Examining the link between adherence to the planetary health diet pattern and mortality in the us: a prospective cohort study.

Background: Though the Planetary Health Diet (PHD) is designed to enhance both human and environmental health, there is limited understanding of how adherence to PHD influences the risk of mortality in the general US adult population. This study aimed to evaluate the relationship between the Planetary Health Diet Index for the United States (PHDI-US) and mortality among adults in the overall population of the United States.

Methods: The PHDI-US comprises 16 components, assigned scores ranging from 0 to 150, with higher scores signifying a greater level of adherence to the PHD.

Intestinal microflora and metabolites affect the progression of acute pancreatitis (AP).

Specific intestinal metabolites are closely associated with the classification, severity, and necrosis of acute pancreatitis (AP) and provide novel insights for in-depth clinical investigations. In this study, the gut microbiota and metabolites of 49 AP patients at different treatment stages and severities were analysed via 16S rDNA sequencing and untargeted metabolomics to investigate the trends in gut microbiota composition and metabolome profiles observed in patients with severe AP. These findings revealed an imbalance in intestinal flora homeostasis among AP patients characterized by a decrease in probiotics and an increase in opportunistic pathogens, which leads to damage to the intestinal mucosal barrier through reduced short-chain fatty acid (SCFA) secretion and disruption of the intestinal epithelium.