Expression profiles of miRNAs in the lung tissue of piglets infected with Glaesserella parasuis and the roles of ssc-miR-135 and ssc-miR-155-3p in the regulation of inflammation.

MicroRNAs (miRNAs) have been shown to play an important regulatory role in the process of pathogenic infection. However, the miRNAs that regulate the pathogenic process of G. parasuis and their functions are still unknown.

Mutating the arginine residue within the FRNK motif of telosma mosaic virus (TelMV) HC-Pro protein attenuates viral infection and confers effective protection against TelMV in passion fruit (Passiflora edulis).

Background: Telosma mosaic virus (TelMV, Potyvirus, Potyviridae) is an emerging viral pathogen that threatens passion fruit plantations worldwide. However, an efficient strategy for controlling such a virus is not yet available. Cross protection is a phenomenon in which pre-infection of a plant with one mild strain prevents or delays subsequent infection by the same or closely related virus.

COF/InS S-Scheme Photocatalyst with Enhanced Light Absorption and HO-Production Activity and fs-TA Investigation.

Photocatalytic hydrogen peroxide (HO) synthesis from water and O is an economical, eco-friendly, and sustainable route for HO production. However, single-component photocatalysts are subjected to limited light-harvesting range, fast carrier recombination, and weak redox power. To promote photogenerated carrier separation and enhance redox abilities, an organic/inorganic S-scheme photocatalyst is fabricated by in situ growing InS nanosheets on a covalent organic framwork (COF) substrate for efficient HO production in pure water.

Triethanolamine-modified layered double oxide for efficient CO capture with low regeneration energy.

Various adsorbents for CO capture have been developed to mitigate the greenhouse effect. In this work, a novel CO adsorbent was fabricated by depositing triethanolamine (TEOA) onto the surface of nickel-cobalt-aluminum layered double oxide (NiCoAl-LDO) via the impregnation method. The CO capacity of the TEOA-LDO composite reached 1.

GLP-1 Receptor Agonist Improves Mitochondrial Energy Status and Attenuates Nephrotoxicity In Vivo and In Vitro.

High-sugar and high-fat diets cause significant harm to health, especially via metabolic diseases. In this study, the protective effects of the antidiabetic drug exenatide (synthetic exendin-4), a glucagon-like peptide 1 (GLP-1) receptor agonist, on high-fat and high-glucose (HFHG)-induced renal injuries were investigated in vivo and in vitro. In vivo and in vitro renal injury models were established.

Activation of mitophagy improves cognitive dysfunction in diabetic mice with recurrent non-severe hypoglycemia.

Recurrent non-severe hypoglycemia (RH) in patients with diabetes might be associated with cognitive impairment. Previously, we found that mitochondrial dysfunction plays an important role in this pathological process; however, the mechanism remains unclear. The objective of this study was to determine the molecular mechanisms of mitochondrial damage associated with RH in diabetes mellitus (DM).

Cotyledon peeling method for passion fruit protoplasts: a versatile cell system for transient gene expression in passion fruit .

Passion fruit () is a perennial evergreen vine that grows mainly in tropical and subtropical regions due to its nutritional, medicinal and ornamental values. However, the molecular biology study of passion fruit is extremely hindered by the lack of an easy and efficient method for transformation. The protoplast transformation system plays a vital role in plant regeneration, gene function analysis and genome editing.

S-Scheme Heterojunction Photocatalysts for HO Production.

Photocatalysis opens a new door to HO formation via a low-cost, clean, mild, and sustainable process, which holds great promise for the next generation of massive HO production. However, fast photogenerated electron-hole recombination and slow reaction kinetics are the main obstacles for its practical application. An effective solution is to construct the step-scheme (S-scheme) heterojunction, which remarkably promotes carrier separation and boosts the redox power for efficient photocatalytic HO production.

Direct leaf-peeling method for areca protoplasts: a simple and efficient system for protoplast isolation and transformation in areca palm (Areca catechu).

Background: Areca palm (Areca catechu) is a woody perennial plant of both economical and medicinal importance grown in tropical and subtropical climates. Yet, the molecular biology study of areca palm is extremely impeded by its unavailability of a transformation method. An efficient protoplast isolation and transformation system could be highly desirable to overcome this barrier.

A Zinc Finger Motif in the P1 N Terminus, Highly Conserved in a Subset of Potyviruses, Is Associated with the Host Range and Fitness of Telosma Mosaic Virus.

P1 is the first protein translated from the genomes of most viruses in the family , and it contains a C-terminal serine-protease domain that -cleaves the junction between P1 and HCPro in most cases. Intriguingly, P1 is the most divergent among all mature viral factors, and its roles during viral infection are still far from understood. In this study, we found that telosma mosaic virus (TelMV, genus ) in passion fruit, unlike TelMV isolates present in other hosts, has two stretches at the P1 N terminus, named N1 and N2, with N1 harboring a Zn finger motif.

Immunogenicity and protection against Glaesserella parasuis serotype 13 infection after vaccination with recombinant protein LolA in mice.

Glaesserella parasuis is a pathogen causing Glässer's disease characterized by fibrinous polyserositis, polyarthritis, and meningitis. Owing to the low cross-immunogenicity of different bacterial antigens in commercial vaccines, finding and identifying effective immunoprotective antigens will facilitate the development of novel subunit vaccines. In this study, LolA, identified by bioinformatics approaches, was cloned and successfully expressed as a recombinant protein in Escherichia coli, and its immunogenicity and protection were evaluated in a mouse model.

A Bifunctional CdS/MoO /MoS Catalyst Enhances Photocatalytic H Evolution and Pyruvic Acid Synthesis.

The best use of photogenerated electrons and holes is crucial to boosting photocatalytic activity. Herein, a bifunctional dual-cocatalyst-modified photocatalyst is constructed based on CdS/MoO /MoS hollow spheres for hydrogen evolution coupled with selective pyruvic acid (PA) production from lactic acid (LA) oxidation. MoS and MoO are simultaneously obtained from the conversion of CdMoO in one step.

Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells.

Diabetes mellitus can result in severe complications, such as neurodegenerative diseases including cognitive impairment and dementia. The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, is a novel antidiabetic drug with neuroprotective effects against neurodegenerative diseases. In this study, we explored the protective effect of liraglutide on SH-SY5Y cells exposed to methylglyoxal (MG), a byproduct of glucose metabolism that plays a key role in the development of diabetic encephalopathy.

Altered Caffeine Metabolism Is Associated With Recurrent Hypoglycemia in Type 2 Diabetes Mellitus: A UPLC-MS-Based Untargeted Metabolomics Study.

Background: Recurrent hypoglycemia (RH) is well known to impair awareness of hypoglycemia and increase the risk of severe hypoglycemia; the underlying mechanism requires further understanding. We aimed to investigate the metabolic characteristic profile for RH in type 2 diabetes mellitus (T2DM) patients and explore the potential metabolic mechanism and prevention strategies.

Methods: We screened 553 community-based T2DM patients.

In-plasma-catalysis for NO degradation by Ti self-doped TiO /γ-AlO catalyst and nonthermal plasma.

In an attempt to realize the efficient treatment of NO , a mixed catalyst of Ti self-doped TiO and γ-AlO was constructed by reducing commercial TiO. The degradation effect on NO was evaluated by introducing the mixed catalyst into a coaxial dual-dielectric barrier reactor. It was found that the synthesized TiO could achieve considerable degradation effects (84.

A facile and effective strategy to develop a super-hydrophobic/super-oleophilic fiberglass filter membrane for efficient micron-scale water-in-oil emulsion separation.

In order to achieve efficient micron-scale water-in-oil emulsion separation, a facile and effective strategy is developed to prepare a super-hydrophobic/super-oleophilic fiberglass filter membrane (FGm). Methyl-trichlorosilane (MTS) is successfully cross-linked on the surface of the fiberglass filter membrane (FGm) and aggregates into a 3D nanowire array to provide low surface energy. Nano fumed hydrophobic silica (SH-SiO) is used to construct the well-defined nanosphere structure on the surface of FGm and enhance the ability of the membrane to resist extreme conditions.

Photocatalytic H Evolution Coupled with Furfuralcohol Oxidation over Pt-Modified ZnCdS Solid Solution.

Coupling photocatalytic H production with organic synthesis attracts immense interest in the energy and chemical engineering field for the low-cost, clean, and sustainable generation of green energy and value-added products. Nevertheless, the performance of current photocatalysts is greatly limited by grievous charge recombination and tardy H evolution. To tackle these issues, a Pt nanocluster-modified ZnCdS solid solution is fabricated for photocatalytic H production and selective furfuralcohol oxidation.

Optimizing Atomic Hydrogen Desorption of Sulfur-Rich NiS Cocatalyst for Boosting Photocatalytic H Evolution.

Low-cost transition-metal chalcogenides (MS ) are demonstrated to be potential candidate cocatalyst for photocatalytic H generation. However, their H -generation performance is limited by insufficient quantities of exposed sulfur (S) sites and their strong bonding with adsorbed hydrogen atoms (SH ). To address these issues, an efficient coupling strategy of active-site-enriched regulation and electronic structure modification of active S sites is developed by rational design of core-shell Au@NiS nanostructured cocatalyst.

Hierarchically Porous ZnO/g-CN S-Scheme Heterojunction Photocatalyst for Efficient HO Production.

The design of photocatalysts with hierarchical pore sizes is an effective method to improve mass transport, enhance light absorption, and increase specific surface area. Moreover, the construction of a heterojunction at the interface of two semiconductor photocatalysts with suitable band positions plays a crucial role in separating and transporting charge carriers. Herein, ZIF-8 and urea are used as precursors to prepare hierarchically porous ZnO/g-CN S-scheme heterojunction photocatalysts through a two-step calcination method.

Inorganic Metal-Oxide Photocatalyst for H O Production.

Hydrogen peroxide (H O ) is a mild but versatile oxidizing agent with extensive applications in bleaching, wastewater purification, medical treatment, and chemical synthesis. The state-of-art H O production via anthraquinone oxidation is hardly considered a cost-efficient and environment-friendly process because it requires high energy input and generates hazardous organic wastes. Photocatalytic H O production is a green, sustainable, and inexpensive process which only needs water and gaseous dioxygen as the raw materials and sunlight as the power source.

Dual-Single-Atom Tailoring with Bifunctional Integration for High-Performance CO Photoreduction.

Single-atom photocatalysis has been demonstrated as a novel strategy to promote heterogeneous reactions. There is a diversity of monoatomic metal species with specific functions; however, integrating representative merits into dual-single-atoms and regulating cooperative photocatalysis remain a pressing challenge. For dual-single-atom catalysts, enhanced photocatalytic activity would be realized through integrating bifunctional properties and tuning the synergistic effect.

CsPbBr Nanocrystal Induced Bilateral Interface Modification for Efficient Planar Perovskite Solar Cells.

Organic-inorganic halide perovskite solar cells (PSCs) have drawn tremendous attention owing to their remarkable photovoltaic performance and simple preparation process. However, conventional wet-chemical synthesis methods inevitably create defects both in the bulk and at the interfaces of perovskites, leading to recombination of charge carriers and reduced stability. Herein, a bilateral interface modification to perovskites by doping room-temperature synthesized CsPbBr nanocrystals (CN) is reported.

Influence of calcination temperature on photocatalytic HOproductivity of hierarchical porous ZnO microspheres.

Photocatalytic production of HOfrom water and atmospheric oxygen has been recognized as a green and sustainable chemical process, due to the abundance of raw materials and sustainable solar energy. Herein, flower-like hierarchical ZnO microspheres were prepared by hydrothermal method followed by calcination at different temperatures, and their photocatalytic performance in HOproduction was examined under simulated sunlight irradiation. The calcination temperature plays a vital role in the structure, morphology, and surface area of the final ZnO products as well as their optical and electrochemical properties, which are determining factors in their photocatalytic activity.

Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research.

Objective: It remains unknown whether obesity has an effect on the pituitary-thyroid feedback control axis in subclinical hypothyroidism (SCH). We aimed to investigate the association of thyroid homeostasis with obesity in a SCH population.

Methods: Our study consisted of a community-based and cross-sectional study from the Epidemiological Survey of Thyroid Diseases in Fujian Province, China.