Association of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study.

Objective: To evaluate the association between the LHCGR rs2293275 (N312S) genotype and ovarian aging phenotypes in Han Chinese women, focusing on diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI).

Study Design: This multicenter population-based study included 1,240 women aged 18-40 years diagnosed with DOR (n = 711) or POI (n = 529), alongside 72,846 ethnically and regionally matched controls from the Han Chinese Genomes Database (PGG.Han).

Photodynamic Therapy Combined with Curettage for Actinic Keratosis on the Face and Scalp: An Efficient Management for Field Cancerization.

Background: Actinic keratosis (AK) frequently manifests as multiple regional lesions on the exposed areas of the face and scalp. The simultaneous treatment of extensive lesions with varying degrees poses a significant challenge.

Objective: This study evaluated the efficacy and patient satisfaction of 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) combined with curettage in managing extensive AK on the face and scalp.

Novel repetitive elements in plant-specific tails of Gγ proteins as the functional unit in G-protein signalling in crops.

Heterotrimeric G proteins act as molecular switches in signal transduction in response to stimuli in all eukaryotes. However, what specifies G protein signalling in plants and how the mechanism evolved and diverged remain unsolved. Here, we found that the recently evolved tails of three Gγ subunits, Dense and erect panicle 1 (DEP1), G protein gamma subunit 2 of type C (GGC2), and Grain size 3 (GS3), determine their distinct functions and specify grain size in rice (Oryza sativa L.

Eye-sparing treatment for sinonasal tumors invading the orbit in the era of personalized therapy.

Few studies investigated the eye-sparing treatment in patients with sinonasal carcinomas (SNCs) from the perspective of modern precision radiation, and the eye-sparing treatment in patients with grade III orbital invasion was rarely discussed. This retrospective study included patients with primary SNCs who accepted eye-sparing treatment from October 2000 to June 2022 at a single institution. Patients' clinical information and follow-up data (including visual data) were obtained.

Royal Jelly Enhances the Social Status of Submissive Rats by Restoring Balance to the Disturbed Gut-Brain Communication.

Royal jelly (RJ) has long been considered a crucial dietary component in dictating caste differentiation in honeybees. As a nutritional additive, royal jelly imparts a broad range of benefits to mammals and humans; however, its precise impact on the social hierarchy of these advanced animals is not yet fully understood. This study aims to determine whether the benefits of royal jelly can be transferred to rats to alter their social ranks and uncover the underlying mechanisms.

mRNA mA regulates gene expression via H3K4me3 shift in 5' UTR.

Background: N-methyladenosine (mA) is a prevalent and conserved RNA modification in eukaryotes. While its roles in the 3' untranslated regions (3' UTR) are well-studied, its role in the 5' UTR and its relationship with histone modifications remain underexplored.

Results: We demonstrate that mA methylation in the 5' UTR of mRNA triggers a downstream shift in H3K4me3 modification.

Piperlongumine induces ROS accumulation to reverse resistance of 5-FU in human colorectal cancer via targeting TrxR.

Resistance is a major concern for colorectal cancer patients undergoing chemotherapy. Piperlongumine (PL) has been proven to effectively reverse drug resistance in several types of cancers; however, the mechanisms associated with the reversal effect and the targets of PL in cancer drug resistance are still unclear. In this research, the reversal effects and associated mechanisms of PL in 5-Fluorouracil (5-FU) resistance colorectal cancer were investigated both in vitro and in vivo.

Mechanism of nano-plastics induced inflammation injury in vascular endothelial cells.

Nano-plastics, emerging pollutants in the environment, have raised global concern due to their widespread presence in daily life and the potential toxicity to human health. Upon entering human body, nano-plastics can readily interact with vascular endothelial cells within the bloodstream, potentially leading to endothelial dysfunction. However, our understanding of the toxic impact of nano-plastics on vascular endothelial cells remains insufficient, and the underlying mechanism are yet to be elucidated.

The regulatory roles of plant miRNAs in biotic stress responses.

Throughout their life cycle, plants are inevitably confronted with various challenges imposed by adverse environmental conditions, including both biotic and abiotic stresses. To adapt to these environmental fluctuations, plants have evolved a highly efficient regulatory mechanism, in which microRNAs (miRNAs) play pivotal roles. miRNAs are a class of 20-24 nucleotide non-coding RNAs generated from MIR genes, which regulate gene expression at the post-transcriptional level through mRNA degradation or translational repression.

Onet: Twin U-Net Architecture for Unsupervised Binary Semantic Segmentation in Radar and Remote Sensing Images.

Segmenting objects from cluttered backgrounds in single-channel images, such as marine radar echoes, medical images, and remote sensing images, poses significant challenges due to limited texture, color information, and diverse target types. This paper proposes a novel solution: the Onet, an O-shaped assembly of twin U-Net deep neural networks, designed for unsupervised binary semantic segmentation. The Onet, trained with an intensity-complementary image pair and without the need for annotated labels, maximizes the Jensen-Shannon divergence (JSD) between the densely localized features and the class probability maps.

Real-World Insights Into cN3 Larynx and Hypopharynx Cancer: Treatment Modalities, Long-Term Outcomes, and Prognostic Factors.

Objectives: cN3 larynx and hypopharynx cancer is rare with a poor prognosis. This study evaluates treatment approaches, effectiveness, and prognosis for these patients in real-world settings. It aims to offer targeted and practical clinical guidance to enhance their treatment results and quality of life.

Prediction of vedolizumab efficacy in ulcerative colitis: a nomogram incorporating pathological feature and serological marker.

Vedolizumab (VDZ) is a humanized, gut-selective biologic used in the treatment of ulcerative colitis (UC). However, data on predictive factors for treatment response are limited. This study aims to develop a nomogram to predict VDZ treatment responsiveness in UC.

The anti-inflammatory effects of saponins from natural herbs.

Inflammation is a protective mechanism that also starts the healing process. However, inflammatory reaction may cause severe tissue damage. The increased influx of phagocytic leukocytes may produce excessive amount of reactive oxygen species, which leads to additional cell injury.

Roles of Microglia in Synaptogenesis, Synaptic Pruning, and Synaptic Plasticity in Physiological Conditions and Central Nervous System Disorders.

Microglia are resident immune cells in the brain that have been widely studied for their immune surveillance and phagocytosis. In recent years, the important role of microglia in synapse formation, elimination, and plasticity is gradually being recognized. Synapses are the main communication mode between neurons.

Trace Elements and Temperature Combined to Regulate Zooplankton Community Structures in Mountain Streams.

Zooplankton, as an important component of mountain river ecosystems, play a crucial role in the cycling of matter and the flow of energy. However, the depth and systematic research on the formation mechanisms and influencing factors of zooplankton communities in mountain streams are poorly understood. Here, we conducted field sampling and investigated the spatiotemporal distribution of the zooplankton community structure and the major environmental factors in mountain streams to explore the principles underlying their effects on the zooplankton community.

Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury.

Alleviating the multiple types of programmed neuronal death caused by mechanical injury has been an impetus for designing neuro-therapeutical approaches after traumatic brain injury (TBI). The aim of this study was to elucidate the potential role of PSMD14 (proteasome 26S subunit, non-ATPase 14) in neuron death and the specific mechanism through which it improves prognosis of TBI patients. Here, we identified differential expression of the PSMD14 protein between the controlled cortical impact (CCI) and sham mouse groups by LC-MS proteomic analysis and found that PSMD14 was significantly upregulated in neurons after brain injury by qPCR and western blot.

Evolution of supramolecular structure for bamboo cellulose during successive freeze-thaw-pyrolyzing process.

Motivated by "bamboo as a substitute for plastic (BASP)" initiative, replacing plastic products with bamboo attracted worldwide attention. However, the BASP products often suffered from mechanical failure under freeze-thaw process, during which varying cellulose supramolecular structure played a critical role. Herein, the structural evolution of supramolecular for cellulosic models including bamboo fiber, parenchyma and pulps were carefully determined during successive freeze-thaw-pyrolyzing process (-80 °C-1600 °C).

Identification of body fluid sources based on microbiome antibiotic resistance genes using high-throughput qPCR.

Identifying the origin of body fluids is a critical step in forensic investigation. Recently, the development of high-throughput sequencing technology has led to the use of microbiomes for body fluid identification in forensic studies. However, high-throughput sequencing data are difficult to analyze, the sequencing protocol is complicated.

Effectiveness, acceptability, and cost-effectiveness of digital health interventions for diabetes self-management in adults with or without hypertension: an umbrella review protocol.

Objective: This review will synthesize evidence on the effectiveness, acceptability, and cost-effectiveness of digital health interventions in implementing and maintaining effective self-management among adults (≥ 18 years) with diabetes, with or without comorbid hypertension.

Introduction: Diabetes and hypertension are becoming the most challenging global health burdens. Growing evidence underscores the effectiveness of digital health interventions for diabetes and hypertension.

Fluorescent Microorganism-Based Composite: Enhancing Curcumin Delivery Efficiency and its Antitumor Application in Prostate Cancer.

Prostate cancer is a major global health concern, ranking as the second most common malignancy in men and the fifth leading cause of cancer-related deaths. Although curcumin exhibits potent antioxidant, anti-inflammatory, and antitumor properties, its clinical application is limited by poor solubility, low bioavailability, and rapid metabolism. In this study, we developed a microorganism-metal-organic framework (MOF)-based carrier (1-CP1) by combining a novel Zn(II) coordination polymer, [Zn(Hbcb)(PYTPY)] (1), with CP1.

Diagnostic value and safety of contact laser-assisted endobronchial ultrasound-guided tunnel drilling biopsy in mediastinal and hilar lymphadenopathy: a retrospective study.

Introduction: Mediastinal and hilar lymphadenopathies are primarily diagnosed pathologically. Contact laser-assisted endobronchial ultrasound-guided tunnel drilling biopsy (EBUS-TDB), which uses a laser as a tunneling and incision tool, may yield more satisfactory specimens than conventional endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), thereby improving the diagnostic yield. This study aims to evaluate the diagnostic value and safety of contact laser-assisted EBUS-TDB compared to EBUS-TBNA in the assessment of mediastinal and hilar lymph nodes.

MEIS1-mediated Apoptosis via TNFR1 in Endometriosis.

Abnormal apoptosis both maintains endometrial cell growth and induces endometrial pathogenesis. The etiology of endometriosis is unclear and no treatment is curative. Therefore, the aim herein was to identify genes involved in the pathogenesis of endometriosis.

Are adding carbon sources and activated sludge helpful to the full-scale packing-reinforced multistage biological contact oxidation process?

The performance of wastewater treatment plants (WWTPs) is closely related to the structure and function of microbial communities which are frequently regulated by inoculating carbon source or new microbes. However, the status of microbial communities may be determined by the homeostasis of the bioreactors or properties of the influent especially in full-scale wastewater treatment plants. In this study, a full-scale packing-reinforced multistage biological contact oxidation process (PMBCOP) was used for investigating the durative impacts of carbon source addition and new sludge inoculation on the structure, stability and metabolic pathways of microbial communities.

Electroacupuncture induces analgesia by regulating spinal synaptic plasticity via the AMPA/NMDA receptor in a model of cervical spondylotic radiculopathy: secondary analysis of an experimental study in rats.

Objective: Cervical spondylotic radiculopathy (CSR) is characterized by neuropathic pain (NP). Although the analgesic effect of electroacupuncture (EA) has been widely recognized in clinical practice, the mechanism of EA in the treatment of CSR remains unknown. We previously reported that 7 days of EA improved behavioral markers of NP, attenuated increases in α-synuclein, synapsin 1 and 2, postsynaptic density (PSD)-95 and growth-associated protein (GAP)-43, and improved ultrastructural changes within synapses in a rat model of CSR.

Enhancement of oil dispersion and marine oil snow formation by surface-active biomasses from diatom.

Following the Deepwater Horizon oil spill event, the formation of marine oil snow (MOS) has attracted much attention from marine environmental scientists. This study investigates the crude oil dispersion as well as the MOS formation in the presence of Phaeodactylum tricornutum and Chaetoceros sp. through laboratory experiments.