High-Density Polyethylene Janus Fibrous Membrane with Enhanced Breathability and Moisture Permeability via PDA Assisted Hydrophilic Modification.

Functional fibrous membranes with high mechanical properties are intensively developed for different application fields. In this study, to enhance moisture and air permeability without compromising mechanical strength, a facile float-surface modification strategy is employed to fabricate Janus fibrous membranes with distinct hydrophobicity/hydrophilicity using the high-density polyethylene (HDPE) fibrous membranes. By coating one side of the HDPE fibrous membranes with polydopamine (PDA) and a superhydrophilic polyelectrolyte, the obtained Janus HDPE fibrous membranes demonstrate an excellent water transmission rate (577.

Synergistic effects enabled efficient photocatalytic removal of ofloxacin antibiotic in wastewater by layered double hydroxides loaded lignin-derived carbon fibers.

The environmental problems caused by the abuse of antibiotics are raising serious attention, and the removal of antibiotics in wastewater is meaningful yet challenging. In this work, lignin-derived carbon fibers loaded layered double hydroxides (LDH@LCF) has been prepared for the removal of ofloxacin (OFX) from wastewater via photocatalysis, which exhibit a high degradation efficiency of 96 % under visible light and maintained 90 % after five reuses. The effects of Zn/Fe in the samples and other parameters affecting the photocatalytic efficiency of OFX have been systematically investigated.

Multidisciplinary team discussion based on etiological treatment improves refractory chronic cough outcomes.

Background: Refractory chronic cough (RCC) causes significant impairments in the life quality of patients. Further research into the identification of etiologies and development of the treatment schedules for RCC is needed.

Patients And Methods: We established an multidisciplinary team (MDT) clinic, by integrating respiratory medicine, otorhinolaryngology, and gastroenterology departments, to investigate cough etiologies and the effectiveness of treatment.

A multicentre, randomised, double-blind, double-dummy, parallel-controlled, phase 3 clinical trial assessing the efficacy and safety of intravenous nemonoxacin malate vs. levofloxacin for community-acquired pneumonia in adult patients.

Background: Nemonoxacin malate is a novel non-fluorinated quinolone for oral and intravenous (IV) administration. This phase 3, multicentre, randomised, double-blind, double-dummy, parallel-controlled clinical trial (NCT02205112) evaluated the efficacy and safety of IV nemonoxacin vs. levofloxacin for the treatment of community-acquired pneumonia (CAP) in adult patients.

Crosslinking and fluorination reinforced PTFE nanofibrous membrane with excellent amphiphobic performance for low-scaling membrane distillations.

Membrane distillation (MD) has emerged as a promising technology for desalination and concentration of hypersaline brine. However, the efficient preparation of a structurally stable and salinity-resistant membrane remains a significant challenge. In this study, an amphiphobic polytetrafluoroethylene nanofibrous membrane (PTFE NFM) with exceptional resistance to scaling has been developed, using an energy-efficient method.

Benralizumab efficacy and safety in severe asthma: A randomized trial in Asia.

Background: Benralizumab is indicated as add-on therapy in patients with uncontrolled, severe eosinophilic asthma; it has not yet been evaluated in a large Asian population with asthma in a clinical trial.

Objective: To evaluate the efficacy and safety of benralizumab in patients with severe asthma in Asia.

Methods: MIRACLE (NCT03186209) was a randomized, Phase 3 study in China, South Korea, and the Philippines.

Profiles of Cough and Associated Risk Factors in Nonhospitalized Individuals With SARS-CoV-2 Omicron Variant Infection: Cross-Sectional Online Survey in China.

Background: Cough is a common symptom during and after COVID-19 infection; however, few studies have described the cough profiles of COVID-19.

Objective: The aim of this study was to investigate the prevalence, severity, and associated risk factors of severe and persistent cough in individuals with COVID-19 during the latest wave of the Omicron variant in China.

Methods: In this nationwide cross-sectional study, we collected information of the characteristics of cough from individuals with infection of the SARS-CoV-2 Omicron variant using an online questionnaire sent between December 31, 2022, and January 11, 2023.

3D stem cell spheroids with urchin-like hydroxyapatite microparticles enhance osteogenesis of stem cells.

Cell therapy (also known as cell transplantation) has been considered promising as a next-generation living-cell therapy strategy to surpass the effects of traditional drugs. However, their practical clinical uses and product conversion are hampered by the unsatisfied viability and efficacy of the transplanted cells. Herein, we propose a synergistic enhancement strategy to address these issues by constructing 3D stem cell spheroids integrated with urchin-like hydroxyapatite microparticles (uHA).

Highly conductive and porous lignin-derived carbon fibers.

Bio-based carbon fibers derived from lignin have gained significant attention due to their diverse and renewable sources, ease of extraction, and low cost. However, the current limitations of low specific surface area and insufficient electrical conductivity hinder the widespread application of lignin-derived carbon fibers (LCFs). In this work, highly conductive and porous LCFs are developed through melt-blowing, pretreatment, and carbonization processes.

Interfacial-Crystallization-Constructed Fractal Nanofiber-Based Bio-Platforms Enable Highly Effective Culture of Three-Dimensional Stem Cell Spheroids.

Artificial cell spheroids are gaining importance in tissue engineering and regenerative medicine fields. Biomimetic construction of stem cell spheroids is nevertheless challenging, and bioplatforms permitting controllable and high-efficient fabrication of functional stem cell spheroids are needed. Here, a fractal nanofiber-based bioplatform is developed based on a tunable interfacial-induced crystallization approach, allowing a programmed culture of artificial stem cell spheroids under an ultralow cell seeding density.

Mediating effect of anxiety and depression between family function and hope in patients receiving maintenance hemodialysis: a cross-sectional study.

Objectives: This study aimed to explore the levels of hope in patients receiving maintenance hemodialysis (MHD), and whether anxiety and depression mediate the relationship between family function and hope.

Methods: The family APGAR index, hospital anxiety and depression scale, and Herth hope index were recorded using the self-reported questionnaires completed by 227 MHD patients.

Results: The family function can directly predict hope, positively predict hope through depression (β = 0.

Silk Nanofibril-Palygorskite Composite Membranes for Efficient Removal of Anionic Dyes.

To develop membrane materials with good performance for water purification that are green and low cost, this work reports an organic-inorganic composite membrane composed of silk nanofibrils (SNFs) and palygorskite (PGS). To improve the stability of the the composite membrane, genipin was used as a crosslinking agent to induce the conformational transition of SNF chains from random coils to β-sheets, reducing the swelling and hydrolysis of the membrane. The separation performance can be adjusted by tailoring the component ratio of the nanomaterial.

Lignin-based carbon fibers: Insight into structural evolution from lignin pretreatment, fiber forming, to pre-oxidation and carbonization.

Lignin remains the second abundant source of renewable carbon with an aromatic structure. However, most of the lignin is burnt directly for power generation, with an effective utilization rate of <2 %, making value addition on lignin an urgent requirement. From this perspective, preparation of lignin-based carbon fibers has been widely studied as an effective way to increase value addition on lignin.

Hierarchically structural layered double oxides with stretchable nanopores for highly effective removal of protein-bound uremic toxins.

The global outbreak and prevalence of coronavirus disease 2019 (COVID-19) has triggered an urgent demand for family hemodialysis equipment. It is particularly vital to design and apply superior adsorbents to adsorb toxins for reducing the usage of dialysate. In this work, hierarchically structural MgAl layered double oxides (LDO) with stretchable nanopores were exploited through a facile one-pot trisodium citrate (TSC) assistant hydrothermal reaction followed by calcination treatment for effectively adsorbing protein-bound uremic toxins such as hippuric acid (HA) or indoxyl sulfate (IS).

Effect of pre-oxidation temperature and heating rate on the microstructure of lignin carbon fibers.

Lignin is a biopolymer with high carbon content, making lignin-based carbon fiber an important research direction. In the process of carbonization to prepare carbon fibers, lignin fibers are easily softened and fused, which destroys the microstructure of fibers, thereby reducing the quality of lignin-based carbon fibers. Therefore, it is non-negligible to pre-oxidize lignin fibers before carbonization to prevent fiber fusion and maintain fiber structure.

Nurses' knowledge, attitude, and practice regarding the use of physical restraints in children in the intensive care setting in China: A cross-sectional multicentre study.

Objective: The objectives of this study were to investigate paediatric nurses' knowledge, attitude, and practice (KAP) regarding the use of physical restraints and to explore the factors related to the use of physical restraints. Findings will provide a reference to develop standard procedures and training.

Background: Nurses' KAP regarding the use of physical restraints affect the use of physical restraints in the paediatric intensive care unit and neonatal intensive care unit.

High-performance TFNC membrane with adsorption assisted for removal of Pb(II) and other contaminants.

Rapid and thorough removal of heavy metal ions in wastewater is critical for the urgent need of clean water. Herein, we prepared a high-performance thin film nanofibrous composite (TFNC) membrane consisting of a polyacrylonitrile (PAN)-UiO-66-(COOH) composite nanofibrous substrate (CPAN) and a calcium alginate (CaAlg) skin layer. Owing to abundant adsorption sites of UiO-66-(COOH) MOF, the optimal CPAN-2 nanofibrous substrate showed excellent adsorption capacity for lead ions.

Diagnosis and treatment of primary pulmonary enteric adenocarcinoma: Report of Six cases.

Background: Primary pulmonary enteric adenocarcinoma (PEAC) is a very rare subtype of invasive adenocarcinoma, and there have been no large studies on PEAC to date. Therefore, it is necessary to obtain much more information about the clinical and pathological features, diagnosis, differential diagnosis, and treatment of PEAC.

Case Summary: All clinical data of six patients with confirmed PEAC from 2013 to 2018 were collected, and data on diagnosis, differential diagnosis, and treatment of PEAC are discussed combined with all the associated literature.

Hypertension as a sequela in patients of SARS-CoV-2 infection.

Background: COVID-19 is a respiratory infectious disease caused by SARS-CoV-2, and cardiovascular damage is commonly observed in affected patients. We sought to investigate the effect of SARS-CoV-2 infection on cardiac injury and hypertension during the current coronavirus pandemic.

Study Design And Methods: The clinical data of 366 hospitalized COVID-19-confirmed patients were analyzed.

A multicenter, prospective, observational study on montelukast monotherapy or montelukast-based combinations treating cough variant asthma.

Background: Evidence of treatment against cough variant asthma (CVA) is insufficient for the clinical practice in China. We aimed at evaluating the real-world effectiveness of montelukast (MONT) alone or in combination with low-dose inhaled corticosteroids (ICS) and low-dose ICS plus long-acting beta-2-agonists (LABA) for Chinese CVA patients in a multicentre, prospective, cohort study.

Methods: Adult patients diagnosed with CVA defined as chronic cough >8 weeks with a positive bronchial provocation test and normal chest X-ray findings were enrolled at respiratory clinics.

A hospital-wide reduction in central line-associated bloodstream infections through systematic quality improvement initiative and multidisciplinary teamwork.

Background: Few data are available on hospital-wide incidence of central line-associated bloodstream infection (CLABSI) rates in patients with central venous catheter (CVC) in China, where many systemic obstacles holding back evidence-based guidelines implementation exist.

Methods: This study was conducted prospectively in 2 phases. The baseline and intervention phases were performed in a teaching hospital in China, between January 2017 and October 2018.

Hydrogen-rich saline ameliorated LPS-induced acute lung injury via autophagy inhibition through the ROS/AMPK/mTOR pathway in mice.

Acute lung injury (ALI), a common complication of many serious health issues, such as serious infection, burns, and shock, is one of the most common critical illnesses in clinical practice with a high mortality rate of 30-40%. There are still short of effective prevention and treatment measures. Evidence is growing that hydrogen-rich saline (HRS) may be an effective drug for the prevention and treatment of ALI.

Anionic Surfactant-Triggered Steiner Geometrical Poly(vinylidene fluoride) Nanofiber/Nanonet Air Filter for Efficient Particulate Matter Removal.

The emergence of Steiner minimal tree is of fundamental importance, and designing such geometric structure and developing its application have practical effect in material engineering and biomedicine. We used a cutting-edge nanotechnology, electrospinning/netting, to generate a Steiner geometrical poly(vinylidene fluoride) (PVDF) nanofiber/nanonet filter for removing airborne particulate matter (PM). Manipulation of surface morphologies by precise control of charged situation enabled the creation of two-dimensional nanonets with Steiner geometry.

Effect of Different Heat Treatments on In Vitro Digestion of Egg White Proteins and Identification of Bioactive Peptides in Digested Products.

Unlabelled: Chicken eggs are ingested by people after a series of processes, but to date, only a few studies have explored the nutrient variations caused by different heat treatments. In this work, the impacts of different heat treatments (4, 56, 65, and 100 °C on the in vitro digestibility of egg white proteins were investigated by hydrolysis with pepsin or pepsin + pancreatin to simulate human gastrointestinal digestion, and the digested products were identified using Nano-LC-ESI-MS/MS. Egg white proteins treated at 65 °C had the highest in vitro pepsin digestibility value whereas the pepsin + pancreatin digestibility increased significantly (P < 0.