Research on computing task scheduling method for distributed heterogeneous parallel systems.

With the explosive growth of terminal devices, scheduling massive parallel task streams has become a core challenge for distributed platforms. For computing resource providers, enhancing reliability, shortening response times, and reducing costs are significant challenges, particularly in achieving energy efficiency through scheduling to realize green computing. This paper investigates the heterogeneous parallel task flow scheduling problem to minimize system energy consumption under response time constraints.

PAI-1-driven SFRP2 cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy.

The abscopal effect of radioimmunotherapy, wherein tumor shrinkage occurs beyond the irradiated field, is therapeutically promising but clinically rare. The mechanisms underlying this effect remain elusive. Here, in vivo genome-wide CRISPR screening identifies SFRP2 as a potential stromal regulator of the abscopal effect.

Enhancing Photoelectrochemical Seawater Splitting Efficiency by a Dual-Strategy Approach of W Doping and CoOOH Layer Deposition on BiVO Photoanodes.

Photoelectrochemical (PEC) seawater splitting offers a sustainable pathway for hydrogen production, yet its practical application is hindered by sluggish reaction kinetics and severe photocorrosion in chloride-rich environments. This study presents a dual-strategy modification of BiVO photoanodes through tungsten (W) doping and cobalt oxyhydroxide (CoOOH) nanolayer deposition to synergistically enhance the PEC performance and stability in natural seawater. W doping optimizes the electronic structure of BiVO by reducing the bandgap from 2.

Effects of DOM Chemodiversity on Microbial Diversity in Forest Soils on a Continental Scale.

Soil dissolved organic matter (DOM) is a critical reservoir of carbon and nutrients in forest ecosystems, playing a central role in carbon cycling and microbial community dynamics. However, the influence of DOM molecular-level diversity (chemodiversity) on microbial community diversity and spatial distribution remains poorly understood. In this study, we used Fourier transform ion cyclotron resonance mass spectrometry and high-throughput sequencing to analyze soil DOM and microbial diversity along a ~4,000 km forest transect in China.

A study on the genetic comorbidity between autoimmune diseases and pulmonary hypertension: an observational study and POST-GWAS analysis.

The causal relationship between various prevalent autoimmune diseases (ADs) and pulmonary hypertension (PH) has yet to be fully understood, and the contribution of genetic factors to their coexistence remains largely unexplored. We utilized Post-GWAS and the Medical Information Mart for Intensive Care (MIMIC) database to investigate the relationship between autoimmune diseases and PH. After a series of MR Analyses, only Type 1 diabetes Mellitus (T1DM) (OR = 1.

Development and Validation of a F-Flortaucipir PET Visual Stratification Method.

Tau PET quantitation methods have been used in research settings and clinical trials to measure tau burden for diagnostic, staging, and prognostic purposes. However, these methods require specialized software, skilled analysts, and advanced image processing. We developed a novel F-flortaucipir PET (FTP, or Tauvid) visual read method enabling stratification of patients with Alzheimer disease (AD) according to the tau level without the need for quantitation.

Efficient evaluation of osteotoxicity and mechanisms of endocrine disrupting chemicals using network toxicology and molecular docking approaches: triclosan as a model compound.

This study aimed to demonstrate the utility of a network toxicology strategy in elucidating osteotoxicity and the molecular mechanisms of endocrine-disrupting chemicals (EDCs) using triclosan exposure in postmenopausal osteoporosis (PMOP) as a case study. The potential targets of triclosan were identified using the Comparative Toxicogenomics Database, SwissTargetPrediction, and TargetNet. PMOP-related targets were obtained from GeneCards, DisGeNET, and DrugBank.

Anwulignan Alleviates Bone Cancer Pain by Modulating the PPARα/CXCR2 Signaling Pathway in the Rat Spinal Cord.

Aims: Advanced cancer patients frequently endure severe pain from bone metastases, and few effective treatments for bone cancer pain (BCP) exist. Although Anwulignan is known for its antioxidant, anti-inflammatory, and antitumor properties, its effects on BCP remain unclear. This study aims to explore the analgesic effects and mechanisms of Anwulignan on bone cancer pain.

Alternative Splicing Analysis Reveals Adrenergic Signaling as a Novel Target for Protein Arginine Methyltransferase 5 (PRMT5) in the Heart.

Adrenergic signaling is critical for maintaining cardiac function and works by regulating heart rate, contractility, and stress responses. Protein arginine methyltransferase 5 (PRMT5), a key enzyme involved in gene expression, signal transduction, and RNA processing, has been revealed to be an important factor in heart disease. However, its specific effects on adrenergic signaling have not been fully elucidated.

Donor-Π-Acceptor Self-adaptive Conjugated Perylene Derivative with Low Solubility, High Capacity, and Swift Ion Transport Kinetics for High performance Organic Cathode.

Organic perylene has been heralded as a promising candidate due to abundant structural diversity and tunability. However, its practical application is severely plagued by facile solubility, scarce redox-active sites, and andante kinetics behaviors. Herein, the perylene derivative (DPL), i.

Exploring the neurotoxic effects of cylindrospermopsin in early development of zebrafish: An integrated impact of oxidative stress, inflammatory response, and apoptosis.

The increasing global spread of cyanobacteria and their toxin Cylindrospermopsin (CYN) is a growing concern.This study aimed to examine the toxic effects of CYN on the early neurodevelopment of zebrafish, and to identify the underlying mechanisms. The findings indicated that zebrafish exposed to varying concentrations of CYN exhibited general developmental toxicity, including typical malformations, diminished embryonic movement, and shortened body length.

Deciphering the effects of long-term exposure to conventional and biodegradable microplastics on the soil microbiome.

Despite recent advances in the understanding of the impacts of microplastics (MPs) on the soil microbiome under short-term exposure, little information is known regarding the long-term ecological effects of MPs in soil, especially biodegradable MPs (BMPs). Here, we systematically compared the effects of four prevalent microplastics, including two conventional MPs (CMPs) and two BMPs, on the soil microbiome over short- and long-term exposure durations. The soil microbial community were not significantly affected by the MP addition under short-term exposure; however, the soil microbial composition was obviously impacted by MP exposure under long-term exposure, some MP-adapted microbes (e.

Insights into phosphorylation-induced influences on conformations and inhibitor binding of CDK6 through GaMD trajectory-based deep learning.

The phosphorylation of residue T177 produces a significant effect on the conformational dynamics of CDK6. Gaussian accelerated molecular dynamics (GaMD) simulations followed by deep learning (DL) are applied to explore the molecular mechanism of the phosphorylation-mediated effect on the conformational dynamics of CDK6 bound by three inhibitors 6ZV, 6ZZ and 0RS, in which 6ZV and 6ZZ have been used to test clinical performance. The DL finds that the β-sheets, αC helix as well as the T-loop are involved in obvious differences of conformation contacts and suggests that the T-loop plays a key role in the function of CDK6.

Metabolomic analyses reveal that graphene oxide alleviates nicosulfuron toxicity in sweet corn.

Nicosulfuron can repress the growth and quality of sweet corn (), and graphene oxide has been used for sustainable agriculture. However, the underlying mechanism of the toxicity of nicosulfuron that is mediated in sweet corn remains elusive. To explore the potential mechanism of GO-mediated nicosulfuron toxicity in sweet corn in this study, we investigated the effects of graphene oxide on nicosulfuron stress in the sweet corn sister inbred lines of H01 and H20.

Targeted long-read sequencing facilitates effective carrier screening for complex monogenic diseases including spinal muscular atrophy, α-/β-thalassemia, 21-hydroxylase deficiency, and fragile-X syndrome.

Background: Next-generation sequencing (NGS) has been applied for carrier screening, effectively reducing the incidence of severe diseases. However, some severe, high-prevalent and complex diseases, including spinal muscular atrophy (SMA), α-/β-thalassemia, 21-hydroxylase deficiency (21-OHD), and fragile-X syndrome (FXS), cannot be fully addressed by NGS, resulting in a high residual risk ratio. This study aims to evaluate the clinical utility of a long-read sequencing (LRS) panel for carrier screening of these five complex diseases.

Mitochondria-targeted nanovesicles for ursodeoxycholic acid delivery to combat neurodegeneration by ameliorating mitochondrial dysfunction.

Mitochondria are pivotal in sustaining oxidative balance and metabolic activity within neurons. It is well-established that mitochondrial dysfunction constitutes a fundamental pathogenic mechanism in neurodegeneration, especially in the context of Parkinson's disease (PD), this represents a promising target for therapeutic intervention. Ursodeoxycholic acid (UDCA), a clinical drug used for liver disease, possesses antioxidant and mitochondrial repair properties.

Hydroxyethyl Cellulose as Water-Soluble Co-Binder for High Mass Loading LiNi0.5Mn1.5O4 Lithium-Ion Battery Cathodes.

Combining high-voltage cobalt-free LiNi0.5Mn1.5O4 (LNMO) with fluorine-free water-soluble binders holds the promise of achieving more sustainable and environment-friendly lithium-ion batteries (LIBs).

Expert consensus on clinical genome sequencing interpretation and reporting.

Genome sequencing (GS) refers to a technology that comprehensively and systematically detects the DNA sequences of an individual's nuclear and mitochondrial genomes. It aims to identify genetic variants and investigate their roles in human health and disease progression. As an emerging diagnostic tool, GS offers significant support for clinical diagnosis due to its high throughput, accuracy, and comprehensiveness.

Research on path planning of mobile robots based on improved A algorithm.

To address the issues of low search efficiency, excessive node expansion, and the presence of redundant nodes in the traditional A* algorithm, this article proposes an improved A* algorithm for mobile robot path planning. Firstly, a multi-neighborhood hybrid search method is introduced, optimizing the traditional eight-neighborhood and twenty-four-neighborhood into a new sixteen-neighborhood. The choice between eight-neighborhood search and sixteen-neighborhood search is determined based on the presence of obstacles in the eight-neighborhood around the current node, effectively enhancing the search efficiency of the algorithm and reducing the number of nodes expanded during the search process.

Modified protocol for pterygium surgery without blades and electrocoagulation.

Purpose: To evaluate the efficacy, safety, and outcomes of a blade- and cautery-free surgical protocol for pterygium removal.

Methods: Pterygium removal surgery was done in 69 eyes (67 patients; 24 males and 43 females) who were followed up for at least 6 months. The surgery was characterized by blunt separation of the pterygium from the head to the limbal arc using the tip of Vannas scissors and modified procedures, such as transpositional flapping and suture closure.

Distinct airway mycobiome signature in patients with pulmonary hypertension and subgroups.

Background: The association between lung microbiome and pulmonary hypertension (PH) remain unknown. This study aims to define the airway mycobiome signature and its potential correlation with clinical parameters of PH.

Methods: Overall, 244 patients with PH and 120 healthy controls (CON) were recruited from three independent centers.

Hippocampal Sclerosis: A Review on Current Research Status and Its Mechanisms.

Hippocampal sclerosis (HS) is a pathological condition characterized by significant loss of hippocampal neurons and gliosis. This condition represents the most common neuropathological change observed in patients with temporal lobe epilepsy (TLE) and is also found in aging individuals. TLE related to HS is the most prevalent type of drug-resistant epilepsy in adults, and its underlying mechanisms are not yet fully understood.

Non-methane hydrocarbons in the continental seas of China: Spatiotemporal variability, controlling factors, and environmental effects.

Coastal regions, as hotspots for non-methane hydrocarbons (NMHCs) emissions, warrant more consideration for their vital impacts on marine climate regulation. This study examined the spatiotemporal distributions, emissions, and environmental effects of NMHCs in the Bohai Sea (BS) and Yellow Sea (YS) during summer and winter. The NMHC concentrations show clear spatial and seasonal variability, with higher levels observed in summer.

Power-free knee rehabilitation robot for home-based isokinetic training.

Robot-assisted isokinetic training has been widely adopted for knee rehabilitation. However, existing rehabilitation facilities are often heavy, bulky, and extremely energy-consuming, which limits the rehabilitation opportunities only at designated hospitals. In this study, we introduce a highly integrated and lightweight (52 kg) knee rehabilitation robot that can provide home-based isokinetic training without external power.