Publications by authors named "Wang Qin-Yi"
Aim: To assess the global and regional burden of hip fractures associated with type 1 diabetes (T1D) from 1990 to 2021.
Materials And Methods: The population attributable fraction was calculated by combining the published risk ratio with T1D prevalence (age ≥ 20 years) from the Global Burden of Disease study to estimate the T1D-associated hip-fracture burden. Trends were assessed using the age-standardized incidence rate (ASIR) and estimated annual percentage change (EAPC).
Purpose: This study aimed to understand how age, health status, and lifestyle impact bone mineral density (BMD) in middle-aged and older adults, focusing on predicting osteoporosis risk.
Methods: This study included 2836 participants aged 50-88 from the Health Improvement Program of Bone (HOPE) conducted from 2021 to 2023. We used logistic regression to make a prediction tool.
Article Synopsis
- The study examines the rising burden of HIV in the Asia-Pacific region from 1990 to 2019, highlighting a lack of comprehensive evidence despite increasing severity.
- Findings show that countries with low sociodemographic indicators, particularly Papua New Guinea and Nepal, experience significantly high rates of age-standardized disability-adjusted life years (ASDR), mortality (ASMR), and incidence (ASIR) related to HIV/AIDS.
- Unsafe sex is identified as the leading cause of HIV-related ASDR across 29 countries in the region, emphasizing the need for targeted public health policies tailored to each country's socioeconomic status to reduce the impact of HIV/AIDS.
Unlabelled: Postmenopausal patients with osteoporosis who have a recent fracture are at very high risk of fracture, and this study finds that stratified treatment based on fracture risk would be a cost-effective treatment option for this population.
Purpose: To evaluate the cost-effectiveness of four anti-osteoporosis medications (denosumab, zoledronate, teriparatide, and alendronate) for postmenopausal osteoporotic women in mainland China, using a stratified treatment strategy recommended by the American Association of Clinical Endocrinologists and the American College of Endocrinology (AACE/ACE).
Methods: A microsimulation Markov model was used to compare the cost-effectiveness of the four treatments in postmenopausal osteoporotic patients of different ages (65, 70, 75, and 80 years), with a recent fracture from the Chinese healthcare perspective.
Background: Osteoporotic vertebral fractures are often clinically silent and unrecognized. The present study aimed to determine whether routine chest radiographs could be a potential screening tool for identifying missed vertebral fractures in men aged over 50 years or postmenopausal women, especially those with type 2 diabetes mellitus (T2DM). In this study, we aimed to determine the prevalence of undetected vertebral fractures in elderly Chinese patients with and without T2DM.
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- The study focuses on identifying risk factors for very low bone mineral density (BMD) among older men and postmenopausal women in China, linked to a higher risk of fractures.
- The research analyzed data from 1,084 participants, finding that 5.8% had T-scores lower than -3, with age and weight as significant predictors for low BMD.
- A nomogram was developed to help identify individuals at risk for very low BMD, showing a strong predictive ability with an area under the ROC curve of 0.861.
Background: There is a positive association between serum magnesium and hemoglobin levels in the general population. However, no studies have evaluated the association between serum magnesium and hemoglobin levels in patients with primary hyperparathyroidism (PHPT). We aimed to investigate whether there is a relationship between serum magnesium and hemoglobin levels in the patient population with PHPT.
View Article and Find Full Text PDFBackground: The occurrence of hypomagnesemia in patients with primary hyperparathyroidism (PHPT) has been noted previously; however, the association of hypomagnesemia and severity of primary hyperparathyroidism remains unknown. The present study aimed to evaluate the association of hypomagnesemia with biochemical and clinical manifestations in patients with PHPT.
Methods: This was a retrospective study conducted at a tertiary hospital.
Background: The evidence supporting the use of antiresorptive and anabolic agents for fracture prevention in elderly patients is still inconclusive. Whether it is too late to alter the course of the disease in this age-group has remained uncertain.
Objectives: The objective of this study was to determine the efficacy and safety of antiresorptive and anabolic agents in elderly patients.
Clinical features, diagnosis and treatment of Paget's disease of bone in mainland China: A systematic review.
Rev Endocr Metab Disord
December 2020
Paget's disease of bone (PDB) is a metabolic bone disease with distinct geographical and ethnic differences in its pathogenesis. In this study, we aimed to retrospectively analyze the clinical features and the status of diagnosis and treatment of PDB in mainland China to improve the clinician's understanding of this disease. For this purpose, we conducted a systematic review of 118 articles, including a total of 332 patients with PDB.
View Article and Find Full Text PDFTumors require a vascular supply to grow and can achieve this via the expression of pro-angiogenic growth factors. Many potential oncogenic mutations have been identified in tumor angiogenesis. Somatic mutations in the small GTPase KRAS are the most common activating lesions found in human cancer, and are generally associated with poor response to standard therapies.
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