Rational design of a series of non-centrosymmetric antiperovskite and double antiperovskite borate fluorides.

Non-centrosymmetric (NCS) compounds can exhibit many symmetry-dependent functional properties, yet their rational structure design remains a great challenge. Herein, a strategy to introduce F-centered octahedra to construct a perovskite-type framework filled by π-conjugated [BO] dimers is proposed to obtain NCS compounds. The first examples of antiperovskite or double antiperovskite borate fluorides, [(M/Ba)Ca]F[BO] (M = K, Rb) and [CsBaCa]F[BO], have been successfully designed and synthesized.

Achieving High Piezoelectric Performance Across Multidomains Design in K(Ta,Nb)O-Based Lead-free Single Crystals.

In light of environmental issues, the lead-free ferroelectric single crystal K(TaNb)O (KTN) has attracted considerable interest due to its excellent piezoelectric properties. This research focus on improving the piezoelectric performance of KTN by engineering domains through polarization in the [011] direction. The full-matrix parameters of KTN crystals after polarization along the [011] direction were determined.

CD3D silencing alleviates diabetic nephropathy via inhibition of JAK/STAT pathway.

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes that poses a significant burden to global health. This investigation aims to illustrate the functional role of CD3D and its relevant mechanisms in DN progression. The pivotal genes between the GSE47183 and GSE30528 datasets were identified using bioinformatics methods.

ACuGaS (A = Rb, Cs): Design and Synthesis of Two New Cavity-Chalcopyrite Chalcogenides Based on "Iterative Substitution" Strategy.

Two new non-centrosymmetric chalcogenides, ACuGaS (A=Rb, Cs) have been successfully synthesized by an "iterative substitution" strategy based on chalcopyrite CuFeS structural template. Benefiting from the substitution of Fe cations by Ga cations, ACuGaS (A = Rb, Cs) exhibit wide suitable band gap of 2.48 and 2.

BaGeFQ (Q = S, Se) and BaGeFSe: new F-based chalcohalides with enhanced birefringence.

Three new F-based chalcohalides, BaGeFQ (Q = S, Se) and BaGeFSe, have been successfully synthesized. On going from BaGeFSe (Δ = 0.063@1064 nm) to BaGeFQ (Q = S, Se) (Δ = 0.

Reticular chemistry-aided effective design of new second-order nonlinear optical selenites.

Noncentrosymmetric (NCS) compounds are particularly important for modern optoelectronic technology, yet their rational structural design remains a great challenge. Herein, assisted by the idea of bottom-up reticular chemistry, seven new NCS selenites, AM[SeO][SeO] (A = K/Rb/Cs; M = Al/Ga/In), have been successfully designed and synthesized by assembling main-group metal octahedral units and SeO units, to construct honeycomb layers with regular channels to accommodate a variety of cations, and using planar hexagonal shapes to orientate the groups within the network. Based on this strategy, the overall symmetry of the solid-state compounds was effectively controlled, and by modifying locally connected atoms or groups, without disrupting the overall prototypical framework, a series of iso-reticular analogues have been obtained, which greatly increases the probability of NCS structures.

KRbBPO: Design and Synthesis of a Deep-Ultraviolet Nonlinear Optical Crystal with Balanced Performance Derived from π-Conjugated and Non-π-Conjugated Groups.

A new deep-ultraviolet (DUV) nonlinear optical (NLO) material KRbBPO (KRBPO) has been designed and synthesized by adjusting the B/P molar ratio to 8:1. The KRBPO crystals were synthesized by a flux method and crystallized in noncentrosymmetric (NCS) and polar space group This compound exhibits a double-layer structure in which the A layer is composed of [BO] and [BO] units and the B layer is formed by interconnected [BO] and [BO] groups, and the two layers are connected by [PO] tetrahedron. The theoretical calculations and experiments show that the synergistic interaction of π-conjugated and non-π-conjugated units leads to relatively well-balanced NLO properties of the title compound, including moderated SHG (0.

Ae[TO][SnOQ] (Ae = Sr, Ba; T = Si, Ge; Q = S, Se) and Ba[CO][MQ] (M = Ge, Sn; Q = S, Se): Design and Syntheses of a Series of Heteroanionic Antiperovskite-Type Oxychalcogenides.

The heteroanionic materials (HAMs) have attracted more and more attention because they can better balance the functional properties of materials. However, their rational structural design is still a great challenge. Here, by using the antiperovskite BaS[GeS] as a template and calculating the tolerance factor () as a reference, eight heteroanionic oxychalcogenides with balanced properties were finally synthesized by a partially group-substitution method.

KY(BO): A Potential UV Nonlinear-Optical Crystal Designed by a Chemical Substitution Strategy.

Nonlinear-optical (NLO) crystals capable of controlling and manipulating light to generate coherent radiation at challenging wavelengths are of significant interest. However, designing a new UV NLO crystal remains difficult due to the rigid requirements for structure and properties. Herein, we have successfully designed and synthesized a novel noncentrosymmetric (NCS) rare-earth borate UV NLO crystal, KY(BO), through the heterovalence substitution of YAl(BO).

BaScBSiO: A Mixed-Coordination Borosilicate with a Low B/Si Ratio Exhibiting Enhanced Second Harmonic Generation Response.

Rational chemical substitution is an effective way to regulate structure and enrich property. Herein, a new noncentrosymmetric borosilicate, BaScBSiO, was successfully synthesized by substituting CaO units in BaCaBSiO with ScO octahedra, with comparatively strong covalency. This substitution not only effectively prevents polymerization of the B-O groups, resulting in an intriguing structural transformation from tetrahedral-coordinated borosilicate of BaCaBSiO to mixed-coordinated borosilicate BaScBSiO, but also enhances its second harmonic generation response (2 × KDP), that is nearly four times higher than its parent structure while keeping a short ultraviolet (UV) cutoff edge (λ < 190 nm).

Micheliolide ameliorates lipopolysaccharide-induced acute kidney injury through suppression of NLRP3 activation by promoting mitophagy via Nrf2/PINK1/Parkin axis.

Background: Sepsis-associated acute kidney injury (SA-AKI) represents a frequent complication of in critically ill patients. The objective of this study is to illuminate the potential protective activity of Micheliolide (MCL) and its behind mechanism against SA-AKI.

Methods: The protective potential of MCL on SA-AKI was investigated in lipopolysaccharide (LPS) treated HK2 cells and SA-AKI mice model.

Assembly of π-Conjugated [BO] Units by Mer-Isomer [YOF] Octahedra to Design a UV Nonlinear Optical Material, CsYBOF.

Achieving the extreme balance of the key performance requirements is the crucial to breakthrough the application bottleneck for nonlinear optical (NLO) materials. Herein, by assembly of the π-conjugated [BO] functional species with the aid of structure-directing property of mer-isomer [YOF] octahedra, a new ultraviolet (UV) NLO material, CsYBOF with aligned arrangement of coplanar [BO] groups has been synthesized. The polar material exhibits the rare coexistence of the largest second harmonic generation response of 5.

LaMgGaS: a chemical stable divalent lanthanide chalcogenide.

Divalent lanthanide inorganic compounds can exhibit unique electronic configurations and physicochemical properties, yet their synthesis remains a great challenge because of the weak chemical stability. To the best of our knowledge, although several lanthanide monoxides epitaxial thin films have been reported, there is no chemically stable crystalline divalent lanthanide chalcogenide synthesized up to now. Herein, by using octahedra coupling tetrahedra single/double chains to construct an octahedral crystal field, we synthesized the stable crystalline La(II)-chalcogenide, LaMgGaS.

Pb[OPb](SiO)X (X = Cl, Br): The First Pb-Containing Halogen Silicates with Mirror-Symmetric Pseudo-Aurivillius Bilayers.

Two new congruently melting Pb-containing halogen silicates, Pb[OPb](SiO)X (X = Cl, Br), have been synthesized using a high-temperature solution method. Their crystal structures were determined by single-crystal X-ray diffraction, and both compounds crystallize in the orthorhombic space group . In both structures, the mirror-symmetric bilayer composed of Pb-O polyhedra is observed for the first time in Pb-containing silicates and belongs to α-PbO derivatives and is related to the Aurivillius phase.

Efficient Single-Phase Tunable Dual-Color Luminescence with High Quantum Yield Greater than 100% for Information Encryption and LED Applications.

In modern society, the investigation of highly efficient photoluminescent bulk materials with excitation-induced tunable multicolor luminescence and multiexciton generation (MEG) is of great significance to information security and the application of optoelectronic devices. In this study, two bulk Cu-based halide crystals of (CHNO)CuBr·Br and (CHNO)CuI·I·HO, respectively, with one-dimensional structures were grown by a solvent evaporation method. Unexpectedly, (CHNO)CuI·I·HO displayed excitation-induced tunable dual-color luminescence; one band is a brilliant green-yellow emission centered at 547 nm with a high photoluminescence quantum yield (PLQY) of up to 169.

CsIn(InSe)(PSe): A Multi-Chromophore Chalcogenide with Excellent Nonlinear Optical Property Designed by Group Grafting.

Non-centrosymmetric (NCS) and polar materials capable of exhibiting many important functional properties are indispensable for electro-optical technologies, yet their rational structural design remains a significant challenge. Here, we report a "group grafting" strategy for designing the first multi-chromophore selenophosphate, CsIn(InSe)(PSe), that crystallizes in a NCS and polar space group of Cm. The structure features a unique basic building unit (BBU) [In(InSe)(PSe)], formed through "grafting [InSe] supertetrahedra on the root of [In(PSe)] groups".

Ultra-Broad-Band-Excitable Cu-Based Halide (CHN)CuI with High Stability for LED Applications.

Currently, organic-inorganic hybrid cuprous-based halides are receiving substantial attention for their eco-friendliness, distinctive structures, and outstanding photophysical properties. Nevertheless, most of the reported cuprous-based halides demand deep ultraviolet excitation with a narrow excitation range that can meet the commercial requirement. Herein, zero-dimensional (0D) cuprous-based halide (CHN)CuI single crystals (SCs) were synthesized, with an ultrabroad band excitation ranging 260-450 nm and a greenish-yellow emission band peaking at 560 nm.

Impact of different genetic mutations on granulocyte development and G-CSF responsiveness in congenital neutropenia.

Congenital neutropenia (CN) is a genetic disorder characterized by persistent or intermittent low peripheral neutrophil counts, thus increasing susceptibility to bacterial and fungal infections. Various forms of CN, caused by distinct genetic mutations, exhibit differential responses to granulocyte colony-stimulating factor (G-CSF) therapy, with the underlying mechanisms not fully understood. This study presents an in-depth comparative analysis of clinical and immunological features in 5 CN patient groups (severe congenital neutropenia [SCN]1, SCN3, cyclic neutropenia [CyN], warts, hypogammaglobulinaemia, infections and myelokathexis [WHIM], and Shwachman-Bodian-Diamond Syndrome [SBDS]) associated with mutations in ELANE, HAX1, CXCR4, and SBDS genes.