A novel interpretable deep learning-based computational framework designed synthetic enhancers with broad cross-species activity.

Enhancers play a critical role in dynamically regulating spatial-temporal gene expression and establishing cell identity, underscoring the significance of designing them with specific properties for applications in biosynthetic engineering and gene therapy. Despite numerous high-throughput methods facilitating genome-wide enhancer identification, deciphering the sequence determinants of their activity remains challenging. Here, we present the DREAM (DNA cis-Regulatory Elements with controllable Activity design platforM) framework, a novel deep learning-based approach for synthetic enhancer design.

Maternal Depressive Symptoms and Risk for Childhood Depression: Role of Executive Functions.

Objective: Offspring of mothers with depression are at increased risk for executive function (EF) deficits and later depressive symptoms, but limited studies have examined EF as an intermediary pathway. This study examined the role of EF in mediating the association between maternal and child depressive symptoms.

Method: Data were from a longitudinal birth cohort comprising 739 participants followed from the antenatal period for 12 years.

The value of amide proton transfer imaging in assessing brain damage in patients with obstructive sleep apnea.

Objective: To investigate the application value of amide proton transfer (APT) magnetic resonance imaging in evaluating brain damage in patients with obstructive sleep apnea (OSA).

Materials And Methods: 49 OSA patients and 25 healthy individuals matched for age and sex were included as case and control groups. All study participants underwent conventional 3D T1WI and APT imaging of the head.

Pin1: Advances in pancreatic cancer therapeutic potential and inhibitors research.

The peptidyl-prolyl cis/trans isomerase NIMA-interaction 1 (Pin1) catalyzes the transition of the proline ring from the cis to trans conformation, resulting in conformational and functional changes in proteins that are regulated by proline-guided serine/threonine phosphorylation. In recent years, Pin1 has emerged as a novel molecular target for the diagnosis and treatment of various malignant tumors. Notably, it has been found that Pin1 is highly expressed in pancreatic cancer.

Comparative analyses of bacterial contamination and microbiome of broiler carcasses in wet market and industrial processing environments.

The slaughtering environment is crucial for the food hygiene and safety of poultry products. Despite the global dominance of industrial processing, live bird slaughtering in wet markets persists due to cultural, religious, and economic reasons. This study aims to reveal the correlation between hygiene scales in wet markets and bacterial contamination levels on broiler carcasses, with a particular focus on pathobiont transmission risks and microbiome characteristics.

Role of complement factor D in cardiovascular and metabolic diseases.

In the genesis and progression of cardiovascular and metabolic diseases (CVMDs), adipose tissue plays a pivotal and dual role. Complement factor D (CFD, also known as adipsin), which is mainly produced by adipocytes, is the rate-limiting enzyme of the alternative pathway. Abnormalities in CFD generation or function lead to aberrant immune responses and energy metabolism.

Strontium ranelate modulates circular RNA BACH1/microRNA-155-5p to ameliorate root resorption and tooth anchoring during orthodontic tooth movement.

The tooth movement is a fundamental requirement during any orthodontic treatment. This study aimed to investigate the action and mechanism of strontium ranelate (SR) in orthodontic tooth movement (OTM). Rats were given SR by gavage daily, along with lentiviral vectors interfering with circBACH1 or miR-155-5p.

PrescDRL: deep reinforcement learning for herbal prescription planning in treatment of chronic diseases.

Treatment planning for chronic diseases is a critical task in medical artificial intelligence, particularly in traditional Chinese medicine (TCM). However, generating optimized sequential treatment strategies for patients with chronic diseases in different clinical encounters remains a challenging issue that requires further exploration. In this study, we proposed a TCM herbal prescription planning framework based on deep reinforcement learning for chronic disease treatment (PrescDRL).

Room-temperature non-volatile optical manipulation of polar order in a charge density wave.

Utilizing ultrafast light-matter interaction to manipulate electronic states of quantum materials is an emerging area of research in condensed matter physics. It has significant implications for the development of future ultrafast electronic devices. However, the ability to induce long-lasting metastable electronic states in a fully reversible manner is a long-standing challenge.

Efficacy and safety of reoperation for residual or recurrent hemifacial spasm after microvascular decompression: a systematic review and meta-analysis.

The efficacy and safety of revision microscopic microvascular decompression (microscopic MVD) for treating residual or recurrent hemifacial spasm (HFS) remain uncertain. We conducted a systematic review and meta-analysis to evaluate the benefits and risks associated with this reoperation, focusing primarily on spasm relief, facial palsy, and hearing impairment. This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines.

Mass spectrometry unveils heat-induced changes in yolk oxylipins and key lipid molecules during home cooking.

Introduction: Oxylipins, as a widespread class of metabolic markers following oxidative stress, and several studies have reported dietary regulation of lipid metabolism. However, there is a lack of investigation of dietary oxylipins, especially cooking-induced changes in food lipid oxidation.

Objectives: Investigated the effects of cooking methods and lipid profiles on polyunsaturated fatty acids derived oxylipins generation within egg yolks.

Protocatechuic acid grafted chitosan/oxidized glucomannan hydrogel with antimicrobial and anti-inflammatory effects for enhancing wound repair.

Oxidative stress, inflammation, and bacterial infection are critical barriers to wound healing. In this work, a composite wound dressing was designed to promote wound healing and reduce complications. A hydrogel with antibacterial, anti-inflammatory, and antioxidant properties was prepared by crosslinking chitosan (CS) and oxidized konjac glucomannan with Mg.

Synergistic effects of dual reactive compatibilizers for high-performance fully biodegradable polylactic acid/poly (butyleneadipate-co-terephthalate) composites.

The PLA-g-(GMA-co-St) graft copolymer (PGS) was prepared using melt-free radical grafting technology, PGS and ESO were simultaneously employed as compatibilizers for the poly (lactic acid)/poly (butylene adipate-co-terephthalate) (PLA/PBAT) blends. The effects of the type and amount of compatibilizers on the properties of the blends were studied. The results reveal that the epoxy groups in PGS and ESO can interact with the terminal groups of PLA and PBAT.

SHP-1 alleviates acute liver injury caused by Escherichia coli sepsis through negatively regulating the canonical and non-canonical NFκB signaling pathways.

SHP-1, as a protein tyrosine phosphatase, plays a key role in inflammation-related diseases. However, its function and regulatory mechanism in the imbalance of inflammatory response and acute liver injury during sepsis are still unknown. Herein, we constructed a murine model of Escherichia coli (E.

Extraction of curcuminoids from Curcuma longa L. by fatty acid-based ionic liquid aqueous solution: Experimental and mechanism study.

Curcuminoids originated from the plant Curcuma longa L. show high medical values. Herein, ionic liquids (ILs) were synthesized using fatty acids and alcohol amines to extract curcuminoids.

Cerebrospinal Fluid Lactate Levels as a Prognostic Indicator in Patients With Cryptococcal Meningitis Who Are HIV Negative: A Retrospective Cohort Study.

Background: Cryptococcal meningitis (CM) is a severe central nervous system infection. In patients with HIV infections and coexisting CM, elevated baseline cerebrospinal fluid (CSF) lactate levels can predict increased mortality. However, the CSF lactate level's significance in patients with CM who are HIV negative remains unclear, necessitating further investigation to elucidate the potential distinctions and enhance patient management.

A Study on Sensitivity Improvement of the Fiber Optic Acoustic Sensing System Based on Sagnac Interference.

A new pickup structure was introduced and modified to improve the resolution of the linear Sagnac optical fiber acoustic sensing system. The maximum strains corresponding to the material, diameter, wall thickness, and height of the pickups were analyzed by simulation. An aluminum cylinder with a diameter of 110 mm, a wall thickness of 3 mm, and a height of 120 mm was chosen as the basic pickup.

The Relationship between Plant-Based Diet Indices and Sleep Health in Older Adults: The Mediating Role of Depressive Symptoms and Anxiety.

Background: The goal of our research was to determine the effects of plant-based dietary patterns on sleep health among older adults and to examine the parallel mediated effects of anxiety and depression.

Methods: This investigation utilized data obtained from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS) and contained 6853 participants. Logistic regression and the restricted cubic splines (RCSs) model were employed to examine how plant-based dietary patterns affect sleep health.

Optimization of Ultrasonic-Assisted Extraction, Characterization and Antioxidant and Immunoregulatory Activities of Polysaccharides.

This study aimed to enhance the ultrasonic-assisted extraction (UAE) yield of seawater polysaccharides (APPs) and investigate its structural characteristics and bioactivities. The optimization of UAE achieved a maximum crude polysaccharides yield of 14.78%.