Removal of antibiotic resistance genes by Cl-UV process: Direct UV damage outweighs free radicals in effectiveness.

Antibiotic resistance genes (ARGs) pose significant environmental health problems and have become a major global concern. This study investigated the efficacy and mechanism of the Cl-UV process (chlorine followed by UV irradiation) for removing ARGs in various forms. The Cl-UV process caused irreversible damage to nearly all ARB at typical disinfectant dosages.

Alteration of chromatin states perturb the transcription regulation of gene during hydronephrosis.

Background: Gene expression is abnormal in disease compared to normal tissue same as the regulatory elements. Regulatory element binding with transcription factors managed transcription of gene, which usually require chromatin accessible.

Methods: To reveal potential epigenetic mechanism during hydronephrosis, we first used RNA-seq to finger out the disfunction genes during hydronephrosis, then combined with ATAC-seq, and BS-seq to reveal the related disfunction regulatory elements.

Dural suturing for the resolution of high-flow cerebrospinal fluid leakage after extended endoscopic endonasal approach surgery.

High-flow cerebrospinal fluid (CSF) leakage is a major complication after surgery via the extended endoscopic endonasal approach (EEA). Thus, surgeons are still searching for techniques to avoid postoperative cerebrospinal fluid (poCSF) leakage. Recently, several surgeons have attempted dural suturing to prevent poCSF leakage.

The efficacy of miR-141-3p to facilitate the healing of wounds and prevent scarring in mice by blocking the JNK/ERK pathway via HDAC6 silencing.

Purpose: Adipose-derived mesenchymal stem cells (ADSCs) exosomes (AD-Exos) are a novel and promising therapeutic approach for skin damage repair. This investigation seeks to assess the potential clinical utility of miR-141-3p found in AD-exos for expediting wound healing.

Methods: ADSCs were isolated from the wounded patients' tissue and validated via flow cytometry, and the mineralization and adipogenic capabilities of ADSCs were assessed respectively.

Impacts of irrigation expansion on moist-heat stress based on IRRMIP results.

Irrigation rapidly expanded during the 20 century, affecting climate via water, energy, and biogeochemical changes. Previous assessments of these effects predominantly relied on a single Earth System Model, and therefore suffered from structural model uncertainties. Here we quantify the impacts of historical irrigation expansion on climate by analysing simulation results from six Earth system models participating in the Irrigation Model Intercomparison Project (IRRMIP).

Carbon gain in upper but loss in deeper cropland soils across China over the last four decades.

Increasing soil organic carbon (SOC) in agricultural systems is a primary nature-based option for mitigating climate change, improving soil fertility, and ensuring food security. However, the consequences of global warming and increases in carbon inputs on cropland SOC stocks over the last few decades remain largely unknown, particularly in deeper soil layers. Here, by using repeated measurements, we reassess variations in SOC stocks across a 0 to 100 cm soil profile at the same locations in China's upland croplands in 1980 and 2023.

Biophysical effects of croplands on land surface temperature.

Converting natural vegetation to croplands alters the local land surface energy budget. Here, we use two decades of satellite data and a physics-based framework to analyse the biophysical mechanisms by which croplands influence daily mean land surface temperature (LST). Globally, 60% of croplands exhibit an annual warming effect, while 40% have a cooling effect compared to their surrounding natural ecosystems.

The 2023 report of the synergetic roadmap on carbon neutrality and clean air for China: Carbon reduction, pollution mitigation, greening, and growth.

The response to climate change and air pollution control demonstrates strong synergy across scientific mechanisms, targets, strategies, and governance systems. This report, based on a monitoring indicator system for coordinated governance of air pollution and climate change, employs an interdisciplinary approach combining natural and social sciences. It establishes 20 indicators across five key areas: air pollution and climate change, governance systems and practices, structural transformation and technologies, atmospheric components and emission reduction pathways, and health impacts and co-benefits.

Chlorine and UV combination sequence: Effects on antibiotic resistance control and health risks of ARGs.

The effective control of antibiotic resistance in aquatic environments is urgent. The combined chlorine and UV processes (Cl-UV, UV/Cl, and UV-Cl) are considered potential control processes for controlling antibiotic resistance. This study compared the effectiveness of these three processes in real water bodies and the potential health risks associated with antibiotic resistance genes (ARGs) after treatments.

Clinical and molecular prognostic nomograms for patients with papillary renal cell carcinoma.

Objective: To summarize the clinicopathological characteristics and prognostic factors of papillary renal cell carcinoma (pRCC) and to construct clinical and molecular prognostic nomograms using existing databases.

Methods: Clinical prognostic models were developed using the Surveillance, Epidemiology, and End Results (SEER) database, while molecular prognostic models were constructed using The Cancer Genome Atlas (TCGA) database. Cox regression and LASSO regression were employed to identify clinicopathological features and molecular markers related to prognosis.

Dynamic Polymer/Metal-Organic Framework Hybrid Microcapsules for Self-Healing Anticorrosion Coatings.

An ideal microcapsule effectively preserves an active substance and can rapidly release it to elicit a self-healing anticorrosion effect. However, the development of highly efficient microcapsules remains a challenge. In this study, polymer/metal-organic framework hybrid microcapsules with dynamic properties were constructed as self-healing anticorrosion coatings.

Spermatic cord myxoma: A rare case report.

Rationale: Spermatic cord myxomas are rare benign tumors, typically characterized by the production of mucopolysaccharides. These tumors are infrequently found in the urinary system, making this case noteworthy.

Patient Concerns: A 55-year-old male presented with a painless swelling on the right side of his scrotum, which had persisted for over 3 months.

Improved alternate wetting and drying irrigation increases global water productivity.

Rice is the staple food for half of the world's population but also has the largest water footprint among cereal crops. Alternate wetting and drying (AWD) is a promising irrigation strategy to improve paddy rice's water productivity-defined as the ratio of rice yield to irrigation water use. However, its global adoption has been limited due to concerns about potential yield losses and uncertainties regarding water productivity improvements.

A dual-band broadband absorber using frequency selective surface for satellite antenna.

A dual-band broadband absorber based on frequency selective surface (FSS) is proposed. This double-layer absorber consists of two layers of FSS structure; each layer has a unique construction and plays its wave-absorbing function in different frequency bands. In the low-frequency band, layer I is a transmission channel, and layer II effectively absorbs electromagnetic waves.

The association between brominated flame retardants exposure with Parkinson's disease in US adults: a cross-sectional study of the National Health and Nutrition Examination Survey 2009-2016.

Background: Increasing evidence suggests that environmental factors play a crucial role in the pathogenesis of Parkinson's disease (PD). Humans are simultaneously exposed to multiple brominated flame retardants (BFRs) in the environment. However, the relationship between BFRs and PD remains unclear.

Enhancing low-temperature nitrification biofilter with Acinetobacter harbinensis HITLi7 for efficient ammonia nitrogen removal in engineering applications.

Low temperature has always been a significant limitation for the biological removal of ammonia nitrogen (NH-N) from water. Acinetobacter harbinensis HITLi7 (HITLi7) was used to enhance the low-temperature nitrification biofilter (LTNB) with a treatment capacity of 20,000 m/d. At 2 °C, with an empty bed contact time of 3 h, the LTNB achieved NH-N removal levels of 1.

Slowdown in China's methane emission growth.

The unprecedented surge in global methane levels has raised global concerns in recent years, casting a spotlight on China as a pivotal emitter. China has taken several actions to curb the methane emissions, but their effects remain unclear. Here, we developed the Global ObservatioN-based system for monitoring Greenhouse GAses for methane (GONGGA-CH) and assimilate GOSAT XCH observations to assess changes in China's methane emissions.

The Influence of Planting Sites on the Chemical Compositions of Chrysanthemum morifolium Flowers (Chuju) as Revealed by Py-GC/MS Combined with Multivariate Statistical Analysis.

Chuju, a cultivar of Chrysanthemum morifolium, has been traditionally cultivated for over 2000 years in China for both ornamental and medicinal purposes. To date, investigations into the chemical composition of this plant have indicated that it contains compounds with extensive biological activities, although detailed information on the chemical composition of Chuju remains scarce. In the present study, the chemical compositions of Chuju flowers were investigated across five sites in the core Chuju planting area in Anhui province, China.

Design and fabrication of intermetallic NiCo electrocatalysts for the alkaline HER.

The design and fabrication of highly efficient electrocatalysts are crucial for reducing energy consumption, improving hydrogen production rates, and prolonging the service life of alkaline electrolyzers. In this study, intermetallic 1-NiCo electrocatalysts were designed using DFT calculations and fabricated through a one-step solid-state reaction method. The DFT calculations indicated that 1-NiCo presented a lower H adsorption Gibbs free energy and a moderate HO dissociation barrier compared to the commonly used Ni catalyst and disordered NiCo alloy.

Cu(OH)NO/γ-AlO catalyzes Fenton-like oxidation for the advanced treatment of effluent organic matter (EfOM) in fermentation pharmaceutical wastewater: The synergy of Cu(OH)NO and γ-AlO.

The secondary effluent of fermentation pharmaceutical wastewater exhibits high chromaticity, elevated salinity, and abundant refractory effluent organic matter (EfOM), presenting significant treatment challenges and environmental threats. Herein, Cu(OH)NO/γ-AlO was fabricated through ultrasound-assisted impregnation and calcination to catalyze the Fenton-like oxidation for degrading organic pollutants in this secondary effluent. Under neutral conditions, with 400.

Ketogenic Diets Alter the Gut Microbiome, Resulting in Decreased Susceptibility to and Cognitive Impairment in Rats with Pilocarpine-Induced Status Epilepticus.

A ketogenic diet (KD) is a high-fat, low-carbohydrate, and low-protein diet that exerts antiepileptic effects by attenuating spontaneous recurrent seizures, ameliorating learning and memory impairments, and modulating the gut microbiota composition. However, the role of the gut microbiome in the antiepileptic effects of a KD on temporal lobe epilepsy (TLE) induced by lithium-pilocarpine in adult rats is still unknown. Our study provides evidence demonstrating that a KD effectively mitigates seizure behavior and reduces acute-phase epileptic brain activity and that KD treatment alleviates hippocampal neuronal damage and improves cognitive impairment induced by TLE.