FKBP Prolyl Isomerase 11: A Novel Oncogene Interacting With SRSF1 in Esophageal Squamous Cell Carcinoma.

Esophageal squamous cell carcinoma (ESCC) is one of the main subtypes of esophageal carcinoma with high morbidity. This study aimed to explore the role of FKBP prolyl isomerase 11 (FKBP11) in ESCC and investigate the underlying mechanism. FKBP11 levels in ESCC tumor tissues and cell lines were measured.

Integrating network pharmacology and component analysis to investigate the potential mechanisms of Sheng-Hui-Yi-Zhi decoction in the treatment of Alzheimer's disease.

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment.

Objective: To elucidate the potential mechanisms of Sheng-Hui-Yi-Zhi (SHYZ) for the treatment of AD and explore the effective substances of SHYZ.

Methods: Liquid chromatography-mass spectrometry (LC-MS) was used to identify the active components of SHYZ.

Mechanical Behavior of Flexible Fiber Assemblies: Review and Future Perspectives.

Flexible fibers, such as biomass particles and glass fibers, are critical raw materials in the energy and composites industries. Assemblies of the fibers show strong interlocking, non-Newtonian and compressible flows, intermittent avalanches, and high energy dissipation rates due to their elongation and flexibility. Conventional mechanical theories developed for regular granular materials, such as dry sands and pharmaceutical powders, are often unsuitable for modeling flexible fibers, which exhibit more complex mechanical behaviors.

HSF-IBI: A Universal Framework for Extracting Inter-Beat Interval from Heterogeneous Unobtrusive Sensors.

Heartbeat inter-beat interval (IBI) extraction is a crucial technology for unobtrusive vital sign monitoring, yet its precision and robustness remain challenging. A promising approach is fusing heartbeat signals from different types of unobtrusive sensors. This paper introduces HSF-IBI, a novel and universal framework for unobtrusive IBI extraction using heterogeneous sensor fusion.

Non-Contact Stable Arterial Pulse Measurement Using mmWave Array Radar.

Pulse signals can serve as important indicators of one's cardiovascular condition. However, capturing signals with stable morphology using radar under varying measurement periods remains a significant challenge. This paper reports a non-contact arterial pulse measurement method based on mmWave radar, with stable signals achieved through a range-angle focusing algorithm.

The Phenotype Changes of Astrocyte During Different Ischemia Conditions.

Objectives: Dementia is becoming a major health problem in the world, and chronic brain ischemia is an established important risk factor in predisposing this disease. Astrocytes, as one major part of the blood-brain barrier (BBB), are activated during chronic cerebral blood flow hypoperfusion. Reactive astrocytes have been classified into phenotype pro-inflammatory type A1 or neuroprotective type A2.

Effect of Seminal Plasma on the Freezability of Boar Sperm.

Background: Seminal plasma is an important component of semen and has a significant effect on sperm function. However, the relationship between seminal plasma and sperm freezing capacity has not been fully studied.

Purpose: Exploring metabolites and proteins related to the boar sperm freezing capacity in seminal plasma, by metabolomic and proteomic approaches, and directly verifying the protective effect of seminal plasma on the cryopreservation of boar sperm using high and low freezability seminal plasma as base freezing extender.

Using electrical resistivity techniques (ERT and SP) for nondestructive detection of seepage channels at the Leitai heritage site, China.

Seepage accelerates the weathering and destruction of cultural heritage sites, posing a major preservation challenge, while the concealed nature of seepage channels complicates their detection due to noninvasive requirements. In this study, we applied a comprehensive geophysical approach, integrating electrical resistivity tomography (ERT) and self-potential (SP) techniques, to image seepage channels within the Leitai heritage site. These potential seepage channels have already caused a collapse pit measuring 3.

Fully distributed energy management strategy for DC bus charging stations with three charging modes.

Although electric vehicles supplied through distributed generators (DGs) have been universally researched to reduce CO emissions, the accurate current sharing regarding islanded multi-bus DC charging stations considering three charging modes of electric vehicles, i.e., constant current mode, constant power mode and constant voltage mode, is rarely realized.

ALG5 downregulation inhibits osteogenesis and promotes adipogenesis by regulating the N-glycosylation of SLC6A9 in osteoporosis.

Osteoporosis is characterized by decreased bone mass and accumulation of adipocytes in the bone marrow. The mechanism underlying the imbalance between osteoblastogenesis and adipogenesis in bone marrow mesenchymal stem cells (BMSCs) remains unclear. We found that ALG5 was significantly downregulated in BMSCs from osteoporotic specimens.

Effect of Ar on Temperature and Flow Distribution in Monocrystalline Graphene Growth: Inert Gas Is Active.

Monocrystalline graphene growth has always been an intriguing research focus. Argon (Ar) is merely viewed as a carrier gas due to its inert chemical properties throughout the whole growth procedure by the chemical vapor deposition method. In this work, the influence of Ar on temperature and flow fields was investigated in consideration of its physical parameter difference among all involved gases.

The prognostic value of pulmonary hypertension in intensive care unit patients from Beth Israel Deaconess Medical Center (BIDMC).

Background: The impact of pulmonary hypertension (PH) on critically ill patients has not been fully understood. Our objective was to explore the possible relationship between PH and the outcomes in Intensive Care Unit (ICU) patients, and to determine risk factors of in-hospital mortality of ICU PH patients.

Methods: The Medical Information Mart for Intensive Care (MIMIC)-IV database was used.

SENP3 inhibition suppresses hepatocellular carcinoma progression and improves the efficacy of anti-PD-1 immunotherapy.

The importance of SUMOylation in tumorigenesis has received increasing attention, and research on therapeutic agents targeting this pathway has progressed. However, the potential function of SUMOylation during hepatocellular carcinoma (HCC) progression and the underlying molecular mechanisms remain unclear. Here, we identified that SUMO-Specific Peptidase 3 (SENP3) was upregulated in HCC tissues and correlated with a poor prognosis.

·Role of Cathepsin K in Bone Invasion of Pituitary Adenomas: A Dual Mechanism Involving Cell Proliferation and Osteoclastogenesis.

This study aimed to investigate the regulation and underlying mechanism of Cathepsin K (CTSK) in bone-invasive pituitary adenomas (BIPAs). A total of 1437 patients with pituitary adenomas were included and followed up. RNA sequencing, immunohistochemistry, and qRT-PCR were used to analyze CTSK expression.

Investigating the Current-Carrying Friction Mechanism of n-Type and p-Type Two-Dimensional TMD under a Positive Electric Field.

Nanofriction plays an important role in the performance and lifetime of n-type or p-type TMD-based semiconductor nanodevices. However, the mechanism of nanofriction in n-type and p-type TMD semiconductors under an electric field is still blurry. In this paper, monolayers of n-MoSe and p-WSe materials were prepared by chemical vapor deposition (CVD), and their nanofriction behavior under positive electric field was investigated.

The recovery trajectory of patient-reported outcomes in elderly patients with frailty undergoing lumbar spine fusion: a propensity score-matching analysis.

Objective: The objective of this study was to assess the complicated relationship between frailty, perioperative complications, and patient-reported outcomes (PROs) in elderly patients (≥ 75 years old) undergoing lumbar spine fusion (LSF).

Methods: Consecutive patients who underwent LSF between March 2019 and December 2021 were recruited in this study. Frail patients (modified frailty index [mFI] score ≥ 2) were propensity score matched to nonfrail patients (mFI score 0-1) on the basis of age, sex, and the number of fused levels.

Emerging frontiers of nickel-aluminium layered double hydroxide heterojunctions for photocatalysis.

The unique benefits of nickel-aluminium layered double hydroxide (Ni-Al LDH)-based heterojunctions, including large surface area, tunable bandgap and morphology, abundant reaction sites, and high activity, selectivity, and photostability, make them extremely promising for photocatalytic applications. Given the importance and benefits of Ni-Al LDH-based heterojunctions in photocatalysis, it is necessary to provide a summary of Ni-Al LDH-based heterojunctions for photocatalytic applications. Hence, in this review, we thoroughly described the material design for Ni-Al LDH-based heterojunctions, along with their recent developments in various photocatalytic applications, , H evolution, CO reduction, and pollutant removal.

Luminescence of the CsZrCl under High Pressure.

The photoluminescence (PL) and Raman spectra of the CsZrCl crystal over a wide range of pressures were studied in this work for the first time. PL measurements were performed up to 10 GPa, while the Raman spectra were measured up to 20 GPa. The PL data revealed a linear blue shift of the emission maximum from about 2.

Characterization and structural analysis of a versatile aromatic prenyltransferase for imidazole-containing diketopiperazines.

Prenylation modifications of natural products play essential roles in chemical diversity and bioactivities, but imidazole modification prenyltransferases are not well investigated. Here, we discover a dimethylallyl tryptophan synthase family prenyltransferase, AuraA, that catalyzes the rare dimethylallylation on the imidazole moiety in the biosynthesis of aurantiamine. Biochemical assays validate that AuraA could accept both cyclo-(L-Val-L-His) and cyclo-(L-Val-DH-His) as substrates, while the prenylation modes are completely different, yielding C2-regular and C5-reverse products, respectively.

MRI guided copper deprivator activated immune responses and suppressed angiogenesis for enhanced antitumor immunotherapy.

Copper plays an important role in the regulation of PD-L1, suggesting that reducing copper levels within tumors may enhance anti-cancer immunotherapy. Tumor microenvironment responsive copper nanodeprivator (TMECN) was developed for enhancing immunotherapy of tumor via the cross-link of mercaptopolyglycol bipyridine and dimercaptosuccinic acid modifying FePt nanoalloy using the disulfide bond. Upon entering tumor cells, the disulfide bond in TMECN is cleaved by the overexpressed glutathione, exposing abundance of sulfhydryl groups.

The application of ChatGPT in nursing: a bibliometric and visualized analysis.

Objective: With the development of ChatGPT, the number of studies within the nursing field has increased. The sophisticated language capabilities of ChatGPT, coupled with its exceptional precision, offer significant support within the nursing field, which includes clinical nursing, nursing education, and the clinical decision-making process. Preliminary findings suggest positive outcomes, underscoring its potential as a valuable resource for enhancing clinical care.