The KSR1/MEK/ERK signaling pathway promotes the progression of intrauterine adhesions.

Ras kinase suppressor 1 (KSR1) serves as a scaffold protein within the RAS-RAF pathway and plays a role in tumorigenesis, immune regulation, cell proliferation, and apoptosis. However, the specific role of KSR1 in the formation and progression of fibrotic diseases, such as intrauterine adhesions (IUA), remains unclear. This study aims to investigate KSR1 expression in IUA and the mechanisms underlying its role in promoting IUA progression.

Platelet-rich fibrin promotes mesothelial cell proliferation and peritoneal repair by up-regulating calretinin to prevent postoperative intestinal adhesion.

As the most common postoperative complication, intestinal adhesions can cause intestinal obstruction, female infertility, and even endanger life. The currently developed materials for preventing intestinal adhesions mainly focus on physical barriers and reducing inflammatory reactions, while neglecting the importance of effectively promoting rapid repair of the peritoneum. We previously found that platelet-rich fibrin (PRF) can prevent postoperative intestinal adhesions.

Ratiometric electrochemiluminescence biosensor based on red blood cell membrane as an efficient antifouling interface for ultrasensitive analysis of circulating tumor cells in human serum.

Electrochemiluminescence (ECL) biosensors are suitable for trace detection of serum biomarkers due to their high sensitivity and rapid response. However, human serum contains many interfering biomolecules that affect the output signals and operating life of biosensors. On this basis, a highly bioactive ECL sensing platform based on red blood cell membrane (RBCM) as an antifouling interface was developed for sensitive and accurate detection of circulating tumor cells (CTCs).

The Relationship Between Social Anxiety and Depression Among Rural High School Adolescents: The Mediating Role of Social Comparison and Social Support.

: This study aimed to explore the impact of social anxiety on depression among high school students and examine the parallel mediating roles of social comparison and social support. : A total of 806 rural high school students were surveyed using the Short Mood and Feelings Questionnaire, the Social Phobia Inventory, the Chinese version of the Social Comparison Orientation Scale, and the Multidimensional Scale of Perceived Social Support. : Social anxiety and social comparison were significantly and positively correlated with depression, while social support exhibited a significant negative correlation with depression.

Quercetin-derived carbon dots promote proliferation and migration of Schwann cells and enhance neurite outgrowth.

Quercetin, a flavonoid known for its antioxidant properties, has recently garnered attention as a potential neuroprotective agent for treatment of the injured nervous system. The repair of peripheral nerve injuries hinges on the proliferation and migration of Schwann cells, which play a crucial role in supporting axonal growth and myelination. In this study we synthesized Quercetin-derived carbon dots (QCDs) and investigated their effects on cultured Schwann cells and the NG108-15 cell line.

Neutrophils-mediated accelerated blood clearance phenomenon in beagles and rats based on the cross-injection of non-PEGylated and PEGylated nanoemulsions.

The initial injection of PEGylated nanoparticles can activate antibodies and the complement system, leading to the accelerated blood clearance (ABC) phenomenon, characterized by reduced circulation time and abnormal liver and spleen accumulation upon re-exposure. However, PEGylation is not essential for ABC induction, as non-PEGylated nanoparticles can also trigger the similar ABC phenomenon. In this study, we found non-PEGylated nanoemulsions (CE) could accelerate the blood clearance of subsequent injection of PEGylated nanoemulsions (PE) in beagles and rats, which was independent of antibodies and the complement system, but was associated with an increase in neutrophil numbers and phagocytic activity.

Composition and diversity of rumen mycobiota in Jiani yaks ( jiani): insights into microbial ecology and functions.

This study aimed to explore the diversity and functions of rumen mycobiota in 14‑ (PLf) and 15‑rib (DLf) Jiani yaks using ITS sequencing. A total of 1,079,105 and 1,086,799 filtered sequences were obtained for the PLf and DLf groups, respectively, with 491 ASVs common to both. No significant difference regarding the α‑diversity of mycobiota within the two groups was observed.

Improving dietary energy and antioxidative properties benefit early maternal BMI and further manage adverse pregnancy outcomes with better weight gain.

Dietary characteristics affect maternal status in early pregnancy, which is important for later outcomes. However, Chinese dietary guidelines for pregnant women are not specific to obesity, overweight, and underweight. Moreover, since pregnancy is a prolonged process, an intermediate factor is needed to connect early maternal BMI with pregnancy outcomes.

A rare case of rib chondrosarcoma with purely mesenchymal cells metastases to thyroid.

Metastasis to the thyroid gland is uncommon. The most common malignant tumors that metastasize to the thyroid gland include renal cell carcinoma, colorectal cancer, lung cancer, and breast cancer. Metastasis of chondrosarcoma to thyroid is extremely rare.

Involvement of disulfidptosis in the pathophysiology of autism spectrum disorder.

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, with oxidative stress recognized as a key pathogenic mechanisms. Oxidative stress disrupts intracellular dynamic- thiol/disulfide homeostasis (DTDH), potentially leading to disulfidptosis, a newly identified cell death mechanism. While studies suggest a link between DTDH and ASD, direct evidence implicating disulfidptosis in ASD pathogenesis remains limited.

A deep learning approach to understanding controlled ovarian stimulation and in vitro fertilization dynamics.

Infertility, recognized by the World Health Organization (WHO) as a disease affecting the male or female reproductive system, presents a global challenge due to its impact on one in six individuals worldwide. Given the high prevalence of infertility and the limited available resources in fertility care, infertility creates substantial obstacles to reproductive autonomy and places a considerable burden on fertility care providers. While existing research are exploring to use artificial intelligence (AI) methods to assist fertility care providers in managing in vitro fertilization (IVF) cycles, these attempts fail in accurately predicting specific aspects such as medication dosage and intermediate ovarian responses during controlled ovarian stimulation (COS) within IVF cycles.

[Determination of 17 perfluorinated/polyfluoroalkyl compounds in serum by high-throughput solid-phase extraction-ultra-high performance liquid chromatography-tandem mass spectrometry].

Perfluorinated/polyfluoroalkyl compounds (PFASs) are a group of synthetic chemicals. Since the 1940s, PFASs have been widely used in industrial and daily consumer fields. PFASs can enter the human body through various pathways, such as drinking water, food, and air.

A Systemic Review and Meta-Analysis of the Risk of Venous Thromboembolic Events in Parkinson's Patients.

Introduction: Parkinson's disease (PD) is a common neurodegenerative disorder affecting more than 10 million people worldwide. The actual prevalence and relative risk of venous thromboembolism (VTE) in PD have not been systematically examined, especially in various study designs and surgical settings. To address this gap in knowledge, we conducted a meta-analysis on the risk of VTE and in PD.

Variant and Infectious Burden Associated With Intracranial Artery Stenosis in Moyamoya Disease.

Background: The mechanisms driving the progression of moyamoya disease (MMD) remain unrecognized. There is evidence suggesting that genetic and environmental factors may be associated with intracranial artery stenosis. Here, we aimed to investigate the characteristics of infectious exposure and the association of the (RING finger protein 213) variant and infectious burden (IB) with intracranial artery stenosis of MMD.

Barriers to implementation of preoperative urostomy site marking in nurse-physician cooperation: A qualitative study based on the Theoretical Domains Framework.

Objective: This study aimed to understand the barriers to nurse-physician collaboration in implementing preoperative stoma site marking using qualitative research methods following Theoretical Domain Framework.

Methods: A qualitative descriptive study using semi-structured interviews was conducted from March to June 2023 in the urology departments of nine tertiary hospitals in China. Twelve urologists and eight enterostomal therapists (ETs) were recruited using purposive sampling.

A medium bandgap dimeric acceptor with a high open-circuit voltage for efficient organic solar cells.

Dimeric acceptors (DMAs) exhibit significant potential for optimizing both the efficiency and stability of organic solar cells (OSCs). However, medium band-gap DMAs with a high open-circuit voltage () for efficient OSCs remain underexplored. In this study, we designed and synthesized a medium bandgap dimeric acceptor, designated DYO-1, through the strategy of alkoxy side-chain substitutions.

White-Matter fiber tract and resting-state functional connectivity abnormalities in young children with autism spectrum disorder.

Autism spectrum disorder (ASD) is a complex developmental disorder characterized by difficulties in social interaction and communication and repetitive behaviors. Although abnormal brain development has been shown to exist in children with ASD, the link between structural brain abnormalities and resting-state functional connectivity (rsFC) disruptions in children with ASD remains understudied. To address this limitation, we utilized the population-based bundle-to-region connectome, providing a detailed understanding of the connectivity between cortical regions and white matter (WM) tracts.

A retrospective study of risk factors for thrombosis in patients with ITP.

Objectives: ITP is not only a bleeding disease but also a potential thrombotic disease.

Methods: This retrospective study analyzed the factors associated with the occurrence of thrombosis events in ITP patients.

Results: The overall incidence of thrombosis was 4.

Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes.

Objective: To assess whether trigger-day progesterone (P) levels in conventional fertilization (c-IVF)/intracytoplasmic sperm injection (ICSI) cycles are associated with blastocyst culture outcomes.

Methods: In this retrospective analysis, 747 eligible patients (747 cycles) who adopted the gonadotropin-releasing hormone (GnRH) antagonist protocol and underwent c-IVF/ICSI between January 2021 to June 2024 were recruited. The P cutoff values were 1.

Interface Phenomena in Molecular Junctions through Noncovalent Interactions.

Noncovalent interactions, both between molecules and at the molecule-electrode interfaces, play essential roles in enabling dynamic and reversible molecular behaviors, including self-assembly, recognition, and various functional properties. In macroscopic ensemble systems, these interfacial phenomena often exhibit emergent properties that arise from the synergistic interplay of multiple noncovalent interactions. However, at the single-molecule scale, precisely distinguishing, characterizing, and controlling individual noncovalent interactions remains a significant challenge.

A Two-Stage Location-Allocation Optimization Method for Fixed UAV Nests in Power Inspection Considering Node Failure Scenarios.

This paper explores the configuration and deployment of UAV nests for power inspection operations, focusing on potential nest failures. It proposes a two-stage location-allocation method. The problem is divided into two subproblems, each modeled as an integer linear programming (ILP) problem.