Efficacy of local-regional radiotherapy in de novo metastatic nasopharyngeal carcinoma patients receiving chemo-immunotherapy: A multicenter, propensity score matching study.

Background: To evaluate the efficacy of local-regional radiotherapy (LRRT) in de novo metastatic nasopharyngeal carcinoma (dm NPC) patients receiving chemo-immunotherapy as first-line treatment and select the beneficiaries from LRRT.

Methods And Materials: M1-NPC patients receiving platinum-based chemo-immunotherapy with or without LRRT from four centers were included in this study. The propensity score matching (PSM) analysis was employed to balance the baseline characteristics between the LRRT and non-LRRT groups.

One-Pot Assay Based on CRISPR/Cas13a Technology for HEV RNA Point-of-Care Testing.

Hepatitis E virus (HEV) poses a serious threat to both public health and animal food safety, thereby highlighting the demands for rapid, sensitive, and easy-to-use detection. This study aimed to develop a One-Pot assay using CRISPR/Cas13a for detecting HEV RNA, suitable for point-of-care testing (POCT) in resource-limited settings. CRISPR/Cas13a combined with reverse transcription polymerase chain reaction (RT-PCR) and reverse transcription recombinase-aided amplification (RT-RAA) was applied to a One-Pot assay device.

Switching to intracytoplasmic sperm injection provides no benefit in couples of poor embryonic development in the previous fertilization cycle.

This study aimed to evaluate the effectiveness of changing the insemination method in women who experienced poor embryonic development during the preceding cycle. A total of 15,886 conventional IVF in 9,311 women, performed between August 2015 and June 2023, were included in this study. Of these, 270 couples experienced IVF failure due to poor embryonic development in the first oocyte retrieval (OR) cycle, which was cancelled before transfer.

Deciphering the past status and future tendency: a comprehensive scientometric study on developmental dysplasia of the hip.

Background: Developmental dysplasia of the hip is a common musculoskeletal disorder in newborns and young children, attracting considerable controversy. The purpose of the present study was to analyze the research trends and hotspots over the past three decades in this field.

Methods: All related publications were collected from the Web of Science Core Collection from 1994 to 2023.

Genetic diversity and phylogeography of the endemic species Prunus mira in the Qinghai-Tibetan Plateau.

Studying the evolutionary history of plants in the Qinghai-Tibetan Plateau region provides a theoretical basis for the conservation and use of plant genetic resources. In this study, we analyzed five chloroplast gene fragments to examine the genetic diversity and phylogeography of Prunus mira in 577 individuals from 32 populations. The results indicated that P.

Association Between Systemic Immune-Inflammatory Index (SIRI) and Diabetic Foot Ulcers in Individuals with Diabetes: Evidence from the NHANES.

Diabetic Foot Ulcer (DFU) is a common and challenging complication of diabetes mellitus, associated with high recurrence, hospitalization, disability, and mortality rates. The Systemic Immune Inflammatory Index (SIRI) based on complete blood counts has been shown to correlate with several diseases but has not been widely studied in DFU.This study aimed to explore the relationship between SIRI and the presence of DFU in individuals with diabetes using data from the National Health and Nutrition Examination Survey (NHANES).

Increased expression of () predicts poor prognosis and is correlated with immune-cell infiltration in glioma.

Background: The poor response of patients with gliomas to existing immunotherapy has resulted in negligible improvement in prognosis. It is widely acknowledged that serves as a transcriptional activator implicated in tumorigenesis across various cancer types. However, its specific role within glioma remains unclear.

An implemented predictive coding model of lexico-semantic processing explains the dynamics of univariate and multivariate activity within the left ventromedial temporal lobe during reading comprehension.

During language comprehension, the larger neural response to unexpected versus expected inputs is often taken as evidence for predictive coding-a specific computational architecture and optimization algorithm proposed to approximate probabilistic inference in the brain. However, other predictive processing frameworks can also account for this effect, leaving the unique claims of predictive coding untested. In this study, we used MEG to examine both univariate and multivariate neural activity in response to expected and unexpected inputs during word-by-word reading comprehension.

Identification of Mycobacterium marinum in subcutaneous abscesses of an infected patient's foot.

Introduction: Mycobacterium marinum is a well-known pathogenic non-tuberculous mycobacterium for skin and soft tissue infections. Infection, often presenting as superficial lesions, is seen after exposure of skin abrasions to contaminated water or infected fish and is known as "swimming pool" or "fish tank" granuloma. This study reported a case of M.

Establishing meaningful change thresholds for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire CLL-specific module domain scores: An analysis based on the TRANSCEND CLL 004 study in patients with relapsed or refractory chronic lymphocytic leukaemia or small lymphocytic lymphoma.

Introduction: The study aimed to establish meaningful thresholds at patient and group levels for the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire CLL-specific module (EORTC QLQ-CLL17) domain scores in adults with relapsed or refractory (R/R) chronic lymphocytic leukaemia (CLL).

Material And Methods: Data for the analysis were from the TRANSCEND CLL 004 study (NCT03331198). EORTC QLQ-CLL17 and selected anchor measures were assessed at baseline and multiple postbaseline visits up to 24 months after treatment initiation.

Radiomics of multimodal ultrasound for early prediction of pathologic complete response to neoadjuvant chemotherapy in breast cancer.

Rationale And Objectives: To construct and validate a clinical-radiomics model based on radiomics features extracted from two-stage multimodal ultrasound and clinicopathologic information for early predicting pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients treated with NAC.

Materials And Methods: Consecutive women with biopsy-proven breast cancer undergoing multimodal US pretreatment and after two cycles of NAC and followed by surgery between January 2014 and November 2023 were retrospectively collected for clinical-radiomics model construction (n = 274) and retrospective test (n = 134). The predictive performance of it was further tested in a subsequent prospective internal test set recruited between January 2024 to July 2024 (n = 76).

Pyrazine derivative synthesis in a continuous-flow system: a green synthesis of pyrazinamide from pyrazine esters and amines catalyzed by Lipozyme® TL IM from .

Pyrazinamide derivatives have been extensively studied for their biological activities, such as anti-tuberculosis activity and antiviral activities. In this work, a continuous-flow system was developed for the synthesis of pyrazinamide derivatives from pyrazine esters and amines (aliphatic amine, benzylamines and morpholine) catalyzed by Lipozyme® TL IM from , which was used for the first time. The reaction parameters including solvent, substrate ratio, reaction temperature and reaction time/flow rate were also studied in detail.

Designing Silk Biomaterials toward Better Future Healthcare: The Development and Application of Silk-Based Implantable Electronic Devices in Clinical Diagnosis and Therapy.

Implantable medical electronic devices (IMEDs) have attracted great attention and shown versatility for solving clinical problems ranging from real-time monitoring of physiological/ pathological states to electrical stimulation therapy and from monitoring brain cell activity to deep brain stimulation. The ongoing challenge is to select appropriate materials in target device configuration for biomedical applications. Currently, silk-based biomaterials have been developed for the design of diagnostic and therapeutic electronic devices due to their excellent properties and abundant active sites in the structure.

Identification of CSPG4 as a Biomarker and Therapeutic Target for Infantile Post-Hemorrhagic Hydrocephalus via Multi-Omics Analysis.

Intraventricular hemorrhage in preterm neonates has become a major global health problem and is associated with a high risk of post-hemorrhagic hydrocephalus (PHH). Identifying diagnostic markers and therapeutic targets is a focal challenge in the PHH prevention and control. Here, this study applies multi-omics analyses to characterize the biochemical, proteomic, and metabolomic profiles of the cerebrospinal fluid (CSF) in clinical human cohorts to investigate disease development and recovery processes occurring due to PHH.

Diagnostic value of SAT-TB in smear-negative pulmonary tuberculosis: A diagnostic accuracy study.

This study aimed to evaluate the diagnostic value of rapid simultaneous RNA amplification and testing for tuberculosis (SAT-TB) in smear-negative pulmonary tuberculosis (PTB). We performed a multicenter prospective analysis of 206 patients with smear-negative suspected PTB between December 2018 and March 2022. We collected sputum or bronchoalveolar lavage fluid (BALF) for simultaneous SAT-TB and Xpert Mycobacterium tuberculosis/rifampin (MTB/RIF) assays.

Correction: Liu et al. Optimization of Antibacterial Activity and Biosafety through Ultrashort Peptide/Cyclodextrin Inclusion Complexes. 2023, , 14801.

In the original publication [...

Prescription Design of Sinomenine Gel Based on Molecular Dynamics Simulations.

Sinomenine (SIN) is a drug for the treatment of rheumatoid arthritis, most of which is administered orally, but it is prone to adverse gastrointestinal effects. Gel can overcome the gastrointestinal adverse effects caused by oral administration. In this paper, a multiscale computational pharmaceutics strategy was developed to guide the systematic study of formulation factors of a SIN gel and, further, to guide the formulation design.

Suppression of Interfacial Oxidation in Core/Shell InP Quantum Dots through Solvent Assisted Core-Etching Strategy for Efficient Green Light-Emitting Diodes.

Indium phosphide (InP) quantum dots (QDs) are promising alternative heavy-metal CdSe QDs for light-emitting diode (LED) application. However, their highly reactive core surface is prone to oxidation, which reduces the photoluminescence quantum yield (PL QY) and impedes subsequent shell growth. Traditional etching methods using HF aqueous solution are problematic as water can induce reoxidation during or after etching.

Navigating the complex role of senescence in liver disease.

Cellular senescence, an irreversible state of cell cycle arrest characterized by phenotypic changes and a specific secretory profile, plays a dual role in liver health and disease. Under physiological conditions, senescence aids organ repair and regeneration, but its accumulation due to aging or pathological stress significantly contributes to chronic liver diseases, including alcoholic liver disease, metabolic dysfunction-associated steatohepatitis, liver fibrosis, and hepatocellular carcinoma. Senescence is identified by a range of cellular and molecular changes, such as morphological alterations, expression of cell cycle inhibitors, senescence-associated β-galactosidase activity, and nuclear membrane changes.

Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center.

Background: Rectal cancer has become one of the leading malignancies threatening people's health. For locally advanced rectal cancer (LARC), the comprehensive strategy combining neoadjuvant chemoradiotherapy (NCRT), total mesorectal excision (TME), and adjuvant chemotherapy has emerged as a standard treatment regimen, leading to favorable local control and long-term survival. However, in recent years, an increasing attention has been paid on the exploration of organ preservation strategies, aiming to enhance quality of life while maintaining optimal oncological treatment outcomes.

High-Responsivity Self-Powered Photoelectrochemical UV Photodetector Based on Integrated Self-Supporting SiC/ZnS Heterojunction Nanowire Arrays.

In the realm of photodetector (PD) technology, photoelectrochemical (PEC) PDs have garnered attention owing to their inherent advantages. Advances in this field depend on functional nanostructured materials, which are pivotal in improving the separation and transport of photogenerated electron-hole pairs to improve device efficiency. Herein, a highly photosensitive PEC UV PD is built using integrated self-supporting SiC/ZnS heterojunction nanowire array photoelectrodes through anodization and chemical deposition.

Recent advances in modifications, biotechnology, and biomedical applications of chitosan-based materials: A review.

Chitosan, a natural polysaccharide with recognized biocompatibility, non-toxicity, and cost-effectiveness, is primarily sourced from crustacean exoskeletons. Its inherent limitations such as poor water solubility, low thermal stability, and inadequate mechanical strength have hindered its widespread application. However, through modifications, chitosan can exhibit enhanced properties such as water solubility, antibacterial and antioxidant activities, adsorption capacity, and film-forming ability, opening up avenues for diverse applications.

Enhanced photocatalytic performance in seawater of donor-acceptor type conjugated polymers through introduction of alkoxy groups in the side chain.

Previous studies have demonstrated that the donor (D)-acceptor (A) structure enables conjugated polymers (CPs) to effectively inhibit charge recombination, reduce exciton binding energy to a minimum, and broaden the light absorption spectrum, ultimately enhancing photocatalytic activity. Besides, side chain engineering is an effective approach to enhance photocatalytic performance by regulating surface chemistry and energy band structure of CPs. Herein, three D-A type CPs, namely TPD-T, TPD-MOT and TPD-DOT, were designed and synthesized using thieno[3,4-c]pyrrole-4,6-dione (TPD) as A units and thiophene with different alkyl/alkoxy groups side chain (as 3-octylthiophene (T), 3-methoxythiophene (MOT) and 3,4-ethylenedioxythiophene (DOT)) as D units, via an atom- and step-economic CH/CH cross-coupling polycondensation.