Proteomic analysis of giant panda testicular tissue of different age groups.

Background: The reproductive ability of male giant pandas has been a major complicating factor in the conservation of the species. While it is well known that the testis produces sperm and secretes androgens, a process that requires precise regulation of various proteins, at present, there has been no systematic study on the composition of proteins in the testis of the giant pandas. Therefore, this study aims to apply proteomics to explore the regulation of proteins in the testes of giant pandas.

Polyfunctional IL-21 IFNG T follicular helper cells contribute to checkpoint inhibitor diabetes mellitus and can be targeted by JAK inhibitor therapy.

Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, but their use is limited by the development of autoimmunity in healthy tissues as a side effect of treatment. Such immune-related adverse events (IrAE) contribute to hospitalizations, cancer treatment interruption and even premature death. ICI-induced autoimmune diabetes mellitus (ICI-T1DM) is a life-threatening IrAE that presents with rapid pancreatic beta-islet cell destruction leading to hyperglycemia and life-long insulin dependence.

Convergence of autism proteins at the cilium.

Hundreds of high confidence autism genes have been identified, yet the relevant etiological mechanisms remain unclear. Gene ontology analyses have repeatedly identified enrichment of proteins with annotated functions in gene expression regulation and neuronal communication. However, proteins are often pleiotropic and these annotations are inherently incomplete.

Decellularized adipose matrix hydrogel-based in situ delivery of antagomiR-150-5p for rat abdominal aortic aneurysm therapy.

Abdominal aortic aneurysm (AAA) is a progressive aortic disease featured by inflammation, vascular smooth muscle cells (VSMCs) depletion, and elastin degradation. MicroRNAs were related to AAA formation, which bring the approach for precise and targeted drug therapy for AAA. We developed a new strategy based on decellularized adipose matrix (DAM) hydrogel immobilized on the adventitia to release antagomiR-150-5p for preventing the AAA development.

Indian Shot ( L). Leaves Provide Valuable Insights into the Management of Inflammation and Other Associated Disorders Offering Health Benefits.

Background: Throughout history, plants have played a crucial role in advancing medicinal treatments by providing a diverse range of compounds for the development of innovative therapies. L. a tropical herb of the Cannaceae family, also known as Indian shot, has a rich history of traditional use in treating ailments like inflammation, malaria, dysentery, fever, dropsy, and diarrhea.

Case Report: Anomalous origin of the right coronary artery leading to cardiac arrest induced by sexual activity: a previously unreported pathogenetic condition.

Background: The Anomalous Origin of the Right Coronary Artery from the Left Coronary Sinus (ARCA-LCS) is a rare congenital cardiac condition where the right coronary artery emerges from the left sinus instead of the right coronary sinus of Valsalva. The clinical significance of ARCA-LCS lies in its potential to cause myocardial ischemia or sudden cardiac death, particularly under physical exertion. In this case, a patient experienced sudden cardiac arrest during sexual activity, which has not previously been reported.

Experimental Study and Molecular Dynamics Simulation of Oil Displacement Using Different Microemulsions in the Fang2 Block of Songfangtun Oilfield.

After many years of mining in the Fang2 block of the Songfangtun oilfield, the conventional water drive development method can no longer meet the requirement of greatly improving the recovery rate, and ternary composite drive (TCD) technology is adopted for this purpose. TCD is one of the most important methods to further improve crude oil recovery, and it has entered the industrialization and promotion stage, but there are still problems of fouling in the injection and extraction system and high production and maintenance costs. In order to reduce formation damage and improve recovery in the Songfangtun oilfield, an alkali-free microemulsion system was developed by replacing the weak base sodium carbonate with sodium chloride, but its emulsification capacity was weak and the recovery enhancement value was lower than that of the weak base TCD.

Suppression of KLF5 targets RREB1 to restrain the proliferation of ovarian cancer cells through ERK/MAPK signaling pathway.

The overexpression of Kruppel-like factor 5 (KLF5) appears in several types of cancer. KLF5 may be an effective therapeutic target for treating OC, but its function in ovarian cancer (OC) remains unknown. The KLF5 mRNA expression levels in several OC cell lines were analyzed using RT-qPCR.

A tracking control method for electricity-carbon emission forecasting.

This paper introduces a novel carbon emission prediction method based on tracking control, leveraging historical CO emission prediction errors and feed-forward integration of electricity consumption data to enhance forecasting accuracy and minimize lag. Comparative analysis with pre-trained models such as LSTM and ARDL using Python showcases the proposed method's substantial reduction in prediction errors compared to singular reliance on electricity data, while also significantly reducing computational time in contrast to LSTM models. The findings establish a valuable reference for policymakers and researchers in refining carbon emission prediction methodologies and formulating effective carbon reduction policies.

Promise of the gut microbiota in prevention and traditional Chinese medicine treatment of diabetic peripheral neuropathy.

The pathogenesis of diabetic peripheral neuropathy (DPN) has not been fully elucidated, and treatment options are limited. Currently, the main strategies for treating DPN are strict glycemic control and symptomatic pain relief. In this editorial, we comment on an article by Li which suggested that modulating the gut microbiota using traditional Chinese medicine (TCM) may be a promising strategy for alleviating DPN symptoms.

CD7-targeting pro-apoptotic extracellular vesicles: A novel approach for T-cell haematological malignancy therapy.

T-cell haematological malignancies progress rapidly and have a high mortality rate and effective treatments are still lacking. Here, we developed a drug delivery system utilizing 293T cell-derived extracellular vesicles (EVs) modified with an anti-CD7 single-chain variable fragment (αCD7/EVs). Given the challenges of chemotherapy resistance in patients with T-cell malignancy, we selected cytochrome C (CytC) and Bcl2 siRNA (siBcl2) as therapeutic agents and loaded them into αCD7/EVs (αCD7/EVs/CytC/siBcl2).

Superior Temperature Sensing and Capacitive Energy-Storage Performance in Pb-Free Ceramics.

The ultrafast charge/discharge rate and high power density (P) endow lead-free dielectric energy storage ceramics (LDESCs) with enormous application potential in electric vehicles. However, their low energy storage density and single energy storage performance (ESP) limit their further development and applicability in rugged environments. Here, through the design of vacancy defects and phase structure regulation, Pb-free (BiNa)TiO-based ceramics with an optimal composition can achieve a large maximum polarization (>44 µC cm) under a moderate electric field (410 kV cm), resulting in an extremely high recoverable energy storage density (≈6.

ROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine.

The treatment of brain diseases has always been the focus of attention. Due to the presence of the blood-brain barrier (BBB), most small molecule drugs are difficult to reach the brain, leading to undesirable therapeutic outcomes. Recently, nanomedicines that can cross the BBB and precisely target lesion sites have emerged as thrilling tools to enhance the early diagnosis and treat various intractable brain disorders.

Self-Selective (220) Directional Grown Copper Current Collector Design for Cycling-Stable Anode-Less Lithium Metal Batteries.

Anode-less lithium metal batteries (ALLMB) are promising candidates for energy storage applications owing to high-energy-density and safety characteristics. However, the unstable solid electrolyte interphase (SEI) formed on anode copper current collector (CuCC) leads to poor reversibility of uneven lithium deposition/stripping. Though the well-known knowledge of lithium salt-derived inorganic-rich SEI (iSEI) benefiting uniform lithium deposition, how to design a lithium salt-philic CuCC with undiscovered salt-philic facet that favors lithium salt adsorption and catalyzing salt decomposition into iSEI, remains unexplored yet.

Emergency neurosurgical hybrid operating platform for acute intracranial hemorrhage (E-HOPE).

Background: Precise diagnosis and rapid treatment for acute complex intracranial hemorrhage (ICH) are crucial. The neurosurgical hybrid operating platform integrates traditional open neurosurgery operating room functionalities with endovascular therapy capabilities and is developing in the neurosurgical practice. However, its effect on the emergent complicated neurovascular cases needs pilot exploration.

High-Entropy Electrolytes with High Disordered Solvation Structures for Ultra-Stable Zinc Metal Anodes.

Aqueous zinc-ion batteries (ZIBs) are playing an increasingly important role in the field of energy storage. However, their practical applications are handicapped by severe dendrite formation and side reactions on zinc anodes. Herein, a low-concentration high-entropy (HE) electrolyte strategy is proposed to achieve high reversibility and ultra-durable zinc metal anode.

Proteinase K impact on anaerobic co-digestion of modified biodegradable plastic and food waste: Step-by-step analysis with microorganism.

This study was designed to explore the key impact of Proteinase K (PK) on every step of anaerobic co-digestion. The results of step-by-step experiments indicated that PK promoted the hydrolysis of biodegradable plastic by initiating self-hydrolysis reactions, directly promoting the hydrolysis step of anaerobic co-digestion. Subsequently, PK indirectly promoted the acidogenesis and acetogenesis steps by impacting the proliferation of acid-producing bacteria.

Presence and sources of per- and polyfluoroalkyl substances (PFASs) in the three major rivers on Hainan Island.

Per- and polyfluoroalkyl substances (PFASs) have attracted considerable attention because of their toxicity, persistence and bioaccumulation potential. With the construction of the Hainan Free Trade Port and the rapid development of economy, environmental pollution on Hainan Island is becoming increasingly prominent. PFASs have been detected in the seawater and sediments of mangrove ecosystems on Hainan Island.

Robotic-Assisted Direct Anterior Approach Total Hip Arthroplasty: A 6.5-Fold Reduction in Fluoroscopic Radiation Exposure.

Introduction: Direct anterior approach (DAA) for total hip arthroplasty (THA) is increasing in popularity. Fluoroscopy is commonly utilized during DAA THA to increase the accuracy of component placement. The objective of this study was to compare the mean fluoroscopy time and radiation dose for DAA THA when utilizing robotic-assistance (RA), computer-assisted navigation (CAN), or manual (M) technique.

From greenwashing to genuine sustainability: Insights from FinTech and banking executives in emerging market experience.

Greenwashing is the practice of deceiving stakeholders by making inflated or fraudulent promises about environmental responsibility. This study investigates greenwashing challenges in FinTech and banking industries, identifying effective strategies to foster genuine sustainability. The study employs a qualitative methodology, utilizing semi-structured interviews conducted with 12 respondents from the FinTech and banking sectors in Pakistan.

Enhancing performance in gravity-driven membrane systems through pre-coating with aluminum-based flocs: Mechanism and energy saving analysis.

The gravity-driven membrane (GDM) system is an energy-efficient and environmentally sustainable water purification process; however, after prolonged operation, its membrane flux remains relatively low, making it necessary to adopt effective strategies for improving system performance. In this study, the effects of hydrostatic pressure (60, 100, 200 mbar) and pre-coating with aluminum-based flocs (ABF) on GDM flux and organic matter removal were investigated, and the regulatory mechanisms of the bio-cake layer were explored through interactions between morphological structure, composition and microbes. The results showed that the stable flux of the GDM-ABF system at a hydrostatic pressure of 60 mbar was almost equal to that at 100 mbar, and it outperformed higher hydrostatic pressure in organic matter removal, resulting in a more porous bio-cake layer structure.

In vivo kinematic changes of the medial longitudinal arch during barefoot and high-heeled shoes walking.

Background: The medial longitudinal arch (MLA) is crucial for maintaining balance and center of gravity stability during human walking. High-heeled shoes (HHS) will affect the kinematics of the MLA which further affects the overall function of the foot. However specific motion effects of HHS on MLA during walking remain unclear.

Alleviating osteoarthritis-induced damage through extracellular vesicles derived from inflammatory chondrocytes.

The role of extracellular vesicles (EVs) derived from inflammatory chondrocytes in EV-based therapy for osteoarthritis (OA) has received little attention. We examined the effects of EVs derived from both normal rat chondrocytes (nEVs) and IL-1β-treated rat chondrocytes (iEVs) on IL-1β-treated rat chondrocytes, macrophages, and osteoblasts, alongside mRNA-seq and miRNA-seq analyses of both them. Additionally, nEVs and iEVs were administered intra-articularly in the joints of rat models subjected to anterior cruciate ligament transection (ACLT), and the morphological alterations across the joints were assessed.

Interventions to enhance the core competencies of clinical nursing preceptors: A systematic review.

Unlabelled: Aim This systematic review aimed to identify intervention studies on core competencies of clinical nursing preceptors, evaluate their quality using quantitative indicators, and summarize the effectiveness of the intervention programs and limitations of included studies.

Design: This review was reported in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 checklist.

Data Sources: Between May 1, 2024 and May 30, 2024, we searched PubMed, Web of Science, CINAHL, Medline, EMBASE and ProQuest (Health & Medical Collection) to get relevant literature published between January 2010 and May 2024.