Luteolin-Manganese Nanozyme Induces Apoptosis and Ferroptosis for Enhanced Cancer Therapy.

Cancer presents a significant global public health challenge that impacts millions of individuals worldwide. The incorporation of natural products into cancer treatment has the potential to mitigate many of the side effects commonly associated with chemotherapy. This study builds on the advantages of enhancing the anticancer activity of natural flavonoids through metal chelation by synthesizing a natural antioxidant flavonoid complex, termed Lu-Mn nanozyme, which involves the chelation of luteolin with manganese ions.

Robust and High-Wettability Cellulose Separators with Molecule-Reassembled Nano-Cracked Structures for High-Performance Supercapacitors.

Separators in supercapacitors (SCs) frequently suffer from high resistance and the risk of short circuits due to inadequate electrolyte wettability, depressed mechanical properties, and insufficient thermal stability. Here, we develop a high-performance regenerated cellulose separator with nano-cracked structures for SCs via a binary solvent of superbase-derived ionic liquid and dimethylsulfoxide (DMSO). The unique nano-cracks with an average width of 7.

Metabolic Engineering of for Producing Different Types of Triterpenoids.

Triterpenoids widely exist in nature with diverse structures and possess various functional properties and biological effects. However, research on triterpenoids biosynthesis in is still limited to squalene, which restricts the development of to produce high-value triterpenoids. In this study, was developed as an efficient and flexible platform for the biosynthesis of different types of triterpenoids.

Timing Matters: Preconditioning Effects of Cathodal Transcranial Direct Current Stimulation on Intermittent Theta-Burst Stimulation-Induced Neuroplasticity in the Primary Motor Cortex.

Background: Recent advances have highlighted the interplay between intermittent theta-burst stimulation (iTBS) and transcranial direct current stimulation (tDCS) in neuroplasticity modulation. However, the synergistic potential of these modalities in optimizing plasticity, particularly with cathodal tDCS preconditioning before iTBS, remains poorly understood.

Objective: This study examined the effects of cathodal high-definition tDCS (HD-tDCS) preconditioning on iTBS-induced neuroplasticity in the primary motor cortex at different timing intervals.

High-Capacity Multilayered Luminescent Encryption Technology Based on Er-Implanted Silicon Treated by Pulsed Laser Annealing.

Luminescent encrypted labels can effectively solve the problem of counterfeiting. However, they suffer from complex design and fabrication, low space utilization, and limited capacity of encrypted information. Herein, we create multilayer infrared luminescent encryption labels using femtosecond-laser-activated Er-doped silicon.

Absence of genetic association between insulin-like growth factors and esophageal cancer.

This study aimed to explore the causal relationship between concentrations of various insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) and esophageal cancer (ESC), addressing the gap in understanding the genetic link between IGF1 and ESC. A two-sample Mendelian randomization (MR) analysis was conducted using single nucleotide polymorphisms linked to IGFs/IGFBPs and ESC from the IEU Open GWAS Project. This analysis included ESC GWAS data from 1996 individuals of European descent and genetic variant data from 3310 individuals of European ancestry.

Lobular endocervical glandular hyperplasia: Two case report and literature review.

Rationale: Lobular endocervical glandular hyperplasia is a rare proliferative lesion of the endocervical glands with an unclear pathogenesis. The condition lacks specific clinical manifestations and signs and often leading to clinical underdiagnosis and misdiagnosis.

Patient Concerns: A 27-year-old female patient presented with a history of abnormal vaginal bleeding over the previous 3 months.

A single epidural administration of butorphanol combined with patient-controlled intravenous analgesia relieves postpartum contraction pain after cesarean section: A randomized clinical trial.

Background: Numerous studies have shown that butorphanol exerts an inhibitory effect on visceral pain. The aim of this study was to observe the effects of a single epidural administration of butorphanol combined with patient-controlled intravenous analgesia on postpartum uterine contraction pain after cesarean section.

Methods: We randomly allotted 121 women undergoing cesarean section surgery procedure to 3 groups: 31 cases were excluded; and 90 cases were divided into group S (blank control, n = 30), group I (intravenous butorphanol, n = 30), and group E (butorphanol administered into the epidural cavity, n = 30).

Clinical effect analysis of timed strengthening moxibustion combined with continuing nursing on symptoms of qi deficiency and blood stasis type.

This study is based on the theory of meridian flow and aims to evaluate the clinical effect of timed strengthened moxibustion combined with continuous nursing on patients with shoulder-hand syndrome after stroke accompany with qi deficiency and blood stasis. This is a retrospective study. This study included 60 patients who visited the acupuncture and moxibustion Department of the local college of Chinese medicine from January 2022 to January 2023.

Predictive effect of modified frailty index on postoperative nausea and vomiting in thyroid cancer patients.

Postoperative nausea and vomiting (PONV) are common complications following thyroid cancer surgery, impacting patient well-being, prognosis, and potentially leading to severe complications. Frailty, a critical risk factor for postoperative complications, has not been thoroughly investigated concerning PONV in thyroid cancer patients. This study aimed to explore the correlation between frailty and PONV in thyroid cancer patients.

The value of red blood cell distribution width in perioperative cardiac function assessment in children with congenital heart disease: A retrospective cohort study.

Congenital heart disease (CHD) is the leading cause of birth defects in children, with high morbidity and mortality rates. Despite advances in surgical and interventional treatments, perioperative management of CHD remains challenging, particularly in complex cases and neonates. Effective perioperative assessment of cardiac function is essential for optimizing surgical outcomes and improving postoperative prognosis.

Determination of mid-infrared optical properties of complex media using partial Mueller matrix ellipsometry.

Tailoring optical and radiative properties has attracted significant attention recently due to its importance in advanced energy systems, nanophotonics, electro-optics, and nanomanufacturing. Metamaterials with micro- and nanostructures exhibit exotic radiative properties with tunability across the spectrum, direction, and polarization. Structures made from anisotropic or nanostructured materials have shown polarization-selective absorption bands in the mid-infrared.

Periodontitis-related myocardial fibrosis by expansion of collagen-producing SiglecF+ neutrophils.

Backgrounds And Aims: Patients with periodontitis (PD) are prone to developing myocardial infarction (MI), yet the prognosis and mechanisms remain unclear. Given the presumed close association of neutrophils with both conditions, this study aims to elucidate the roles of neutrophils in mediating the interaction between PD and MI.

Methods: Three prospective cohorts and PD + MI mouse model were investigated to assess the effects of PD on MI prognosis.

Effect of Microporous Surface Zirconia on Mechanical Properties and Biological Behavior of Human Gingival Fibroblasts.

As a commonly used material in prosthodontics, zirconia has garnered widespread attention. Addressing the shortcomings of existing zirconia materials, this study aims to investigate the mechanical properties of microporous surface zirconia ceramics and their impact on the biological behavior of human gingival cells. Microporous surface zirconia was developed using a novel ceramic plasticity process, sintered at 1460°C for densification.

The Overexpression of RTN4 Significantly Associated With an Unfavourable Prognosis in Patients With Lower-Grade Gliomas.

Gliomas, the most prevalent primary malignancy of the central nervous system, is characterised by its high mortality rates and unfavourable prognosis. Despite extensive research, the underlying mechanisms of glioma pathogenesis remain elusive. The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases provided the lower-grade gliomas (LGG) transcriptome and related clinical data, which were downloaded separately.

Periodic Macroporous KTaO Fabricated for Photocatalytic Hydrogen Production from Pure Water Splitting.

Periodic macroporous materials are extensively utilized in photocatalytic hydrogen production from water splitting owing to their smooth mass transfer and abundant active sites. Therefore, it is essential to develop highly stable materials featuring interconnected channels and appropriate surface states to enhance the photocatalytic capability. Periodic macroporous KTaO (PM-KTaO) with a pyrochlore structure emerges as the ideal candidate to fulfill these requirements.

Modified carbon dot-mediated transient transformation for genomic and epigenomic studies in wheat.

Genotype restriction poses a significant bottleneck to stable transformation in the vast majority of plant species, thereby severely impeding advancement in plant bioengineering, particularly for crops. Nanoparticles (NPs) can serve as effective carriers for the transient delivery of nucleic acids, facilitating gene overexpression or silencing in plants in a genotype-independent manner. However, the applications of NP-mediated transient systems in comprehensive genomic studies remained underexplored in plants, especially in crops that face challenges in genetic transformation.

Quantification of Pectolinarin in Rat Plasma Using UPLC-MS/MS and Its Pharmacokinetic Analysis.

Pectolinarin is a flavonoid compound known for its wound-healing properties, including anti-inflammatory and antibacterial effects. In this study, we employed UPLC-MS/MS to quantify pectolinarin in rat plasma and investigate its pharmacokinetics. Plasma samples were processed using an acetonitrile precipitation method.

Comprehensive Analysis of Clinical and Molecular Features in Cancer Patients Associated With Major Human Oncoviruses.

Viral infections contribute to a higher incidence of cancer than any other individual risk factor. This study aimed to compare the clinical and molecular features of four viral-associated cancers: stomach adenocarcinoma (STAD), head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), and cervical squamous cell carcinoma (CESC). Patients were categorized based on viral infection status, as provided in the clinical data, into virus-associated and non-virus-associated groups, followed by a comprehensive comparison of clinical and molecular features.

[Effects of autophagy on myocardial injury in rats with common bile duct ligation].

Objective: To investigate the impact of autophagy on cardiac tissue injury following common bile duct ligation (CBDL) in rats.

Methods: Twenty-four SPF grade healthy adult male Sprague-Dawley (SD) rats were randomly divided into four groups, with 6 rats in each group. The sham-operated (Sham) group underwent only dissection of the common bile duct without ligation.

[Correlation analysis between mechanical power normalized to dynamic lung compliance and weaning outcomes and prognosis in mechanically ventilated patients: a prospective, observational cohort study].

Objective: To explore the correlation between mechanical power normalized to dynamic lung compliance (Cdyn-MP) and weaning outcomes and prognosis in mechanically ventilated patients.

Methods: A prospective, observational cohort study was conducted. Patients who underwent invasive mechanical ventilation (IMV) for more than 24 hours and used a T-tube ventilation strategy for extubation in the intensive care unit (ICU) of Lianyungang First People's Hospital and Lianyungang Second People's Hospital between January 2022 and December 2023 were enrolled.

Constructing a 3D co-culture synovial tissue model for rheumatoid arthritis research.

The development and exploration of highly effective drugs for rheumatoid arthritis remains an urgent necessity. However, current disease research models are no longer sufficient to meet the rapid development of high-throughput drug screening. In this study, bacterial cellulose simulating the structure of extracellular matrix was used as a 3D culture platform, and THP-1-derived M1 macrophages, representing the inflammatory component, human umbilical vein endothelial cells (HUVECs), simulating the vascular component, and rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs), embodying the synovial pathology, were co-cultured to simulate the pathological microenvironment in RA synovial tissues, and synovial organoids were constructed.

Asiatic acid improves the damage of HaCaT cells induced by nitrogen mustard through inhibiting endoplasmic reticulum stress.

Nitrogen mustard (NM) belongs to vesicant agents. Blisters are one of the important characteristics of NM skin damage. It is urgent to further elucidate the mechanism and develop effective countermeasures for the skin damage induced by NM.

Association between the intake of potentially risky beverages and the occurrence of endometrial polyps: a case-control study.

Background: This case-control study aimed to examine the association between the frequency of potentially risky beverage consumption, levels of anxiety, and the prevalence of endometrial polyps.

Methods: A total of 418 participants were enrolled in the study, comprising 206 cases and 212 controls. The case group consisted of patients who visited the gynecological clinic at the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine and were diagnosed with endometrial polyps (Eps) based on international diagnostic criteria.

Influence of regional environmental variables on the radiative forcing of atmospheric microplastics.

Atmospheric microplastics (AMPs) can absorb and scatter radiation, which can be quantified by radiative forcing. Although the radiative forcing of AMPs is commonly positive at the global scale, regional environmental variables affect the radiative forcing of aerosols, potentially reversing its directions and cause opposite radiative impacts in the atmosphere. In this study, the total suspended particles were collected within one year in Tianjin, China, and the monthly average concentration of AMPs of 200.