Leaf rust (LR) is one of the most common diseases of wheat. The resistance gene provides wide resistance to LR, but loses its function under high temperatures. Despite the importance of this gene, the mechanism of resistance is unclear.
View Article and Find Full Text PDFNanocoating represents an effective strategy for creating a protective barrier on probiotic surfaces, preventing them from damage. Here, we developed HAQ microcapsules comprising Limosilactobacillus fermentum RC4, which were nanocoated with hyaluronic acid and quinoa protein. We characterized the stability and safety, and investigated the intermolecular forces and transcriptome to elucidate the mechanisms underlying the nanocoating.
View Article and Find Full Text PDFChestnut (Ctanea mollissima Blume) is a nut with high nutritional value, yet studies on the quality of different chestnut varieties are limited. We evaluated 24 chestnut varieties from the Yanshan area by analyzing their physicochemical properties, nutritional components, mineral element content, and aroma profiles. A chestnut quality evaluation model was established by analyzing chestnut quality indicators.
View Article and Find Full Text PDFUnlabelled: Myophage Mu is a representative of contractile nanomachines with a simple tail baseplate. It has the capacity to infect a range of intestinal bacteria and has extensive applications in genetic engineering research. Nevertheless, a comprehensive understanding of the entire structure and contractile mechanisms of Mu remains elusive.
View Article and Find Full Text PDFPurpose: Disease relapse and graft-versus-host disease (GVHD) represent significant clinical challenges for high-risk hematological malignancies (HM) patients undergoing HLA-matched sibling donor transplantation (MSDT). How to balance the effect of GVHD and Graft versus leukemia (GVL) remains unclear for high-risk HM patients receiving MSDT. Here, we conducted a retrospective study to compare the efficacy in preventing disease relapse of 2 lymphocyte-depleting antibodies (r-ATG vs p-ALG) as the GVHD prevention strategy.
View Article and Find Full Text PDFJ Phys Condens Matter
February 2025
Scandium (Sc) can orderly occupy interstitial sites within the Ω phase of aluminum alloys, forming a new phase that significantly enhances the thermal stability of the alloy. However, Sc is relatively expensive and rare. In this work, we employ first-principles calculations to delve into the physical essence interstitial ordering of Sc in enhancing thermal stability at the electronic level, thereby revealing the crucial factors responsible for this improvement.
View Article and Find Full Text PDFJ Phys Condens Matter
January 2025
Scandium (Sc) can orderly occupy interstitial sites within the Ω phase of aluminum alloys, forming a new phase that significantly enhances the thermal stability of the alloy. However, Sc is relatively expensive and rare. In this work, we employ first-principles calculations to delve into the physical essence interstitial ordering of Sc in enhancing thermal stability at the electronic level, thereby revealing the crucial factors responsible for this improvement.
View Article and Find Full Text PDFThe hybrid CNN-transformer structures harness the global contextualization of transformers with the local feature acuity of CNNs, propelling medical image segmentation to the next level. However, the majority of research has focused on the design and composition of hybrid structures, neglecting the data structure, which enhance segmentation performance, optimize resource efficiency, and bolster model generalization and interpretability. In this work, we propose a data-oriented octree inverse hierarchical order aggregation hybrid transformer-CNN (nnU-OctTN), which focuses on delving deeply into the data itself to identify and harness potential.
View Article and Find Full Text PDFDetection of biomarkers of breast cancer incurs additional costs and tissue burden. We propose a deep learning-based algorithm (BBMIL) to predict classical biomarkers, immunotherapy-associated gene signatures, and prognosis-associated subtypes directly from hematoxylin and eosin stained histopathology images. BBMIL showed the best performance among comparative algorithms on the prediction of classical biomarkers, immunotherapy related gene signatures, and subtypes.
View Article and Find Full Text PDFNeurodegenerative diseases (NDDs), mainly including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD), are sporadic and rare genetic disorders of the central nervous system. A key feature of these conditions is the slow accumulation of misfolded protein deposits in brain neurons, the excessive aggregation of which leads to neurotoxicity and further disorders of the nervous system.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
April 2025
Two-dimensional antiferromagnetic materials have attracted wide attention in both performance and application, which are of great significance for spin valves and next-generation magnetic random access memory devices. The spin-phonon coupling effect plays a crucial role in magnon dynamics. However, there is still a lack of research on the spin-phonon coupling effect of two-dimensional antiferromagnetic flakes.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
The global solar market is booming with a rapid growth in installed integrated devices, while photovoltaic (PV) systems are suffering from waste heat, which causes the decline of the photovoltaic conversion efficiency (PCE). This study presents the seamless integration of the ionic thermoelectric generator (iTEG) layer with traditional PV modules, facilitating the exploitation of waste heat and augmenting the overall power output. Experimental results validate the effectiveness of the iTEG, demonstrating substantial power generation and a consistent energy output.
View Article and Find Full Text PDFIndividual cerebral small vessel disease (SVD) markers independently predict poor prognosis after stroke. However, the impact of a single SVD, especially cumulative SVD burden, on outcomes in acute ischemic stroke (AIS) after intravenous thrombolysis remains unclear. This study evaluated the occurrence of SVD in patients with AIS who were treated with intravenous thrombolytic therapy using multimodal magnetic resonance imaging.
View Article and Find Full Text PDFSinonasal inverted papilloma (SNIP) is less malignant and usually occur in the maxillary sinus. However, cases invading the pterygopalatine fossa are extremely rare. In this article, we describe a rare case of a man in his early 60s who presented with left nasal congestion, headache, epistaxis, and facial numbness.
View Article and Find Full Text PDFIndian J Radiol Imaging
January 2025
Aging is tightly associated with reduced immune protection but increased risk of autoimmunity and inflammatory conditions. Regulatory T cells are one of the key cells to maintaining immune homeostasis. The age-dependent changes in CD4Foxp3 regulatory T cells (Tregs) have been well documented.
View Article and Find Full Text PDFZhonghua Yi Xue Yi Chuan Xue Za Zhi
December 2024
Background: B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor T-cell (CAR T-cell) therapy has exhibited remarkable efficacy in refractory or relapsed multiple myeloma (R/R MM), but recurrence and rapid progression of disease are still observed within a short time after treatment. Long-term pomalidomide therapy, which potentiates T-cell functionality, might enhance the efficacy of BCMA CAR T-cell therapy.
Methods: We performed a single-center retrospective clinical study.
Angew Chem Int Ed Engl
January 2025
Organic molecule in solutions is the energy storage unit in the organic redox flow batteries (ORFBs), of which the aggregation is acknowledged pivotal but has been rarely investigated. By establishing a pyridinium library, the manipulation over the aggregation in solutions is investigated at the molecular level. Both theoretical calculations and physiochemical methods are used to characterize the aggregate's structure, and salient findings are as follows.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
February 2025
We report here an electrocatalyst that exhibits superior performance in the electrooxidation of ethanol. The reactive centers of the catalyst have a nest-type configuration with outer Zn-NC nest covering inner PtZn intermetallic compound nanoparticles loaded on carbon support (ZnNC⊂PtZn/C). The high-energy stepped facets of the inner PtZn nanoparticles confined and shaped by the outer Zn-NC nest is highly active for the critical C-C bond cleavage of ethanol in oxidation, confirmed by experimental characterizations and density functional theory calculations.
View Article and Find Full Text PDFObjective: To explore the effect of the "internet + health education system" in nursing care after stapler circumcision.
Methods: A total of 260 patients underwent stapler circumcision in the Outpatient Department of our hospital from January 2022 to July 2022, of whom 130 received routine nursing after operation (the control group), and the other 130 internet + medical nursing service based on the internet + health education system (the experimental group). We followed up the patients on the 1st, 3rd, 7th and 30th day after surgery, recorded their Visual Analogue Scale (VAS) scores within 24 hours postoperatively, their satisfaction scores with surgery and nursing, the incidence of complications and falloff of the stapler nails, and compared them between the two groups.
Background: Most acute cerebral infarctions (ACI) may develop vascular dementia (VD), which involves almost all types of cognitive impairment. Unfortunately, there is currently no effective treatment for VD. Most patients exhibit mild cognitive impairment (MCI) before the development of VD.
View Article and Find Full Text PDF