high-fat diet (HFD).

Novel fluorescence-based and portable detection platforms using nitrogen-doped carbon dots for environmental monitoring of dichloran fungicide.

A novel fluorescence sensor utilizing label-free nitrogen self-doped carbon dots (NCDs) was developed for the sensitive, selective, and rapid determination of dichloran fungicide, popularly used in agricultural and horticultural fields. The NCDs were prepared from maleic anhydride and diethylenetriamine via a one-step pyrolysis process. They demonstrated strong blue fluorescence emission with a quantum yield of 12 %.

Applications and Predictors of Outcomes Following Stereo-Electroencephalography in Pediatric Patients With Drug-Resistant Epilepsy.

Aims: This study aims to evaluate the role of stereo-electroencephalography (SEEG) in managing pediatric patients with drug-resistant epilepsy. We further explore prognostic factors influencing surgical outcomes following SEEG-guided resective or disconnective surgery.

Methods: A retrospective review was conducted on pediatric patients who underwent SEEG at the Pediatric Epilepsy Center, Peking University First Hospital, between July 2017 and July 2022.

Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatment.

Background: Ferroptosis is an intracellular iron-dependent cell death that is distinct from apoptosis, necrosis, and autophagy. Increasing evidence indicated that ferroptosis plays a crucial role in suppressing tumors, thus providing new opportunities for cancer therapy. The drug cepharanthine, commonly used to treat leukopenia, has been discovered to function as an anticancer agent to multiple types of cancer via diverse mechanisms.

Effect of electroacupuncture on regulation of the basic fibroblast growth factor/glycogen synthase kinase-3β pathway in Parkinson's disease mice.

Objectives: To observe the effect of electroacupuncture (EA) on basic fibroblast growth factor (BFGF)/glycogen synthase kinase-3β (GSK-3β) pathway in Parkinson's disease (PD) mice, so as to explore the potential mechanisms of EA in treating PD.

Methods: Fifty C57/BL6 male mice were randomly divided into the control, model, EA, inhibitor and EA+inhibitor (combination) groups, with 10 mice in each group. The PD mouse model was established by intraperitoneal injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine.

Molecular evolution and geographic migration of severe fever with thrombocytopenia syndrome virus in Asia.

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a recently identified tick-borne virus that has emerged in the twenty-first century. Its primary clinical manifestations include fever and thrombocytopenia, and its high morbidity and mortality rates have garnered significant attention. It is crucial to have a comprehensive understanding of the spatial and temporal characteristics of SFTSV migration in order to prevent and control this disease.

Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice.

Background: A significant increase in mitochondrial fatty acid oxidation (FAO) is now increasingly recognized as one of the metabolic alterations in diabetic cardiomyopathy (DCM). However, the molecular mechanisms underlying mitochondrial FAO impairment in DCM remain to be fully elucidated.

Methods: A type 2 diabetes (T2D) mouse model was established by a combination of high-fat diet (HFD) and streptozotocin (STZ) injection.

Divergent evolutionary paces among eudicot plants revealed by simultaneously duplicated genes produced billions of years ago.

Polyploidization often occurs more than once along an evolutionary lineage to form extant plants. Major core eudicot plants share a whole-genome triplication (ceWGT), through which thousands of simultaneously duplicated genes are retained in extant genomes, providing a valuable starting line to check the difference in their evolutionary paces. Here, by characterizing the synonymous nucleotide substitutions (Ks) between these duplicates from 28 representative plants from 21 families, we checked the various evolutionary rates among plants among plants subjected to different rounds of extra polyploidization events.

Derm-T2IM: Harnessing Synthetic Skin Lesion Data via Stable Diffusion Models for Enhanced Skin Disease Classification using ViT and CNN.

This study explores the utilization of Dermatoscopic synthetic data generated through stable diffusion models as a strategy for enhancing the robustness of machine learning model training. Synthetic data plays a pivotal role in mitigating challenges associated with limited labeled datasets, thereby facilitating more effective model training and fine-tuning. In this context, we aim to incorporate enhanced data transformation techniques by extending the recent success of few-shot learning in text-to-image latent diffusion models.

Functional characterization of Mrr-family nuclease SLL1429 involved in MMC and phage resistance.

Cyanobacteria, autotrophic prokaryotes capable of oxygenic photosynthesis, are important atmospheric carbon fixers of Earth and potential alternatives for producing green fuels and chemicals. However, they face significant environmental stress during growth, such as Ultraviolet radiation, salt, and cyanophage exposure, which can impact their physiology and growth. Nucleases, such as Mrr (Methylated adenine Recognition and Restriction) endonuclease, play key roles in stress response, DNA repair, or anti-phage functions, but these in cyanobacteria remains underexplored.

Direct Cyclization of 1,3-Diketones with Malonate-Based Iodonium Ylides to Generate Dihydrofurans.

While iodonium ylides are important reantants in a wide range of reactions, the exploration of electron-transfer property of iodonium ylides remains an underdeveloped topic. Herein, we describe a direct cyclization of 1,3-diketones with malonate-based iodonium ylides to give a diverse array of dihydrofurans in moderate yields. The control experiments suggest that the electron transfer between enol and iodonium ylide gives reactive species, thus enabling a cyclization cascade process to take place to give dihydrofurans.

EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research.

Shotgun metagenomics has become a pivotal technology in microbiome research, enabling in-depth analysis of microbial communities at both the high-resolution taxonomic and functional levels. This approach provides valuable insights of microbial diversity, interactions, and their roles in health and disease. However, the complexity of data processing and the need for reproducibility pose significant challenges to researchers.

MicrobiomeStatPlots: Microbiome statistics plotting gallery for meta-omics and bioinformatics.

The rapid growth of microbiome research has generated an unprecedented amount of multi-omics data, presenting challenges in data analysis and visualization. To address these issues, we present MicrobiomeStatPlots, a comprehensive platform offering streamlined, reproducible tools for microbiome data analysis and visualization. This platform integrates essential bioinformatics workflows with multi-omics pipelines and provides 82 distinct visualization cases for interpreting microbiome datasets.

Noninvasive Quantification of Hepatic Steatosis Using Ultrasound-Derived Fat Fraction (CHESS2303): A Prospective Multicenter Study.

Ultrasound-derived fat fraction (UDFF) is designed to assess the hepatic fat content quantitatively. A multicenter study that verifies the diagnostic performance of UDFF for detecting hepatic steatosis has not yet been reported. This study aimed to evaluate the performance of UDFF for diagnosing and grading hepatic steatosis.

Prognostic Significance of Homocysteine Levels in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Propensity Score Matching and Weighting Analysis.

Background: Elevated homocysteine (Hcy) levels have been linked to poorer outcomes in acute coronary syndrome. This study aimed to assess the predictive value of elevated Hcy levels for major adverse cardiac events (MACE) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).

Methods: This retrospective cohort study included 183 STEMI patients who underwent primary PCI at a tertiary university hospital in southern China from January 2020 to December 2021.

Effects of n-3 Polyunsaturated Fatty Acid Supplementation on Cardiovascular Indices in Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials.

Background: Individuals with type 2 diabetes (T2DM) face a significantly increased risk of cardiovascular disease. This study aims to explore the impact of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular indices in this population. Although the benefits of n-3 PUFAs on cardiovascular health and glycemic outcomes are highly regarded, previous research reports have shown inconsistent results.

A Soft Nonpolar-Soluble Two-Dimensional Perovskite for General Construction of Mixed-Dimensional Heterojunctions.

Constructing mixed-dimensional heterojunctions through ion exchange between functional organic ammonium halides and the already-deposited bulk 3D perovskite films is a widely adopted strategy to effectively passivate and stabilize perovskite solar cells (PSCs). Such process poses challenges in precisely controlling the composition and distribution of the heterojunctions across the film, in particular for large-area applications. Here, a soft 2D perovskite based on tetrapheptyl-ammonium iodide (TPAI), noted as TPAPbI is reported.

Space-coded microchip for multiplexed respiratory virus detection via CRISPR-Cas12a and RPA.

Multiple infections of respiratory viruses are common in patients with clinical respiratory diseases, but current detection methods still have problems such as complex equipment and long detection time. Rapid, low-cost, and on-site detection of human respiratory viruses is crucial for both clinical diagnosis and population screening. In this research, we created a space-coded microfluidic chip (SC-Chip) for the recognition of nine respiratory viruses: influenza A virus, influenza B virus, severe acute respiratory syndrome coronavirus 2, human coronavirus OC43, human coronavirus NL63, human coronavirus HKU1, human respiratory syncytial virus, human parainfluenza virus, and human metapneumovirus.

Technological innovations review in reducing formaldehyde emissions through adhesives and formaldehyde scavengers for building materials.

The issue of formaldehyde pollution in indoor building materials was receiving increasing attention from scholars. With the increasing number of research cases on building materials, a systematic evaluation of the effectiveness of existing representative technologies was crucial for the future development of building materials. Adhesives and formaldehyde scavengers were common additive materials in building materials.