Clinical-grade human dental pulp stem cells improve adult hippocampal neural regeneration and cognitive deficits in Alzheimer's disease.

Disrupted hippocampal functions and progressive neuronal loss represent significant challenges in the treatment of Alzheimer's disease (AD). How to achieve the improvement of pathological progression and effective neural regeneration to ameliorate the intracerebral dysfunctional environment and cognitive impairment is the goal of the current AD therapy. We examined the therapeutic potential of clinical-grade human derived dental pulp stem cells (hDPSCs) in cognitive function and neuropathology in AD.

Surface-enhanced Raman scattering of R6G dimerization during self-healing of gel.

Traditional surface-enhanced Raman scattering (SERS) substrates seeking uniformity and reproducibility of the Raman signal often assume and require that hot spots remain consistently stable during Raman testing. Recently, the non-uniform accumulation in SERS sample pre-concentration strategies have inspired the direct use of self-healing noble metal aerogels (NMAs), as the sample pretreatment presented in this work, and uncovered more diverse Raman information of substances during the dynamic process of laser irradiation. Rare characteristic peaks such as 820 cm⁻ for R6G within a specific concentration range were observed, and potential processes including R6G dimerization and desorption were analyzed.

Research trends and hotspots of the applications of single-cell RNA sequencing in cardiovascular diseases: a bibliometric and visualized study.

Background: Cardiovascular diseases (CVDs) are the leading causes of death globally. The use of single-cell RNA sequencing (scRNA-seq) in CVDs has gained significant attention in recent years, and there is a growing body of literature on the subject. However, a thorough and impartial analysis of the existing state and trends of scRNA-seq in CVDs is lacking.

The possible mechanism and research progress of ACE2 involved in cardiovascular injury caused by COVID-19: a review.

ACE2 is the earliest receptor discovered to mediate the entry of SARS-CoV-2. In addition to the receptor, it also participates in complex pathological and physiological processes, including regulating the RAS system, apelin, KKS system, and immune system. In addition to affecting the respiratory system, viral infections also interact with cardiovascular diseases.

Metal oxide hybridization enhances room temperature phosphorescence of carbon dots-SiO matrix for information encryption and anti-counterfeiting.

Room temperature phosphorescent (RTP) carbon dot (CD) materials have been widely used in various fields, but it is difficult to achieve a long lifetime, high stability and easy synthesis. In particular, realizing the phosphorescence emission of CDs using a metal oxide (MO) matrix is a challenge. Here, solid gels are synthesized hydrolysis, and then RTP CDs are synthesized based on a SiO matrix (CDs@SiO) and hybridized with a MO matrix (CDs@SiO-MO) by high-temperature calcination.

One-Step Preparation of High-Stability CsPbX/CsPbX Composite Microplates with Tunable Emission.

The core-shell structure is an effective means to improve the stability and optoelectronic properties of cesium lead halide (CsPbX (X = Cl, Br, I)) perovskite quantum dots (QDs). However, confined by the ionic radius differences, developing a core-shell packaging strategy suitable for the entire CsPbX system remains a challenge. In this study, we introduce an optimized hot-injection method for the epitaxial growth of the CsPbX substrate on CsPbX surfaces, achieved by precisely controlling the reaction time and the ratio of lead halide precursors.

Decomposition of exotic versus native aquatic plant litter in a lake littoral zone: Stoichiometry and life form analyses.

The decomposition rates and stoichiometric characteristics of many aquatic plants remain unclear, and our understanding of material flow and nutrient cycles within freshwater ecosystems is limited. In this study, an in-situ experiment involving 23 aquatic plants (16 native and 7 exotic species) was carried out via the litter bag method for 63 days, during which time the mass loss and nutrient content (carbon (C), nitrogen (N), and phosphorus (P)) of plants were measured. Floating-leaved plants exhibited the highest decomposition rate (0.

Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.

Acute liver injury is the basis of the pathogenesis of diverse liver diseases. However, the mechanism underlying liver injury is complex and not completely understood. In our study, we revealed that CERK, which phosphorylates ceramide to produce ceramide-1-phosphate (C1P), was the sphingolipid pathway-related protein that had the most significantly upregulated expression during acute liver injury.

Correlation of circulating fibroblast growth factor 21 levels with inflammatory factors and the degree of coronary artery stenosis in patients with acute myocardial infarction.

Background: Fibroblast growth factor 21 (FGF21) is a secreted protein that plays an important role in atherosclerosis and pathological cardiac remodeling. However, the correlation between FGF21 and the degree of coronary artery stenosis and its potential role in acute myocardial infarction (AMI) remain unclear. We examined whether changes in FGF21 levels in AMI correlate with the degree of coronary artery stenosis and the levels of inflammatory factors, and preliminarily investigated the effects of FGF21 on inflammatory factor levels and myocardial injury in rats with AMI.

The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer's disease?

Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by a progressive cognitive decline. Sporadic AD, accounting for more than 95% of cases, may arise due to the influence of environmental factors. It was reported that periodontitis, a common oral ailment, shares several risk factors with AD, including advanced age, smoking, diabetes, and hypertension, among others.

Efficacy and Safety of Loxoprofen Sodium Hydrogel Patch in Patients with Chronic Inflammatory Pain: A 4-Week Real-World Study.

Purpose: Chronic inflammatory pain is usually treated with oral non-steroidal anti-inflammatory drugs (NSAIDs). However, oral NSAIDs can cause some adverse events, and local preparation is an important alternative drug. Currently, small sample clinical studies show that loxoprofen sodium hydrogel patch (LX-P) has good analgesic and anti-inflammatory effects; however, there is a lack of real-world clinical research data.

Stability Enhancement in All-Inorganic Perovskite Light Emitting Diodes via Dual Encapsulation.

Addressing the challenge of lighting stability in perovskite white light emitting diodes (WLEDs) is crucial for their commercial viability. CsPbX (X = Cl, Br, I, or mixed) nanocrystals (NCs) are promising for next-generation lighting due to their superior optical and electronic properties. However, the inherent soft material structure of CsPbX NCs is particularly susceptible to the elevated temperatures associated with prolonged WLED operation.

Inhibiting microRNA-200a-3p attenuates pyroptosis via targeting the SIRT1/NF-κB/NLRP3 pathway in HO-induced HAEC.

Atherosclerosis is a chronic inflammatory disease of the arterial wall caused by many factors. Endothelial cell dysfunction is the initial factor in the development of atherosclerosis, and ROS activates the assembly of inflammasomes and induces the pyroptosis of vascular endothelial cells. Whether HO induced human aortic endothelial cells (HAECs) pyroptosis and the underlying mechanisms remain unclear.

Clinical Efficacy of 2-Needle Joint Lavage for Osteoarthritis-Related Knee Pain and Predictors of Response Based on Knee MRI Osteoarthritis Knee Score: A Medical Records Review Study.

Background: Knee osteoarthritis (OA) is notoriously difficult to treat. Pain is the key symptom for patients to seek medical attention. This study aimed to evaluate the therapeutic efficacy of joint lavage (JL) for OA-related knee pain and to explore the knee pathological changes detected by magnetic resonance imaging that may affect the prognosis of patients who received JL.

Ultrastable CsPbBr@CsPbBr@TiO Composites for Photocatalytic and White Light-Emitting Diodes.

Although cesium halide lead (CsPbX, X = Cl, Br, I) perovskite quantum dots (QDs) have excellent photovoltaic properties, their unstable characteristics are major limitations to application. Previous research has demonstrated that the core-shell structure can significantly improve the stability of CsPbX QDs and form heterojunctions at interfaces, enabling multifunctionalization of perovskite materials. In this article, we propose a convenient method to construct core-shell-structured perovskite materials, in which CsPbBr@CsPbBr core-shell micrometer crystals can be prepared by controlling the ratio of Cs/Pb in the precursor and the reaction time.

Phenotyping cardiogenic shock that showed different clinical outcomes and responses to vasopressor use: a latent profile analysis from MIMIC-IV database.

Background: Cardiogenic shock (CS) is increasingly recognized as heterogeneous in its severity and response to therapies. This study aimed to identify CS phenotypes and their responses to the use of vasopressors.

Method: The current study included patients with CS complicating acute myocardial infarction (AMI) at the time of admission from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.

Studies on the optical stability of CsPbBr with different dimensions (0D, 1D, 2D, 3D) under thermal environments.

The thermal stability of phosphor materials had long been a bottleneck in their commercialization. Nowadays, cesium lead halide perovskite CsPbBr has been considered a potential replacement for the next generation of optoelectronic devices due to its excellent optical and electronic properties, however, the devices inevitably generate high temperatures on the surface under prolonged energization conditions in practical applications, which can be fatal to CsPbBr. Despite the various strategies that have been employed to improve the thermal stability of CsPbBr, systematic studies of the thermal stability of the basis CsPbBr are lacking.

Preparation of CsPb(Cl/Br)/TiO:Eu composites for white light emitting diodes.

The inherent single narrow emission peak and fast anion exchange process of cesium lead halide perovskite CsPbX (X = Cl, Br, I) nanocrystals severely limited its application in white light-emitting diodes. Previous studies have shown that composite structures can passivate surface defects of NCs and improve the stability of perovskite materials, but complex post-treatment processes commonly lead to dissolution of NCs. In this study, CsPb(Cl/Br) NCs was in-situ grown in TiO hollow shells doped with Eu ions by a modified thermal injection method to prepare CsPb(Cl/Br)/TiO:Eu composites with direct excitation of white light without additional treatment.

Resveratrol suppresses neuroinflammation to alleviate mechanical allodynia by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in a rat model of spinal cord injury.

Background: Neuropathic pain (NP) is one of intractable complications of spinal cord injury (SCI) and lacks effective treatment. Resveratrol (Res) has been shown to possess potent anti-inflammatory and anti-nociceptive effects. In this study, we investigated the analgesic effect of Res and its underlying mechanism in a rat model of SCI.

In Situ Fabrication of Lead-Free Double Perovskite/Polymer Composite Films for Optoelectronic Devices and Anticounterfeit Printing.

Lead-free double perovskites (DP) have the potential to become a rising star in the next generation of lighting markets by addressing the toxicity and instability issues associated with traditional lead-based perovskites. However, high concentrations of hydrochloric acid (HCl) were often employed as a solvent in the preparation of most DPs, accompanied by slow crystallization at high temperatures, which not only raised the risk and cost in the preparation process, but also had a potential threat to the environment. Here, an in situ fabrication strategy was proposed to realize the crystallization of DP in the polymer at low temperature with a mild dimethyl sulfoxide (DMSO) solvent, and subsequently obtained optically well-behaved CsNaAgBiCl/PMMA composite films (CFs) by doping with Ag, generating bright orange luminescence with a photoluminescence quantum yield (PLQY) of up to 21.

Proteomic analysis of small extracellular vesicles from the plasma of patients with hepatocellular carcinoma.

Purpose: Liver cancer is one of the most common tumors with the seventh-highest incidence and the third-highest mortality. Many studies have shown that small extracellular vesicles (sEVs) play an important role in liver cancer. Here, we report comprehensive signatures for sEV proteins from plasma obtained from patients with hepatocellular carcinoma (HCC), which might be valuable for the evaluation and diagnosis of HCC.

Experimental Detection and Simulation of Terahertz Spectra of Aqueous L-Arginine.

Terahertz (THz) wave is a good candidate for biological sample detection, because vibration and rotation energy levels of biomolecule are in THz band. However, the strong absorption of THz wave by water in biological samples hinders its development. In this paper, a method for direct detection of THz absorption spectra of L-arginine suspension was proposed by using a strong field THz radiation source combined with a polyethylene cell with micrometer thickness in a THz time-domain spectroscopy system.