Identification of QTLs for early maturity-related traits based on RIL population of two elite cotton cultivars.

Background: Early-maturity cotton varieties have the potential to be cultivated in a wider geographical area, extending as far north as 46 °N in China, and confer to address the issue of competition for land between grain and cotton by reducing their whole growth period (WGP). Therefore, it is of great importance to develop cotton varieties with comprehensive early maturity and high yield following investigating the regulatory mechanism underlying early maturity and identifying early maturity-related genes.

Results: In this study, 'SCRC19' and 'SCRC21', two excellent cultivars with significantly different WGP, along with their recombinant inbred lines (RILs) consisting of 150 individuals were re-sequenced, yielding 4,092,677 high-quality single nucleotide polymorphisms (SNPs) and 794 bin markers across 26 chromosomes.

Alkene Epoxidation with Water by Confined Active Co Sites on BiVO Photoanodes under Visible Light.

Heterogeneous photoelectrocatalysis systems have recently seen significant growth in organic transformations, but are limited by the inherent physicochemical properties of electrode materials. To enhance selectivity in these processes, we propose an innovative advancement in the rational design of photoanodes. Specifically, we incorporated cobalt porphyrin co-catalysts with confined Co sites onto bismuth vanadate films as a photoanode.

Effect of the Deubiquitinating Peptidase 7 (USP7) on Hepatitis B Virus (HBV) Replication and the Antiviral Efficacy of Entecavir (ETV).

Hepatitis B is a viral infection of the liver caused by the hepatitis B virus (HBV). Entecavir (ETV) is considered the primary therapeutic option for HBV treatment, primarily functioning by inhibiting HBV replication. Ubiquitin-specific peptidase 7 (USP7), a deubiquitinating enzyme, plays a crucial role in regulating DNA repair mechanisms.

Activity of cefiderocol in combination with tetracycline analogues against carbapenem-resistant Acinetobacter baumannii.

Therapeutic options for carbapenem-resistant Acinetobacter baumannii (CA-AB) are quite limited. Cefiderocol, a novel siderophore cephalosporin, has shown potent in vitro activity against CR-AB, and new tetracycline analogues such as eravacycline and omadacycline have been available in recent years. However, the synergism of cefiderocol with tetracycline analogues against CR-AB has not been well investigated.

Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial.

A randomized double-blind phase 3 trial (CHOICE-01, NCT03856411) demonstrated that combining toripalimab with chemotherapy substantially improves progression-free survival (PFS) in advanced non-small cell lung cancer (NSCLC) patients without pretreatment. This study presents the prespecified final analysis of overall survival (OS) and biomarkers utilizing circulating tumor DNA (ctDNA) and tissue-based sequencing. Additionally, the analysis revealed a higher median overall survival (OS, 23.

A chromosome-level genome assembly of Serangium japonicum Chapin, 1940 (Coleoptera: Coccinellidae).

Serangium japonicum (Coleoptera; Coccinellidae) plays a crucial role as a predatory coccinellid in ecosystems, exhibiting adept predation on diverse whitefly species and effectively regulating their population dynamics. Nonetheless, the absence of high-quality genomic data has hindered our comprehension of the molecular mechanisms underlying this predatory beetle. This study performed genome sequencing of S.

Porous Organic Polymers for CO Capture and Catalytic Conversion.

Overuse of fossil fuels and anthropogenic activities have led to excessive emissions of carbon dioxide, leading to global warming, and measures to reduce atmospheric carbon dioxide concentrations are needed to overcome this global challenge. Therefore, exploring an environmentally friendly strategy for capturing airborne CO and converting it into high-value-added chemicals offers a promising pathway toward "carbon neutrality". In recent years, porous organic polymers have attracted much attention for carbon capture and the catalytic conversion of carbon dioxide because of their high specific surface area, high chemical stability, nanoscale porosity, and structural versatility, which make them easy to functionalize.

Surface-enhanced Raman spectroscopy: a half-century historical perspective.

Surface-enhanced Raman spectroscopy (SERS) has evolved significantly over fifty years into a powerful analytical technique. This review aims to achieve five main goals. (1) Providing a comprehensive history of SERS's discovery, its experimental and theoretical foundations, its connections to advances in nanoscience and plasmonics, and highlighting collective contributions of key pioneers.

Automatic Pavlov ratio measurement method based on spinal landmarks identification by a deep-learning model.

Background: Cervical canal stenosis is one of the important pathogenic factors of cervical spondylosis. The accuracy of the Pavlov ratio measurement is crucial for the diagnosis and treatment of cervical spinal stenosis. Manual measurement is influenced by observer variability, accompanied by its inefficiency, which affects clinical evaluation.

The timing of surgical interventions following the implantation of coronary drug-eluting stents in patients undergoing gastrointestinal cancer surgery: a multicenter retrospective cohort study.

Abstract: We aim to investigate the optimal timing for surgical interventions to maximize patient benefit.

Background: The guidelines recommending a minimum deferral of six months for non-cardiac surgeries following drug-eluting stent percutaneous coronary intervention (DES-PCI) do not adequately address the requirements for individuals undergoing gastrointestinal cancer surgery (GCS).

Methods: The study encompassed 2,501 patients treated from January 2017 to December 2021, all of whom underwent GCS within one year after DES-PCI.

Trends, age shifts, and potential delayed peaks post-pandemic of early-onset brain and central nervous system cancers in individuals aged 20-49: a cross-sectional study.

Background: Central nervous system (CNS) cancers are highly lethal and increasingly affect younger populations aged 20-49, posing significant challenges to global healthcare systems. Current research on early-onset CNS cancer trends is limited and outdated, with uncertain impacts from the COVID-19 pandemic. This study explores the epidemiology of early-onset CNS cancer and the pandemic's effects.

JUMPlib: Integrative Search Tool Combining Fragment Ion Indexing with Comprehensive TMT Spectral Libraries.

The identification of peptides is a cornerstone of mass spectrometry-based proteomics. Spectral library-based algorithms are well-established methods to enhance the identification efficiency of peptides during database searches in proteomics. However, these algorithms are not specifically tailored for tandem mass tag (TMT)-based proteomics due to the lack of high-quality TMT spectral libraries.

Improved HO Photogeneration on KBr Doped-Polymeric Carbon Nitride Via Optimize the Oxygen Reduction Path.

The photosynthesis of hydrogen peroxide (HO) from oxygen (O) represents a promising catalytic pathway, the limited efficiency of the oxygen reduction constitutes a primary barrier to enhancing production. In this content, alkali metal potassium (K) and Br-doped g-CN photocatalysts (K-CN) were successfully constructed by one-pot method. The introduction of K is not only beneficial to the transmission of space charge and the separation efficiency of photogenerated carriers, but also promotes the efficient production of HO by 2e oxygen reduction reaction.

Impact of Potassium Doping on a Two-Dimensional Kagome Organic Framework on Ag(111).

Alkali element doping has significant physical implications for two-dimensional materials, primarily by tuning the electronic structure and carrier concentration. It can enhance interface electronic interactions, providing opportunities for effective charge transfer at metal-organic interfaces. In this work, we investigated the effects of gradually increasing the level of K doping on the lattice structure and electronic properties of an organometallic coordinated Kagome lattice on a Ag(111) surface.

One-Pot Synthesis of Multicentric DIL@PDIL Catalyst for Mild CO Conversion to Cyclic Carbonates.

Among the various studies on CO utilization, the sustainable and cost-effective fixation of CO into cyclic carbonates remains one of the most intriguing subjects. To this end, a novel type of composite dicationic ionic liquid material, DIL@PDIL, was developed. This composite consists of a dicationic ionic liquid (DIL), DMAP[TMGH]Br, supported on a polymeric dicationic ionic liquid (PDIL), P-DVB/Im[TMGH]Br.

Achieving Photocatalytic Overall Nitrogen Fixation via an Enzymatic Pathway on a Distorted CoP Configuration.

Photocatalytic nitrogen (N) fixation over semiconductors has always suffered from poor conversion efficiency owing to weak N adsorption and the difficulty of N≡N triple bond dissociation. Herein, a Co single-atom catalyst (SAC) model with a C-defect-evoked CoP distorted configuration was fabricated using a selective phosphidation strategy, wherein P-doping and C defects co-regulate the local electronic structure of Co sites. Comprehensive experiments and theoretical calculations revealed that the distorted CoP configuration caused a strong charge redistribution between the Co atoms and adjacent C atoms, minimizing their electronegativity difference.

Investigation of T lymphocyte subsets in children with Mycoplasma pneumoniae pneumonia.

This study aims to characterize the majority of immune cell subsets in peripheral blood mononuclear cells in children with Mycoplasma pneumoniae pneumonia (MPP) by a 21-color flow cytometry panel. Patients who met the predetermined eligibility criteria for pneumonia diagnosis were recruited for the research study. Multi-color flow cytometry was conducted on the peripheral blood mononuclear cells of each patient group, which were then subjected to dimensionality reduction and cluster analysis.

Hybrid Enzyme-Electrocatalyst Cascade Modified Gas-Diffusion Electrodes for Methanol Formation from Carbon Dioxide.

We propose a hybrid electrocatalytic-bioelectrocatalytic reaction cascade integrated on a gas diffusion electrode for CO reduction under selective formation of methanol. Ag-BiO selectively reduces gaseous CO to formate at neutral pH conditions. A subsequent enzymatic cascade comprising formaldehyde dehydrogenase and alcohol dehydrogenase, which are both nicotinamide adenine dinucleotide (NAD)-dependent, further reduce formate sequentially to formaldehyde and methanol.

Liquid Crystalline Nanorods by Synchronized Polymerization, Self-Assembly and Oriented Attachment for Utilization in Magnetically Responsive Displays.

The creation of anisotropic nanoparticles (NPs) by polymerization and/or self-assembly (SA) has significantly promoted the applications of polymer nanomaterials in many fields. However, polymer nanorods are not easily accessible via conventional polymerization or SA. Here we report a one-step route to synthesize single-domain smectic liquid crystalline (LC) nanorods utilizing oriented attachment (OA) that was usually found in the synthesis of inorganic NPs, synchronized with polymerization and SA.

Copper-Catalyzed [2,3]-Sigmatropic Rearrangement of Azide-Ynamides via Selenium Ylides.

A copper-catalyzed [2,3]-sigmatropic rearrangement of azide-ynamides via selenium ylides is disclosed, which leads to the practical and divergent synthesis of a variety of tricyclic heterocycles bearing a quaternary carbon stereocenter in generally moderate to excellent yields. Significantly, this method represents the first [2,3]-sigmatropic rearrangement of the selenium ylide based on alkynes and an unprecedented [2,3]-sigmatropic rearrangement via α-imino copper carbenes.

A Three-Tiered Golf Anode towards Ultralong-Life Zn-Mn Aqueous Batteries.

Zn-Mn aqueous batteries (ZMABs) are widely recognized as a promising candidate for large-scale energy storage due to their cost-effectiveness, high safety and environmental friendliness. However, the practical application of ZMABs is hindered by inherent electrical contact loss, hydrogen evolution and dendrite growth on traditional anodes. Here, a three-tiered golf anode with high conductivity is developed to simultaneously enhance the reversibility of Zn and Mn metals.

Photothermal Miniemulsion Polymerization by Amphiphilic Gold Nanoclusters.

Gold nanoclusters (AuNCs), which are approximately 2 nm in size, exhibit distinctive photophysical and catalytic properties, but their performance is often compromised by environmental factors. To mitigate these challenges, attempts have been made to incorporate AuNCs into polymer matrices to enhance their stability. Miniemulsion polymerization has proven to be an effective method for fabricating organic-inorganic composites.

Towards the Use of Low-Concentration CO Sources by Direct Selective Electrocatalytic Reduction.

The direct CO reduction reaction (CORR) from simulated flue gas of various CO concentrations could minimize extra energy for pre-concentration processes to highly concentrated CO as a feedstock. We investigate the challenges for CORR caused by low CO concentrations and provide strategies concerning the impact of the chosen electrocatalyst material and the selection of the electrolyte to attain high CO selectivity. We continuously feed CO mixed with N (the typical dilutant in flue gas) in various ratios to gas diffusion electrodes in a model flow-through electrolyzer.