PPZ1-TORC1 pathway mediates ferroptosis and antifungal resistance in Candida albicans.

Candida albicans (C. albicans), a common fungal pathogen, is responsible for infections such as oral candidiasis. Given the widespread misuse of antifungal medications and the increasing resistance, it is critical to explore new strategies to eradicate C.

Comparative efficacy of anaerobic digestion systems in removing antimicrobial resistance genes from swine wastewater.

Swine farm wastewater is a major reservoir of antimicrobial resistance genes (ARGs). Anaerobic digestion (AD), widely implemented in farms, has been extensively studied for ARG removal. However, a comparative study on ARG removal efficiency across the four principal AD systems - up-flow anaerobic sludge blanket (UASB), continuous stirred tank reactor (CSTR), buried biogas digester (BBD), and septic tank (SPT) - is lacking.

A scoping review of digital technology applications in palliative care.

Background: In the current era of rapid technological development, digital technology is progressively transforming the medical field. In palliative care, its integration is an inevitable trend, offering new possibilities for improving care delivery and patient outcomes.

Objective: This study aimed to review the application of digital technologies in palliative care, focusing on their advantages, challenges, and measurable impacts across diverse care settings.

Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade.

Background: Periprosthetic osteolysis and subsequent aseptic loosening are the leading causes of failure following total joint arthroplasty. Osteogenic impairment induced by wear particles is regarded as a crucial contributing factor in the development of osteolysis, with endoplasmic reticulum (ER) stress identified as a key underlying mechanism. Therefore, identifying potential therapeutic targets and agents that can regulate ER stress adaption in osteoblasts is necessary for arresting aseptic loosening.

Syringable Microcapsules for Sustained, Localized, and Controllable siRNA Delivery.

The clinical use of small interfering RNA (siRNA) and antisense oligonucleotides often requires invasive routes of administration, including intrathecal or intraocular injection. Additionally, these treatments often necessitate repeated injections. While nanoparticle formulation and chemical modifications have extended siRNA therapeutic durability, challenges persist, such as the side effects of bolus injections with high toxicity and maximum exposure in the acute phase.

YAP/TAZ mediates resistance to KRAS inhibitors through inhibiting proapoptosis and activating the SLC7A5/mTOR axis.

KRAS mutations are frequent in various human cancers. The development of selective inhibitors targeting KRAS mutations has opened a new era for targeted therapy. However, intrinsic and acquired resistance to these inhibitors remains a major challenge.

Exposure to oxygenated polycyclic aromatic hydrocarbons and endocrine dysfunction: Multi-level study based on hormone receptor responses.

Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are a class of emerging environmental contaminants that exhibit high toxicity compared to parent PAHs. In addition to carcinogenic, teratogenic and mutagenic effects, recent studies show their potential to cause endocrine disruption, but the reports are controversial. In this study, we employed hormone receptors (ERα/AR/GRα/TRβ)-mediated dual luciferase reporter gene assay and molecular docking, and found that five typical OPAHs exhibited agonistic activity towards hormone receptors, and hydrogen bonding and hydrophobic interactions were the primary binding forces involved in OPAHs-receptor interactions.

Exploring potential causal genetic variants and genes for endometrial cancer: Open Targets Genetics, Mendelian randomization, and multi-tissue transcriptome-wide association analysis.

Background: Endometrial cancer (EC) is the most common gynecological malignancy in developed countries, with incidence rates continuing to rise globally. However, the precise mechanisms underlying EC pathogenesis remain largely unexplored. This study aims to prioritize genes associated with EC by leveraging multi-omics data through various bioinformatic methods.

A Review on MXene/Nanocellulose Composites: Toward Wearable Multifunctional Electromagnetic Interference Shielding Application.

With the rapid development of mobile communication technology and wearable electronic devices, the electromagnetic radiation generated by high-frequency information exchange inevitably threatens human health, so high-performance wearable electromagnetic interference (EMI) shielding materials are urgently needed. The 2D nanomaterial MXene exhibits superior EMI shielding performance owing to its high conductivity, however, its mechanical properties are limited due to the high porosity between MXene nanosheets. In recent years, it has been reported that by introducing natural nanocellulose as an organic framework, the EMI shielding and mechanical properties of MXene/nanocellulose composites can be synergically improved, which are expected to be widely used in wearable multifunctional shielding devices.

MACC1 ablation suppresses the dedifferentiation process of non-CSCs in lung cancer through stabilizing KLF4.

Metastasis-associated in colon cancer-1 (MACC1) was identified as a new player in lung cancer development, and some stemness-related genes can be novel transcriptional targets of MACC1. Cancer stem cells (CSCs) are responsible for sustaining tumorigenesis and plasticity. Both CSCs and non-CSCs are plastic and capable of undergoing phenotypic transition, especially the dedifferentiation of non-CSCs switch to CSC-like cells.

Portable Electroanalytical Platform Based on Eco-Friendly Biomass-Based Hydrogels with Bimetallic MOF Composites for Trace Acetaminophen Determination.

Accurate acetaminophen (APAP) determination using smartphone-based portable sensing hinges on developing sensing interfaces with effective catalytic performance and high electron transfer efficiency. Herein, we report that various Ni-based bimetallic-organic framework materials (MOFs) were synthesized through the hydrothermal method. These MOFs were incorporated with multiwalled carbon nanotubes (MWCNTs) during the synthesis of chitosan-cationic guar gum hydrogels (HG).

CD34+ orbital fibroblasts contribute to the pathogenesis of thyroid eye disease via miR-182-5p.

Context: CD34+ orbital fibroblasts (OFs) play a pathogenic role in thyroid eye disease (TED). Several micro (mi)RNAs have been shown to promote TED progression.

Objective: This study aims to explore the regulatory effect of miRNAs on CD34+ OFs, to find potential therapeutic target.

Application of nirmatrelvir/ritonavir for the treatment of severe COVID-19 in a 3-year-old child.

Introduction: Nirmatrelvir/ritonavir (Paxlovid) is an effective antiviral drug for treating coronavirus disease 2019 (COVID-19) in adults. However, Paxlovid treatment of children, especially those who are under 12 years and with severe underlying diseases, is rare.

Case Report: A three-year-old COVID-19 patient (weighing 14.

Observation on the therapeutic effect of probiotics on early oral feeding in the treatment of severe acute pancreatitis.

Objectives: To evaluate the clinical efficacy of probiotics and early oral feeding in patients with severe acute pancreatitis.

Methods: A prospective, randomized, controlled trial was conducted involving 66 patients, who were randomly divided into a control group ( = 32) receiving standard enteral nutrition and an observation group ( = 34) receiving additional Bifidobacterium quadruplex live bacterial tablets. Serum inflammatory markers, including white blood cells (WBC), interleukin-6 (IL-6), tumor necrosis factor- (TNF-α), and C-reactive protein (CRP), were measured on days 1, 3, and 7 post-admission.

Evaluating Reproductive Carrier Screening using Biotinidase Deficiency as a Model: Variants Identified, Variant Rates and Management.

Purpose: To review biotinidase gene (BTD) variants identified in a large, diverse, reproductive carrier screening (RCS) cohort and outline management of heterozygotes with pathogenic or likely pathogenic (P/LP) variants.

Methods: This retrospective observational study included samples tested from January 2020 to September 2022 in a 274-gene panel. The study involved females aged 18 to 55 years.

Assessment of carbon stocks and influencing factors in terrestrial ecosystems based on surface area.

The topography of the border ecological barrier area in southern Yunnan is complex, and utilizing the vertically projected area to estimate carbon stocks may lead to significant errors. This study uses multisource data and multiple models to investigate the spatial and temporal variations in surface carbon stocks and the factors affecting them in the study area. Results show: The difference between the surface area and planar area in the study area is large, and the spatial and temporal changes of surface land use and carbon stock based on this are more significant, showing an inverted V-shape trend in time and a spatial distribution pattern of "high southeast, low northwest".

Polystyrene microplastics exacerbate acetochlor-induced reproductive toxicity and transgenerational effects in zebrafish.

Microplastic (MPs) can adsorb co-existing pollutants, and alter their behavior and toxicity. Meanwhile, amide herbicides like acetochlor (ACT) are widely used in agriculture, with potential endocrine-disrupting effects that raise ecological concerns. The aim of this research was to examine the effects of MPs on the reproductive endocrine disruption caused by ACT and the effects of maternal transmission.

Specific Transcriptional Regulation Controls Plant Organ-Specific Infection by the Oomycete Pathogen Phytophthora sojae.

The organs of a plant species vary in cell structure, metabolism and defence responses. However, the mechanisms that enable a single pathogen to colonise different plant organs remain unclear. Here we compared the transcriptome of the oomycete pathogen Phytophthora sojae during infection of roots versus leaves of soybeans.

Low-and intermediate-grade lateral sinus dural arterio venous fistulas: Factors affecting the outcome of endo vascular treatment over 18-year experience in a high-volume neurovascular center.

Background And Purpose: Lateral sinus dural arteriovenous fistulas (LS-DAVFs) carry a higher rate of recurrence after endovascular treatment (EVT). Our objective was to investigate the independent predictors of recurrence and unfavorable functional outcome of low-and intermediate-grade LS-DAVFs after EVT.

Materials And Methods: Retrospectively reviewed our database of prospectively collected information for all patients with low and intermediate-grade LS-DAVFs that underwent EVT from May 2004 to December 2021.

Characterization of volatile metabolites in temperate and tropical sweet corn cultivars under various post-harvest storage conditions.

Different post-harvest storage conditions and genetic variability influence the flavor and quality of sweet corn. In this study, the changes in the soluble sugar content and volatile substances were comprehensively analyzed in three temperate and three tropical commercial sweet corn cultivars under various storage conditions. The three tropical cultivars exhibited higher contents of soluble total sugar, moisture, and soluble reducing sugar.

A new cooperative control solution of subway BAS: an improved fuzzy PID control algorithm.

The building automation system (BAS) of a subway is the core component of monitoring and managing urban rail transit systems. For the current problems such as low control efficiency, insufficient accuracy, and poor stability of metro BAS, this article proposes a cooperative control framework based on an improved fuzzy proportional-integral-derivative (PID) algorithm. Firstly, the concept of an integrated supervisory control system (ISCS) for subways is introduced by summarizing the previously implemented engineering construction and combining it with advanced automation technology.

Erratum: Interferon-α Promotes the Expression of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma: Erratum.

[This corrects the article DOI: 10.7150/jca.19486.

Multi-Omics Approaches to Discover Biomarkers of Thyroid Eye Disease: A Systematic Review.

Thyroid eye disease (TED) is an organ-specific autoimmune disorder that significantly impacts patients' visual function, appearance, and well-being. Despite existing clinical evaluation methods, there remains a need for objective biomarkers to facilitate clinical management and pathogenesis investigation. Rapid advances in multi-omics technologies have enabled the discovery and development of more informative biomarkers for clinical use.

Deep-Learning-Based Radiomics to Predict Surgical Risk Factors for Lumbar Disc Herniation in Young Patients: A Multicenter Study.

Objective: The aim of this study is to develop and validate a deep-learning radiomics model for predicting surgical risk factors for lumbar disc herniation (LDH) in young patients to assist clinicians in identifying surgical candidates, alleviating symptoms, and improving prognosis.

Methods: A retrospective analysis of patients from two medical centers was conducted. From sagittal and axial MR images, the regions of interest were handcrafted to extract radiomics features.