Publications by authors named "Wang Penglong"
The processing of traditional Chinese medicine(TCM) is a core theory within TCM, embodying deep philosophical, cultural, and natural scientific wisdom. Among the various techniques, the "synergistic processing of medicinal materials and excipients" has garnered significant attention due to its uniqueness. This study explored the impact of the adjuvant Glycyrrhizae Radix et Rhizoma on the dynamic process of component transformation during the processing of Aconiti Lateralis Radix Praeparata using techniques such as acidic dye colorimetry, UPLC-Q-TOF-MS/MS, density functional theory(DFT), and molecular dynamics simulations(MDS).
View Article and Find Full Text PDFThis study employed supramolecular chemistry of traditional Chinese medicine to compare the material basis between different decocting methods(co-decocting and single decocting) and explained the chemical basis of Rhei Radix et Rhizoma-Coptidis Rhizoma in alleviating the disadvantage of bitter and cold medicines damaging the stomach. The spectroscopic differences between the co-decoction and single decoctions were characterized by ultraviolet-visible absorption spectrum, infrared spectrum, and circular dichroism spectrum. Five characteristic alkaloids, such as berberine, were selected as the indicators to compare the sample solubility and dissolution of medicinal components between the co-decoction and single decoctions by high performance liquid chromatography.
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- Endosymbiotic bacteria are crucial for the health and fitness of the poultry red mite, an ectoparasite that feeds on bird blood.
- The study identified a diverse bacterial community in the mite's midgut and determined that certain bacteria increased after blood feeding, indicating their adaptation to a blood diet and role in digestion.
- Antibiotic treatments that disrupted these bacteria led to problems in blood digestion and reproduction in the mites, emphasizing the importance of these microbes and suggesting potential approaches for managing mite populations in poultry farming.
The supramolecular chemistry of small chiral molecules has attracted widespread attention owing to their similarity to natural assembly codes. Two-component low-molecular-weight (LMW) hydrogels are crucial as they form helical structures chirality transfer, enabling diverse functions. Herein, we report a pair of two-component chiral LMW hydrogels based on the small molecular drugs baicalin (BA), scutellarin (SCU) and berberine (BBR).
View Article and Find Full Text PDFThe 2030 Agenda for Sustainable Development issued by the United Nations is an important foundation for countries to achieve common economic, social and environmental development. Important progress has been made in the evaluation of the Sustainable Development Goals (SDGs) in Hainan Island; nevertheless, there is still a lack of understanding around the trade-offs and synergies between the SDGs. Studying the trade-offs and synergies between Hainan Island's sustainable development goals is of great significance for the coordinated development of these goals and the promotion of the construction of free trade ports.
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- * Researchers developed a plant-based antibacterial hydrogel using Kudzu powder and berberine that is highly effective against bacteria, showing excellent adhesion and fast degradation.
- * The hydrogel demonstrates strong antibacterial properties with low toxicity, suggesting its potential for wide clinical use and innovative applications in medicine.
Surface hydrophobicity of organisms provides biological self-protection. The hydrophobicity of pest surface, acting as a main obstacle for the pest control, can lead to low utilization and high loss of pesticides. Dermanyssus gallinae is a notorious pest in egg-laying hens, whose control primarily depends on acaricide spraying, while its surface hydrophobicity and potential influence on pesticide effectiveness are not clear.
View Article and Find Full Text PDFBoranes with closed polyhedral structures feature peculiar bonding and structural characteristics, rendering them widely applicable in diverse research areas ranging from basic functionalization reactions to applications such as medicine, nanomaterials, molecular electronics, and neutron capture therapy. Among the closed borane family, the neutral and cationic heptaborane B clusters have been missing in contemporary boron cluster chemistry to date. Herein, we report a polyhedral expansion protocol to construct a neutral derivative of -heptaborane (B) from -hexaborane (B) mediated by borane.
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- Insufficient T cell activation and a complex tumor microenvironment (TME) limit the effectiveness of immunotherapy, presenting challenges for cancer treatment.* -
- A novel hydrogel composed of glycyrrhizic acid, copper ions, and celastrol is developed to enhance TME regulation through chemo-dynamic therapy, promoting cellular apoptosis and anti-tumor effects.* -
- The hydrogel boosts T cell activity and infiltration by polarizing tumor-associated macrophages and enhancing antigen presentation, showing potential when combined with anti-PD-L1 therapy for addressing both primary and metastatic tumors.*
Article Synopsis
- Studies show that the arrangement of chiral molecules greatly impacts how they self-assemble, but the effects of epimerization (changes in a single chiral center) had not been previously examined.
- This research focused on two epimers of glycyrrhetinic acid—18 α and 18 β—derived from Glycyrrhiza uralensis, which exhibit different medicinal properties.
- The findings revealed that 18 β-GA can create a nanoparticle structure through a 'head-to-tail' arrangement, while 18 α-GA struggles to assemble due to steric hindrance caused by a 'head-to-head' connection, highlighting how small structural changes can affect molecular behavior and potential applications in medicine.
Dermanyssus gallinae, a worldwide pest in birds, has developed varying degrees of resistance to insecticides. The ATP-binding cassette (ABC) transporters are essential for the removal of xenobiotics from arthropods. However, our knowledge about ABC transporter proteins in D.
View Article and Find Full Text PDFBackground: Dermanyssus gallinae, the poultry red mite (PRM), is a worldwide ectoparasite posing significant economic challenges in poultry farming. The extensive use of pyrethroids for PRM control has led to the emergence of pyrethroid resistance. The objective of this study is to detect the pyrethroid resistance and explore its associated point mutations in the voltage-gated sodium channel (VGSC) gene among PRM populations in China.
View Article and Find Full Text PDFFree radical damage and oxidative stress are thought to play a crucial role in the development of neurodegenerative diseases. Walnut peptides, especially walnut oligopeptides, have been shown to protect nerve cells from oxidative stress and inflammatory damage, as well as improve memory function. In this study, walnut peptides were obtained from walnut meal through enzymatic hydrolysis, ultrafiltration, and gel filtration chromatography.
View Article and Find Full Text PDFThe removal of antibiotics from aquatic solutions remains a global environmental challenge. In this work, the photocatalytic removal of a typical antibiotic-tetracycline (TC) using hydroxyapatite (HAp) as a catalyst was investigated. It was impressive that TC could be efficiently degraded by HAp under visible light irradiation, even though both HAp and TC exhibited poor harvesting in visible light region.
View Article and Find Full Text PDFIn Dermanyssus gallinae, a hematophagous mite, the initiation of vitellogenesis induced by blood feeding is essential for its reproduction. However, the precise gene structures and physiological functions of Vg in D. gallinae and its upstream gene, Target of Rapamycin (TOR), have not been fully understood.
View Article and Find Full Text PDFObjective: To explore the anti-inflammatory components and mechanism of the non-volatile ingredients of patchouli.
Methods: High performance liquid chromatography-heated electron spray ionization-high resolution mass spectroscope (HPLC-HESI-HRMS) was used to analyze the chemical constituents of the non-volatile ingredients of patchouli. The anti-inflammatory activity of ingredients was evaluated using lipopolysaccharide (LPS) induced RAW264.
Article Synopsis
- * It identifies the transcription factor CncC and its partner Maf as key players in this resistance, indicating their overexpression in resistant mite strains and their regulation of ABC transporter genes.
- * The research further shows that beta-cypermethrin induces reactive oxygen species (ROS), activating the CncC/Maf pathway, which enhances resistance by upregulating ABC transporters in the mites.
Article Synopsis
- Mahuang Fuzi decoction (MGF), a traditional herbal remedy, is known for treating inflammatory diseases, but its complex phytochemical interactions and effects are still being studied.
- Techniques like dynamic light scattering and electron microscopy were used to analyze the morphology and interactions of MGF and its supermolecule form (MGF SA), finding distinct structural differences when compared to a simple mixture of its components (MIX).
- The study revealed that components in MGF exhibit self-assembly properties, leading to uniform particle formations in MGF SA, which may enhance its clinical effectiveness against inflammation compared to other forms.
Hematite (α-FeO) photoanode is a promising candidate for efficient PEC solar energy conversion. However, the serious charge recombination together with the sluggish water oxidation kinetics of α-FeO still restricts its practical application in renewable energy systems. In this work, a CoOOH/α-FeO/SnO photoanode was fabricated, in which the ultrathin SnO underlayer is deposited on the fluorine-doped tin oxide (FTO) substrate, α-FeO nanorod array is the absorber layer, and CoOOH nanosheet is the surface modifier, respectively.
View Article and Find Full Text PDFMitochondrial DNA single nucleotide polymorphisms (mtSNPs) have been associated with a reduced risk of developing Parkinson's disease (PD), yet the underlying mechanisms remain elusive. In this study, we investigate the functional role of a PD-associated mtSNP that impacts the mitochondrial-derived peptide (MDP) Small Humanin-like Peptide 2 (SHLP2). We identify m.
View Article and Find Full Text PDFThe β-amylase () gene family encodes important enzymes that catalyze the conversion of starch to maltose in various biological processes of plants and play essential roles in regulating the growth and development of multiple plants. So far, have been extensively studied in (). However, the characteristics of the gene family in the crucial economic crop, cotton, have not been reported.
View Article and Find Full Text PDFposes a severe hazard to the healthy development of the sheep industry and threatens the welfare of sheep. Ivermectin is the primary anthelmintic used for the prevention and treatment of parasitism. However, the widespread and uncontrolled application of ivermectin has resulted in the development and spread of resistant strains of .
View Article and Find Full Text PDFToxoplasma gondii is a zoonotic protozoan that can parasitize nucleated cells of all warm-blooded animals, and seriously harm human and livestock. Toltrazuril (TOL) has insecticidal activity against parasites of the phylum Apicomplexan at multiple development stages, but the clinical application is limited by its poor water solubility. To improve the dissolution of TOL, nine ternary solid dispersions (SD) were prepared with PEG6000 as the carrier and various alkalizers as the pH modifier.
View Article and Find Full Text PDFBackground: Due to the influence of extreme weather, the environment in China's main cotton-producing areas is prone to drought stress conditions, which affect the growth and development of cotton and lead to a decrease in cotton yield.
Results: In this study, 188 upland cotton germplasm resources were phenotyped for data of 8 traits (including 3 major yield traits) under drought conditions in three environments for two consecutive years. Correlation analysis revealed significant positive correlations between the three yield traits.
Article Synopsis
- Deaths from bacterial infections are increasing due to antibiotic overuse and bacterial resistance, highlighting the urgent need for new treatment options.
- Researchers developed a new type of carrier-free binary nanoparticle (GA-BBR NPs) made from traditional herbal ingredients, which showed strong antibacterial properties and was created using an eco-friendly, cost-effective method.
- The nanoparticles not only effectively kill multidrug-resistant bacteria and help remove biofilms but also promote wound healing without causing significant toxicity, indicating their potential for clinical use in treating infections.