Publications by authors named "Wang ShuaiWen"
Article Synopsis
- - The study investigated MRI features to identify and differentiate the morphological and functional abnormalities associated with Parkinson's disease (PD) compared to normal aging changes in healthy individuals.
- - Participants included 32 PD patients, 42 age-matched healthy controls (HCg1), and 33 younger controls (HCg2), with a focus on assessing cortical volume and brain connectivity.
- - Results showed reduced cortical volumes in the frontal lobe and temporal lobe for HCg1 compared to HCg2, while PD patients didn't have significant volume differences from HCg1 but displayed lower connectivity, highlighting distinct changes caused by PD versus age-related changes.
Article Synopsis
- A systematic review was conducted to evaluate how effective machine learning (ML)-based radiomics is in predicting IDH mutations in glioma patients by analyzing articles from several major databases.
- The review included 14 studies with a total of 1,740 patients, revealing that ML had a high area under the curve (AUC) of 0.90, indicating strong diagnostic accuracy.
- Key factors influencing the diagnostic capability were found to include the modeling methods used, the grade of glioma, and whether the model integrated MRI and clinical data.
Hepatitis-hydropericardium syndrome (HHS), caused by fowl adenovirus serotype 4 (FAdV-4), has been widely spread across China, resulting in great financial losses in the poultry industry. Therefore, efficient vaccines against this disease urgently need to be developed. In our study, the fiber-2 and penton base proteins derived from the FAdV-4 JS strain were expressed in a prokaryotic system () in a soluble form.
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- The study investigates the role of gray matter (GM) atrophy and white matter (WM) lesions in cognitive decline among patients who experienced delayed neurological sequelae (DNS) after carbon monoxide poisoning.
- Researchers analyzed GM volume, cortical thickness, and WM lesions in 33 dementia patients, 24 with mild cognitive impairment, and 51 healthy controls, finding significant GM atrophy in both patient groups compared to controls.
- The findings suggest that the atrophy in GM and the presence of WM lesions contribute to cognitive decline, with the default mode network and other cognitive networks being particularly affected.
Purpose: To investigate early neurological deficits-related change patterns in gray matter (GM) volume in patients with carbon monoxide poisoning (COP) and GM volume differences between patients with and without delayed neurological sequelae (DNS) and those with and without T2 hyperintense lesions after COP.
Methods: Forty-one COP patients (24 patients with DNS) and 36 sex- and age-matched healthy controls (HC) were enrolled in this study. The neurological assessments were administered within 24 h after MRI scans.
Fowl adenovirus serotype 4 (FAdV-4) infection results in serious hepatitis-hydropericardium syndrome (HHS) in broilers, which has caused great economic losses to the poultry industry; however, the specific host responses to FAdV-4 remain unknown. In this study, we identified 141 high-confidence protein-protein interactions (PPIs) between the main viral proteins (Hexon, Fiber 1, Fiber 2, and Penton bases) and host proteins via a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay. We found that heat shock protein 70 (Hsp70), the protein with the highest score, and its cofactor DnaJ heat shock protein 40 family member C7 (DnaJC7) could negatively regulate the replication of FAdV-4.
View Article and Find Full Text PDFBackground: Betaine, an osmoprotective compatible solute, has been used to improve L-threonine production in engineered Escherichia coli L-threonine producer. Betaine supplementation upregulates the expression of zwf encoding glucose-6-phosphate dehydrogenase, leading to the increase of NADPH, which is beneficial for L-threonine production. In E.
View Article and Find Full Text PDFPurpose: Functional MRI has played a fundamental role in Parkinson's disease(PD) study. In this paper, we performed an independent component analysis (ICA) based on functional networks to reveal the intricate variations on the morphology and functional properties of brain. Our analysis aims at discovering the differences between PD patients with sensorimotor function impairment and normal controls(NC), thus helping to understand the coordination neurological function degeneration in PD objectively.
View Article and Find Full Text PDFObjective: Quantitative assessment of white blood flow in semi-oval center of patients with delayed neuropathological sequelae (DNS) after carbon monoxide poisoning treated with acupuncture combined with hyperbaric oxygen (HBO) based on magnetic resonance multi-inversion time arterial spin labeling imaging (mTI-ASL), and to evaluate its efficacy indirectly.
Methods: Twenty-six patients with clinically diagnosed DNS were randomly divided into an observation group (13 cases) and a control group (13 cases). The conventional therapy combined with HBO were given in the control group.
Article Synopsis
- - This meta-analysis evaluates the effectiveness of three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) in diagnosing intracranial aneurysms (IA) by analyzing data from 18 studies with a total of 3463 patients.
- - Results showed high diagnostic performance with sensitivity (89%) and specificity (94%), indicating that 3D-TOF-MRA is reliable for detecting IAs, especially in cases without subarachnoid hemorrhage.
- - The study concludes that 3D-TOF-MRA is an excellent tool for assessing intracranial aneurysms and could be an important option for managing patients with this condition.