Publications by authors named "Wang Shengshu"
Article Synopsis
- - The study investigates the relationship between sleep quality and blood pressure among centenarians in Hainan, particularly looking at how inflammatory indicators may play a role in this connection.
- - Among 967 centenarians analyzed, 71.4% were found to have hypertension, with those experiencing poor sleep quality having a 43% higher risk of developing high blood pressure.
- - The research identifies specific inflammatory markers such as complement C3 and lymphocyte count as mediators in the relationship between sleep quality and blood pressure, highlighting that both inadequate and excessive sleep durations are linked to higher pulse pressure.
Background: We investigated the associations between IgM, IgG, IgA, and IgE levels and all-cause mortality risk in Chinese centenarians.
Methods: All participants were from the China Hainan Centenarian Cohort Study. Eligible participants were divided into quartiles based on their IgM, IgG, IgA, and IgE levels.
Background: The association between smoking cessation and decreased mortality existed among former smokers has been well documented. However, evidence is limited for smokers with long-term exposure. This study aims to quantify the association between smoking cessation and mortality by years since quitting in older adults with long-term smoking history.
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- Elaeagnus mollis is identified as a valuable woody oil plant due to its seeds containing high levels of lipids and vitamin E, though the mechanisms for synthesizing these components are not fully understood.
- A chromosome-level reference genome for E. mollis has been created, revealing 36,796 protein-coding sequences and suggesting two significant whole genome duplication events in its evolutionary history.
- The study also highlights the identification of key genes related to high lipid and vitamin E content in E. mollis seeds, providing foundational knowledge for better utilization of these resources and exploration of genetic potentials.
Article Synopsis
- This study examined how sleep duration and quality impact overall mortality among centenarians in Hainan, China, using data from a specific cohort study.
- A total of 994 centenarians were analyzed, revealing that while most slept around 8 hours at night, those who took more than 2 hours of daytime sleep had a significantly increased risk of death, particularly among males.
- The findings suggest that excessive sleep duration correlates with higher mortality risk, with a notable threshold at 9 hours, and highlight important sleep patterns in the aging population that may inform future health strategies.
Background: As a population ages, blood pressure levels gradually increase, leading to a higher incidence of hypertension and increased cardiovascular diseases risk. This study examines factors affecting hypertension grading among centenarians in the Hainan Province.
Methods: Data from 2014 to 2016 were accessed from the cross-sectional database "Hypertension Levels and Epidemiological Characteristics of the Elderly and Centenarians in Hainan province of China".
Article Synopsis
- The study explored the link between anemia and overall mortality rates in Chinese centenarians, specifically analyzing a group of 1,002 participants over a nine-year period.
- Results indicated that anemia significantly increased the risk of death, with a 29% higher likelihood of mortality and even higher rates in those with severe anemia (about 1.6 times more likely to die).
- The findings underscore the importance of addressing anemia in elderly populations, highlighting the need for more research to understand its causes and impact on health outcomes.
Unlabelled: The Cellulose Synthase gene () superfamily and COBRA-like () gene family are essential for synthesizing cellulose and hemicellulose, which play a crucial role in cell wall biosynthesis and the hardening of plant tissues. Our study identified 126 and 31 genes from the () genome. Phylogenetic analysis and conservative domain analysis unfolded that and genes were divided into seven and two subfamilies, respectively.
View Article and Find Full Text PDFBackground: Reflux esophagitis has an increasing prevalence and complex and diverse symptoms. Identifying its risk factors is crucial to understanding the etiology, prevention, and management of the disease. The occurrence of reflux esophagitis may be associated with food reactions, () infection, and metabolic syndromes.
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- * A total of 816 patients participated, predominantly male (4.33:1 ratio), with an average age of 35; most experienced infrequent bouts (one to two times a year) and faced delays in diagnosis.
- * Findings indicated that lacrimation was the most common symptom, with fewer patients receiving effective treatment, emphasizing the need for improved cluster headache management in China.
Background: Azvudine and nirmatrelvir/ritonavir are approved to treat mild-to-moderate coronavirus disease 2019 (COVID-19) in adults with a high risk for progression to severe infection. We sought to compare the antiviral effectiveness and clinical outcomes of elderly severe patients with COVID-19 receiving these two antiviral agents.
Methods: In this observational study, we identified 249 elderly patients with severe COVID-19 infection who were admitted to the Second Medical Center of the People's Liberation Army General Hospital from December 2022 to January 2023, including 128 azvudine recipients, 66 nirmatrelvir/ritonavir recipients and 55 patients not received antiviral treatments.
Article Synopsis
- Cardiometabolic diseases (CMDs) are linked to a higher risk of cognitive decline in elderly individuals, though an active lifestyle may help reduce this risk.
- A study tracking over 2,500 seniors revealed that those with more healthy lifestyle factors had a lower chance of cognitive decline; specifically, an active lifestyle significantly lessened the risk associated with CMDs.
- However, the study did not include dietary factors, which could also influence cognitive health outcomes.
The Beijing Healthy Aging Cohort Study (BHACS) was established to supplement the limited data of a large representative cohort of older people based on the general population and was designed to evaluate the prevalence, incidence, and natural history of cognitive decline, functional disability, and conventional vascular risk factors. The aim was to determine the evolution of these conditions by estimating the rates and determinants of progression and regression to adverse outcomes, including dementia, cardiovascular events, cancer, and all-cause death. It can therefore provide evidence to help policy makers develop better policies to promote healthy aging in China.
View Article and Find Full Text PDFCholesterol paradox in the community-living old adults: is higher better?
J Geriatr Cardiol
December 2023
Objective: To evaluate the associations of lipid indicators and mortality in Beijing Elderly Comprehensive Health Cohort Study.
Methods: A prospective cohort was conducted based on Beijing Elderly Comprehensive Health Cohort Study with 4499 community older adults. After the baseline survey, the last follow-up was March 31, 2021 with an average 8.
Association of Sleep Status With Cognitive Functions in Centenarians: Evidence From Hainan Centenarian Cohort.
J Gerontol B Psychol Sci Soc Sci
March 2024
Objectives: This study aimed to analyze the association between sleep quality, sleep duration, and cognitive functions among centenarians.
Methods: The baseline data of the China Hainan Centenarians Cohort Study served as the foundation for this study. Logistic regression was utilized to demonstrate the relationship between sleep status and cognitive impairment.
Objective: This study, based on the China Hainan Centenarians Cohort Study (CHCCS), aims to comprehensively describe the characteristic of daytime, night and total sleep duration, sleep quality and different sleep mode of Hainan centenarians and their associations with activity of daily living (ADL) functions.
Method: The baseline data of CHCCS was used. ADL function was evaluated the Bathel index, sleep quality was evaluated by Pittsburgh sleep quality index (PSQI), sleep status including daytime, night and total sleep duration as well as sleep quality and sleep mode.
Article Synopsis
- Hypoalbuminemia is linked to higher mortality risk in Chinese centenarians, with a notable percentage (17.4%) having low albumin levels.
- A study of 1002 centenarians indicated that those with hypoalbuminemia had a 55% higher chance of dying, and this risk doubled when combined with multiple cardiometabolic diseases (CMDs).
- The findings highlight the importance of early detection and management for older adults with low albumin levels, especially if they have multiple CMDs to improve survival outcomes.
Objective: The objective of this study is to analyze the association between sleep quality, sleep duration, sleep patterns, and depressive states among centenarians due to the crucial impact of depression on the well-being of elderly individuals, particularly the oldest. Recognizing easily identifiable manifestations and risk factors is essential since the onset of depressive states tends to be insidious.
Methods: The baseline data from the China Hainan Centenarians Cohort Study (CHCCS) served as the basis for this study.
Background: Estimates of survival in the older can be of benefit in various facets, particularly in medical and individual decision-making. We aim to validate the value of a combination of nutrition status evaluation and comorbidity assessment in predicting long-term survival among community-dwelling older.
Methods: The Charlson Comorbidity Index (CCI) was applied for comprehensive evaluation of comorbidities.
Objective: To explore the factors affecting short-term prognosis of circulatory failure patients undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO) treatment.
Methods: A total of 136 patients undergoing VA-ECMO were enrolled in this study and subsequently divided into the death group (n=35) and the survival group (n=101) based on whether death occurred during hospitalisation. Extracorporeal membrane oxygenation (ECMO) running time, length of intensive care unit stay, length of hospital stay, costs, and ECMO complications were then compared between the two groups.
Background: β1-blockers could improve clinical outcomes in patients with coronary artery disease by lowering the heart rate, blood pressure, and myocardial contractility. Moreover, recent studies have suggested that β1-blockers may also have the potential to reduce bleeding risk.
Objectives: This study aimed to evaluate the association between β1-blockers and bleeding risk in the patients prescribed with potent dual antiplatelet therapy (DAPT) after acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI).
Objective: The study assessed the association between migraine and cardiovascular disease (CVD) mortality in the US population.
Background: Previous studies have drawn different conclusions about the association between migraine and CVD mortality based on different populations; therefore, it is important to explore the relationship between migraine and CVD mortality in the US population.
Methods: This prospective cohort study included 10,644 participants from the National Health and Nutrition Examination Survey (NHANES) 1999-2004.
Article Synopsis
- Chronic lung diseases (CLDs) and cardiovascular diseases (CVDs) significantly contribute to health burdens, and this study used two large Chinese cohort studies to explore their interconnection.
- The study included over 24,000 participants and found that CLDs were a strong predictor of developing CVDs, with specific associations mediated by body mass index (BMI) and depressive symptoms.
- Results indicated that while CLDs increased the risk of CVDs, CVDs also predicted the onset of CLDs, highlighting a bidirectional relationship between these chronic diseases.
Background: As the focal point of epidemic prevention and control, the mental health of COVID-19 patients cannot be ignored. Online Mindfulness-Based Stress Reduction (MBSR) allows for the provision of conveniently accessible, effective and low-cost interventions on a large scale. We aim to evaluate the effectiveness of an online MBSR intervention in alleviating anxiety and depression among asymptomatic/mild patients limited by COVID-19-related restrictions.
View Article and Find Full Text PDFBackground: Cardiovascular disease has become the leading cause of death worldwide, but there is a lack of data on whether cardiovascular health (CVH) is associated with elderly mortality in China. We investigated the relationship between the ideal CVH score of Chinese elderly and the all-cause mortality.
Methods: The Beijing Elderly Comprehensive Health Cohort Study included a total of 4,499 participants aged 60 years and above.