Mechanisms of Ferroptosis in bone disease: A new target for osteoporosis treatment.

Osteoporosis (OP) is a common disease in the elderly, characterized by decreased bone strength, reduced bone density, and increased fracture risk. There are two clinical types of osteoporosis: primary osteoporosis and secondary osteoporosis. The most common form is postmenopausal osteoporosis, which is caused by decreased estrogen production after menopause.

PsbHLH58 positively regulates sucrose accumulation by modulating Sucrose synthase 4 in 'Fengtang' plum (Prunus salicina Lindl.).

Sugar content is an important factor that largely determines fruit quality. 'Fengtang' plum (Prunus salicina Lindl.) is recognized for its high soluble sugar content, and the Sucrose synthase 4 (PsSUS4) functions as the controlling step in sucrose accumulation.

[Research progress on artemisinin and its derivatives in treatment of orthopedics-related diseases].

As research into the mechanisms of orthopedic diseases continues to deepen, the shortcomings of traditional single-target the-rapies are becoming increasingly apparent. Consequently, the search for multi-target drugs has become the mainstream research direction for orthopedics-related diseases. Artemisinin, a sesquiterpene lactone compound extracted from Artemisia annua, has led to the gradual synthesis of various derivatives such as dihydroartemisinin, artesunate, artemether, and arteether.

Brain functional gradients are related to cortical folding gradient.

Cortical folding is closely linked to brain functions, with gyri acting more like local functional "hubs" to integrate information than sulci do. However, understanding how anatomical constraints relate to complex functions remains fragmented. One possible reason is that the relationship is estimated on brain mosaics divided by brain functions and cortical folding patterns.

Lead acetate-based test strip method for rapid and quantitative detection of residual sulfur dioxide in Chinese herbal medicines.

To prevent the residual sulfur dioxide in Chinese herbal medicines (CHM) caused by sulfur fumigation, which may lead to severe health issues, there is an urgent need for a rapid and quantitative detection technique. Sodium borohydride was used as a reducing agent to convert sulfur dioxide into hydrogen sulfide, which was then detected using lead acetate test strip. An accurate testing apparatus was designed, consisting of reaction bottle cap, reaction bottle, lead acetate test strip, and sulfur dioxide detector.

The Potential of Microorganisms for the Control of Grape Downy Mildew-A Review.

(Berk.et Curtis) Berl. Et de Toni is the pathogen that causes grape downy mildew, which is an airborne disease that severely affects grape yield and causes huge economic losses.

Contribution of gut microbiota to hepatic steatosis following F-53B exposure from the perspective of glucose and fatty acid metabolism.

Altered gut microbiota is a pathogenic mechanism of 6:2 Cl-PFESA (F-53B)-induced hepatic steatosis, indicated by correlations between gut microbiota and lipid indices. However, the detailed mechanism remains unknown. In this study, adult zebrafish were exposed to 0.

QTL mapping for seed vigor-related traits under artificial aging in common wheat in two introgression line (IL) populations.

Background: Seed vigor recognized as a quantitative trait is of particular importance for agricultural production. However, limited knowledge is available for understanding genetic basis of wheat seed vigor.

Methods: The aim of this study was to identify quantitative trait loci (QTL) responsible for 10 seed vigor-related traits representing multiple aspects of seed-vigor dynamics during artificial aging with 6 different treatment times (0, 24, 36, 48, 60, and 72 h) under controlled conditions (48 °C, 95% humidity, and dark).

Fully integrated microneedle biosensor array for wearable multiplexed fitness biomarkers monitoring.

Fitness monitoring has become increasingly important in modern lifestyles; the current fitness monitoring always relies on physical sensors, making it challenging to detect pertinent issues at a deeper level when exercising. Here, we report a fully integrated wearable microneedle sensor that simultaneously measures fitness related biomarkers (e.g.

Combining Bulk and Single Cell RNA-Sequencing Data to Identify Hub Genes of Fibroblasts in Dilated Cardiomyopathy.

Background: Dilated cardiomyopathy (DCM) is the second leading cause of heart failure, with intricate pathophysiological underpinnings. In order to shed fresh light on the mechanistic research of DCM, we combined bulk RNA-seq and single-cell RNA-seq (scRNA-seq) data to examine significant cells and genes implicated in the disease.

Methods: This analysis employed publicly accessible bulk RNA-seq and scRNA-seq DCM datasets.

Defect engineering of air-stable LiFeO towards an ultra-high capacity cathode prelithiation additive.

Antifluorite-type LiFeO (LFO) belongs to a class of promising prelithiation materials for next-generation high-energy lithium-ion batteries. Unfortunately, the incomplete de-lithiation performance and inferior air stability hinder its application. In this work, ultra-high capacity is achieved by selective doping of Zr into the Fe sites (LFO-Zr) of LFO to form a large number of defects.

Evolution of passing network in the Soccer World Cups 2010-2022.

This study investigates the evolution of passing networks (PN) at both team and player levels in the FIFA World Cups (WC) from 2010 to 2022. Analyzing 256 matches (7328 player observations) using a multiple-camera tracking system across four WCs, we considered six playing positions: goalkeeper ( = 521), central defender ( = 1192), fullback ( = 1223), midfielder ( = 2039), winger ( = 1320), and central forward ( = 1033). We used 17 network metrics and considered contextual variables such as team formation, and team ranking.

Polyhedral magnetic nanoparticles induce apoptosis in gastric cancer stem cells and suppressing tumor growth through magnetic force generation.

Gastric cancer is a prevalent malignant tumor worldwide, posing challenges due to its poor prognosis and limited treatment options. Cancer stem cells (CSCs) were demonstrated as a subset of cancer cells responsible for tumor initiation and progression, and their inherent resistance to conventional chemotherapy and radiotherapy critically contributes to tumor recurrence and metastasis. Promoting the eradication of cancer stem cells is crucial for enhancing the efficacy of cancer treatments.

Spatial distribution, trophic magnification, and risk assessment of per- and polyfluoroalkyl substances in Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis): Risks of emerging alternatives.

The Yangtze finless porpoise (YFP, Neophocaena asiaeorientalis asiaeorientalis) is the only freshwater cetacean found in China. However, per- and polyfluoroalkyl substances (PFASs) risks in YFPs remain unclear. In this study, legacy PFASs, their precursors and alternatives, were determined in YFP muscles (n = 32), liver (n = 29), kidney (n = 24), skin (n = 5), and blubbers (n = 25) collected from Poyang Lake (PL) and Yangtze River (YR) between 2017 and 2023.

Flexible nanoplatform facilitates antibacterial phototherapy by simultaneously enhancing photosensitizer permeation and relieving hypoxia in bacterial biofilms.

Antimicrobial phototherapy has gained recognition as a promising approach for addressing bacterial biofilms, however, its effectiveness is often impeded by the robust physical and chemical defenses of the biofilms. Traditional antibacterial nanoplatforms face challenges in breaching the extracellular polymeric substances barrier to efficiently deliver photosensitizers deep into biofilms. Moreover, the prevalent hypoxia within biofilms restricts the success of oxygen-reliant phototherapy.

Crack-induced abrupt capacity degradation in commercial LiNiCoMnO (NCM811)/SiO -graphite pouch batteries.

Reasons for abrupt capacity fading in commercial LiNiCoMnO (NCM811)/SiO -graphite pouch batteries were evaluated using electrochemical methods. These approaches consist of charge and discharge curves, differential curves and electrochemical impedance spectroscopy (EIS), and some advanced verification techniques constituting scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). The predominance testament concerning capacity attenuation through experimental verification after the battery is disassembled proves that the silicon-based anode material deteriorates further, bringing about a significant number of cracks with the progression of cycles.

Wearable Vertical Graphene-Based Microneedle Biosensor for Real-Time Ketogenic Diet Management.

Ketogenic diets have attracted substantial interest in the treatment of chronic diseases, but there are health risks with long-term regimes. Despite the advancements in diagnostic and therapeutic methods in modern medicine, there is a huge gap in personalized health management of this dietary strategy. Hence, we present a wearable microneedle biosensor for real-time ketone and glucose monitoring.

Advances in exosome modulation of ferroptosis for the treatment of orthopedic diseases.

Current treatments for orthopaedic illnesses frequently result in poor prognosis, treatment failure, numerous relapses, and other unpleasant outcomes that have a significant impact on patients' quality of life. Cell-free therapy has emerged as one of the most promising options in recent decades for improving the status quo. As a result, using exosomes produced from various cells to modulate ferroptosis has been proposed as a therapeutic method for the condition.

Sarcopenia, adiposity and large discordance between cystatin C and creatinine-based estimated glomerular filtration rate in patients with cancer.

Background: Creatinine-based estimated glomerular filtration rate (eGFR) may overestimate kidney function in patients with sarcopenia. While cystatin C-based eGFR (eGFR) is less affected by muscle mass, it may underestimate kidney function in patients with obesity. We sought to evaluate the relationship between body composition defined by computed tomography (CT) scans and discordance between creatinine, eGFR and eGFR in adult patients with cancer.

Smart Janus textiles for biofluid management in wearable applications.

Janus textiles with asymmetric wettability have shown great potential in wearable applications due to their ability to manage biofluids efficiently. This review summarizes recent advances in smart Janus textiles for biofluid control and monitoring, focusing on wearable technologies. We first introduce the design configurations and fabrication approaches of Janus textiles, including asymmetric generation and asymmetric decoration strategies.

Combined exposure with microplastics increases the toxic effects of PFOS and its alternative F-53B in adult zebrafish.

Microplastics (MPs) can adsorb and desorb organic pollutants, which may alter their biotoxicities. Although the toxicity of perfluorooctane sulfonate (PFOS) and its alternative 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) to organisms has been reported, the comparative study of their combined toxic effects with MPs on aquatic organisms is limited. In this study, adult female zebrafish were exposed to 10 μg/L PFOS/F-53B and 50 μg/L MPs alone or in combination for 14 days to investigate their single and combined toxicities.

A New Strategy for Obesity Treatment: Revealing the Frontiers of Anti-obesity Medications.

Obesity dramatically increases the risk of type 2 diabetes, fatty liver, hypertension, cardiovascular disease, and cancer, causing both declines in quality of life and life expectancy, which is a serious worldwide epidemic. At present, more and more patients with obesity are choosing drug therapy. However, given the high failure rate, high cost, and long design and testing process for discovering and developing new anti-obesity drugs, drug repurposing could be an innovative method and opportunity to broaden and improve pharmacological tools in this context.