Phase 2 study of serplulimab with the bevacizumab biosimilar HLX04 in the first-line treatment of advanced hepatocellular carcinoma.

Introduction: This study aimed to evaluate the safety and preliminary efficacy of serplulimab, a novel programmed death-1 inhibitor, with or without bevacizumab biosimilar HLX04 as first-line treatment in patients with advanced hepatocellular carcinoma.

Methods: This open-label, multicenter phase 2 study (clinicaltrials.gov identifier NCT03973112) was conducted in China and consisted of four treatment groups: group A (serplulimab 3 mg/kg plus HLX04 5 mg/kg, subsequent-line), group B (serplulimab 3 mg/kg plus HLX04 10 mg/kg, subsequent-line), group C (serplulimab 3 mg/kg, subsequent-line) and group D (serplulimab 3 mg/kg plus HLX04 10 mg/kg, first-line).

Research on a molecularly imprinted electrochemical sensor based on a graphene quantum dot-gold nanoparticle composite for the determination of 17β-estradiol.

In this study, a molecularly imprinted electrochemical sensor (MIECS) was constructed based on the combination of graphene quantum dots-gold nanoparticles (GQDs-AuNPs), molecular imprinting polymer (MIP), and electrochemical technology for the ultra-sensitive detection of 17β-estradiol (E). GQDs-AuNPs were synthesized and modified on the surface of glassy carbon electrodes (GCE). Safranine T was used as the functional monomer and E was the template molecule for self-assembly and electropolymerization, thus generating an MIP film on the electrode surface.

Amino acid transporter GmAAP6-like contributes to seed quality and responds to jasmonic acid pathway under MSX toxicity stress.

Amino acid transporters participate in the transport and distribution of amino acids in plants and are vital for plant growth and development. Despite their importance, few works have investigated the functions of amino acid permeases (AAP) amino acid transporters in soybean. In this study, we re-identified the AAP family genes in soybean using a new public genome database and cloned a soybean AAP gene renamed GmAAP6-like.

Drug protection against radiation-induced neurological injury: mechanisms and developments.

In daily life, individuals are frequently exposed to various forms of radiation, which, when adhering to safety standards, typically result in relatively minor health effects. However, accidental exposure to radiation levels that exceed these safety standards can lead to significant health consequences. This study focuses on the analysis of radiation-induced damage to the nervous system and the mechanisms of pharmacological protection.

Establishment of a survival rabbit model for laryngotracheal stenosis: A prospective randomized study.

Objective: To develop a reproducible survival rabbit model for laryngotracheal stenosis (LTS).

Methods: Seventy New Zealand white (NZW) rabbits were randomly divided into experimental groups ( = 30) and a control group ( = 40). In experimental groups, a nylon brush was inserted retrograde from the tracheotomy through the subglottis and rotated until a full layer circumferential mucosal injury to cartilage exposure, assisted by fiberoptic laryngoscopy (FOL) visualization.

Brain endocannabinoid control of metabolic and non-metabolic feeding behaviors.

The central endocannabinoid (eCB) system in brain shows a crucial role in the regulation of feeding behaviors, influencing both metabolic and non-metabolic mechanisms of appetite control, which has been paid much attention. Although there are already many review articles discussing eCB modulation of feeding behaviors, our paper attempts to summarize the recent advancements through synapses, circuits, and network in brain. Our focus is on the dual role of eCB signalling in regulating metabolic energy balance and hedonic reward-related feeding.

Effects of Yersinia pseudotuberculosis outer membrane vesicles on Pseudomonas aeruginosa antigens immune response.

Outer membrane vesicles (OMVs) are immunogenic self-adjuvanting vesicles produced by Gram-negative bacteria such as Pseudomonas aeruginosa and Yersinia pseudotuberculosis. While the effects of OMVs on different antigens immune stimulation are not clear. In this study, we constructed recombinant Yersinia pseudotuberculosis ΔlpxL strain,with pBlue-PcrV and pBlue-OprF/I, and then purified ΔlpxL rOMVPcrV (rOMVyp2P)and ΔlpxL rOMVOprF/I (rOMVyp2F) and analyzed its effect on immune response and protection against Pseudomonas aeruginosa PAO1 infection.

Pharmacokinetics, pharmacodynamics, safety, and immunogenicity of HLX14 versus reference denosumab in healthy males: A randomized phase I study.

Denosumab is a human IgG2 monoclonal antibody against receptor activator of nuclear factor kappa-B ligand (RANKL) for the treatment of osteoporosis and bone loss. HLX14 is a proposed biosimilar of denosumab. This randomized, parallel-group, two-part, phase I study aimed to compare the pharmacokinetics, pharmacodynamics, safety, and immunogenicity of HLX14 with reference denosumab in Chinese healthy adult male participants.

Toward Damage-Less Robotic Fragile Fruit Grasping: A Closed-Loop Force Control Method for Pneumatic-Driven Soft Gripper.

Fragile fruit uploading and packaging are labor-intensive and time-consuming steps in postharvest industry. With the aging of the global population, it is supposed to develop robotic grasping systems to replace manual labor. However, damage-less grasping of fragile fruit is the key problem in robotization.

Holistic numerical simulation of a quenching process on a real-size multifilamentary superconducting coil.

Superconductors play a crucial role in the advancement of high-field electromagnets. Unfortunately, their performance can be compromised by thermomagnetic instabilities, wherein the interplay of rapid magnetic and slow heat diffusion can result in catastrophic flux jumps, eventually leading to irreversible damage. This issue has long plagued high-J NbSn wires at the core of high-field magnets.

Organic Optoelectronic Synaptic Transistor with Enhanced UV Light Response Based on Insulating Polymer-Assisted p-n Heterojunction.

Optoelectronic synaptic transistors possess the capability to simultaneously accomplish perception and process functions within a single device, thereby not only addressing the limitations of von Neumann architectures but also serving as a promising candidate for emulating neural vision systems. The extensive range of organic semiconductor materials offers a plethora of possibilities for device fabrication; however, the severe recombination of photogenerated carriers imposes limitations on the utilization of organic p-n bulk heterostructures in synaptic transistor construction. By incorporating an insulating polymer and implementing a p-n planar heterojunction architecture, the 30% PCBM@PAN-DPPDTT transistor was constructed using the PCBM/DPPDTT heterojunction and the PCBM@PAN photoresponsive charge trapping layer.

Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies.

With more than 20 anti-PD-1/PD-L1 antibodies currently marketed, anti-PD-1 therapy has become a cornerstone of tumor immunotherapy. These agents, however, exhibit notable disparities in their characteristics and clinical performance. For instance, in the field of small cell lung cancer (SCLC) where the majority of anti-PD-1 antibodies have yielded limited success, serplulimab produced impressive survival improvements and was approved for this indication by China's National Medical Products Administration.

Mechanical characterization and structural analysis of elastodontic appliances under intraoral and artificial aging conditions.

Background: This study focused on the aging mechanism and degradation of mechanical and structural features of elastodontic appliances (EA) under artificial and intraoral aging to achieve oral myofunctional therapy with particular removable silicone elastomer devices.

Materials And Methods: EAs artificially aged in saliva with different pH values were investigated through cyclic compression testing along with characterization techniques (Scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy), and characterization analysis was also performed on clinically retrieved EAs.

Results: Artificial aging was found to have minimal effect on the structural properties of EAs, and intraorally aged samples showed perceptible micro-morphology.

Rural Road Extraction in Xiong'an New Area of China Based on the RC-MSFNet Network Model.

High-resolution remote sensing imagery, reaching meter or sub-meter levels, provides essential data for extracting and identifying road information. However, rural roads are often narrow, elongated, and have blurred boundaries, with textures that resemble surrounding environments such as construction sites, vegetation, and farmland. These features often lead to incomplete extraction and low extraction accuracy of rural roads.

MeHA: A Computational Framework in Revealing the Genetic Basis of Animal Mental Health Traits Under an Intensive Farming System-A Case Study in Pigs.

Intensively farmed animals such as pigs inevitably experience a certain degree of psychological stress, which leads to a reduction in production performance. Mental health traits are currently difficult to measure, resulting in a gap in understanding their genetic basis. To address this challenge, we propose a computational framework called mental health of animals (MeHA), capable of revealing genes related to animal mental health traits.

Vacancy-Induced Symmetry Breaking in Titanium Dioxide Boosts the Photocatalytic Hydrogen Production from Methanol Aqueous Solution.

The key to optimizing photocatalysts lies in the efficient separation and oriented migration of the photogenerated carriers. Herein, we report that breaking continuous TiO tetragonal () symmetry in titanium dioxide material by oxygen vacancy engineering could induce a dipole field within the bulk phase and thus facilitate the separation and transfer of photogenerated electron-hole pairs. After further loading of Cu single-atom co-catalysts, the obtained catalyst attained a hydrogen (H) yield rate of 15.

Flynotyper 2.0: an updated tool for rapid quantitative assessment of Drosophila eye phenotypes.

About two-thirds of the genes in the Drosophila melanogaster genome are also involved in its eye development, making the Drosophila eye an ideal system for genetic studies. We previously developed Flynotyper, a software that uses image processing operations to identify and quantify the degree of roughness by measuring disorderliness of ommatidial arrangement in the fly eye. This software has enabled researchers to quantify morphological defects of thousands of eye images caused by genetic perturbations.

Electro-Optically Configurable Synaptic Transistors With Cluster-Induced Photoactive Dielectric Layer for Visual Simulation and Biomotor Stimuli.

The integration of visual simulation and biorehabilitation devices promises great applications for sustainable electronics, on-demand integration and neuroscience. However, achieving a multifunctional synergistic biomimetic system with tunable optoelectronic properties at the individual device level remains a challenge. Here, an electro-optically configurable transistor employing conjugated-polymer as semiconductor layer and an insulating polymer (poly(1,8-octanediol-co-citrate) (POC)) with clusterization-triggered photoactive properties as dielectric layer is shown.

Recent advancements in polymeric heart valves: From basic research to clinical trials.

Valvular heart diseases (VHDs) have become one of the most prevalent heart diseases worldwide, and prosthetic valve replacement is one of the effective treatments. With the fast development of minimal invasive technology, transcatheter valves replacement has been exploring in recent years, such as transcatheter aortic valve replacement (TAVR) technology. In addition, basic research on prosthetic valves has begun to shift from traditional mechanical valves and biological valves to the development of polymeric heart valves.

Genome-wide analysis of HD-Zip genes in Sophora alopecuroides and their role in salt stress response.

We aimed to identify HD-Zip (homologous domain leucine zipper) family genes based on the complete Sophora alopecuroides genome sequence. Eighty-six Sophora alopecuroides HD-Zip family (SaHDZ) genes were identified and categorized into four subclasses using phylogenetic analysis. Chromosome localization analysis revealed that these genes were distributed across 18 chromosomes.

Flynotyper 2.0: An updated tool for rapid quantitative assessment of eye phenotypes.

Unlabelled: About two-thirds of the genes in the genome are also involved in its eye development, making the eye an ideal system for genetic studies. We previously developed Flynotyper, a software that uses image processing operations to identify and quantify the degree of roughness by measuring disorderliness of ommatidial arrangement in the fly eye. This software has enabled researchers to quantify morphological defects of thousands of eye images caused by genetic perturbations.

Dynamic structural twist in metal-organic frameworks enhances solar overall water splitting.

Photocatalytic overall water splitting holds great promise for solar-to-hydrogen conversion. Maintaining charge separation is a major challenge but is key to unlocking this potential. Here we discovered a metal-organic framework (MOF) that shows suppressed charge recombination.

Introducing Hydrogen-Bonding Microenvironment in Close Proximity to Single-Atom Sites for Boosting Photocatalytic Hydrogen Production.

Inspired by enzymatic catalysis, it is crucial to construct hydrogen-bonding-rich microenvironment around catalytic sites; unfortunately, its precise construction and understanding how the distance between such microenvironment and catalytic sites affects the catalysis remain significantly challenging. In this work, a series of metal-organic framework (MOF)-based single-atom Ru catalysts, namely, Ru/UiO-67-X (X = -H, --(NH), --(NH)), have been synthesized, where the distance between the hydrogen-bonding microenvironment and Ru sites is modulated by altering the location of amino groups. The -NH group can form hydrogen bonds with HO, constituting a unique microenvironment that causes an increased water concentration around the Ru sites.