Publications by authors named "Wang Xiu-li"

Article Synopsis
  • Paclitaxel, an anti-cancer drug, triggers cognitive impairment by inducing necroptosis—a type of programmed cell death—in hippocampal neurons, linked to the RIPK1-RIPK3-MLKL signaling pathway.
  • Flow cytometric analysis revealed that paclitaxel-treated cells showed a higher incidence of necroptosis, marked by increased cell death and altered cell structure compared to control cells.
  • The use of necrostatin-1, an inhibitor of RIPK1, not only reduced necroptosis in cultures but also improved cognitive function in mice treated with paclitaxel, suggesting that targeting necroptosis may be a therapeutic strategy to mitigate cognitive side effects of cancer treatment.
View Article and Find Full Text PDF
Article Synopsis
  • * There's a critical need for high-performance, recyclable bio-derived materials, prompting the development of polyolefin-like polyesters (PBCS) through innovative molecular designs.
  • * PBCS showcase impressive mechanical and gas barrier properties, excellent biocompatibility, and can be easily processed, while also being able to regenerate high-purity monomers without solvents, maintaining quality after repolymerization.
View Article and Find Full Text PDF

Objectives: This study was designed to compare the clinical data of vesicoureteral reflux (VUR) in children with and without an allergic constitution.

Methods: The clinical data of patients hospitalized with VUR due to a urinary tract infection (UTI) between September 1, 2019, and December 31, 2020, were retrospectively analyzed. The patients were divided into two groups: an anallergic constitution group (AC group) and a non-allergic constitution (NAC group), and their UTIs and VUR were compared at baseline and during the follow-up period.

View Article and Find Full Text PDF

Both the circular economy and fire-safety of polymer plastics have become a global consensus. Herein, an integrated strategy for selectively self-recyclable, highly-transparent and fire-safe polycarbonate plastic is proposed by thermally responsive phosphonium-phosphate (DP). During its service life, DP, as a flame-retardant with good compatibility, enables polycarbonate plastic with high transparency in visible light, excellent self-extinguishing and high fire-safety.

View Article and Find Full Text PDF
Article Synopsis
  • Carbon neutrality requires innovative technologies for renewable energy, heat regulation, and material recycling in green buildings, but integrating these functions into one coating is challenging.* -
  • The newly developed coating, inspired by mussels, uses cellulose nanofibers and Mica-TiO to generate electricity through triboelectric effects and provides fire resistance, even maintaining performance after flame exposure.* -
  • This coating reflects heat effectively and lowers temperatures during the day by 5.3 °C, while being easily recyclable, positioning it as a promising solution for sustainable building materials.*
View Article and Find Full Text PDF

Organic polymer materials, as the most abundantly produced materials, possess a flammable nature, making them potential hazards to human casualties and property losses. Target polymer design is still hindered due to the lack of a scientific foundation. Herein, we present a robust, generalizable, yet intelligent polymer discovery framework, which synergizes diverse capabilities, including the in situ burning analyzer, virtual reaction generator, and material genomic model, to achieve results that surpass the sum of individual parts.

View Article and Find Full Text PDF

Nitrofurans are important synthetic broad-spectrum antibacterial drugs with the basic structure of 5-nitrofuran. Due to their toxicity, it is essential to develop a sensitive sensor with strong anti-interference capabilities for their detection. In this work, two {PMoO}-based compounds, [H(HPTTP)]{Cu[MoO(OH)(PO)(HPO)(HPO)]}·HO ( = 13 for (), 7 for (); HPTTP = 4,4',4″,4‴-(1-pyrrole-2,3,4,5-tetrayl)tetrapyridine), exhibiting similar coordination but distinct stacking modes.

View Article and Find Full Text PDF

Purpose: To evaluate the diagnostic performance of contrast-enhanced (CE) ultrasound using Sonazoid (SNZ-CEUS) by comparing with contrast-enhanced computed tomography (CE-CT) and contrast-enhanced magnetic resonance imaging (CE-MRI) for differentiating benign and malignant renal masses.

Materials And Methods: 306 consecutive patients (from 7 centers) with renal masses (40 benign tumors, 266 malignant tumors) diagnosed by both SNZ-CEUS, CE-CT or CE-MRI were enrolled between September 2020 and February 2021. The examinations were performed within 7 days, but the sequence was not fixed.

View Article and Find Full Text PDF

Polyolefin separators are the most commonly used separators for lithium batteries; however, they tend to shrink when heated, and their Li transference number (t ) is low. Metal-organic frameworks (MOFs) are expected to solve the above problems due to their high thermal stability, abundant pore structure, and open metal sites. However, it is difficult to prepare high-porosity MOF-based membranes by conventional membrane preparation methods.

View Article and Find Full Text PDF
Article Synopsis
  • Paclitaxel (PTX) is a common chemotherapy drug that can cause peripheral neuropathy (PIPN), negatively impacting patients' quality of life, and its mechanism involves necroptosis of dorsal root ganglion neurons.* -
  • The study used rat models to demonstrate that PTX triggers necroptosis through increased expression of RIP3 and MLKL proteins, which can be inhibited by necrostatin-1 (Nec-1).* -
  • Additionally, the drug minocycline was shown to reduce PTX-induced microglial polarization and subsequently lower the levels of necroptosis markers, improving pain symptoms in the rats, indicating a new potential strategy for treating PIPN.*
View Article and Find Full Text PDF

Persistent organic pollutants (POPs) sourced by the forest fire release are emerging as significant contributors. Despite their increasing importance, the impact of forest fires on POPs remains inadequately explored and an unclear understanding. Herein, the research, choosing four typical forest combustibles, focuses on the relationship between typical POPs and wildfire parameters by assessing the predominant compounds and their concentration in POPs emissions from such fuels through molecular-level analysis.

View Article and Find Full Text PDF
Article Synopsis
  • Candidalysin, a toxin produced by Candida albicans, plays a crucial role in how the fungus causes disease, but its specific interactions with human proteins were not well understood until now.
  • Researchers used a high-throughput method to identify potential human protein targets of eight Ece1 peptides, discovering that CCNH, which is involved in DNA damage repair, interacts with candidalysin.
  • Candidalysin was found to increase the formation of double-strand DNA breaks by activating CCNH, disrupting the DNA repair pathway, which highlights how this fungal toxin may help the fungus persist in infections.
View Article and Find Full Text PDF

The 3-succinate-30-stearyl glycyrrhetinic acid(18-GA-Suc) was inserted into glycyrrhetinic acid(GA)-tanshinone Ⅱ_A(TSN)-salvianolic acid B(Sal B) liposome(GTS-lip) to prepare liver targeting compound liposome(Suc-GTS-lip) mediated by GA receptors. Next, pharmacokinetics and tissue distribution of Suc-GTS-lip and GTS-lip were compared by UPLC, and in vivo imaging tracking of Suc-GTS-lip was conducted. The authors investigated the effect of Suc-GTS-lip on the proliferation inhibition of hepatic stellate cells(HSC) and explored their molecular mechanism of improving liver fibrosis.

View Article and Find Full Text PDF

Aim: Senescence of alveolar type II (AT2) cells is an important driver of pulmonary fibrosis. This study aimed to investigate whether and how dysregulation of hydrogen sulfide (H S) production affected AT2 cell senescence, and then explored the effect of H S on the communication between AT2 and fibroblasts.

Methods: ICR mice were intratracheally administered with bleomycin (3 mg/kg).

View Article and Find Full Text PDF
Article Synopsis
  • A new method for recycling plastic waste is introduced using a special diphenylacetylene monomer that reacts to light.
  • This monomer integrates into the structure of polyethylene terephthalate (PET) plastics through a simple one-step process that both breaks down and rebuilds the material.
  • The process enhances the plastics' resistance to UV damage and improves their mechanical strength over time, offering a promising advancement in traditional plastic recycling methods.
View Article and Find Full Text PDF
Article Synopsis
  • The oral microbiome, composed of various microorganisms, is important in cancer development and progression and is recognized as one of the "Hallmarks of Cancer".
  • Factors like maternal transmission and environmental conditions influence the composition and function of the oral microbiota, and disruptions (dysbiosis) can lead to systemic diseases.
  • The review highlights the interaction between oral microbiota and their environment, the health effects of this multi-kingdom community, and explores potential mechanisms and therapeutic strategies for targeting oral microbiota in cancer prevention and treatment.
View Article and Find Full Text PDF

To mimic natural photonic crystals having color regulation capacities dynamically responsive to the surrounding environment, periodic assembly structures have been widely constructed with response materials. Beyond monocomponent materials with stimulus responses, binary and multiphase systems generally offer extended color space and complex functionality. Constructing a rule for predicting response sensitivity can provide great benefits for the tailored design of intelligently responsive photonic materials.

View Article and Find Full Text PDF

Retiform hemangioendothelioma (RH) is a type of low-grade malignant angiosarcoma. It commonly involves the skin and subcutaneous tissue of the lower extremities, but a few cases have been reported in the gut. However, hepatic RH has not been previously reported.

View Article and Find Full Text PDF

Background: Iliopsoas plane block (IPB) is a novel analgesic technique for hip surgery that retains quadriceps strength. However, evidence from randomized controlled trial is remains unavailable. We hypothesized that IPB, as a motor-sparing analgesic technique, could match the femoral nerve block (FNB) in pain management and morphine consumption, providing an advantage for earlier functional training in patients underwent hip arthroplasty.

View Article and Find Full Text PDF

Structural colorations have been recognized as a significant way to replace conventional organic dyes for paints, inks, packaging, and cosmetics because of brilliant colors, high stability, and eco-friendliness. However, most current structural-color pigments present an iridescent appearance, and it remains difficult to mitigate a trade-off between lowering the iridescence effect and maintaining the color saturation and brightness. Here, we demonstrate a universal yet economical approach to prepare cellulose structural-color pigments with different sizes.

View Article and Find Full Text PDF

There will be generated some adverse conditions in the process of acquculture farming with the continuous improvement of the intensive degree of modern aquaculture, such as crowding stress, hypoxia, and malnutrition, which will easily lead to oxidative stress. Se is an effective antioxidant, participating and playing an important role in the antioxidant defense system of fish. This paper reviews the physiological functions of selenoproteins in resisting oxidative stress in aquatic animals, the mechanisms of different forms of Se in anti-oxidative stress in aquatic animals and the harmful effects of lower and higher levels of Se in aquaculture.

View Article and Find Full Text PDF

This experiment was done to study the zeolite molecular sieve as a drug-binding effector, the non-antibiotic drug potassium diformate uniformly disperse in the internal aqueous phase of the 'egg box' structure formed by pectin-calcium ions. With oil phase as the intermediate phase and Xanthan gum Chitosan as the external water phase, the W/O/W type sustained release bacteriostatic microcapsules with pH response were prepared and characterized by Fourier transform infrared, thermogravimetric, SEM, and TEM. It can be obtained through characterization experiments that the inner water phase, oil phase, and outer water phase were formed by observation, and W/O/W emulsion microcapsules were obtained and the bacteriostasis effect of microcapsules was verified by bacteriostasis experiment.

View Article and Find Full Text PDF

Objective: This study aimed to investigate the effect of resveratrol (Res) on paclitaxel (PTX)-induced cognitive impairment and elucidate the underlying molecular mechanisms.

Methods: Morris Water Maze (MWM) test was used to evaluate the mice's spatial learning and memory abilities. Western blotting was applied to detect protein expression of receptor-interacting protein (RIP3), mixed lineage kinase domain-like protein (MLKL), silencing information regulator 2 related enzyme 1 (SIRT1), peroxisome proliferator activated receptor coactivator-1 (PGC-1α), NADPH oxidase 2 (NOX2), NOX4, postsynaptic density zone 95 (PSD95), arginase-1 (Arg-1) and inducible nitric oxide synthase (iNOS).

View Article and Find Full Text PDF