KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated mA modification of ATG4a to promote NPCs senescence and IVDD progression.

Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses. However, the specific mechanisms that regulate the senescence of NPCs remain unknown. In this study, we observed impaired autophagy in IVDD-NPCs, which contributed to the upregulation of NPCs senescence and the senescence-associated secretory phenotype (SASP).

Downregulation of miR-214 promotes dilated Cardiomyopathy Progression through PDE5A-Mediated cGMP regulation.

Dilated cardiomyopathy (DCM) is a myocardial disorder resulting in a substantial decline in cardiac function and potentially leading to heart failure. This research combines bioinformatics analysis with empirical validation to explore the roles and mechanisms of miR-214 in DCM. Using the DEseq2 R package, a total of 125 differentially expressed circulating miRNAs (DE c-miRNAs) and 784 DE genes (DEGs) were identified.

Functionalized flattened bamboo board: In-situ immersion assembly of flame-retardant, waterproof and anti-mold composite coatings.

The flattened bamboo board (FB) represents a promising innovation in the bamboo industry. To address the challenges of flammability and hygroscopicity, composite coatings consisting of melamine (MEL), phytic acid (PA), cerium ions (Ce), and sodium laurate (La) are assembled on the FB surface through an in-situ impregnation strategy. The resulting MEL/PA-Ce@La FB exhibits exceptional flame retardancy.

Hypoxia-Preconditioned BMSC-Derived Exosomes Induce Mitophagy via the BNIP3-ANAX2 Axis to Alleviate Intervertebral Disc Degeneration.

Intervertebral disc degeneration (IVDD) is a chronic degenerative disease involving the aging and loss of proliferative capacity of nucleus pulposus cells (NPCs), processes heavily dependent on mitochondrial dynamics and autophagic flux. This study finds that the absence of BCL2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) is associated with senescence-related NPC degeneration, disrupting mitochondrial quality control. Bone marrow mesenchymal stem cells (BMSCs) have multidirectional differentiation potential and produce extracellular vesicles containing cellular activators.

Revealing climatic and groundwater impacts on the spatiotemporal variations in vegetation coverage in marine sedimentary basins of the North China Plain, China.

The North China Plain (NCP) is one of the three great plains in China and also serves as a vital region for grain, cotton, and oil production. Under the influence of regional hydrothermal changes, groundwater overexploitation, and seawater intrusion, the vegetation coverage is undergoing continuous alterations. However, a comprehensive assessment of impacts of precipitation, temperature, and groundwater on vegetation in marine sedimentary regions of the NCP is lacking.

Digital-Twin-Assisted Skill Learning for 3C Assembly Tasks.

The utilization of robots in computer, communication, and consumer electronics (3C) assembly has the potential to significantly reduce labor costs and enhance assembly efficiency. However, many typical scenarios in 3C assembly, such as the assembly of flexible printed circuits (FPCs), involve complex manipulations with long-horizon steps and high-precision requirements that cannot be effectively accomplished through manual programming or conventional skill-learning methods. To address this challenge, this article proposes a learning-based framework for the acquisition of complex 3C assembly skills assisted by a multimodal digital-twin environment.

Injectable nanocomposite hydrogels with enhanced lubrication and antioxidant properties for the treatment of osteoarthritis.

Osteoarthritis (OA) is a chronic inflammatory joint disease characterized by progressive cartilage degeneration, synovitis, and osteoid formation. In order to effectively treat OA, it is important to block the harmful feedback caused by reactive oxygen species (ROS) produced during joint wear. To address this challenge, we have developed injectable nanocomposite hydrogels composed of polygallate-Mn (PGA-Mn) nanoparticles, oxidized sodium alginate, and gelatin.

In situ retention of lignin-rich bamboo green effectively improves the surface properties of flattened bamboo.

Bamboo has tremendous carbon sequestration potential, and bamboo green is underutilized. This work devised a green-keeping technique in bamboo flattening that preserved natural bamboo green in-situ. The impacts of flattening and green-keeping on bamboo morphology, chemical composition, physical qualities, and composite applications were examined.

Enhanced Mitochondrial Targeting and Inhibition of Pyroptosis with Multifunctional Metallopolyphenol Nanoparticles in Intervertebral Disc Degeneration.

Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain, characterized by excessive reactive oxygen species generation and inflammation-induced pyroptosis. Unfortunately, there are currently no specific molecules or materials available to effectively delay IVDD. This study develops a multifunctional full name of PG@Cu nanoparticle network (PG@Cu).

Rabdosichuanin C inhibits productions of pro-inflammatory mediators regulated by NF-κB signaling in LPS-stimulated RAW264.7 cells.

Chronic pharyngitis (CP) is an inflammatory disease of the pharyngeal mucosa and its lymphatic tissues that is difficult to treat clinically. However, research on the exact therapeutic agents and molecular mechanisms of CP is still unclear. In this study, we investigated Rabdosichuanin C (RC) to attenuate lipopolysaccharide (LPS)-induced inflammatory damage in RAW264.

Ameliorative effect of black tea extract on the skin of D-galactose-induced aging mice.

Aging is a universal and irreversible process, and the skin is an important feature that reflects the aging of the organism. Skin aging has been a focus of attention in recent years because it leads to changes in an individual's external features and the loss of many important biological functions. This experiment investigated the improvement effect of black tea extract (BTE) on the skin of aging mice under D-galactose induction.

Integrated bioinformatics analysis for identifying key genes and pathways in female and male patients with dilated cardiomyopathy.

Dilated cardiomyopathy (DCM) is a common cause of heart failure, and males are more likely to suffer from DCM than females. This research aimed at exploring possible DCM-associated genes and their latent regulatory effects in female and male patients. WGCNA analysis found that in the yellow module, 341 and 367 key DEGs were identified in females and males, respectively.

Structure and Physical Properties of Conductive Bamboo Fiber Bundle Fabricated by Magnetron Sputtering.

The variety of conductive fibers has been constantly enriched in recent years, and it has made rapid development in the fields of electronic textiles, intelligent wearable, and medical care. However, the environmental damage caused by the use of large quantities of synthetic fibers cannot be ignored, and there is little research on conductive fibers in the field of bamboo, a green and sustainable material. In this work, we used the alkaline sodium sulfite method to remove lignin from bamboo, prepared a conductive bamboo fiber bundle by coating a copper film on single bamboo fiber bundles using DC magnetron sputtering, and analyzed its structure and physical properties under different process parameters, finding the most suitable preparation condition that combines cost and performance.

In-situ magnetite deposited wood composites with extensive electromagnetic interference shielding performance.

Wood is an insulator material, using its porous structure to endow it with efficient microwave absorption and broaden its application range is still a major challenge. Here, wood-based FeO composites with excellent microwave absorption properties and high mechanical strength were prepared by alkaline sulfite method, in-situ co-precipitation method and compression densification method. The results showed that the magnetic FeO was densely deposited in the wood cells, and the prepared wood-based microwave absorption composites had both high electrical conductivity, magnetic loss, excellent impedance matching performance and attenuation performance, as well as effective microwave absorption properties.

Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat Metabolic Disorders to Maintain Health.

Each person's body is host to a large number and variety of gut microbiota, which has been described as the second genome and plays an important role in the body's metabolic process and is closely related to health. It is common knowledge that proper physical activity and the right diet structure can keep us healthy, and in recent years, researchers have found that this boost to health may be related to the gut microbiota. Past studies have reported that physical activity and diet can modulate the compositional structure of the gut microbiota and further influence the production of key metabolites of the gut microbiota, which can be an effective way to improve body metabolism and prevent and treat related metabolic diseases.

Effects of Different Delignification and Drying Methods on Fiber Properties of Moso Bamboo.

Bamboo has become an important kind of fibrous raw material in the world due to its fast-growing property and abundance of natural fiber. During the purification and utilization of bamboo fiber, the removal of lignin is vital and it is affected by the chemical treatment system and drying method. In this paper, the effects of three different delignification chemical systems and three drying methods (air drying, drying and freeze drying) on the physical and chemical properties of bamboo fiber were comparatively studied.

Modulation of Intestinal Flora by Dietary Polysaccharides: A Novel Approach for the Treatment and Prevention of Metabolic Disorders.

Intestinal flora is numerous and diverse, and play a key role in maintaining human health. Dietary polysaccharides are widely present in the daily diet and have a moderating effect on the intestinal flora. Past studies have confirmed that intestinal flora is involved in the metabolic process in the human body, and the change in intestinal flora structure is closely related to the metabolic disorders in the human body.

Deep Learning Based Tongue Prickles Detection in Traditional Chinese Medicine.

Tongue diagnosis is a convenient and noninvasive clinical practice of traditional Chinese medicine (TCM), having existed for thousands of years. Prickle, as an essential indicator in TCM, appears as a large number of red thorns protruding from the tongue. The term "prickly tongue" has been used to describe the flow of qi and blood in TCM and assess the conditions of disease as well as the health status of subhealthy people.

Pressure-Steam Heat Treatment-Enhanced Anti-Mildew Property of Arc-Shaped Bamboo Sheets.

Bamboo is one of the most promising biomass materials in the world. However, the poor anti-mildew property and poor dimensional stability limits its outdoor applications. Current scholars focus on the modification of bamboo through heat treatment.

Polysaccharide Regulation of Intestinal Flora: A Viable Approach to Maintaining Normal Cognitive Performance and Treating Depression.

The intestinal tract of a healthy body is home to a large variety and number of microorganisms that will affect every aspect of the host's life. In recent years, polysaccharides have been found to be an important factor affecting intestinal flora. Polysaccharides are widely found in nature and play a key role in the life activities of living organisms.

Study on Bamboo Longitudinal Flattening Technology.

In this paper, we introduced a bamboo longitudinal flattening technology and analyzed the effects of the softening-flattening process on the physical and mechanical properties of moso bamboo. This is a newer bamboo processing technology that can enhance the utilization and reduce pollution compared with traditional bamboo-based products. Results showed that the parenchyma cells distorted and compacted due to the flattening process.

Tea Polyphenols: A Natural Antioxidant Regulates Gut Flora to Protect the Intestinal Mucosa and Prevent Chronic Diseases.

The intestinal tract of a healthy human body hosts many microorganisms that are closely linked to all aspects of people's lives. The impact of intestinal flora on host health is no longer limited to the gut but can also affect every organ in the body through various pathways. Studies have found that intestinal flora can be altered by external factors, which provides new ideas for treating some diseases.

The active ingredient (DSH-20) of Salvia miltiorrhiza flower reduces oxidative damage and apoptosis in cardiomyocytes by regulating miR-1.

Background: DSH-20, the active ingredient of Salvia miltiorrhiza flower extract, is used to treat cardiovascular diseases. However, its mechanism of action remains unclear. Herein, we investigated the intervention of DSH-20 in HO-induced oxidative damage and apoptosis in cardiomyocytes.

Change in Micro-Morphology and Micro-Mechanical Properties of Thermally Modified Moso Bamboo.

In recent years, saturated steam heat treatment has been considered as an environmentally friendly and cost-effective modification method compared with traditional heat treatment media. In this study, bamboo was treated by saturated steam, and the change in chemical composition, cellulose crystallinity index, micro-morphology, and micromechanical properties were analyzed by a wet chemistry method, Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), nanoindentation, and so on. Results illustrated that the parenchyma cell walls were distorted due to the decomposition of hemicellulose and cellulose in bamboo samples.